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Doctor insights on: Is There A Genetic Test For Hemolytic Disease Of The Newborn

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Is there a genetic test for hemolytic disease of the newborn?

Is there a genetic test for hemolytic disease of the newborn?

Yes: Hemolytic disease of the newborn, causing yellow skin and eyes (jaundice) with anemia, is most commonly due to a "set-up"--a blood type difference between mother and child. Blood types are caused by genes at the ABO and other loci (rhesus being most damaging), with o type or rh negative moms making antibodies to red blood cells of a or b or rh+ fetuses (if mom is o and fetus ab, baby switched), . ...Read more

Dr. Scott McLean
1,241 doctors shared insights

Genetic Testing (Definition)

Prenatal testing for genetic problems may be done before or after conception. Testing for spina bifida or Down syndrome is done after a pregnancy is established. Besides the couples listed above, counseling and diagnosis are also recommended for mothers over the age of 35, and those who have received abnormal screening test results, such as alpha-fetoprotein (AFP). For more information about the alpha-fetoprotein test, and when and why you might have it, see alpha-fetoprotein. For those who may be at risk, genetic counseling and prenatal diagnosis are used to help ...Read more


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What are the tests for hemolytic disease of newborn?

What are the tests for hemolytic disease of newborn?

Test for mom/baby: The baby will get test like coombs testing, hemoglobin or cbc, bilirubin tests and reticule yet counts. The coombs tests shows that an antibody is cause the hemolysis. The antibody specificity can be determined by additional tests. These antibody levels can be measured in mom and baby. Most of these antibodies will cause hemolysis. Some can cause decreased RBC production in the baby. ...Read more

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Can you tell me the three classifications of hemolytic disease of the newborn?

Can you clarify?: The three most common blood group systems to cause hemolytic disease of the newborn are rh (usually d antigen, sometimes others), ABO (more common but less troublesome) and kell, though others can do it as well. Was this your question? If not, please write back. ...Read more

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Are there any major complications to hemolytic disease of the newborn on the baby?

Yes: Hemolytic disease of the newborn can result in significant jaundice and/or anemia, either of which may require emergency medical intervention. Even when the jaundice subsides, the infant is at risk for anemia for the first several weeks of life. ...Read more

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How often is hemolytic disease of the newborn fatal?

How often is hemolytic disease of the newborn fatal?

Depends on form: Decades ago when i started rh hemolytic disease was often fatal during pregnancy & problamatic in newborns. Surviving infants often needed many exchange transfusions & had worrisome futures. Then a treatment called Rhogam came along & has ended that nightmare. In 26 yrs, I have transfused 1-2 ABO babies primarily for late stage anemia but had no fatalities. Rh disease is a problem without rx. ...Read more

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Please tell me the dangers of hemolytic disease of the newborn (abo)?

Usually mild: Most of these kids have a brief issue with moderate elevations in bilirubin in the first first few days, but may face anemia days and weeks down the road.I remember a single ABO kid needing a transfusion at 6 weeks when this issue arose in 3 decades as a pediatrician. ...Read more

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If my 2nd son had hemolytic disease of the newborn, what are the chances the rest of my babies will as well?

If my 2nd son had hemolytic disease of the newborn, what are the chances the rest of my babies will as well?

Depends: Hemolytic disease of the newborn, which is due to rh or ABO incompatibility, happens when the newborn's blood type is incompatible with the mother's, and the mother has passed antibody to the baby in utero. In ABO disease, the mother must be type o and the baby either a or b. In rh disease, the mother must be rh- and the baby rh+. So, subsequent risk depends on the fetus' blood type. ...Read more

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How can hemolytic disease of the newborn occur?

Antibodies: Mom has an antibody against an antigen that baby has on the red cells acquired from dad. The antibody crosses the placenta. Rhogam has done wonders to prevent antibodies against rh/d from causing the devastating illness that used to be common. ...Read more

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Can symptoms of hemolytic disease of the newborn happen a week after birth?

Can symptoms of hemolytic disease of the newborn happen a week after birth?

HDN: The process of hemolytic disease of the newborn (HDN) starts soon after birth, however the symptoms (mainly jaundice) may not be detected if clinicians do not maintain a high index of suspicion. HDN due to Rh incompatibility is very rare in the US, but ABO incompatibility should be suspected whenever the mother has type O blood and the baby has either type A or B blood and there jaundice. ...Read more

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Does the possibility of an unborn baby getting antibodies c&d, (hemolytic disease of the newborn) increase with each pregnancy?

Does the possibility of an unborn baby getting antibodies c&d, (hemolytic disease of the newborn)  increase with each pregnancy?

HDN: With each pregnancy the mother increases her chances of developing antibodies which can in turn cross the placenta and harm the fetus. ...Read more

Genetic (Definition)

From a medical standpoint, "genetic" refers to the potential heritability of various medical conditions. While some conditions are inevitable (at some point in one's life) as a consequence of simple genetic heritability (eg huntington's disease), a large number of medical conditions (including all behaviorial health disorders) are the expressed final pathway of a ...Read more


Dr. Payam Mehranpour
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Neonatal (Definition)

The term neonatal is generally used to describe events that occur with an infant within the first 30 days after birth.Some practitioners are looser with the definition & extend the ...Read more