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Doctor insights on: Is Water Retention A Side Effect Of Depakote Er

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Dr. Jeffrey Cohen
249 doctors shared insights

Divalproex (Definition)

Divalproex, is a seizure medicine, the generic name is valporic acid, it has been in the market as an antiseizure medicine for long time, it is a good medicine, helps to control almost all types of common seizures, partial, generalized, absence, myoclonic, atonic, ..Etc.It can be used as a mood stabilizer in psychiatric patients. It has adverse effects on the liver, ...Read more


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Side effect of water retention tablets as I m on that tablet for 2 years now.Many times my heamoglobin goes up n down is it cause of this tablet.?

Side effect of water retention tablets as I m on that tablet for 2 years now.Many times my heamoglobin goes up n down is it cause of this tablet.?

Possibly...: Water retention tablets (or diuretics) that you got from the doctor or in supplement form shouldn't cause big fluctuations in your hemoglobin. In mod to severe dehydration and rehydration the hemoglobin will change... But if you're noticing it, i would look for other causes of the anemia first. ...Read more

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Hi doc.My mother has water retention problem due to wrong medicine side effect of thyroid causing serious swelling.So far none medication worked.Pleas?

Hi doc.My mother has water retention problem due to wrong medicine side effect of thyroid causing serious swelling.So far none medication worked.Pleas?

Immediate medical: Immediate medical consult please. Your primary care physician will evaluate to figure out what medication caused fluid retention. And the following steps will be either lower the dose or discontinue the med for a period of time, or switch to other medication. ...Read more

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I'm taking Depakote ER for bipolar and have had horrible insomnia, palpitations and tremors. Is this side effect or something else?

I'm taking Depakote ER for bipolar and have had horrible insomnia, palpitations and tremors. Is this side effect or something else?

Yes: Yes, those has been among possible side effects of Depakote er. Discuss it with the person who prescribed it to see if they want to change to other mood stabilizer unless you are getting to tolerate it. ...Read more

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How likely is a one-time Kenalog shot to cause side effects such as weight gain or water retention? More likely with multiple doses?

How likely is a one-time Kenalog shot to cause side effects such as weight gain or water retention? More likely with multiple doses?

You are right...: To deduce why you have gained weight and water retention after a single shot of kenalog, one needs to analyze detailed history+finding of physical exam + testing. How to Handle your concerns? Go to articles listed in http://formefirst.com/onWeightControl.html. On possible drug side effects? Go to article in http://formefirst.com/NewDrugUse.html. Thereby you gain insight on how to work well with Dr ...Read more

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Bladder retention appeared when i began using Depakote in 1999. Never considered the cause--not listed side effect. Why continued when later listed?

Bladder retention appeared when i began using Depakote in 1999.  Never considered the cause--not listed side effect.  Why continued when later listed?

Yes it is reported: There was a study of 27, 713 patients who were Depakote users and 93 people that is 0.34%had urinary retention.
Urinary retention is reported by people with multiple sclerosis, depression, high blood pressure, pain and osteoporosis. ...Read more

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Cant take melatonin it causes side effects for me such as water retention what will help me sleep seems like hormones causin this ?

Cant take melatonin    it causes side effects for me such as water retention     what will help me sleep seems like hormones causin this      ?

Unlikely!: Its unlikely the amount of melatonin contained in the presently available sleep "promoters" can have ANY side effects!! More likely perimenopausal ....hope this helps

Dr Z ...Read more

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How long after ending a 12 day prednisone taper will it take for all side effects , eg water retention, to go away?

How long after ending a 12 day prednisone taper will it take for all side effects , eg water retention, to go away?

1-2 weeks: A lot depends on the dosing of prednsone you were taking. Usually water retention effect going away in 1-2 weeks.
Some of the other side effects such as stretch marks, hormonal changes etc may take longer. ...Read more

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Hi. Can tamoxifen have this side effects if uset by male for gyno, water retention, acne and weight gain?

Hi. Can tamoxifen have this side effects if uset by male for gyno, water retention, acne and weight gain?

why use Tamoxifen: Tamoxifen has no serious side effects like you have described. It is very well tolerated drug in general. But who do you have to use it in the first instance? It is only useful for treating breast cancer both in females and in males who suffer from cancer. ...Read more

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My wife is on Paxil (paroxetine) 20mg 1x/day for ocd. Last couple weeks lots of water retention and edema in legs. Pcp says it's Paxil (paroxetine) side efx. Is this possible?

My wife is on Paxil (paroxetine) 20mg 1x/day for ocd.  Last couple weeks lots of water retention and edema in legs.  Pcp says it's Paxil (paroxetine) side efx. Is this possible?

