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Doctor insights on: Is There Any Natural Way To Prevent Organ Rejection From Occurring

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Is there any natural way to prevent organ rejection from occurring?

Is there any natural way to prevent organ rejection from occurring?

Not really: There is intense ongoing experimentation in this process called tolerance-universal acceptance of foreign tissue. Current approaches involve extensive manipulation of the immune system with drugs, radiation, antibodies, etc. That are hardly "natural." tolerance is the holy grail of organ transplantation. Not there yet. Only natural way would be with identical (same placenta) twins. ...Read more

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What steps are taken at the hospital after the operation to prevent organ rejection?

What steps are taken at the hospital after the operation to prevent organ rejection?

Many steps.: Transplant recipients are monitored closely for rejection by testing the function of the transplanted organ with blood tests, certain imaging studies, and at times a biopsy of the graft the recipient is also responsible for taking their anti-rejection drugs and telling the transplant team promptly if there are changes in their condition. Education of the process is key. ...Read more

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How do your prevent immune rejection of islet cells?

How do your  prevent immune rejection of islet cells?

Do not know: The trigger and mechanism of islet cell destruction are not no where near to being well understood, let alone prevention. ...Read more

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How long after a tissue donation do I have to take medications to prevent rejection?

How long after a tissue donation do I have to take medications to prevent rejection?

Generally: for tissue donation (as compared to organ donation) no medications are needed to prevent rejection as the tissues are irradiated thoroughly and go through a very strict process so no blood or blood products are present on them when they are transplanted. Therefore, there is no chance of "rejection". ...Read more

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What is done to prevent rejection after transplant surgery?

What is done to prevent rejection after transplant surgery?

Several things: There are a number of things routinely done to limit the risk of rejection after transplant surgery. The major ones are testing for hla antibodies in the recipient and avoiding organs that express these; crossmatching the actual recipient with donor tissue to be sure they don't react; and using potent immunosuppressive drugs after the transplant to prevent a rejection episode. ...Read more

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After a patient has had bone marrow disease, how can isolating them help to prevent rejection?

After a patient has had bone marrow disease, how can isolating them help to prevent rejection?

Confusing: Can you restate your quetion? Are you talking about a bone marrow transplant? Isolation is required to prevent infections in people after bone marrow transplants, as the immune system is profoundly suppressed for a number of weeks and beyond. ...Read more

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Can you reverse chronic organ rejection?

No: You can delay the process but once you have the diagnosis of chronic rejection it is not reversible. ...Read more

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Are immediate family members better for organ donation in terms of rejection?

Can be advantaged: Immediate family member can be less immunogenic to a person than strangers. However, the survival differences in organ transplants between unrelated and related individuals for similarly aged donors is small. The one exception are the 25% of siblings that share the same hla type, called hla identical. ...Read more

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What causes organ rejection?

What causes organ rejection?

Several factors: As more sophisticated anti-rejection meds became available, the incidence of acute rejection has decreased over the past 40 years. However, no matter how long you take your anti-rejection meds, your immune system (white blood cells) will know your own tissues/organs from transplants. If your body does not have enough anti-rejection meds that suppress your immune system, a rejection occurs. ...Read more

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What part of the immune system is involved in organ rejection?

What part of the immune system is involved in organ rejection?

Innate and Adaptive: Innate or non-specific immunity involves the skin, lining of the GI tract, respiratory tract, gu tract, etc; and adaptive immunity that involves cells (primarily lymphocytes). Both types of immunity can affect the graft and trigger rejection. In addition, immune responses involve the formation of both cells and antibodies (proteins) that are reactive against the transplanted organ. ...Read more

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I saw on CNN a lady who received an organ transplant but it was altered before transplanting to avoid rejection, no drugs needed. How's that possible?

I saw on CNN a lady who received an organ transplant but it was altered before transplanting to avoid rejection, no drugs needed. How's that possible?

Trsplt- No immunosup: Please see the references below. Some protocols are developing to wean people off immunosupression which was unheard of before,I ma not sure if this is what you are referring to: http://www.aafp.org/afp/2008/0101/p65.html http://www.nejm.org/doi/full/10.1056/NEJMoa071074 Proc Natl Acad Sci U S A. 2013 Nov 19;110(47):19054-8. doi: 10.1073/pnas.1317561110. Epub 2013 Oct 28 ...Read more

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What signs and symptoms indicate organ transplant rejection?

What signs and symptoms indicate organ transplant rejection?

Depends on the organ: In general, acute rejection of any transplanted solid organ can cause fever, chills, tiredness, weakness, and poor appetite. Each specific organ may become tender and swollen, and the function of each would diminish. ...Read more

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Is it safe to stop anti rejection drugs for organ transplant after 3 years since no complications developed?

Is it safe to stop anti rejection drugs for organ transplant after 3 years since no complications developed?

No: You should never change your immunosuppressive drug doses without first discussing this with your transplant team. A transplant recipient can reject their graft at any time after the transplant. ...Read more

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How many people on average experience organ transplant rejection? Will that number change if you clone the organ from the patient? (For a paper)

Variable: Depends on organ. Try to "match" donor and recipient as much as possible. Recipient given anti rejection drugs which "turn off" their immune system. A clone, by definition, is genetically identical, so is not recognized as foreign and not rejected! ...Read more

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Can rejection of an organ cause severe itching, my husband had his liver transplanted?

Can rejection of an organ cause severe itching, my husband had his liver transplanted?

Yes: Rejection itself does not cause itching. If the bilirubin is up during an episode of rejection it can irritate the skin and cause itching. ...Read more

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People have anti-rejection drugs for organ replacement why can't you have the same for blood transfusions?

People have anti-rejection drugs for organ replacement why can't you have the same for blood transfusions?

It's not necessary: Rejection of a blood transfusion is called a "transfusion reaction." blood banks can almost always find a donor blood product which won't cause a reaction so anti-rejection drugs are usually not required. ...Read more

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Is it possible for transplant organ rejection to be treated with bone marrow or stem cells from the donor?

Is it possible for transplant organ rejection to be treated with bone marrow or stem cells from the donor?

A research question: No one knows! Theoretically if one can isolate particular immune cells from the donor that can help make the recipient tolerant to the donor's tissues, this kind of transplant may help. However, the vast majority of solid organ transplants have cadavers as donors and thus, it may be difficult to obtain stem cells from the original donor! ...Read more

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Is it true that there are new techniques to remove antigens of donated organs to avoid rejection instead of using immunosuppressive drugs?

Is it true that there are new techniques to remove antigens of donated organs to avoid rejection instead of using immunosuppressive drugs?

Not aware of any: Monoclonal antibody therapy, which blocks immune responses of key white cells (T-cell lymphocytes) is relatively new, but I am unaware of novel techniques to remove antigens from donor organs. You may want to discuss this with a large medical center transplant program if you are interested in new therapies or even in participating in a research study. ...Read more