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Doctor insights on: Is Multiple Myeloma Hereditary

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Which groups are most frequently affected by multiple myeloma?

Which groups are most frequently affected by multiple myeloma?

Blacks in US: Twice the incidence in african americans than caucasians. Some families have a higher incidence. Read more

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Dr. Marvin Ott
125 Doctors shared insights

Kahler Disease (Definition)

I had not heard of "kahler's disease" until seeing multiple questions on healthtap. It is multiple myeloma (mm). "multiple" is from the often seen "multiple" bone lesions (especially in advanced disease). Mm is a cancer of plasma cells [highly specialized b white blood cells (lymphocytes)] that produce antibodies. Sx are crab: hypercalcemia, renal insufficency, anemia, ...Read more


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How will my doctor know if I have multiple myeloma?  

Labs, xrays: There are a series of blood and urine tests that will give the doctor a good idea if you have the disease. These are usually followed by x-rays looking for tell-tale signs of myeloma and a bone marrow test which would identify the cancer cells themselves. Read more

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Is multiple myeloma hereditary?

Rarely: There are a few families where it appears hereditary. Having said this, there are families where more than one individual has the disease and the thought is that this may be due to an environmental cause. Read more

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Me 50 yrs was diagnosed with multiple myeloma about 2 yrs back. My father 80 yrs also diagnosed with same recently. Is MM hereditary or coincidence?

Both: Such conditions may be sporadic but genetic factors may well predispose some families to certain malignancies. An oncologist, having much more experience in multiple myeloma cases, is more qualified to answer this question, however. Read more

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How common is multiple myeloma?

How common is multiple myeloma?

Uncommon: Approximately 1% of all cancers and slightly more than 10 % of blood cancers in the United States. Read more

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When was multiple myeloma discovered?

When was multiple myeloma discovered?

"Multiple Myeloma": Just means multiple bone marrow tumors. A simple description like that does not take modern technology (though it would not be picked up early). Indeed, it has been known since ancient times. There have been a lot of discoveries along the way that explains what it is and how it arises. Here's an article on its history:
http://www. Ncbi. Nlm. Nih. Gov/pubmed/21509678 Read more

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What other tests for multiple myeloma?

What other tests for multiple myeloma?

Blood/Urine/Imaging: Usually workup involves blood and urine tests (spep / upep - serum and urine protein electrophoresis). The preferred initial imaging study is the skeletal survey (x-ray of multiple sites of the body including skull, axial skeleton, and proximal long bones). Bony lesions are usually lytic. Read more

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Multiple myeloma & longevity if treated?

Multiple myeloma: Medial survival in myeloma many years ago was only 1-2 years. Nowadays, with many effective therapy such as lenalidomide, bortezomib, transplant -median survival has increased up to 7 years. Newer medications such as pomalidomide and cerfilzomib hopefully would be approved soon and more medication in pipelines are lining up - all of these would likely to increase the median survival longer. Read more

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What are the causes of multiple myeloma?

No simple answer: Multiple myeloma has been associated with ionizing radiation (atomic bomb level), herbicides, petroleum products, analin hair dyes, autoimmune disease but there is no clear cut association. There are a few families which show an inheritance pattern along with other lymphomas. Read more

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Can anjeer be taken in multiple myeloma..

Anjeer in myeloma: Anjeer is another name for fig. As far as I am aware, you should be fine eating this. Read more

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What is the symptoms for multiple myeloma?

Many symptoms: There may be no symptoms in some people who are found to have myeloma on routine blood tests. Common symptoms include back pain, fatigue, bone fractures. Nausea and vomiting can occur related to kidney or electrolyte problems. Read more

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What is Multiple myeloma a risk factor for?

Multiple issues: It can lead to anemia, increased calcium, renal failure, bone pain and fractures to name a few Read more

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Could multiple myeloma be treated and cured?

Yes: Multiple myeloma can certainly be treated. There a variety of new drugs available. We are likely curing some myeloma patients, but we don't necessarilyl know who these peopple are when we start treatment. Check out the #mmsm tweetchat including an upcoming topic of myeloma cure. Read more

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What are some of the tests for Multiple myeloma?

The tests for Multiple myeloma include:: Albumin, Basic metabolic panel, Bone marrow biopsy, Complete blood count, Ionized calcium, Lactate dehydrogenase, MRI, Skeletal survey, C reactive protein, Protein electrophoresis, 24 hour urine protein electrophoresis, Free kappa lambda light chains, Beta 2 microglobulin. Read more

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What is the objective of treating multiple myeloma?

Depends...: This answer depends. That might not be as satisfying but is true. For a 90yo pt it is palliative -- keeping crab symptoms away with minimal discomfort fro m tx. A new study from dr. Campagnaro in ecog will evaluate. For most, "control" as a chronic disease. For some cure. If young, we like to obtain a "deep" response w/ complete response (cr) & now looking at minimal residual disease (mrd) by flow. Read more

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What is a young age for multiple myeloma? Under 50 years?

MM and age: Mm is a disease of older adults. The median age at diagnosis is 66 years; only 10% and 2% of patients are younger than 50 and 40 years, respectively. Read more

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What is the definition or description of: multiple myeloma?

Plasma cell cancer: Multiple myeloma is a cancer of plasma cells (pcs). Pcs are the specialized b lymphocytes that produce antibodies. When there is a cancer or one (mono-) clone (= monoclonal, m) PC population they can product m-proteins. Symptoms include crab - hypercalcemia, renal (kidney) insufficiency, anemia, bone disease; also infection and pain.
More: http://www. Cancer. Net/cancer-types/multiple-myeloma. Read more

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What are the common symptoms of smoldering multiple myeloma?

None: No symptoms by definition. Smoldering multiple myeloma (SMM) is asymptomatic. If it is "symptomatic" then it is (symptomatic) multiple myeloma (MM). A new International Myeloma Working Group definition of SMM and MM was just published...http://www. Thelancet. Com/journals/lanonc/article/PIIS1470-2045 (14)70442-5/abstract Ultra high risk SMM is now called MM. The trial E3A06 looks at SMM. Read more

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Is it possible for multiple myeloma to be treated and cured?

No: It does not appear that we have a reliable cure for multiple myeloma. We can control it for a long period of time, and we continue to better understand treatment options and make new discoveries. Hopefully the day will come when we can cure multiple myeloma as well as we cure some leukemias and lymphomas. Read more

Dr. Liawaty Ho
753 Doctors shared insights

Multiple Myeloma (Definition)

A cancer of the plasma cells, which are responsible for producing antibodies for your body. Symptoms include kidney insufficiency, anemia, bone ...Read more