Doctor insights on:
Is Thalassemia Treatable
By blood transfusion: In thalassemia patients who are very anemic, and have symptoms from their anemia, periodic transfusions is the usual treatment. If they have had many transfusions, their bodies will get iron overload from the past transfusions (chelation therapy to remove iron may be needed). The cure for thalassemia major is through bone marrow transplantation. ...Read moreSee 1 more doctor answer
Thalassemia: Thalassemia is a deficiency in the production of one of the globin chains (alpha or beta) that make up hemoglobin. Normally synthesis of these is balanced. When imbalanced, one globin accumulates relative to the other forming inclusions that are damaging to the red cells that contain them. There are many thal variants that manifest a wide severity of symptoms from none to transfusion dependence. ...Read moreSee 2 more doctor answers
Thalassemia: Thalassemia major can cause severe anemia and cardiac decompensation in first few months of life if not treated.Thalassemia minor causes mild anemia. Thalassmia intermedia may require transfusions. Severity of anemia causes pallor, jaundice,hematopoises in other organs causing splenomegaly, neurological symptoms, pallor, deformilty of bones of face/skull ...Read more
Millions: Thalassemia is likely the most common one-gene mutation in the world. Overall, an estimated 20-25 million people are carriers (1/300) (about 1/1000 in low-risk peoples, and about 1/30 in high-risk peoples). Low risk: japanese, korean, n. European caucasians, native canadians, native americans. High risk: mediterranean, middle eastern, south asian, south-east asian (western pacific rim), caribbean. ...Read moreSee 1 more doctor answer
More info: Depends on whether thalassemia is trait (minor) or disease (major)---which requires frequent transfusions for major. Also depends on whether you have alpha or beta thalassemia. All thalassema will cause some anemia which can affect the blood system and cardiovascular system as well. Ask your physician to discuss with you the type you have. Good luck. ...Read moreSee 1 more doctor answer
Millions of carriers: Thalassemia is one of the most common gene mutations in the world. Overall, an estimated 20-25 million people are carriers (1/300) (about 1/1000 in low-risk peoples, and about 1/30 in high-risk peoples). Low risk: japanese, korean, n. European caucasians, native canadians, native americans. High risk: mediterranean, middle eastern, south asian, south-east asian (western pacific rim), caribbean. ...Read moreSee 1 more doctor answer
Trait is more common: The thalassemia trait is a fairly common finding in certain ethnic groups (those of mediterranean, african, and some asian descents). The trait is generally a mild condition the contributes to a mild form of anemia that generally does not cause any problems. If both genes are affected, a child will have thalassemia which causes a much more significant type of anemia. That condition is more rare. ...Read moreSee 1 more doctor answer
Yes: The presence of a thalassemia syndrome can often be suspected from new born screening, which leads to diagnosis very early in childhood. All states perform newborn screening for qualitative and quantitative hemoglobin disorders. But, there are hundreds of such disorders, so we can't (nor should we) test for all of them routinely. Making sure your pediatrician knows your family history is importan. ...Read moreSee 1 more doctor answer
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