Doctor insights on:
Is Plasma Cell Myeloma Hereditary
I had not heard of "kahler's disease" until seeing multiple questions on healthtap. It is multiple myeloma (mm). "multiple" is from the often seen "multiple" bone lesions (especially in advanced disease). Mm is a cancer of plasma cells [highly specialized b white blood cells (lymphocytes)] that produce antibodies. Sx are crab: hypercalcemia, renal insufficency, anemia, ...Read more
Not necessarily: This is a very rare form of lymphoma and it is not necessarily hereditary. If you had a family member with lymphoma, the best thing to do is to look at your family history and see if there are any other cancers in your first degree relatives. If not, then this lymphoma was likely sporadic. If there are others with a family history, you can go for genetic counseling. ...Read more
Plasma cell Myeloma
Myelogram test shows- Plasma cell=24%
No haemoparasites seen
Leucopoisesis-More active with Plasmacytosis?
No: I see no correlation.Get a more detailed answer ›
Blood: The genetic defect is in the hemoglobin molecule. ...Read more
Yes/No: In a sense all cancer is "genetic" involving changes to the DNA or epi-genetic - changes to DNA modifiers such as methylation. A related question is is multiple myeloma inherited. The answer is sometimes. The risk is about double with a family history. Here is one clinical trial studying this: https://clinicaltrials.gov/ct2/show/NCT00582621 ...Read moreSee 2 more doctor answers
I Don't Think So: I'm guessing a bit as to what you mean by your question. Sickle cell anemia is caused by a gene mutation on both copies of the beta globin gene. In that sense it is a genetic disease. However, a number of other factors, some of them environmental, can influence the type and severity of problems that patients with ssa have. ...Read more
Is bone marrow transplantation is curative for chronic myeloid leukemia caused by (Philadelphia chromosome) ?
Abnormal blood cells: Sickle cell disease occurs when there is an abnormal type of hemoglobin in blood cells. Thought to be a survivor advantage against malaria, when these cells have too little oxygen they collapse and get stuck in small vessels. This cuts off the blood supply to organs and causes severe pain. Sickle cell traits is when only half the genes code for the abnormal hemoglobin, usually not symptomatic. ...Read moreSee 1 more doctor answer
Red blood disorder: Autosomal recessive disorder when rbc's become rigid and cannot carry oxygen. The hemoglobin is abnormal. Also know as hbss vs hbas or trait. With low oxygen tension the beta chain of the hemoglobin molecule cannot carry oxygen properly and takes a different form-becomes sickle shaped, inelastic. They cannot pass through capillaries and lead to occlusion and ischemia. Rx transfusions, fluids. ...Read moreSee 1 more doctor answer
What is the prognosis (chance of recovery) for multiple myeloma and other plasma cell cancer types?
Better than before: Most patients can now achieve remission either with standard therapy or stem cell transplant. The remissions can be long lived although patients are not cured. Many live a decade or more with good quality of life and this time line continues to get longer with the new targeted therapies. The average life span used to be 2.5 years. ...Read moreSee 1 more doctor answer
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