Possible but rare: Peripheral edema happens in 0.1-1% of people, making it a rare, but possible side effect. Even more rarely (<.1%) people can develop inappropriate ADH (vasopressin) secretion and low sodium. I see that these are being checked for in labs. There are other, much more common, causes for peripheral edema also, though. ...Read more

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What is neuropathy and can it be cured? Dizziness, very disoriented.Tingling hands, fingers, feet, and also swelling , water retention, feels like i'm drunk cannot walk straight, very much afraid of falling, i feel like i'm tilting more to one side .

What is neuropathy and can it be cured? Dizziness, very disoriented.Tingling hands, fingers, feet, and also swelling , water retention, feels like i'm drunk cannot walk straight, very much afraid of falling, i feel like i'm tilting more to one side .

"Neuropathy" : "neuropathy" as a term is usually used to describe or label diseases of the peripheral nerves, so it is also often called "peripheral neuropathy" to emphasize that this is not a term to use to describe diseases of the brain or spinal cord. There are many types of peripheral neuropathy, and several ways to classify them, based on whether the major systems involved are those which provide nervous system input to muscles (motor neuropathies), those that are involved in sensation such as touch, pressure, heat, cold, pain, etc (sensory neuropathies), or those that are involved in control of involunatry functions such as maintenance of blood pressure, sweating, and bowel and bladder function. There are mixed neuropathies, pure motor neuropathies, pure sensory neuropathies, etc. Equally, there are classifications by cause (etiology), such as diabetic neuropathy (which is usually a sensory neuropathy but may involve motor problems or autonomic problems in some patients) or ischemic neuropathy (neuropathy caused by insufficient blood supply to some nerves).

Some neuropathies have a genetic basis, others are acquired. Some are due to other diseases involving nerve secondarily, such as diseases in which the immune system attacks blood vessels, producing vasculitis, which then can produce ischemic neuropathy in the affected nerves. This often produces a clinical pattern called "mononeuropathy multiplex", meaning multiple nerves are involved one at at time with no pattern, whereas a lot of other types of neuropathy as I have described above are "polyneuropathies", involving multiple nerves usually in symmetric patterns, such as in what is called a "stocking and glove" distribution.

So the causes are different, and some are identifiable and curable, others are not curable but are treatable, and some are difficult to treat. So this is a long answer to your main question about "what is neuropathy".

Some of what you describe could be a peripheral polyneuropathy: tingling sensations in your hands and feet, feeling "drunk" which may mean your sense of where you are in space is not working well, leading to a feeling that you may fall. However as dr krob suggested "dizziness", swelling and water retention, and disorientation are not commonly associated with neuropathy and could suggest that you have a serious medical condition which needs prompt evaluation and treatment. Some of these might also cause neuropathy; so, to pick just one possibility (not to say you have this), there are diseases called "collagen vascular diseases" such as lupus which may damage the kidneys, producing water retention, swelling of the legs, feet, and hands, and this may also affect nerves by causing vasculitis, giving you the tingling and perhaps also the "feeling like i'm drunk". So see a physician, very soon. ...Read more

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How can you reduce water retention with home remedies?

Salt? diagnosis?: First avoid added salt, which our caveman kidneys were not designed to handle. Next, if you have new leg swelling, you might have an undiagnosed condition ranging from simple varicose veins to a more complex heart, liver or kidney problem. Better to get evaluated and diagnosed correctly so you will know what to do. ...Read more

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Why does any medication that causes water retention, make me ill. Its in most drugs. . ?

Why does any medication that causes water retention, make me ill.   Its in  most drugs. .  ?

Uncertain: There are clearly groups of medications such as otc arthritis medications that can predispose to water retention. But by no means does all medications alter fluid balance within human body. Excluding entirely medications that induce diuresis (urination). ...Read more

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My face looks abnormal since a while. How do I know if it's water retention or fat?

My face looks abnormal since a while. How do I know if it's water retention or fat?

Water: retention will VARY (actually from DAY TO DAY)
FAT remains the same from WEEK to WEEK

Hope this helps!
Dr Z ...Read more

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Could diseases that cause inflammation throughout the body also cause water retention?

Could diseases that cause inflammation throughout the body also cause water retention?

Very possible: However, every disease is different. For instance autoimmune diseases cause fluid retention through causing kidney disease. Others could cause heart or liver disease, thereby, causing retention. ...Read more

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Best ways to treat water retention weight? I'm so swollen and its so painful; please help.

Best ways to treat water retention weight? I'm so swollen and its so painful; please help.

What is the cause?: First thing to consider is cause of the water retention. Is it a medical problem, is it a dietary problem? You need to see your family physician to get a complete exam including several different blood tests.. ...Read more

Depakote (Definition)

Depakote is the brand name for a medication known as valproic acid. It is most commonly used to treat seizures, though it can also be used as a mood stabilizer in certain psychiatric disorders. It is used to treat multiple seizure types and can be used alone or with other seizure medications if needed. Common side effects include nausea, dizziness, ...Read more


Dr. Adam Lewis
2 doctors shared insights

Side Effect (Definition)

A side effect is a potential negative effect of a medication that is being prescribed for ...Read more