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Doctor insights on: Is Primary Sclerosing Cholangitis Painful

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Dr. Scot Lewey
33 doctors shared insights

Primary Sclerosing Cholangitis (Definition)

Primary sclerosing cholangitis (psc) is a chronic liver disease caused by progressive inflammation and scarring of the bile ducts of the liver. The inflammation impedes the flow of bile to the gut, which can ultimately lead to liver cirrhosis, liver failure and liver cancer. The underlying cause of the inflammation is ...Read more


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Is primary sclerosing cholangitis rare?

Is primary sclerosing cholangitis rare?

Yes: The goal of managing acute attacks is antibiotics and IV fluids. In about 15%, emergency decompression or surgery is needed. Prevention of future attacks of cholangitis is based on removing biliary stones and debris, dilation or resection of strictures, and establishing optimal biliary drainage. Also important to rule out the clonorchis parasite. Your GI doctor can discuss newest treatments. ...Read more

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Primary sclerosing cholangitis, what is this like??

Primary sclerosing cholangitis, what is this like??

Bile duct obstructio: Idiopathic (probably autoimmune) progressive scarring and narrowing of the bile ducts. May need surgical intervention or transplant This reference may help: http://www.mayoclinic.org/diseases-conditions/primary-sclerosing-cholangitis/basics/definition/CON-20029446 ...Read more

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Is cholangitis painful?

Usually: Cholangitis is bile duct inflammation usually occurring secondary to bile duct obstruction from stones. Bacteria in the bile duct are readily absorbed into the bloodstream from the liver and lead to serious infections. Classic findings are right upper abdominal pain (not unlike a gallbladder attack), fever, and jaundice. Some people are so ill that they are lethargic and have no pain complaints. ...Read more

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Primary sclerosing cholangitis - what is the inherited risk?

Very low: PSC is most commonly seen in patients with ulcerative colitis. Patients with PSC have 60-72% association with ulcerative colitis; low genetic and immunologic factors are attributed to PSC. ...Read more

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What's the difference between primary biliary cirrhosis and primary sclerosing cholangitis?

What's the difference between primary biliary cirrhosis and primary sclerosing cholangitis?

Similar symptoms: Distinct diseases that announce themselves in the same way. Both destroy the small bile ducts within the liver and produce jaundice, itching and sometimes failure of the liver. The microscopic picture, labs, and treatment options are as strikingly different as the presentations are similar. ...Read more

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Does primary sclerosing cholangitis usually cause many symptoms?

Does primary sclerosing cholangitis usually cause many symptoms?

It can.: Primary sclerosing cholangitis (= psc, inflammation of bile ducts) can give symptoms such as itching, pain in the right upper abdomen, fevers, chills, night sweats, and jaundice (yellow skin, yellow whites of the eyes). Most people with this illness have ulcerative colitis, which has symptoms of its own (eg. Bloody diarrhea, abdominal pain). Many with psc eventually need liver transplant. ...Read more

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Could you explain what is primary sclerosing cholangitis?

Bile duct scarring: Primary sclerosing cholangitis (psc) is an inflammatory disease of the bile ducts that causes scarring and subsequent obstruction of bile ducts inside and/or outside the liver. This blocks the flow of bile to the gut, which can ultimately lead to cirrhosis of the liver. The underlying cause of psc is not entirely known, but believed to be an auto-immune disorder with a strong association with uc. ...Read more

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What is the definition or description of: primary sclerosing cholangitis?

What is the definition or description of: primary sclerosing cholangitis?

PSC: Primary sclerosing cholangitis (psc) is a chronic liver disease caused by progressive inflammation and scarring of the bile ducts of the liver. The inflammation impedes the flow of bile to the gut, which can ultimately lead to liver cirrhosis, liver failure and liver cancer. The underlying cause of the inflammation is believed to be autoimmunity. ...Read more

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Primary sclerosing cholangitis---what treatments are best?

Depends: On stage. Usually it has poor response to chronic meds, and antibiotics are used for superimposed infections in times of flare ups. ...Read more

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Ulcerative colitis and primary sclerosing cholangitis related?

Yes: Yes there is an association. See this link: http://www.Mayoclinic.Com/health/primary-sclerosing-cholangitis/ds00918/dsection=risk-factors. ...Read more

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Is there any relation between ulcerative colitis and primary sclerosing cholangitis?

Yes: Unfortunately there is a relationship , 5 % of ulcerative colitis ( uc ) will have sclerosing cholangitis (sc ) 25% to 90% of sc patients will have uc, to less extent with crohn's disease. ...Read more

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How can I treat primary sclerosing cholangitis?

How can I treat primary sclerosing cholangitis?

Difficult problem: Psc: autoimmune swelling/scarring of bile ducts within and outside the liver; often associated with infl. Bowel (usually ulc colitis). Increased risk for biliary ca. Med rx for itch, biochem abnormalities, e.g. Urso (bear bile), antihistamines, antibiotics for infections, vitamin supllements for deficiencies. Ercp procedure may open some strictures (narrowing). Ultimately, may need liver transpla. ...Read more

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Why is igm elevated in primary biliary cirrhosis (cholangitis)?

Immune dysregulation: The immune system is not functioning normally in primary biliary cirrhosis. That and the chronic inflammation contrive to raise IgM. ...Read more

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Is primary biliary cirrhosis hereditary?

Is primary biliary cirrhosis hereditary?

Basically no: There's a pair of genes that carry the ability to develop the disease and these run in families, but it's not inherited like sickle cell, huntington's or some of the other familiar entities. http://www.medicalnewstoday.com/releases/151640.php. ...Read more

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Primary peritoneum carcinomatosis, what is this?

Primary peritoneum carcinomatosis, what is this?

Primary starts there: The most common cause of peritoneal carcinomatosis is from ovary. It is not the glandular cells but the surface epithelium of the ovary that gives rise to this tumor which first spreads to omentum and then diffusely to bowel and peritoneum. If in the presence of carcinomatosis the ovaries are normal it is most common to find the site arising from epithelial cells of peritoneal origin. ...Read more

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Whats sclerosing cholangitis?

See below: Complicated for a short answer here. See this site........http://www.mayoclinic.org/primary-sclerosing-cholangitis/. ...Read more

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What is focal sclerosing glomerulonephritis? What causes it?

What is focal sclerosing glomerulonephritis? What causes it?

Pattern: This may be due to anything from IgA nephropathy to lupus to a vasculitis. It's not a specific disease but a pattern of injury. As for more details. ...Read more

Dr. Thomas Fiala
72 doctors shared insights

Cholangitis (Definition)

It is an infection of the bile ducts. Usually there is an obstruction of the bile ducts. Most commonly this is caused by a gallstone, although there are other rarer causes. It can be life threatening. If you have pain in your right upper quadrant, a fever and are jaundiced, ...Read more


Dr. Milton Alvis Jr
27 doctors shared insights

Sclerosing Cholangitis (Definition)

It is an inflammatory condition of the main bile duct that drains bile from the liver. It is important to follow with an experienced gastroenterologist because untreated, the condition can ...Read more