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Doctor insights on: Is Plasma Cell Myeloma Hereditary

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Dr. Stephen Noga Dr. Noga
Internal Medicine - Oncology
30 years in practice
Johns Hopkins University School of Medicine
1

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Which groups are most frequently affected by multiple myeloma?

Which groups are most frequently affected by multiple myeloma?

Blacks in US: Twice the incidence in african americans than caucasians. Some families have a higher incidence.

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Dr. Steven Griggs
125 Doctors shared insights

Kahler Disease (Definition)

I had not heard of "kahler's disease" until seeing multiple questions on healthtap. It is multiple myeloma (mm). "multiple" is from the often seen "multiple" bone lesions (especially in advanced disease). Mm is a cancer of plasma cells [highly specialized b white blood cells (lymphocytes)] that produce antibodies. Sx are crab: hypercalcemia, renal insufficency, anemia, ...Read more


Dr. Liawaty Ho Dr. Ho
Internal Medicine - Hematology & Oncology
19 years in practice
Udayana University Faculty of Medicine
2

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Is plasma cell myeloma hereditary?

Majority Not: Majority of myeloma cases is not hereditary. A small but unknown fraction of cases are familial. The risk of developing myeloma is approximately 3.7-fold higher for persons with a first degree relative with myeloma.

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Dr. Gurmukh Singh Dr. Singh
Pathology
45 years in practice
University of Pune, Armed Forces Medical College
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Plasma cell Myeloma Myelogram test shows- Plasma cell=24% No haemoparasites seen Leucopoisesis-More active with Plasmacytosis?

Plasma cell Myeloma Myelogram test shows- Plasma cell=24% No haemoparasites seen Leucopoisesis-More active with Plasmacytosis?

Need more info: From what you stated, you have a serious disorder of the bone marrow and should consult a hematologist. The subject cannot be adequately addressed in this forum.

Dr. Michael Thompson Dr. Thompson
Internal Medicine - Hematology & Oncology
16 years in practice
Mayo Clinic College of Medicine
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What are the tests for kahler disease?

What are the tests for kahler disease?

Myeloma Tests: Testing for myeloma includes serum protein electrophoresis (spep) with immunofixation, free light chain kappa/lambda ratio, upep, beta-2 microglobulin, ig's, other lab tests; bone marrow biopsy, skeletal survey. Other tests may include MRI of spine/bone marrow, pet/ct. Bmb tests: fish, cytogenetics, pcli (at some centers), gene expression profiling (gep). Other research tests may be done.

Dr. Michael Thompson Dr. Thompson
Internal Medicine - Hematology & Oncology
16 years in practice
Mayo Clinic College of Medicine
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What is the definition or description of: kahler disease?

What is the definition or description of: kahler disease?

Multiple Myeloma: I had not heard of "kahler's disease" until seeing multiple questions on healthtap. It is multiple myeloma (mm). "multiple" is from the often seen "multiple" bone lesions (especially in advanced disease). Mm is a cancer of plasma cells [highly specialized b white blood cells (lymphocytes)] that produce antibodies. Sx are crab: hypercalcemia, renal insufficency, anemia, bone disease; & infection.

Dr. Michael Thompson Dr. Thompson
Internal Medicine - Hematology & Oncology
16 years in practice
Mayo Clinic College of Medicine
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What is the treatment for kahler disease?

What is the treatment for kahler disease?

Myleloma Tx: I've never called multiple myeloma "kahler's disase" but -- http://en. Wikipedia. Org/wiki/multiple_myeloma -- wiki confirms. The treatment options for multiple myeloma have become more complicated due to the number of new drugs in myeloma. This is a good thing. In general we look at transplant eligible or ineligible and personalize therapy based on risk factors.

Dr. Stephen Noga Dr. Noga
Internal Medicine - Oncology
30 years in practice
Johns Hopkins University School of Medicine
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What is the prognosis (chance of recovery) for multiple myeloma and other plasma cell cancer types?

What is the prognosis (chance of recovery) for multiple myeloma and other plasma cell cancer types?

Better than before: Most patients can now achieve remission either with standard therapy or stem cell transplant. The remissions can be long lived although patients are not cured. Many live a decade or more with good quality of life and this time line continues to get longer with the new targeted therapies. The average life span used to be 2.5 years.

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Dr. Michael Thompson Dr. Thompson
Internal Medicine - Hematology & Oncology
16 years in practice
Mayo Clinic College of Medicine
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What types of treatment exist for multiple myeloma and other plasma cell cancer types?

"Many": Myeloma and other plasma cell dyscrasia treatments has evolved from standard cytotoxic approaches (eg mp, vad, hypercvad) to "novel" therapies. Immunomodulatory drugs (imids) - eg thalidomide, lenalolidomide, pomalidomide proteasome inhibitors - eg, bortezomib, carfilzomib, etc other: hsp90 inhibitors, hdaci, b-raf, etc. Over the last few years multiple new drugs have been approved for myeloma.

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Dr. Michael Thompson Dr. Thompson
Internal Medicine - Hematology & Oncology
16 years in practice
Mayo Clinic College of Medicine
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What types of questions should I ask my doctor regarding treatment for multiple myeloma or other plasma cell cancer?

What types of questions should I ask my doctor regarding treatment for multiple myeloma or other plasma cell cancer?

