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Doctor insights on: Is Methrotrexate A Causative Factor For Pulmonary Fibrosis

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Is methrotrexate a causative factor for pulmonary fibrosis?

Is methrotrexate a causative factor for pulmonary fibrosis?

Yes: Rarely Methotrexate can cause fibrosis of the lungs. An inflammation (called pneumonitis) is more common. Lung function should be checked at least yearly while on this drug. ...Read more

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Methotrexate (Definition)

Methotrexate was originally used in the early 1950's as a treatment for cancer but was also found to be effective in many other diseases including rheumatoid arthritis and psoriasis. It has anti inflammatory and immunosuppressive properties which make it an excellent first line therapy for RA ...Read more


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What can cause pulmonary fibrosis?

What can cause pulmonary fibrosis?

Scarred Lungs: Pulmonary fibrosis is essentially scarring of the lungs. There are many different causes for the lungs to scar. The disease can be a long-term chronic problem however in certain cases if the underlying cause of scarring is not addressed, it can be fatal. Furthermore, idiopathic pulmonary fibrosis is almost uniformly fatal. Lung transplantation may be a final resort. ...Read more

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Can liver problems cause pulmonary fibrosis?

Can liver problems cause pulmonary fibrosis?

No: Cirrhosis is associated with two other lung disorders which can cause similar symptoms to pulmonary fibrosis. These are called hepatopulmonary syndrome and portopulmonary hypertension. These only occur if cirrhosis is present. If it goes on long enough without treatment, portopulmonary hypertension can cause permanent injury to the lung. ...Read more

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I have pulmonary fibrosis, cause as yet undetermined (never smoked). Please comment on the safety of putting nebulized DMSO into the lungs.

I have pulmonary fibrosis, cause as yet undetermined (never smoked).  Please comment on the safety of putting nebulized DMSO into the lungs.

Not safe: I would advise you not to put any such chemical into your lungs. I do not know of any good medical/scientifically valid data that supports such a use for dmso. You could actually make matters worse by putting any foreign body/chemicals into your lung. So play it safe. ...Read more

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What is the cause of pulmonary fibrosis?

What is the cause of pulmonary fibrosis?

SILICA,ASBESTOS,BIRD: Fibrosis in the lungs has many causes 1inhalation of silica dust, asbestos, grain dust, bird and animal droppings 2 radiation therapy for breast cancer 3medications like chemotherapeutic drugs and amiodarone, methotrexate, nitrofurantoin 4 secondary effect of other diseases likeinterstitial lung disease 5 idiopathic when no cause can be found 6 sarcoidosis and wegnors granulomata 7 connective tissue di. ...Read more

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Does pulmonary fibrosis cause my lungs to thicken?

Yes: Pulmonary fibrosis causes the inner latticework of the lungs to thicken. Given that this latticework supports oxygen and carbon dioxide exchange, and that exchange is dependent on the thinness of the transport membrane, pulmonary fibrosis makes the lungs work less efficiently, leading to shortness of breath. ...Read more

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Can GERD cause pulmonary fibrosis?

Yes: This is one of the theories, that persistent reflux causes damage to sensitive predispose area & cause scar & tissue destruction called fibrosispulmonary fibrosis. ...Read more

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Can pulmonary fibrosis cause heart trouble?

Can pulmonary fibrosis cause heart trouble?

At the very end: At the end stages of pulmonary fibrosis, it can cause elevated blood pressure in the lungs, which can affect the heart. Also, the lack of oxygen from the fibrosis can also affect the heart. But, again, this occurs in the very end stages of the disease, usually. ...Read more

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Does pulmonary fibrosis cause my lungs to scar up?

Does pulmonary fibrosis cause my lungs to scar up?

Yes...: Pulmonary fibrosis does cause lung scarring. This can be minimized with treatment including treatment aimed at the underlying cause, if possible. ...Read more

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Some doctors say acid reflux can cause pulmonary fibrosis some says its not m worried had LPR since years?

Some doctors say acid reflux can cause pulmonary fibrosis some says its not m worried had LPR since years?

