Doctor insights on:
Is Paraneoplastic Syndrome Hereditary
Tumor related: A paraneoplastic syndrome is a condition related to presence of a neoplastic growth but not to the local presence of cancer cells It is mediated by humoral factors expressed by the tumor or from an immune response against the tumor. They most commonly result from the cancers of the lung, breast, ovaries or lymphoma. Symptoms include difficulty in walking, swallowing, and vewrtigo ...Read more
Multiple symptoms: There are several paraneoplastic syndromes. Most are related to the production of excess hormones or tumor necrosis factor or high blood calcium. Neurologic processes can also occur. Your symptoms could be due to a lot of things, but don't sound like a specifric paraneoplastic syndrome to me. ...Read more
Paraneoplastic syndrome is a syndrome (constellation of symptoms of variable types) that occurs in association (para-) with cancer (-neoplastic).
Some specialized testing can detect antibodies involved in paraneoplastic syndrome, but sometimes it is not detectable.
The body parts effected depends on the type of syndrome but may involve the entire body -- eg myasthenia gravis and thymoma. ...Read more
Cancer related hormo: Cancers like lung cancer can produce chemicals which have hormone like effects on the body. This can cause, for example the calcium level or blood counts to go up. These are called paraneoplastic syndromes, they usually go away once the tumor is removed or controlled with chemotherapy. ...Read more
Serum Ab: It is a clinical diagnosis. But detection of some well characterized paraneoplastic antibodies in serum or CSF can be helpful. For example, anti-hu (encephalomylitis/sclc), anti-yo (cerebellar degeneration/breast or gyn cancer), anti-calcium channel (lambert-eaton syndrome), etc. Of note, negative antibody does not exclude the diagnosis. ...Read more
Maybe: Some defined antibodies are associated with paraneoplastic syndromes (note: plural). In those cases the testing may be positive. However, a person could have a paraneoplastic syndrome with negative testing for the known paraneoplastic antibodies. It is possible that studies are being done to characterize tests for paraneoplastic syndromes. That might be experimental. ...Read more
Hem/Onc: See a hematologist oncologist.Get a more detailed answer ›
Many: Neurologic paraneoplastic syndromes are caused by an abnormal immune response to the tumor, which makes the body accidentally attack its own nervous tissue. Muscle weakness, stiff limbs, dizziness, coordination problems, vision problems, confusion, difficulty swallowing, memory problems and numbness are some of the many possible symptoms. ...Read more
How long does paraneoplastic syndrome last if the entire tumor was removed and no further treatment is necessary?
Tough to know: The paraneoplastic syndrome is caused by an inappropriate immune response. The immune system was "allowed" to mount an attack on your body (sometimes attacking nerves, blood vessels, muscle, etc). Treating the tumor could result in a reset so that the immune system is rebooted, but this could take weeks to years and is highly dependent on specific factors that vary from person to person. ...Read more
What are paraneoplastic syndrome symptoms&what is treatment? I have tn, pn, and fibro also. Lost90lbs in 6 mo. Unintentionally. Plz help me.
Paraneoplastic simply refers to problems caused by tumors. Tn? Pn? Abbreviations?
But your weight loss certainly needs investigation. ...Read more
See below: Most paraneoplastic neuropathies are due to immune responses to neural proteins secreted by cancer cells. Most have been associated with small cell lung cancer_ others with cancer of the ovaries, breast, lymphoma, thymine, melanoma, and testicular cancer. Symptoms can include encephalitis, cerebellar degeneration, sympathy, motor neuron disease, Gillian Barre syndrome, myopathy and Eaton-Lambert myo ...Read more
Why the antibodies test- paraneoplastic syndrome of mayo clinic and Aetna does not approved by the FDA?
