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Doctor insights on: Itching Kidney Failure Multiple Myeloma

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Dr. Lonnie Smith
124 doctors shared insights

Kahler Disease (Definition)

I had not heard of "kahler's disease" until seeing multiple questions on healthtap. It is multiple myeloma (mm). "multiple" is from the often seen "multiple" bone lesions (especially in advanced disease). Mm is a cancer of plasma cells [highly specialized b white blood cells (lymphocytes)] that produce antibodies. Sx are crab: hypercalcemia, renal insufficency, anemia, ...Read more


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How will my doctor know if I have multiple myeloma? 

Labs, xrays: There are a series of blood and urine tests that will give the doctor a good idea if you have the disease. These are usually followed by x-rays looking for tell-tale signs of myeloma and a bone marrow test which would identify the cancer cells themselves. ...Read more

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My brother (51) is in the final stages of multiple myeloma and was told he will die of kidney failure. Blood tranfusions weekly. Timeline estimate?

My brother (51) is in the final stages of multiple myeloma and was told he will die of  kidney failure. Blood tranfusions weekly. Timeline estimate?

Get extra support: Agree with prior answer that difficult to say. If not already involved ask for a palliative medicine specialist to work with your hematology-oncology team. They might be able to provide additional prognostication opinions as they monitor his progress and also provide additional support for the time that he has. ...Read more

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Kidney biopsy shows the reason for kidney failure is multiple myeloma. No bone damage, hemo. More than 12. Will kimo therapy help to recover fully?

Seek opinion from a: This is unusual way to make a diagnosis of multiple myeloma(mm). Typically we need to do a bone marrow biopsy and look for cancer cells in the marrow. These cells produce abnormal proteins(m protein) which will show up either in the blood(commonly) or in the urine. We use a test called protein electrophoresis. If these tests have not been done, seek a second opinion. Chemo will help to control mm. ...Read more

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How does multiple myeloma affect the kidney?

How does multiple myeloma affect the kidney?

Nephropathy: Myeloma produces proteins called light chains which can essentially "clog up" the kidney producing myeloma nephropathy. Myeloma also produces humoral substances which can damage the kidney. ...Read more

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What is the current prognosis of african american women with multiple myeloma with renal failure?

What is the current prognosis of african american women with multiple myeloma with renal failure?

Depends: This can best be answered by your treating physician. It often depends on age, other medical disorders, previous treatments, response to velcade (bortezomib). Most patients will have improvement in renal failure if this is the first treatment they receive, and the treatment usually includes velcade (bortezomib). ...Read more

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Why sickle cell anemeia / multiple myeloma cause diabetes insipidus ? Is it because it may obstruct the blood flow to the kidneys and damage them?

Why sickle cell anemeia / multiple myeloma cause diabetes insipidus ? Is it because it may obstruct the blood flow to the kidneys and damage them?

Basically right: Even sickle cell trait ruins much of the concentrating ability of the kidneys by adulthood. Myeloma is more likely to damage and obstruct the tubules themselves. Both produce a kidney lesion that prevents the urine from becoming concentrated, rather than a pituitary diabetes insipidus. ...Read more

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I have Multiple Myeloma & I'm hypocellular I have been offered steroid injection for pain is it safe?

I have Multiple Myeloma & I'm hypocellular I have been offered steroid injection for pain is it safe?

Steroid is treatment: Steroids are part of the standard treatment of myeloma. Usually the steroid (typically dexamethasone) is administered with another agent. It is usually administered by mouth. It's not clear what your pain is or what kind of injection is proposed. ...Read more

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M54, if m protein is high, no mark on x ray, blood count normal. Does this means no multiple myeloma.

It depends on severa: Besides m protein level, a bone marrow eaxmination is required to determine the plasma cell number/count. If the bone marrow does not have more than 10% plasma cells, then it is not a myeloma, which usually has lots of plasma cells in the bone marrow. ...Read more

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I'm suffering from seizures after stopping thalidomide. I've used other to stop them but they won't go away. A Multiple Myeloma patient ?

