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Doctor insights on: Is Zoloft The Most Effective Medication For Anxiety And Depression

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Is Zoloft (sertraline) the most effective medication for anxiety and depression?

Is Zoloft (sertraline) the most effective medication for anxiety and depression?

One of several: Zoloft (sertraline) is an effective drug for treating anxiety and depression. Other drugs in its class (ssris) are also effective for these conditions. The most effective drug is the one you tolerate which works.

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Dr. Pamela Pappas
4,578 Doctors shared insights

Depression (Definition)

Depression is a mood disorder that can affect behavior and emotions. Symptoms of depression include feeling down most of the time, losing interest in previously enjoyable activities, increase or decrease in appetite or weight, sleeping more or less, becoming easily agitated or lethargic, feeling worthless, feeling guilty, having difficulty concentrating, thinking more about death and dying. Depression can sometimes result in suicidal thoughts and plans. In this case, emergent ...Read more


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Zoloft 100mg helped anxiety but not depression, Effexor (venlafaxine) 150mg helped depression but not anxiety. Is there a medication that will help both?

Zoloft 100mg helped anxiety but not depression, Effexor (venlafaxine) 150mg helped depression but not anxiety. Is there a medication that will help both?

Both can help: Both meds can treat anxiety and depression. My suggestion is to work with your prescriber to try a higher dose of either med to see if one can treat both. Although, generally not recommended I have combined these two meds for the reason you stated. I sometimes find doses of Effexor (venlafaxine) above 150mg cause more anxiety. An alternative idea might be to add buproprion to Zoloft adjusting each.

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What can I do if I take Zoloft is good for my depression not good for anxiety Cymbalta (duloxetine) good fo anxiety not depression? I tried lots of medication

What can I do if I take Zoloft is good for my depression not good for anxiety Cymbalta (duloxetine) good fo anxiety not depression? I tried lots of medication

Both: You can take them both together, providing you tolerate it. They kind of work differently, and unlikely to cause any major drug interactions. ONe is a so called ssri (zoloft) which increases serotonin, and the other SNRI (cymbalta) which increases norepinephrine.

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Zoloft 100mg helped anxiety, Effexor (venlafaxine) 150mg helped depression. Is there a medication that will do both? With minimal sexual side effects?

Zoloft 100mg helped anxiety, Effexor (venlafaxine) 150mg helped depression. Is there a medication that will do both? With minimal sexual side effects?

Mood TX risk/benefit: There are a couple of antidepressants that might help: a new one is Brintellix which has a good side effect profile with little sexual dysfunction reported. Older ones include Remeron and Wellbutrin. Remeron can be added to other treatments. Zoloft and Effexor (venlafaxine) ought not to be taken together due to a risk of a serotonin syndrome...which is life-threatening!

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I was prescribed Zoloft (sertraline) for my anxiety and depression. And. That pill didn't help at all. What other medications can I talk to my dr about taking ins.

I was prescribed Zoloft (sertraline) for my anxiety and depression. And. That pill didn't help at all. What other medications can I talk to my dr about taking ins.

Many choices: If this is your first try at mood maintenance meds, you have many good medicines for a next try: lexapro, celexa, cymbalta (duloxetine). Be sure to give each medicine a decent try - at leat a month. If you have an intolerance, hang in there and give the medicine a full month to "percolate" in your system. Be careful, though, this whole group has a possibility of sexual side effects (decreased libido or climax).

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28yo fem w/ depression, anxiety. Zoloft for ~10 yrs, 50mg then 75. Added welbutrin. Zoloft quit helping, tried lexapro (escitalopram). Big weight gain. Rec new drug?

28yo fem w/ depression, anxiety. Zoloft for ~10 yrs, 50mg then 75. Added welbutrin. Zoloft quit helping, tried lexapro (escitalopram). Big weight gain. Rec new drug?

Antidepressants best: Another antidepressant, possibly snri like Effexor (venlafaxine) may be more helpful at this time. Add ons such as gaba- calm and natural anxiety aids can help. They do cause weight gain usually. Therapy is always an important treatment modality for depression and anxiety, don't think it is not helpful!

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Which is a better anti depressant drug to treat panic attacks, anxiety and depression. Lexapro (escitalopram) or zoloft?

Both Potentially: Lexapro (escitalopram) and zoloft are similar medications and have both been shown to be helpful for panic, anxiety, and depression. There is probably a decreased percentage of side effects with lexapro (escitalopram), (escitalopram) so it might be preferable for that reason. However, plenty of people do well with either medicine, and I have had some patients do well with zoloft after not getting benefit with lexapro (escitalopram).

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If Zoloft (sertraline) is helping reduce my pain, does this suggest my pain is caused by my anxiety/depression?

If Zoloft (sertraline) is helping reduce my pain, does this suggest my pain is caused by my anxiety/depression?

Not necessarily: Zoloft (sertraline) is an SSRI type of drug. This class of medications, though primarily used & indicated for treating depressive mood disorders & related psychiatric phenomenon, also has analgesic properties. PLEASE-Don't misinterpret what I say by thinking you can use Zoloft (sertraline) like aspirin or hydrocodone...YOU CAN'T but over the long haul these medications can alter pain reception & this is independent of mood

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I've started taking Zoloft (sertraline) for my anxiety and depression 5 days ago. Can I have a few drinks just one night every weekend?

