Doctor insights on:
Is Taxol And Tamoxifen The Same Drug
This medication is used to: treat breast cancer that has spread to other parts of the body in men and women. Treat early breast cancer in women who have already been treated with surgery, radiation, and/or chemotherapy. Reduce the risk of developing a more serious type of breast cancer in women who have had ductal carcinoma in situ (dcis; a type of breast cancer ...Read more
My dr. Wants to try me on the cancer drug tamoxifen for infertility. I have never had cancer. Is this healthy?
Benefit/risk: Tamoxifen is a SEAM (selective estrogen receptor modulator). It inhibits estrogen receptor pathway in breast, but stimulates it in ovary and uterus. It may increase fertility for a time, but reduce later due to constant stimulating. Its stimulating effect can also increase risk of uterine cancer. Other side effects from tamoxifen include thrombosis, stroke, etc, esp at long-term use. ...Read more
What do you suggest if my dr. Wants to try me on the cancer drug tamoxifen for infertility. I have never had cancer. Is this ok?
Yes: Tamoxifen is used to prevent breast cancer where it suppresses estrogen binding, it can act as an estrogenic stimulus on ovarian tissue initiating ovulation induction by a mechanism similar to clomiphene citrate. This drug Clomid is able to bind to estrogen receptors in the hypothalamus. Preventing the brain from seeing the negative signal from estrogen This stimulates production of FSH. ...Read more
Immediately a breast cancer survivor. On the drug tamoxifen, I missed a day. Can I take 2 pills in one day?
No...: No, if you missed it completely do not double up. In the future if you miss a dose and remember within 8 hours you can take the dose. A weekly pill case can be a great reminder for taking pills, there are also dose reminder apps available. ...Read more
Yes: Tamoxifen is most commonly prescribed for the treatment of hormone (+) breast cancer. While tamoxifen may cause birth defects during pregnancy, it actually can increase ovulation, thus increasing fertility. Accordingly, premenopausal women taking tamoxifen for breast cancer treatment must use (nonhormonal forms of) birth control. ...Read more
The common ones are bone pain; constipation; coughing; hot flashes; muscle pain; nausea; tiredness; vaginal discharge; weight loss.
Severe ones are even a more comprehensive list - allergic reactions, vaginal bleeding, chest pain, coughing up blood, dark urine, decreased libido and so. ... On. ...Read more
Speak to your doctor:
This is not the usual regimen for tamoxifen. It is usually recommended for daily use and intake for the best effect. Was this recommended by your doctor? If so, you need to find out why this deviates from the standard recommendation.
If you are making up your own regimen, please do not proceed until you speak with your physician. ...Read more
Maybe: Most clinical data has shown benefit of tamoxifen (tam) increasing up to five years. After 5 years it seems to level or possibly even worsen. There may be some cancer cells that not only become resistant but to which tam begins to act as an agonist. That being said there are still the ongoing atlas and atom trials that are trying to get more definite. Another option is ais after 5yrs of tam. ...Read more
Side effects: Tamoxifen is often used after treatment for breast cancer to help reduce recurrence. It is very helpful and should be taken if needed and recommended. However it is not w/o side effects which can include increased risk of blood clots, hot flashes, thinning of the bones (osteoporosis) and endometrial hyperplasia/cancer so if you are concerned d/w dr the risk and benefits as pertains to you. ...Read more
Talk with your doc: There are means for dealing with menopausal symptoms/hot flashes. Soy use is controversial but some antidepressants can help but be careful as some also inhibit tamoxifen metabolism. Effexor/venlefaxine is the most studied and does not do this. There are some patients who have achieved great relief with alternative therapies such as accupuncture. ...Read more
Nolvadex (tamoxifen): Sorry, only by prescription, assuming u care about the quality of the medication. ...Read more
Unclear: There is very little hard data about sage extract. The online advertisers say that sage is a mild estrogen type extract that helps menopausal symptoms. I am not sure if that claim has been validated. Tamoxifen works by blocking the body's estrogen and "starving" the tumor. If sage actually does work, then it would get in the way of tamoxifen's intended effect. ...Read more
No: There have been many studies that have compared tamoxifen to placebo, demonstrating it's effectiveness treating breast cancer; none of these studies, to my knowledge, ever showed any difference between tamoxifen and placebo regarding weight gain. Nevertheless, as many as 10% of women on tamoxifen do report weight gain. This may be due to post-chemotherapy effects or menopause, as well. ...Read more
Novedex vs Nolvadex (tamoxifen): Novedex xt is a product used to increase testosterone & muscle mass; it blocks the conversion of testosterone to estrogen, but apparently does not increase muscle mass. Nolvadex (tamoxifen) is used to treat breast cancer, but it reportedly is used by bodybuilders who use Anabolic steroids to prevent gynecomastia (enlarged breasts due to breast tissue rather than muscle. See following comment. ...Read more
An anti-estrogen.: Nolvadex or tamoxifen is a serm (selective estrogen receptor modulator) that works as an anti-estrogenic drug and is most commonly used as first line treatment for breast cancer in females and males (1% of breast cancer occurs in males). It is related to the steroid drugs, but absolutely should not be used for body building. ...Read more
You may not have: Tamoxifen is well tolerated by most, in estrogen receptor + tive breast cancers will prevent recurrences, immediate reaction can occur but rare, most of the other side effects like hot flashes, thrombo-venous problems, neurological problems may occur slowly but manageable. ...Read more
Yes: Tamoxifen interferes with estrogen action causing hot flashes. Taking estrogen to control hot flashes would defeat the primary reason to take tamoxifen so that is not an option. Some women with hot flashes are helped by taking some antidepressants (ssri). Another option is to try clonidine, a blood pressure medication. Non of these are 100% effective, but some women definitely benefit from them. ...Read more
Not of serious cons: When used for long term use, some degree of missed dosing is common and it is difficult to say if it make any difference, particularly with drug like tamoxifen which stays in the body for several days after the last dose taken. That said you need to avoid frequent interruptions which can be detrimental. ...Read more
No worries: Tamoxifen is a selective estrogen receptor modulator (serm). It sits on estrogen receptor but doesn't activate it. Thus your man boobs should go away w/time. Serms are actually banned & on illegal list in many athletic contests since they can increase pituitary production of lh & fsh, thus stimulating testes to produce more testosterone & sperm. Aromatase inhibitors can also incr t & sperm. ...Read more
Aim for better adher: An occasional missed dose is not a big deal and would not compromise the efficacy of tamoxifen. But better adherence should be executed. One way to do this is to make it a habit to take your medicine same time everyday: it could be timed as the first thing or the last thing you do daily. Then it will become a habit. ...Read more
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