Doctor insights on:
Itp Foods To Avoid
Agg. Systemic mastocytosis. This mean my anaphylaxis food/drug allergies will now end since on Cromolyn? Could ITP dx be part of ASM or can have both?
No, and No: Cromolyn will not end probability of anaphylaxis, and if it happens needs to be treated, ITP isn't part of the disease, yes a patient can have both as separate diseases, aggressive severe mastocytosis is a rare disease, much rare than systemic mastocytosis, which is already a rare disease, diagnosis / management need to be in a tertiary care facility, need to adhere to treatment well & follow up ...Read more
ITP: Thrombocytopenia or low platelet level can be caused by so many things such as drugs, platelet consumption by clots, infections, vitamin deficiency, cancer related etc. Your doctor has to rule out all those possibilities and ultimately to do a bone marrow biopsy to eval bone marrow. See your md and discuss further re-diagnosis approach/treatment and other things you need to know re - itp. ...Read more
Symptom: Most of the time itp patients are asymptomatic and the only abnormality they have is the low platelet level on their blood counts. They can have bruising, tiny red dots on the skin, roof of the mouth etc- (ptechiae) or other type of bleeding such as bleeding in the gum, only if platelet level goes down really low-below 30k or so. ...Read more
Oral steroids: Idiopathic thrombocytopenic purpura is a condition in which autoimmune antibodies against platelets causes an increased rate of destruction. Platelets are needed for normal blood clotting. Heavy periods, nose bleeding, easy brusing, and a rash (purpura) may suggest this problem. Diagnosis requires a blood count and blood clottting studies. Treatment begins with steroids (prednisone). ...Read more
In the old days....: The "i" in itp stood for idiopathic, which means we didn't know what was causing the problem. We now know this to be an autoimmune process where antibodies recognize proteins on the surface of platelets and target them for destruction by the reticuloendothelial system. Most cases follow an infection (usually viral), but they can also be the presenting feature of autoimmune disorders or malignancy. ...Read more
In most cases, itp in children resolves on its own. Your child’s blood may be tested weekly or at longer intervals until the platelet count has returned to normal.
Treatment may be recommended based upon the platelet count, age of the patient, activity level and bleeding symptoms. When treatment is recommended, it may involve the following medications that help keep platelet counts at a safe leve. ...Read more
Bruising, bleeding: People with itp may be at an increased risk of bruising or bleeding, depending on the platelet count and other factors, such as medications. If needed, itp can be treated with steroids or other medications. In some instances, removing the spleen (splenectomy) may be recommended. If you are to require surgery, the surgeon should be made aware of this condition. ...Read more
Good question: What treatments have you had? The medical treatments have typically included steroids, other immunosuppressive medications, rituximab. These medications do not always work, and sometimes they only work temporarily. The main surgical treatment is splenectomy. This does not always work either. The goal is to keep you platelets high enough so that you are not having frequent bleeding. Good luck. ...Read more
Probably not: The risks are (1) heavy bleeding during delivery and with epesiotomy or ceaserean section and (2) maternal antibodies against platelets crossing the placenta and affecting your newborn's platelet count. These are issues best discussed with your ob/gyn and hematologist. For more information try http://www. Mayoclinic. Com/health/idiopathic-thrombocytopenic-purpura/ds00844/dsection=complications. ...Read more
No: Both itp and ttp are diseases in which blood platelet counts fall however, itp typically leads to an increased risk for bleeding but ttp results in blood clot formation in small blood vessels. These clots can damage the kidneys or cause stroke. Both diseases can be treated with plasmaphoresis, a procedure in which anti-platelet antibodies can be removed from the blood (a temporary measure). ...Read more
Can be, but rare: Most people w/ treated itp can expect to live a normal life span. Platelets help the blood clot, so a person w/ extremely low platelets (due to immune system attack in itp) can have fatal bleeding esp in the brain. However, this happens <1% of the time. Your doctor will monitor your platelets, and there are many treatments for itp such as Prednisone that can help maintain a good platelet count. ...Read more
Most patients are able to recover platelet counts and have a mortality rate similar to the general population. For more details see this link.
http://bloodjournal. Hematologylibrary. Org/content/97/9/2549.long. ...Read more
Autoimmune disease: Idiopathic thrombocytopenic purpura (itp) is an autoimmune disease. In this potentially life-threatening disorder self antibodies directed against platelets result in low levels of platelets in the blood. Platelets are necessary for effective blood clotting. People with itp can die from loss of blood after trauma of from a brain hemorrhage. Death is not a psychosomatic disease. ...Read more
It's very rare, but: Does happen. If ones platelet count fall to low enough, spontaneous bleeding can occur. Head bleeds, for example, can be both spontaneous and life-threatening. That being said, the plts that a person with itp does have tend to be more thrombofenic because they are "younger". This helps to mitigate the consequences of low PLT count. Your dr. Can give you additional info. Good luck. ...Read more
Response rate 20-30%: Recent review in blood in may 2012 looked at several articles and found a 5-year response rate in adults to be around 26%. Meaning these patients had a sustained elevation of their platelet count for 5 years. Initially the response rate is close to 60%. It is given weekly for 4 weeks. So in summary, it works well. Hope this helps. ...Read more
Bleeding: You should seek medical care when you notice an increase in the frequency or severity of bruising or bleeding. It does not necessarily require a visit to an emergency room, but you should at least contact your hematologist. ...Read more
What are the possible causes of both ITP & Bernard-Soulier Syndrome in a person? What effect, if any, do they have together? Thanks for your input.
Platelet troubles: Bernard-Soulier features a small number of large platelets, lifelong and without autimmunity being a factor. In ITP, the immune system destroys platelets and those that remain are often quite large. It's possible that you have only one of these, as both feature a diminished number of platelets and increased platelet size. Get a review by a good up-to-date hematologist. ...Read more