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Doctor insights on: Is There A Cure For Retinoblastoma

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Can gleevec (imatinib) cure retinoblastoma?

Can gleevec (imatinib) cure retinoblastoma?

No data yet...: Gleevec (imatinib) inhibits a number of tyrosine kinases in cells (c-kit, pdgfralpha, c-abl) . There is very recent data that Gleevec (imatinib) may have activity in retinoblastoma, but these experiments where done on isolated retinoblastoma cells grown in culture. There are no clinical trials showing that Gleevec (imatinib) can treat retinoblastoma. Future clinical trials may be planned to address this question. ...Read more

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Dr. Steven Bowers
208 doctors shared insights

Retinoblastoma (Definition)

Retinoblastoma are congenital malignant neoplasms that arise from the nuclear ...Read more


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How is retinoblastoma cured?

Aggressive: Depends on size and location, small tumors are treated with laser surgery.Radiation for larger tumors. Chemotherapy if tumor has spread beyond the eye. The eye may need to be removed if the tumor does not respond to other treatments. If cancer has not spread beyond the eye, almost all patients can be cured. ...Read more

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Could hereditary retinoblastoma survivors have more also wonder how is retinoblastoma actually cured?

Could hereditary retinoblastoma survivors have more also wonder how is retinoblastoma actually cured?

Other Cancers, Yes: Children treated in U.S. & other developed countries who receive early detection have a 95% cure rate. Treatment consists of surgery, cryotherapy, chemotherapy; irradiation is avoided if possible. Survivors have a 21% probability at age 50 yrs of developing other cancers, usually Sarcomas & Melanomas; this increases to 38.2% if radiation received; this risk also increases with presence of Lipomas. ...Read more

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What are the risks of operating the retinal detachment on a 2y.O. Who had a prior retinoblastoma, which is considered now cured?

What are the risks of operating the retinal detachment on a 2y.O. Who had a prior retinoblastoma, which is considered now cured?

Risks vs. rewards: The risks of surgery need to be weighed against the benefit of restoring or maintaining sight. If the chances of visual improvement are low, surgery may not be appropriate. If there is a chance of improvement in the long term, however, surgery would be appropriate. Please speak with your retinal surgeon and pediatric ophthalmologist; they should guide you in the right direction. ...Read more

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What is retinoblastoma?

What is retinoblastoma?

Child eye cancer: Retinoblastoma is a malignant tumor of the retina which is seen in children. It currently has one of the highest cure rates of all childhood cancers 95-98%. It used to be treated by removal of the affected eye or radiation, but now more advanced eye sparing techniques are successful. ...Read more

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What is retinoblastoma?

What is retinoblastoma?

Tumor: Retinblastoma is an intraocular tumor that usually affects children from birth through the early teens. It is usually treated successfully, but often requires removal of the affected eye. Rarely it is bilateral. It is iften dianosed when the pupil changes from a dark to whitish color, or when the red reflex in flash pictures is missing in one eye. ...Read more

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What causes retinoblastoma?

Retinoblastoma: Some cases are inherited and some cases are the result of spontaneous mutations of the retinoblastoma gene. ...Read more

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How is a retinoblastoma caused?

How is a retinoblastoma caused?

Chromosme 13: Has a paired site where the rb gene lives. It can be inherited, or occur accidentally (sporadic) mutation. The rb gene loss leads to the eye tumor, but it is also is involved with other tumors, and its chromosomal location is close to a region associated with bone tumors. ...Read more

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What is retinoblastoma diagnosis?

Eye exam: It is diagnosed by an eye exam supported by imaging studies. No blood tests to diagnose it. Getting a good history, and physical exam are in order ...Read more

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What's trilateral retinoblastoma?

Rb affects the eye: And you would think that bilateral is easy, but some species have photosensitivity in the brain region corresponding to the pineal, and that is the third site. ...Read more