Faulty policy: Many insurances consider certain antibody tests for paraneoplastic syndrome screening involving the nervous system experimental and investigational. They base this on various criteria including debt of research & FDA approval. The tests should be considered medically necessary when ordered selectively for evaluating persons with signs & symptoms of specific paraneoplastic syndromes. ...Read more
Could a 1mm lung tumor cause any paraneoplastic syndrome? From my little knowledge these are related to small cell tumors? Thanks for any information
That's really tiny: Paraneoplastic syndromes from occult lung cancer are not subtle. You're paralyzed, or very weak and can barely get out of bed, or you are suddenly blind, or are very and inexplicably hyponatremic, or you are stir-crazy. I'd dismiss paraneoplastic cushingism unless your face is strikingly red and puffy. 1 mm "spots" are extremely common in healthy folks; if considering surgery, be wary. ...Read more
I have either autoimmune pandysautonomia or paraneoplastic syndrome. My anti striational antibody was positive. I have metastatic thyroid ca. Which?
A friend had chronic demyelinating polyneuropathy (cidp), then got chronic lymphocytic leukemia 2 years later. Is cidp paraneoplastic syndrome sometimes?
Not likely: Chronic inflammatory demyelinating polyradiculopathy (cidp) is almost always an autoimmune condition incited by some antecedent infection--c. Jejuni, ebv, cmv, or another infection. Antibodies produced against the virus/ bacteria/ pathogen cross-react with the myelin sheath on the nerve roots, first causing guillain-barre (aidp), then later cidp. It's exceedingly rare that cancer could cause this. ...Read more
I have small fiber neuropathy and paraneoplastic syndrome should I be looking into finding an oncologist?
Need more infromatio: Need more information.Get a more detailed answer ›
Lo back muscles stiff an dull headache sweating an trouble with balance. If this is paraneoplastic syndrome will it show on blood tests?
Is paraneoplastic syndrome a mets, cancer like spread from the lung to elsewhere an is it always seen in cat scan?
Not metastases: Paraneoplastic syndromes result either from substances produced by a tumor (perhaps a pituitary adenoma making prolactin and causing impotence) or from the immune response against a tumor attacking healthy cells (perhaps the attack on an oat cell lung cancer causing blindness). They have nothing to do with whether the tumor has metastasized. ...Read more
Complex ovarian cysts possiblity it could be cancerous...Should it be biopsied or removed? I have a paraneoplastic syndrome been in search if there is any tumors in the body causing my symptoms. A mass or complex cyst was found on my left ovary that has b
There are many things to consider here. One is your age, also do you have children? What was your doctor's recommendation? Have you seen a gyn/oncologist? If not you should do so for a different opinion/perspective. Honestly I can't make a recommendation based on the limited info. I have, therefore I encourage you to get a second opinion.
I hope other doctor's here on avvo. Com can lend their opinion as well.
Good luck. ...Read more
Weak legs, muscle twitches, memory loss, vision problems, apathy after the birth of 4th child three years ago. Paraneoplastic syndrome?
See your doctor...: Your symptoms (regardless of cause) are of concern and you should be seeking care from a physician to discover the cause. Nobody can diagnose you with paraneoplastic syndrome via computer -nor would you want them to as that is a very rare condition that should be managed by a team of physicians (and is secondary to a cancer - which you have not mentioned). Take care of yourself - see your doctor ...Read more
Neurologic and fever: Paraneoplastic syndromes are rare disorders triggered by altered immune system response to a neoplasm. They are defined as clinical syndromes involving nonmetastatic systemic effects. They arise from tumor secretion of hormones, peptides or cytokines arising in tumor and while fever is the most common presentation, several clinical situations observed simulating Cushing and Carcinoid syndrome. ...Read more
Cancer patients: Paraneoplastic syndromes are a heterogeneous group of disorders caused by mechanisms other than metastases, metabolic and nutritional deficits, infections, coagulopathy or side effects of cancer treatment. They may occur before the obvious signs of a malignancy become apparent. ...Read more
Testing: In some patients, paraneoplastic syndromes are clinical findings that accompany existing cancers. These may include changes in the skin, bones, hormone levels, electrolytes, or organ function. Extensive blood testing or scans in a patient with suggestive findings can confirm the diagnosis. ...Read more
Remote effect.: Paraneoplastic syndrome refers to a remote effect of a malignancy. It is a problem not caused by invasion of a body part by cancer, but instead a dysfunction occuring because of the cancer. Examples in nerve and muscle problems, abnormal blood clotting, and various autoimmune problems. ...Read more