I've started taking Zoloft (sertraline) for my anxiety and depression 5 days ago. Can I have a few drinks just one night every weekend?

Don't recommend: Zoloft (sertraline) + alcohol may increase side effects such as dizziness, drowsiness, confusion, and difficulty concentrating. See: http://pubs. Niaaa. Nih. Gov/publications/Medicine/medicine. Htm I hope this helps. Best wishes.

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I have been off of 25mg Zoloft (sertraline) for 19 days. Is it ok to have a few beers? The Zoloft (sertraline) was for anxiety not depression.

Talk over w ur doc: There were probably good reasons why your doctor started you on medication directed towards anxiety. If a 16 year old is taking up to 7 drinks/week as you, indicated, that might be a signal that there are continued anxiety or other emotional issues. Why don't you take the time to talk it over with your doctor.

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Is tofu really healthy? I am switching to a whole food plant based diet to combat my depression and anxiety, I am seeking help and on Zoloft (sertraline).

Is tofu really healthy? I am switching to a whole food plant based diet to combat my depression and anxiety, I am seeking help and on Zoloft (sertraline).

Tofu is fine: If you do not havve any hormonal imbalancces. It can produce estrogen. If not, it will provvide lots of protein. Peace and good health. Frying it a bit tastes better.

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I took Zoloft (sertraline) 50mg for 2 months for severe social anxiety and reactive depression, but it did not work, is it advisable to try it again at 100mg?

I took Zoloft (sertraline) 50mg for 2 months for severe social anxiety and reactive depression, but it did not work, is it advisable to try it again at 100mg?

Did it help at all?: If you saw any benefit i'd go higher--usual dose 100-200mg/day, if not try another med ; therapy.

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How effectively does Zoloft (sertraline) work for anxiety disorders linking to depression?

How effectively does Zoloft (sertraline) work for anxiety disorders linking to depression?

Can help: Zoloft (sertraline) is in the ssri family which can help with both depression and anxiety. Individuals respond to medication differently so if it is not effective, another medication in the same or different family could help.

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How long time does "zoloft 50 mg " need to make an effect on the patient if he have anxiety+mild depression?

How long time does "zoloft 50 mg " need to make an effect on the patient if he have anxiety+mild depression?

Zoloft (sertraline): Like most antidepressants, zoloft (sertraline) requires at least 4-6 weeks to show effectiveness. You may need a higher dose than the 50mg you're now taking. Doctors usually titrate the dose gradually, allowing your body to become accustomed to it. Please work with your doctor to obtain symptom relief. Psychotherapy is also an important part of treating anxiety and depression.

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Why did my dr perscribe wellbutrin and zoloft for depression and anxiety. How do they work together? Is there much success rate with this combo?

Why did my dr perscribe wellbutrin and zoloft for depression and anxiety. How do they work together? Is there much success rate with this combo?

Different mechanisms: These two medications have different mechanisms of action and could have an additive effect without additive side effects. You should have posed the question to your doctor. Exercise is a good treatment for depression. It is not easy getting started, but it is more than worth it. For good health - Have a diet rich in fresh vegetables, fruits, whole grains, milk and milk products, nuts, beans, legumes, lentils and small amounts of lean meats. Avoid saturated fats. Drink enough water daily, so that your urine is mostly colorless. Exercise at least 150 minutes/week and increase the intensity of exercise gradually. Do not use tobacco, alcohol, weed or street drugs in any form. Practice safe sex. Get HPV vaccine.

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On 75mg Zoloft (sertraline) (started at 25 mg) for 4 weeks, . 5 mg (twice a day) clonazapam for 2 weeks, no improvement to anxiety and depression, stick with it?

On 75mg Zoloft (sertraline) (started at 25 mg) for 4 weeks, . 5 mg (twice a day) clonazapam for 2 weeks, no improvement to anxiety and depression, stick with it?

Maybe?: If I were your dr, I would certainly increase the zoloft (sertraline), (sertraline) but don't increase it on your own! Some need higher doses. I would increase it until, 1. You're better. 2. You have side effects or 3. You get to 200 mgs per day. Also, zoloft (sertraline) is better absorbed, up to 50% better with food. I usually give zoloft (sertraline) to be taken in the morning after breakfast. Sometimes, clonazapam can make depression worse.

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Dr. Heidi Fowler
3,258 Doctors shared insights

Anxiety (Definition)

Anxiety is a general term for several disorders that cause nervousness, fear, apprehension, and worrying. These disorders affect how we feel and behave, and they can manifest real physical symptoms. Mild anxiety is vague and unsettling, while severe anxiety can be extremely debilitating, having a serious ...Read more


Dr. Heidi Fowler
1,077 Doctors shared insights

Sertraline (Definition)

Also called zoloft, (sertraline) is one of selective serotonin reuptake inhibitors, with antidepressant/anti-anxiety actions. May cause headaches, nausea & ...Read more