Doctor insights on:
Isordil Titradose Medication
Isordil (isosorbide dinitrate): How do you know you are tolerant to the drug? ...Read more
In a patient with migraines, will their frequency increase if the patient takes isordil (isosorbide dinitrate)?
Isordil (isosorbide dinitrate) & Headaches: Isordil is nitroglycerine, a vasodilator for the heart( seldom other) which can cause headaches. It is dose dependent, the higher the most likely headache. You may take tylenol (acetaminophen) for it. If your migraines get worst talk to the cardiologist about it. ...Read moreSee 2 more doctor answers
Is isordil (isosorbide dinitrate) for chest pressure contraindicated in patients with constrictive pericarditis?
Isosorbide dinitrate: "Allergic reactions to organic nitrates are extremely rare, but they do occur. The isosorbide dinitrate tablet is contraindicated in patients who are allergic to ISDN or any of its other ingredients." See: http://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=8bb91825-b63e-44aa-8edd-4326823f3009 ...Read more
RU in the UK?: Isoket spray is not available in the usa . It's a form of Nitroglycerin and it's used under the tongue for rapid relief of angina spells. In the usa, we use Nitroglycerin as a tablet or a spray and we use Isosorbide Dinitrate tablets for longer lasting relief/prophylaxis of angina. ...Read more
Supply and demand: Angina is caused by heart muscle not getting enough blood to meet its needs, think supply vs demand. By relaxing smooth muscle in the walls of coronary arteries, nitrates increase blood flow. They also dilate the body's veins, so less blood returns to the heart, and the heart walls are less stretched outwards. This reduces tension on the heart wall muscle, and hence demand for oxygen/blood. ...Read moreSee 1 more doctor answer
How long they last: The main difference is how long they last. Most dinitrate products are designed to be taken at least 2 x a day where as most of the mononitrate products once a day. They both are quite effective at controlling angina when appropriately prescribed. Some side effects thought a bit less with mono v. Di, but that varies a lot from person to person. ...Read more
A-HEFT Trial: A large trial looked at the combination of hydralazien and Isordil (isosorbide dinitrate) with african american patients and showed a benefit of improving heart failure status, on top of standard medical therapy. It is thought to be believed due to lack of Nitric Oxide delivery to endothelium in african americans, that is improved by this therapy. Blood pressure tends to be higher in the first place, which improves. ...Read more