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Doctor insights on: Is There A Difference Between Mirtazapine And Amitriptyline In Terms Of Effectiveness For Pain And Sleep

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Is there a difference between mirtazapine and amitriptyline in terms of effectiveness for pain and sleep?

Is there a difference between mirtazapine and amitriptyline in terms of effectiveness for pain and sleep?

No direct answer: These are 2 different drugs. Again, there is "no better than" or "as good as". Treatment of any disorder should be individualized. I would think that Remeron (mirtazapine) is more often prescribed for sleep disorders where as Amitriptyline is more often prescribed for pain when talking about these 2 conditions specifically. ...Read more

Dr. Gregory Moneta
383 Doctors shared insights

Mirtazapine (Definition)

Mirtazepine (remeron) is a noradrenergic/specific serotonergic antidepressant [nassa]. It is used for major depressive d/o, various anxiety disorders, chronic pain, and others. In some, it can help ssri-induced sexual dysfunction & "poop out." it can be sedating and also increase appetite -- good for some ...Read more


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Does elavil or tofranil help with sleep along with depression thinking of changing my remeron (mirtazapine) because still depressed and massive weight gain?

Does elavil or tofranil help with sleep along with depression thinking of changing my remeron (mirtazapine) because still depressed and massive weight gain?

Elavil? Remeron (mirtazapine)?: Elavil (amitriptyline) and tofranil (imipramine) are both sedating antidepressants. These can also contribute to weight gain, however. It is essential to speak with your prescribing doc so you can discuss your current sxs and side effects and determine the best plan for you going forward. ...Read more

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I am on sertraline 100 mg I have stopped taking the amitriptaline and mirtazapine could you recommend what I could take to help with sleep problems?

I am on sertraline 100 mg I have stopped taking the amitriptaline and mirtazapine could you recommend what I could take to help with sleep problems?

Work w/ your Dr: Ever a good idea to stop psych meds w/out professional guidance. Work together to find the right plan for you and add CBT theapy to optimize effects as well as learning skills to better life. This will include sleep skills! Best wishes. ...Read more

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Can I take amitriptyline 20mg and mirtazapine 15mg?

Can I take amitriptyline 20mg and mirtazapine 15mg?

Were they both: Prescribed to be used at the same time for you? Mixing these two medications may increase risk for serotonin syndrome. However, that does not mean that one will of necessity have this side effect. ...Read more

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Dr gave me amitriptyline 50 mg 1 a day & gave me remeron (mirtazapine) 15mg 1day, im allergic to vistaril does remeron (mirtazapine) have that in it. And which 1 is better to use?

Dr gave me amitriptyline 50 mg 1 a day & gave me remeron (mirtazapine) 15mg 1day, im allergic to vistaril does remeron (mirtazapine) have that in it. And which 1 is better to use?

Different drugs: Benadryl, (diphenhydramine) Remeron &amitriptyline can all have the side effect of sedation & each is sometimes prescribed for use as as sleep aid rather than their primary clinical benefit for allergy related symptoms (Benadryl) & antidepressant (Remeron & Amitriptyline). But they are differ in how they are constructed chemically or in the way they work. You & your doctor can decide which medivine may be best. ...Read more

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Would smoking a small amount of weed be safe (for nerve pain) be ok with other meds I'm taking. Amitriptyline, mirtazapine, venlafaxine?

Would smoking a small amount of weed be safe (for nerve pain) be ok with other meds I'm taking. Amitriptyline, mirtazapine, venlafaxine?

Most likely.: While federal regulations prohibit me from recommending the use of schedule I medications such as cannabis I can tell you that there is overwhelmingly scant evidence that its consumption with the drugs that you listed would be risky. That said IF you were to consume it any option other than burning it to ingest it would be preferable: i.e. consider an edible, atomized or nebulized form. ...Read more

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My Dr put me on 10mg elavil a tricylic antidepressants. I am Lexapro (escitalopram) 20mg and remeron 30.mg. I suffer from G A D.Are these o k together. Thanks?

My Dr put me on 10mg elavil a tricylic antidepressants. I am Lexapro (escitalopram) 20mg and remeron 30.mg. I suffer from G A D.Are these o k together. Thanks?

Not recommended...: The Mirtazapine (Remeron) is fine. Elavil (amitriptyline) oral and Lexapro or escitalopram oral both increase affecting serotonin levels in the blood. Too much serotonin is a potentially life-threatening situation. Severe signs and symptoms include high blood pressure and increased heart rate that lead to shock.
...Read more

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Besides remeron, (mirtazapine) what other med is good for sedation and anxiety? Trazodone gives me terrible nightmares & elavil is evil to get used to.

