Doctor insights on:
Pelvic Pain And Sickle Cell Disease
Is anemia a symptom of Sickle Cell Anemia, or is Sickle Cell Anemia a type of anemia and if so do you have the same number of RBCs as everyone else?
An inherited blood disease causing red blood cells to be sickle (curved) shaped instead of round. It shortens life expectancy, and can result in bacterial infections, painful swelling of the hands and feet, fever, arthritis, leg ulcers, fatigue, anemia, eye damage, and ...Read more
Yes: With ss disease a genetic mutation changes the gene sequencing needed for normal hemoglobin production.The alteration changes the way the hemoglobin handles the oxygen molecule as it carries it in the blood.The blood cell then becomes distorted in the small capillaries and the spleen.The cell breaks down rapidly and or remains trapped.Anemia is a chronic problem. ...Read more
Gene mutation: Sickle cell trait is caused bu the presence of a single mutation in the beta chain of human hemoglopin a gene. A mutation in one gene on one of a person's two beta globin genes results in sickle cell trait (sa hemoglobin) while the same mutation in both of a persons genes causes sickle cell anemia. (ss hemoglobin). The term trait means a carrier for the sickle cell mutation. ...Read more
Is a woman with sc blood genotype a sickle cell carrier or patient. And what is the health implication of this especially during pregnancy?
Hgb SC: Is a sickle cell syndrome but the genetics are different. A woman with HGB sc will pass either a HGB s gene, or a HGB c gene to her child. It is important to know what kind of HGB the father has-he should have a hemoglobin electrophoresis to find out how the child might be affected. Pregnancy complications are rare, but the baby can have a low weight, and rarely there are complications for the mom. ...Read moreSee 1 more doctor answer
Anemia, pain, crises: The most frequent presenting signs/symptoms of sickle cell include anemia and typical sickle cell crises which include pain crises (severe pain in arms, legs, shoulders, back), acute chest crisis (shortness of breath, cough, fever, lung infiltrate), dactylitis (pain toes/fingers usually as a toddler) and others. Most patients that have sickle cell trait are completely asymptomatic. ...Read moreSee 1 more doctor answer
My father has a rare type of sickle cell that affects his WBC's instead of RBC's. Is there any information on this type of Sickle Cell Trait?
Get better info: Your dad may have a white cell disorder but it has nothing to do with sickle cell trait which is a specific red cell disorder. You need to consult with your day and find out the proper name for his disorder before we can comment. A doc may have compared it to sickle cell trait to try to explain it. ...Read moreSee 1 more doctor answer
Mutated gene: It is believed a single gene mutation occurred hundreds of years ago in a person in sub-Saharan Africa. When carried as one of a pair (trait), it seemed to confer resistance to malaria. It is transmitted as a recessive gene, meaning the normal gene next to it can do the work. When 2 defective genes are present, (sickle cell disease) the proper work is not done and the blood cells are defective. ...Read moreSee 1 more doctor answer
HgbE beta thal: Your infant may be developing hypersplenism. See a pediatric hemotologist for help. ...Read more
Depends on parents: Sickle cell disease (ss) is inherited from your parents. Both parents must have at least one copy of the mutated beta-hemoglobin gene for the child to be affected. If both parents have ss, 100% chance of ss for child. If one parent ss and the other has sickle cell trait (one normal and one mutated gene), 50% chance of ss for child. If both parents have trait, 25% chance of ss in child. ...Read more
No: True sickle cell disease requires a recessive gene contribution from both parents. These parents are asymptomatic carriers and may not know they have the gene.At conception the sperm carries one s gene that joins with the mothers s gene, so the pair both have the ss information as will every cell in the body. ...Read more
If you suffer from a chronic pain disorder such as sickle cell anemia what natural pain relief is there?
Prevent ss crisis: Hydration, a lot of fluids, oxygenation, Folic Acid supplements, treat infection new studies suggest sickle cell patient cannot vasodilate due to low nitric oxide--resveratrol, present in grapes, red wine increase nitric oxide! ---but I am skeptical. ...Read moreSee 1 more doctor answer
What is the signifigance of a mono clonal T cell beta gene rearrangement found in blood ? All other labs are normal. Is this a sign of lymphoma ?
Probably not: Monoclonal populations of immune cells can be a challenge to diagnose. Conditions like RA can associate with t-cell monoclonal populations. If the counts are otherwise normal, the group of cells should be followed but probably do not represent malignancy per se, though technically are a "neoplastic" proliferation of cells. http://www.ncbi.nlm.nih.gov/pubmed/18474096 Check with your doctor. ...Read more
What is the hemoglobin range of thalassemia disease or trait? Up to when consider is it trait or disease?
It doesn't always...: Patients with sickle cell disease can be immunocompromised because the disease causes the loss of your spleen, an important organ that helps the body fight certain infections. Fevers in patients with sickle cell disease are usually caused by infections. Fevers usually don't accompany pain crises. ...Read moreSee 1 more doctor answer
No: Sickle cell trait is when a person has one mutated copy of the beta-hemoglobin gene and one normal copy. You always inherit the mutated hemoglobin from one of your parents. Thus, one parent always has at least sickle cell trait if the child has sickle cell trait. Therefore trait does not skip a generation. ...Read more
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