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Doctor insights on: Ischemic White Matter Disease

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Dr. Ward Dean
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White Matter (Definition)

White matter is one of the two components of the central nervous system and consists of glial cells and myelinated axons that transmit signals from one region of the cerebrum to another and between the cerebrum and lower brain centers. White matter tissue of the freshly cut brain appears pinkish white to the naked eye because myelin is composed largely of lipid ...Read more


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What is chronic white matter ischemic disease?

What is chronic white matter ischemic disease?

Lack of blood deep : In the brain. This condition is most commonly seen in individuals with one or all of the following: 1. Hypertension 2. Diabetes 3. Hyperlipidemia (high cholesterol) 4. Cigarette smoking 5. Family history of stroke of course there are others but these are most important. Please meet with your neurologist to discuss why and what you can do to help your situation. Good luck and well wishes. ...Read more

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Dr. Ward Dean
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I recently had an MRI of the brain. The results where as follows mild atrophy and mild periventricular white matter ischemic small vessel disease. Wh?

I recently had an MRI of the brain. The results where as follows mild atrophy and mild periventricular white matter ischemic small vessel disease.  Wh?

Arteriosclerosis : You are taking hydrocodone, tramadol & Lyrica for nagging pain plus Ambien for sleep and Buspirone for anxiety. Combination is heavy stuff. Had migraine but not any more? Microvascular disease is the blockage of tiny vessels-arteriosclerosis. These can happen in heart & kidney as well. Check your lipid profile and possible use of statin. For headache & reevaluation of all your meds see neurologist. ...Read more

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What is chronic periventricular white matter microvascular ischemic disease?

What is chronic periventricular white matter microvascular ischemic disease?

Patchy insulation: Chronic means this process has been going on for years in the brain. White matter is the part of the brain where the "communication cables" are, and they are "white" because of myelin insulation. The ventricles are fluid-filled "shock absorber" spaces inside the brain. Ischemic means they have been deprived oxygen, microvascular means in tiny blood vessels. Mini-stroke strips off some insulation. ...Read more

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Dr. Ward Dean
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37 years in practice
802K people helped
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Can ischemic small vessel disease cause gliosis? How would ischemic small vessel disease be treated in a minimal area of white matter in the brain?

Can ischemic small vessel disease cause gliosis?  How would ischemic small vessel disease be treated in a minimal area of white matter in the brain?

Yes.: White matter changes frequently seen on brain MRI are the result of chronic small vessel ischemic disaease and it is the resulting small focus of gliosis that shows on the MRI imaging. Treating your underlying cardiovascular heath is key, not the MRI finding. ...Read more

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Dad, 66, is affected with "chronic ischemic changes in periventri white matter" and "disprop prominence of ventri system c/p to cortical sulci" cure?

Dad, 66, is affected with "chronic ischemic changes in periventri white matter" and "disprop prominence of ventri system c/p to cortical sulci" cure?

Chronic ischemia: What you are seeing on the mr are common aging changes seen on mr. As for a "cure" being available, not at the moment and likely years before any solution. ...Read more

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What is mild chronic ischemic changes in bilateral periventricular white matter?

What is mild chronic ischemic changes in bilateral periventricular white matter?

Described often: Presume on mri, white matter lesions as noted, which are usually nonspecific, but can be associated with hypertension, diabetes, or high blood fats causing "hardening of the arteries" (aka, microvascular angiopathy). This pattern might be consistent with ms in some cases, so needs correlation for relevance. Not a description of stroke, but an indication for prevention of future stroke. ...Read more

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What is mild chronic ischemic changes in bilateral frontal periventricular white matter?

What is mild chronic ischemic changes in bilateral frontal periventricular white matter?

Nonspecific WM: Nonspecific periventricular white matter changes- These are normally small spots without clinical relevance. They are more common for people with high blood pressure, diabetes, head injuries or in people who smoke. They do not have a defined clinical meaning. ...Read more

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Mri report says morphology says in favour of smallt2 and flair hyperintensefoci in bilateral frontal white matter-? Ischemic/? Significant

Mri report says morphology says in favour of smallt2 and flair hyperintensefoci in bilateral frontal white matter-? Ischemic/? Significant

Usually not: This is a very common finding on mris of the brain. Typically it is not significant. However, if you are experiencing neurological symptoms these foci may represent something more sinister and you should see your doctor. ...Read more

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Dr. Ward Dean
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37 years in practice
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