Besides remeron, (mirtazapine) what other med is good for sedation and anxiety? Trazodone gives me terrible nightmares & elavil is evil to get used to.

Buspar (buspirone) is another: Buspar (buspirone) is a non-addictive anti-anxiety medication. Studies have also shown that approximately 70% of individuals taking anti-anxiety medications can learn to manage anxiety without medication with a course of focused cognitive-behavioral treatments by a psychologist. ...Read more

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I needed a second opinion. Is it safe to taper off remeron (mirtazapine) 15mg to 7.5mg while increasing a new antidepressant elavil 12.5mg to 25mg at same time?

Yes, it's safe: It's possible to safely "cross-taper" medications like this -- meaning to lower and stop one while gradually raising the other. Remeron (mirtazapine) and Elavil will be fine in this way, and hopefully the Elavil will be helpful by itself. Be well, . ...Read more

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I am taking elavil, nuvigil, remeron, and Xanax (alprazolam) for anxiety/depression/chronic daily fatigue. The first 3 have me in a fog. Will weaning off help me?

I am taking elavil, nuvigil, remeron, and Xanax (alprazolam) for anxiety/depression/chronic daily fatigue. The first 3 have me in a fog. Will weaning off help me?

Yes: Weaning off medication may help. Nuvigil is not usually sedating or causing "fog", the three other medications could. Discuss adjusting medication with treating physician, it is not safe to abruptly stop all of these medications. ...Read more

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I was just prescribed Amitriptyline for aiding sleep and was wondering what the difference is from Ambien (zolpidem) which I used to be prescribed.

I was just prescribed Amitriptyline for aiding sleep and was wondering what the difference is from Ambien (zolpidem) which I used to be prescribed.

New medicine: This medicine works differently than ambien (zolpidem). For that reason, it may work better or worse for you. It can cause you to feel sleepy. It can also cause a feeling of a dry mouth or light headedness. It is used often in Neurology to prevent headaches or for nerve pain also. ...Read more

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Hi, I want to come off mirtazepine and go back on amitriptyline due to weight gain. I can't see my Drfor ages. Please can you advise?

Hi, I want to come off mirtazepine and go back on amitriptyline due to weight gain. I can't see my Drfor ages. Please can you advise?

NEED DOCTOR: This is a problem because you will need a doctor to help the shift. Cannot advise without knowing the doses etc. Best to go slowly whatever you do. ...Read more

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On mirtazapine 30mg amitriptaline 10mg still struggle wit anxiety churning stomach would buspirone help?

On mirtazapine 30mg amitriptaline 10mg still struggle wit anxiety churning stomach would buspirone help?

Maybe: Discuss this in detail with your treating physician. There may be other antidepressants such as Lexapro (escitalopram) or clonazepam which would better help your anxiety.
In my practice, with my anxious patients, I have found excellent results with the SSRI antidepressants at solid therapeutic doses work very well. ...Read more

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What are the advantages of remeron (mirtazapine) and amitryptaline in insomnia managment? Which is better? What time do them take to have effect on insomnia?

What are the advantages of remeron (mirtazapine) and amitryptaline in insomnia managment? Which is better? What time do them take to have effect on insomnia?

Remeron, (mirtazapine) etc: Both Remeron (mirtazapine) ; amitriptylene can be used to aid sleep. Neither is "better, " but are available for use depending on need of the particular patient. It sounds like you have a significant insomnia problem and need a full evaluation of it rather than trying to cover it up with medications. Please work with your doctor to assess and appropriately treat your sleep problem. Take care. ...Read more

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Expert opinions? Which is more sedating mirtazapine or amitryptaline?

Expert opinions? Which is more sedating mirtazapine or amitryptaline?

Roughly equal: This kind of question is hard to answer, as it depends on the dosage of each. Mirtazepine (brand name remeron) is probably better tolerated overall, although it's well-known to cause weight gain. Amitriptyline (brand name Elavil (amitriptyline) ; others) has more dry mouth, constipation, ; orthostasis (dizziness when standing), but can be quite effective if these aren't a problem for an individual patient. ...Read more

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Does amitriptyline help you achieve stage 4 sleep?

Does amitriptyline help you achieve stage 4 sleep?

Reduces REM sleep: Studies have demonstrated reduced REM sleep due to amitriptyline. If you're taking amitriptyline for depression, pain, or headaches and it's helping, then there may not be any need to change the medication. See you prescribing physician to discuss before making any medication changes. Http://www. Ncbi. Nlm. Nih. Gov/pubmed/2284326, http://www. Ncbi. Nlm. Nih. Gov/pubmed/216045 ...Read more

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What's the range of elavil (amitriptyline) dose for sleep? How does it affect sleep?

