Doctor insights on:
Is There Any Natural Way To Prevent Organ Rejection From Occurring
Not really: There is intense ongoing experimentation in this process called tolerance-universal acceptance of foreign tissue. Current approaches involve extensive manipulation of the immune system with drugs, radiation, antibodies, etc. That are hardly "natural." tolerance is the holy grail of organ transplantation. Not there yet. Only natural way would be with identical (same placenta) twins. ...Read moreSee 2 more doctor answers
Many steps.: Transplant recipients are monitored closely for rejection by testing the function of the transplanted organ with blood tests, certain imaging studies, and at times a biopsy of the graft the recipient is also responsible for taking their anti-rejection drugs and telling the transplant team promptly if there are changes in their condition. Education of the process is key. ...Read moreSee 2 more doctor answers
Generally: for tissue donation (as compared to organ donation) no medications are needed to prevent rejection as the tissues are irradiated thoroughly and go through a very strict process so no blood or blood products are present on them when they are transplanted. Therefore, there is no chance of "rejection". ...Read moreSee 1 more doctor answer
Several things: There are a number of things routinely done to limit the risk of rejection after transplant surgery. The major ones are testing for hla antibodies in the recipient and avoiding organs that express these; crossmatching the actual recipient with donor tissue to be sure they don't react; and using potent immunosuppressive drugs after the transplant to prevent a rejection episode. ...Read moreSee 2 more doctor answers
Can be advantaged: Immediate family member can be less immunogenic to a person than strangers. However, the survival differences in organ transplants between unrelated and related individuals for similarly aged donors is small. The one exception are the 25% of siblings that share the same hla type, called hla identical. ...Read more
Several factors: As more sophisticated anti-rejection meds became available, the incidence of acute rejection has decreased over the past 40 years. However, no matter how long you take your anti-rejection meds, your immune system (white blood cells) will know your own tissues/organs from transplants. If your body does not have enough anti-rejection meds that suppress your immune system, a rejection occurs. ...Read moreSee 1 more doctor answer
Innate and Adaptive: Innate or non-specific immunity involves the skin, lining of the GI tract, respiratory tract, gu tract, etc; and adaptive immunity that involves cells (primarily lymphocytes). Both types of immunity can affect the graft and trigger rejection. In addition, immune responses involve the formation of both cells and antibodies (proteins) that are reactive against the transplanted organ. ...Read moreSee 2 more doctor answers
I saw on CNN a lady who received an organ transplant but it was altered before transplanting to avoid rejection, no drugs needed. How's that possible?
Trsplt- No immunosup: Please see the references below. Some protocols are developing to wean people off immunosupression which was unheard of before,I ma not sure if this is what you are referring to: http://www.aafp.org/afp/2008/0101/p65.html http://www.nejm.org/doi/full/10.1056/NEJMoa071074 Proc Natl Acad Sci U S A. 2013 Nov 19;110(47):19054-8. doi: 10.1073/pnas.1317561110. Epub 2013 Oct 28 ...Read more
Is it safe to stop anti rejection drugs for organ transplant after 3 years since no complications developed?
How many people on average experience organ transplant rejection? Will that number change if you clone the organ from the patient? (For a paper)
Variable: Depends on organ. Try to "match" donor and recipient as much as possible. Recipient given anti rejection drugs which "turn off" their immune system. A clone, by definition, is genetically identical, so is not recognized as foreign and not rejected! ...Read more
People have anti-rejection drugs for organ replacement why can't you have the same for blood transfusions?
Is it possible for transplant organ rejection to be treated with bone marrow or stem cells from the donor?
A research question: No one knows! Theoretically if one can isolate particular immune cells from the donor that can help make the recipient tolerant to the donor's tissues, this kind of transplant may help. However, the vast majority of solid organ transplants have cadavers as donors and thus, it may be difficult to obtain stem cells from the original donor! ...Read more
Is it true that there are new techniques to remove antigens of donated organs to avoid rejection instead of using immunosuppressive drugs?
Not aware of any: Monoclonal antibody therapy, which blocks immune responses of key white cells (T-cell lymphocytes) is relatively new, but I am unaware of novel techniques to remove antigens from donor organs. You may want to discuss this with a large medical center transplant program if you are interested in new therapies or even in participating in a research study. ...Read more
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