I'm suffering from seizures after stopping thalidomide. I've used other to stop them but they won't go away. A Multiple Myeloma patient 
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? Relationship.: Thalidomide has neurological side effects but is not commonly thought to cause seizures. In fact, early studies suggested thalidomide might have anti-seizure activity. Myeloma does not commonly cause seizures either, although it might contribute to seizures if it causes electrolyte abnormalities or a skull tumor involves the surface of the brain. Work with your doc to evaluate and treat seizure ...Read more

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How much does it cost to cure "Multiple Myeloma" and is there any permenant cure?

Multiple Myeloma: While there is no defined "cure" for multiple myeloma, chemotherapy and autologous stem cell transplants have been shown to cause remission in many cases. With regard to cost, chemotherapy is expensive if paying cash and autologous stem cell transplant may cost over 100K, so it is important to check with insurance providers regarding this. ...Read more

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My grandmother is suffering from multiple myeloma. What is the process to treat this?

Consult a Oncologist: An oncologist or blood specialist can treat her multiple myeloma. We have many new drugs that can control myeloma. Most of it is chemotherapy drugs but they are easy to tolerate and can add several years to her life if she responds to chemo well. Good luck. ...Read more

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What is the life expectancy of people with multiple myeloma?

Much better now: With all the new targeted drugs for myeloma and several to come, patients live many more years. Some have said this cancer is now more like a chronic disease - still dangerous and needing treatment but it is characterized by longer periods of remission after treatment. Therefore a 65 or 75 year old person may have a normal life span with this disease now. ...Read more

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What percentage of patients with multiple myeloma will survive?

It depends: Survival in myeloma depends on a number of factors. First, is stage. Second is chromosomal abnormalities. Some have a good prognosis, others not so good. In general we think that myeloma is not usually curable with standard therapies, but survival is getting better with our newer agents, so that living 10 years is not unusual. Cure may be possible with allogeneic bone marrow transplant. ...Read more

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Are myelofibrosis and multiple myeloma are related to each other?

No: They are totally different diseases. Myeloma is a malignancy that develops in a type of blood cell called a plasma cell. Myelofibrosis is a disease of the bone marrow microenvironment. ...Read more

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My grandmother is suffering from multiple myeloma, what is the best cure for this?

There is treatment f: There is good treatment available for controlling myeloma. Go seek advice from a specialist(called hematologist). Most multiple myeloma patients do well for 5-10 years when treated by an experienced hematologist. ...Read more

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My father was just diagnosed with multiple myeloma. What is this?

Plasma cell cancer: From the National Cancer Institute --> What You Need To Know Aboutâ„¢ - What is Multiple #Myeloma - via @theNCI http://ow.ly/o7CJR #mmsm and Snapshot: http://ow.ly/ungNs ...Read more

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What is the life expectancy of people with multiple myeloma and lcdd?

Depends on heart: The light chain deposition disease is unlikely to affect survival. In fact a review of myeloma and kidney failure published last year demonstrated no change in outcome in myeloma patients with or without kidney failure. The biggest predictor of outcome is response to chemotherapy. Velcade (bortezomib) (new chemo) has been a game changer. In addition, patients with cardiac involvement do very poorly. ...Read more

Kidney (Definition)

The kidneys are paired organs that lie on either side of the vertebral column. Part of their critical functions include the excretion of urine and removal of nitrogenous wastes products from the blood. They regulate acid-base, electrolyte, fluid balance and blood pressure. Through hormonal signals, the kidneys control the ...Read more


Dr. Tarek Naguib
595 doctors shared insights

Kidney Failure (Definition)

A condition in which your kidneys suddenly stop working normally. Since your kidneys remove waste products and help balance water and salt and other minerals (electrolytes) in your blood, when your kidneys stop working, waste products, fluids, and electrolytes build up in your body. This can cause problems ...Read more