Doctor insights on:
Is Plasma Cell Myeloma Hereditary
Kahler disease is also known as Multiple myeloma. I had not heard of "kahler's disease" until seeing multiple questions on healthtap. It is multiple myeloma (mm). "multiple" is from the often seen "multiple" bone lesions (especially in advanced disease). Mm is a cancer of plasma cells [highly specialized b white blood cells (lymphocytes)] that produce antibodies. Sx are crab: hypercalcemia, renal insufficency, anemia, ...Read more
Plasma cell cancer: Multiple myeloma is a cancer of plasma cells (pcs). Pcs are the specialized b lymphocytes that produce antibodies. When there is a cancer or one (mono-) clone (= monoclonal, m) pc population they can product m-proteins. Symptoms include crab - hypercalcemia, renal (kidney) insufficiency, anemia, bone disease; also infection and pain. More: http://www.Cancer.Net/cancer-types/multiple-myeloma. ...Read more
Plasma cell Myeloma
Myelogram test shows- Plasma cell=24%
No haemoparasites seen
Leucopoisesis-More active with Plasmacytosis?
Myeloma Tests: Testing for myeloma includes serum protein electrophoresis (spep) with immunofixation, free light chain kappa/lambda ratio, upep, beta-2 microglobulin, ig's, other lab tests; bone marrow biopsy, skeletal survey. Other tests may include MRI of spine/bone marrow, pet/ct. Bmb tests: fish, cytogenetics, pcli (at some centers), gene expression profiling (gep). Other research tests may be done. ...Read more
Multiple Myeloma: I had not heard of "kahler's disease" until seeing multiple questions on healthtap. It is multiple myeloma (mm). "multiple" is from the often seen "multiple" bone lesions (especially in advanced disease). Mm is a cancer of plasma cells [highly specialized b white blood cells (lymphocytes)] that produce antibodies. Sx are crab: hypercalcemia, renal insufficency, anemia, bone disease; & infection. ...Read more
Myleloma Tx: I've never called multiple myeloma "kahler's disase" but -- http://en.Wikipedia.Org/wiki/multiple_myeloma -- wiki confirms. The treatment options for multiple myeloma have become more complicated due to the number of new drugs in myeloma. This is a good thing. In general we look at transplant eligible or ineligible and personalize therapy based on risk factors. ...Read more
What is the prognosis (chance of recovery) for multiple myeloma and other plasma cell cancer types?
Better than before: Most patients can now achieve remission either with standard therapy or stem cell transplant. The remissions can be long lived although patients are not cured. Many live a decade or more with good quality of life and this time line continues to get longer with the new targeted therapies. The average life span used to be 2.5 years. ...Read moreSee 1 more doctor answer
"Many": Myeloma and other plasma cell dyscrasia treatments has evolved from standard cytotoxic approaches (eg mp, vad, hypercvad) to "novel" therapies. Immunomodulatory drugs (imids) - eg thalidomide, lenalolidomide, pomalidomide proteasome inhibitors - eg, bortezomib, carfilzomib, etc other: hsp90 inhibitors, hdaci, b-raf, etc. Over the last few years multiple new drugs have been approved for myeloma. ...Read moreSee 1 more doctor answer
What types of questions should I ask my doctor regarding treatment for multiple myeloma or other plasma cell cancer?
1-2-3: Cancer 1-2-3: 1) diagnosis - myeloma vs. ? 2a) stage - iss (not that relevant for individual) 2b) prognostic factors - eg cytogenetics, pcli (if avail), gep (new), bone disease, etc. 3) treatment -- goals (response or quality or....) and options. Some regiments are easy eg rd which is good for a low burden mm disease and working pt vs. More complicated "induction" regimen for high risk/burden. ...Read moreSee 1 more doctor answer
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