Doctor insights on:
Myelogenous Leukemia Vs. Lymphocytic Leukemia
Yes: Myelogenous leukemia involves a different early cell type than lymphocytic leukemia. Both can originate in the bone marrow but the diseases behave differently in both their acute and chronic forms. Different treatment regimens and strategies are used for the two and that is why it is so important to distinguish the exact type of leukemia. There are major differences within these 2 categories. ...Read moreSee 1 more doctor answer
Leukemia is a malignant hematologic neoplasm that originates in the bone marrow and represents a clonal proliferation of hematopoietic elements belonging to any of the myeloid, lymphoid, erythroid, and megakaryocytic lineages. Of note, other hematologic neoplasms like lymphoma or myeloma may demonstrate a leukemic phase without actually originating in the bone marrow ...Read more
Different cells: Myeloid cells and cancer (eg, aml, cml) are different than lymphoid cells and cancer (eg, all, cll). Just as breast cancer and colon cancer are different. Of course they are bone marrow cancers with blood cells and the differences are not like the solid tumor differences i mentioned above. The disease course and treatments are different based on the diagnosis and other factors. ...Read moreSee 1 more doctor answer
Can doctors tell me what does myelogenous leukemia affect and what does lymphocytic leukemia affect?
CML: CML is associated with philadelphia chromosome that result in the abnormal bcr-abl fusion gene. This becomes the target of treatment in cml. Oral tyrosine kinase inhibitor (tki) is the treatment of cml. The 1st generation is gleevec. Other tki that is more specific to block the bcr/abl fusion gene also available- sprycel and tasigna (nilotinib). Bone marrow transplant is available only for specific case. ...Read moreSee 1 more doctor answer
9-22 translocation: A portion of chromosome 9 is tranferred to chromosome 22...When a cytogeneticist looks at this...They see the characteristic "philodephia chromosome" named after the city where the research was conducted. ...Read more
It is Complex!: Why is it so important to know the answer to this question for your practical purpose and guidance, it does not. But if you want to conduct research on this matter be my guest! ...Read more
Translocation: A big word but dna is always recombining when cells divide. In this case, a piece of dna from chromosome 9 moves over to chromosome 22 which essentially turns on a switch that produces an enzyme that promotes uncontrolled cell division and leukemia. Modern drugs are targeted to prevent the action of this enzyme. ...Read moreSee 1 more doctor answer
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