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Doctor insights on: Is Plasma Cell Myeloma Hereditary

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Dr. Bernard Seif
118 doctors shared insights

Kahler Disease (Definition)

I had not heard of "kahler's disease" until seeing multiple questions on healthtap. It is multiple myeloma (mm). "multiple" is from the often seen "multiple" bone lesions (especially in advanced disease). Mm is a cancer of plasma cells [highly specialized b white blood cells (lymphocytes)] that produce antibodies. Sx are crab: hypercalcemia, renal insufficency, anemia, ...Read more


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Is plasma cell myeloma hereditary?

Majority Not: Majority of myeloma cases is not hereditary. A small but unknown fraction of cases are familial. The risk of developing myeloma is approximately 3.7-fold higher for persons with a first degree relative with myeloma. ...Read more

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Plasma cell Myeloma Myelogram test shows- Plasma cell=24% No haemoparasites seen Leucopoisesis-More active with Plasmacytosis?

Need more info: From what you stated, you have a serious disorder of the bone marrow and should consult a hematologist. The subject cannot be adequately addressed in this forum. ...Read more

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What are the tests for kahler disease?

What are the tests for kahler disease?

Myeloma Tests: Testing for myeloma includes serum protein electrophoresis (spep) with immunofixation, free light chain kappa/lambda ratio, upep, beta-2 microglobulin, ig's, other lab tests; bone marrow biopsy, skeletal survey. Other tests may include MRI of spine/bone marrow, pet/ct. Bmb tests: fish, cytogenetics, pcli (at some centers), gene expression profiling (gep). Other research tests may be done. ...Read more

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What is the definition or description of: kahler disease?

Multiple Myeloma: I had not heard of "kahler's disease" until seeing multiple questions on healthtap. It is multiple myeloma (mm). "multiple" is from the often seen "multiple" bone lesions (especially in advanced disease). Mm is a cancer of plasma cells [highly specialized b white blood cells (lymphocytes)] that produce antibodies. Sx are crab: hypercalcemia, renal insufficency, anemia, bone disease; & infection. ...Read more

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What is the treatment for kahler disease?

What is the treatment for kahler disease?

Myleloma Tx: I've never called multiple myeloma "kahler's disase" but -- http://en.Wikipedia.Org/wiki/multiple_myeloma -- wiki confirms. The treatment options for multiple myeloma have become more complicated due to the number of new drugs in myeloma. This is a good thing. In general we look at transplant eligible or ineligible and personalize therapy based on risk factors. ...Read more

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What is the prognosis (chance of recovery) for multiple myeloma and other plasma cell cancer types?

What is the prognosis (chance of recovery) for multiple myeloma and other plasma cell cancer types?

Better than before: Most patients can now achieve remission either with standard therapy or stem cell transplant. The remissions can be long lived although patients are not cured. Many live a decade or more with good quality of life and this time line continues to get longer with the new targeted therapies. The average life span used to be 2.5 years. ...Read more

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What types of treatment exist for multiple myeloma and other plasma cell cancer types?

"Many": Myeloma and other plasma cell dyscrasia treatments has evolved from standard cytotoxic approaches (eg mp, vad, hypercvad) to "novel" therapies. Immunomodulatory drugs (imids) - eg thalidomide, lenalolidomide, pomalidomide proteasome inhibitors - eg, bortezomib, carfilzomib, etc other: hsp90 inhibitors, hdaci, b-raf, etc. Over the last few years multiple new drugs have been approved for myeloma. ...Read more

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What types of questions should I ask my doctor regarding treatment for multiple myeloma or other plasma cell cancer?

What types of questions should I ask my doctor regarding treatment for multiple myeloma or other plasma cell cancer?

1-2-3: Cancer 1-2-3: 1) diagnosis - myeloma vs. ? 2a) stage - iss (not that relevant for individual) 2b) prognostic factors - eg cytogenetics, pcli (if avail), gep (new), bone disease, etc. 3) treatment -- goals (response or quality or....) and options. Some regiments are easy eg rd which is good for a low burden mm disease and working pt vs. More complicated "induction" regimen for high risk/burden. ...Read more

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How bad is multiple myeloma with 40% abnormal plasma cells in bone marrow?

How bad is multiple myeloma with 40% abnormal plasma cells in bone marrow?

Depends: The number of plasma cells is not the only determinant of prognosis. Are there bone lesions on x-ray? Is kidney function normal? Has there been a response to therapy? Many patients with 40% plasma cells at diagnosis can do well for years. ...Read more

Plasma Cell (Definition)

A plasma cell is a special white cell typically found in the bone marrow which is responsible for making antibodies. When it becomes cancerous, it causes a condition ...Read more


Plasma (Definition)

It is the fluid portion of both the blood and lymph system in which the ...Read more