Possible: Recurrent with repeat aspiration, pneumonia, scarring, gradual fibrosis, and connection with any other issues, smoking --- or other anomaly. Best to treat, and avoid the esophageal strictures and more local problems. ...Read more

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After multiple respiratory, cardiac, and other organ tests, pulmonary fibrosis was ruled out as cause for my sob. Reduction of propranolol usage has helped somewhat, but not completely. What next?

After multiple respiratory, cardiac, and other organ tests, pulmonary fibrosis was ruled out as cause for my sob.  Reduction of propranolol usage has helped somewhat, but not completely.  What next?

Reduce completely?: So you've had a thorough investigation, all of which has been negative so far. Reducing your propanolol has helped but not completely. I'd venture to ask why not stop it completely then and replace w/another blood pressure medication. Surely there are others you can take that won't affect your breathing! if you need a rate limiting agent, consider Diltiazem or verapamil, which won't affect lungs. ...Read more

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Can LPR reflux cause pulmonary fibrosis or any lung problem?

Can LPR reflux cause pulmonary fibrosis or any lung problem?

Aspirating a lot?: Exposure of the vocal cords to stomach acid ; pepsin will result in inflammation of the vocal cords (as is also often seen with acid regurgitation). Acute laryngitis may result, but watch out for chronic hoarseness, throat clearing, airway spasms, bronchitis, an asthma-type presentation, and even a higher risk of throat cancer. Impedance ph testing with a symptom diary can best characterize this. ...Read more

Dr. Ted Saha Dr. Saha
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Few doc says acid reflux can cause pulmonary fibrosis few doc says not if silent reflux can cause pulmonary fibrosis wts time frame?

Dr. Ted Saha Dr. Saha
1 doctor agreed:
Few doc says acid reflux can cause pulmonary fibrosis few doc says not if silent reflux can cause pulmonary fibrosis wts time frame?

GERD: Well known extraesophageal( outside of feeding tube) manifestations include asthma, laryngitis, chronic cough, aspiration pneumonia, ch bronchitis, sleep apnea, dental caries, bad breath, and hiccups. Thus, it can damage lung tissues, at least in theory in a normal person. Surgical techniques can be used in the rare pts who are refractory to medical managements. ...Read more

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Can silent reflux cause can acid reflux cause pulmonary fibrosis or COPD orlung cancer ?

Not usually: Acid reflux affects the esophagus and, at times, the upper respiratory passage(larynx, trachea) but i wouldn't expect pulmonary fibrosis or lung cancer as complications. If you have reflux, see your md for treatment and dietary advice in order to protect your esophagus from chronic changes. ...Read more

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How can non-toxic bacteria such as mycobacterium tuberculosis cause pulmonary fibrosis?

Inflammation: Tb is an infection which can cause an inflammatory reaction and scar tissue can be the result of that process. ...Read more

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Can GERD LPR cause pulmonary fibrosis or any type of lung damage?

Can GERD LPR cause pulmonary fibrosis or any type of lung damage?

Yes: GERD- reflux disease can over time cause lung damage, especially if it combined with aspiration, ie reflux material entering the lungs ...Read more

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I hve breathlessness on very mild activity X-ray and pft are normal echo ECG normal, I am worrying for pulmonary fibrosis or COPD can LPR cause breat?

I hve breathlessness on very mild activity X-ray and pft are normal echo ECG normal, I am worrying for pulmonary fibrosis or COPD can LPR cause breat?

Not: If your pft and cxr are normal, COPD and pf have been ruled out. Other tests to consider are: cbc, tsh, and bnp. If all normal, consider a fitness program. Anxiety can also cause marked breathlessness if this applies to you. ...Read more

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How does pulmonary fibrosis affect a person?

How does pulmonary fibrosis affect a person?

Difficulty breathing: It can lead to restrictive lung pattern with progressive worsening of dyspnea with pulmonary hypertension and secondary right sided heart failure. ...Read more

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Dr. Aaron Milstone
624 doctors shared insights

Pulmonary Fibrosis (Definition)

A lung condition in which there is progressive scarring of the lung tissue. Symptoms include shortness of breath, chest pain, fatigue, ...Read more


Dr. Mark Pack
1 doctor shared a insight

Respiratory (Definition)

Pertaining to the work of breathing done by the chest ...Read more