What's the range of elavil (amitriptyline) dose for sleep? How does it affect sleep?

10-150 mg. For sleep: Suppress rem to varying degrees
slight increase in stage n3 sleep (used to be stages 3+4, increase total sleep time, decrease wake after sleep onset, decrease, # awakenings, decrease sleep onset latency (how long it takes to fall asleep). Great website below for this info:473 drug effects on sleep - california state university. ..
Psych. Fullerton. Edu/mwhite/473pdf/473%20drug%20effects... ...Read more

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On amitriptyline 10mg daily for sleep/headaches. Ran out. Took 1500mg 1dose tryptophan 24hrs after to sleep. Risk of SS? Scared now n trying to sleep!

On amitriptyline 10mg daily for sleep/headaches. Ran out. Took 1500mg 1dose tryptophan 24hrs after to sleep. Risk of SS? Scared now n trying to sleep!

Not much risk: There is not much risk or serotonin syndrome after stopping your dose of amitriptyline for one day. The dose you were taking is small. Tryptophan should not cause you any harm. Sleep well. ...Read more

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I have been on amitriptyline 50 mg for about 25 years now. Initially prescribed for back pain after surgery with no sleep. It did help greatly, I stay?

I have been on amitriptyline 50 mg for about 25 years now. Initially prescribed for back pain after surgery with no sleep. It did help greatly, I stay?

Still helping?: If you feel you still need it, it's reasonable to continue it. There's no report of accumulation or dependence (addiction). However, your dose is tiny and after 25 years, I'll bet it isn't doing anything. Have you tried a "drug holiday" (going off it)? ...Read more

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I take trazodone for sleep make me sleep in 10 min but I don't sleep more then 5h do u think elavil (amitriptyline) make me sleep fast as trazodone and sleep longer?

I take trazodone for sleep make me sleep in 10 min but I don't sleep more then 5h do u think elavil (amitriptyline) make me sleep fast as trazodone and sleep longer?

Trazodone doesn't: Usually act this way. It typically takes longer to act, and puts people out longer, with a longer hang over the next morning than Elavil (amitriptyline) or other sleep aids. Elavil (amitriptyline) is another antidepressant in this class, but has a bad reputation for side effects, mostly weight gain (not so for Trazodone). Check with your MD for dosages and also for alternative sleepers... ...Read more

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How to counteract the effect of elavil (amitriptyline) on rem. Sleep?

How to counteract the effect of elavil (amitriptyline) on rem. Sleep?

Not take it?: The ongoing use of Amitriptyline likely is disrupting to your sleep architecture. You could try melatonin to try to normalize your rem sleep or talk to you doctor about rozerem (ramelteon). The only other medicines that might help are for dementia or parkinson's disease. I notice you are taking Aripiprazole and mirtazpine and, these are also likely contributing to your rem disturbance. Talk to your md! ...Read more

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I've taken 7.5mg zopiclone + 5mg Valium & 2 x 30/500 cocodamol for sleep but it is ineffective. I've now had amitriptyline & tramadol. Is this safe?

I've taken 7.5mg zopiclone + 5mg Valium & 2 x 30/500 cocodamol for sleep but it is ineffective. I've now had amitriptyline & tramadol. Is this safe?

Not Safe!: It is never safe to combine these medications. Talk to your doctor about your insomnia. You need a careful evaluation in order to obtain an accurate diagnosis and appropriate treatment. Polypharmacy is never safe! We lose too many young people each year due to unintentional overdose. Be safe and work with your doctor. ...Read more

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Amitriptyline vs nortripyline for GI uses and sleep?

Amitriptyline vs nortripyline for GI uses and sleep?

Both are used: But amitrypiline gets my vote based on my personal experience over almost40 years and the other amount of use of this med for other uses than only depression. Nortyptilline is an ok antidepressant for the right patient. ...Read more

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I was prescribe with amitriptyline 50mg for more than one year still without it iam unable to sleep either day or nigth?

I was prescribe with amitriptyline 50mg for more than one year still without it iam unable to sleep either day or nigth?

Elavil (amitriptyline): As long as it is working for u, no side effects, and u r monitored by physician, u r fine. Just let your doctor know of any changes or if other medications are added. ...Read more

Dr. Heidi Fowler
5,052 Doctors shared insights

Sleep (Definition)

Sleep is a topic that involves concepts such as how long it takes to fall asleep, how many times one wakes up at night, how many hours one sleeps at night, sleep stages, ...Read more


Dr. Jeffrey Satinover
381 Doctors shared insights

Elavil (Definition)

Elavil is a tertiary amine tricyclic which is a kind of tricyclic type drug (serotonin-norepinephrine reuptake inhibiting ...Read more