Doctor insights on:
Is Parkinsons Disease Genetic And What Causes It
Parkinson's causes: Specific gene mutations play a role and genes changed due to environmental exposure may be causal. Having a close relative who has it increases your risk. The triggers are felt to be virus or toxins (herbicides or pesticides). Changes in the brain of parkinson patients include: lower dopamine, lower norepinephrine, and the presence of lewy bodies. ...Read more
From a medical standpoint, "genetic" refers to the potential heritability of various medical conditions. While some conditions are inevitable (at some point in one's life) as a consequence of simple genetic heritability (eg huntington's disease), a large number of medical conditions (including all behaviorial health disorders) are the expressed final pathway of a ...Read more
Since doctors/nurses know the disease process, can they intentionaly cause the disease like Parkinson's to the people who had no genetic disposition?
Make missing protein: The general strategy is this. In parkinson disease, the cells that produce Dopamine are dying, Dopamine levels go down, and the symptoms and problems develop. Via gene therapy, a gene gets introduced that produces dopamine. It goes to where the Dopamine is needed, and problem solved. Except that it isn't so simple with many diseases. It has been helpful in ada deficiency, ie "bubble boy" disease. ...Read more
Early in discovery: The current incidence is 5%. However there have been 2 new genes identified which may shed further light on this matter. The LRRK2 and the Alpha-synuclein genes have been implicated in familial cases of Parkinson's disease. There is more to come! Please visit the Michael J Fox Parkinson's foundation website for more information. Take care. ...Read more
Clinical diagnosis: Parkinson disease may have genetic basis, but the diagnosis is usually made based on signs and symptoms. See this site for genetic basis of the disease. http://www.ncbi.nlm.nih.gov/pubmed/15503301. ...Read more
Yes!!: Current thought says many factors are involved. Pd is more common in areas with high agricultural chemical use & in those working with heavy metals or toxic chemicals. We also know that genetics are involved with several identified mutations causing higher susceptibility & rare families with dominantly inherited pd. I believe the key & cure of pd will be found using genetic breakthroughs. ...Read more
Yes,but: There are several gene mutations that have been detected in pd.Many are very limited in familial clusters & only 10% of pd is thought to be determined by such mutations.The lrrk2 gene is the most common anomaly in late onset pd & detection in an affected patient can be used to as a marker for close family screening. See the nih report: www.Ncbi.Nlm.Nih.Gov/pmc/articles/pmc3280083. ...Read more
Is Parkinson's now thought to be mostly caused by environmental factors, genetic factors, or some complex combination of both?
Combo but not known: The cause of most pakinson's disease is not known. However, there are some rare genetic factors and also possible environmental factors that are associated with the disease. See for more information: https://www.Michaeljfox.Org/understanding-parkinsons/i-have-got-what.Php. ...Read moreSee 1 more doctor answer
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