1-2-3: Cancer 1-2-3: 1) diagnosis - myeloma vs.? 2a) stage - iss (not that relevant for individual) 2b) prognostic factors - eg cytogenetics, pcli (if avail), gep (new), bone disease, etc. 3) treatment -- goals (response or quality or....) and options. Some regiments are easy eg rd which is good for a low burden mm disease and working pt vs. More complicated "induction" regimen for high risk/burden.

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Dr. Peter Wiernik Dr. Wiernik
Internal Medicine - Hematology & Oncology
52 years in practice
University of Virginia School of Medicine
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How bad is multiple myeloma with 40% abnormal plasma cells in bone marrow?

How bad is multiple myeloma with 40% abnormal plasma cells in bone marrow?

Depends: The number of plasma cells is not the only determinant of prognosis. Are there bone lesions on x-ray? Is kidney function normal? Has there been a response to therapy? Many patients with 40% plasma cells at diagnosis can do well for years.

Dr. Craig MacArthur Dr. MacArthur
Pediatrics - Hematology & Oncology
30 years in practice
Washington University School of Medicine
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Is increase in plasma cell 15 percent only related to multiple myloma of other malignancies or infection also?

Is increase in plasma cell 15 percent only related to multiple myloma of other malignancies or infection also?

Myeloma or infection: Multiple myeloma is based on all three of the following for diagnosis: 1) 10% or more monoclonal plasma cells; 2) serum or urine monoclonal protein; 3) organ dysfunction (high serum calcium, high serum creatinine, low hemoglobin, or lytic bone lesions/osteoporosis). If 2) is not present, then bone marrow needs 30% plasma cells. Plasma cells can occur with infections. See a doctor for further help

Dr. Martin Rubenstein Dr. Rubenstein
Internal Medicine - Hematology & Oncology
41 years in practice
Stanford University School of Medicine
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Are stem cell transplants for multiple myeloma effective?

Yes.: Autologous stem cells transplants (from yourself as donor when in near remission) result in improved progression free survival and probably overall survival. Allogeneic transplant (from someone else) is more complex, and many would consider it experimental. Although the procedure may cure the disease, there are significant complications and risks that may offset the benefits.

Dr. Jean Yared Dr. Yared
Internal Medicine - Oncology
years in practice
St Joseph's University Faculty of Medicine
14

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Can stem cell transplants cure multiple myeloma?

Can stem cell transplants cure multiple myeloma?

Remission: Multiple myeloma is treated classically with chemotherapy and autologous stem cell transplantation. Both modalities can put the disease on remission and prolong life substantially. I personally do not offer allogeneic stem cell transplant for multiple myeloma unless on clinical trial or under very stringent circumstances. Multiple myeloma remains an incurable but very treatable disease.

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Dr. David Holtz Dr. Holtz
Gynecology - Oncology
19 years in practice
Jefferson Medical College of Thomas Jefferson University
15
Dr. Timothy Goggins Dr. Goggins
Internal Medicine - Hematology & Oncology
20 years in practice
Albany Medical College
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Is it reasonable to have second autologous stem cell transplant for myeloma?

Yes: This is a very difficult question today because every situation with myeloma is different. We do not double transplant all myeloma patients like we have done in the past. It is sometimes reasonable if the first was previously successful and donor cells remain. We now have so many treatments for myeloma that sometimes we do an allogeneic transplant or treat with other drugs (velcade, carfilzomab.

Dr. Keith Stockerl-Goldstein Dr. Stockerl-Goldstein
Internal Medicine - Hematology & Oncology
26 years in practice
UCLA School of Medicine
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Life expectancy of myeloma patients after autologous stem cell transplant?

Myeloma: There are many things that go into predicting life expectancy of somebody with myeloma who has an autologous stem cell transplant. The rough estimate for somebody getting a transplant in first remission is about 6-7 years now. However, this is something your oncologist or transplant doctor can talk to you about with more specific information.

Dr. Ivan Ip Dr. Ip
Internal Medicine - Hospital-based practice
9 years in practice
Weill Cornell Medical College of Cornell University
18
Dr. Ronald Krauser Dr. Krauser
Internal Medicine - Rheumatology
48 years in practice
Wake Forest University School of Medicine
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Low red blood cells, very low anion gap, and high blood protein. Should I worry about multiple myeloma? Back/hip pain recent.

Low red blood cells, very low anion gap, and high blood protein. Should I worry about multiple myeloma? Back/hip pain recent.

Anything Is possible: There are numerous possible causes. Have your doctor order a serum protein electrophoresis blood test. If there is no monoclonal spike then myeloma is ruled out.

Dr. Ed Friedlander Dr. Friedlander
Pathology
40 years in practice
Northwestern University Feinberg School of Medicine
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Why sickle cell anemeia / multiple myeloma cause diabetes insipidus? Is it because it may obstruct the blood flow to the kidneys and damage them?

Why sickle cell anemeia / multiple myeloma cause diabetes insipidus? Is it because it may obstruct the blood flow to the kidneys and damage them?

Basically right: Even sickle cell trait ruins much of the concentrating ability of the kidneys by adulthood. Myeloma is more likely to damage and obstruct the tubules themselves. Both produce a kidney lesion that prevents the urine from becoming concentrated, rather than a pituitary diabetes insipidus.

Plasma Cell (Definition)

A plasma cell is a special white cell typically found in the bone marrow which is responsible for making antibodies. When it becomes cancerous, it causes a condition ...Read more


Plasma (Definition)

It is the fluid portion of both the blood and lymph system in which the ...Read more