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Doctor insights on: Is Methrotrexate A Causative Factor For Pulmonary Fibrosis

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Is methrotrexate a causative factor for pulmonary fibrosis?

Is methrotrexate a causative factor for pulmonary fibrosis?

Yes: Rarely Methotrexate can cause fibrosis of the lungs. An inflammation (called pneumonitis) is more common. Lung function should be checked at least yearly while on this drug. ...Read more

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Methotrexate (Definition)

Methotrexate was originally used in the early 1950's as a treatment for cancer but was also found to be effective in many other diseases including rheumatoid arthritis and psoriasis. It has anti inflammatory and immunosuppressive properties which make it an excellent first line therapy for RA ...Read more


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What can cause pulmonary fibrosis?

What can cause pulmonary fibrosis?

Scarred Lungs: Pulmonary fibrosis is essentially scarring of the lungs. There are many different causes for the lungs to scar. The disease can be a long-term chronic problem however in certain cases if the underlying cause of scarring is not addressed, it can be fatal. Furthermore, idiopathic pulmonary fibrosis is almost uniformly fatal. Lung transplantation may be a final resort. ...Read more

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Does pulmonary fibrosis cause my lungs to thicken?

Yes: Pulmonary fibrosis causes the inner latticework of the lungs to thicken. Given that this latticework supports oxygen and carbon dioxide exchange, and that exchange is dependent on the thinness of the transport membrane, pulmonary fibrosis makes the lungs work less efficiently, leading to shortness of breath. ...Read more

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Can liver problems cause pulmonary fibrosis?

Can liver problems cause pulmonary fibrosis?

No: Cirrhosis is associated with two other lung disorders which can cause similar symptoms to pulmonary fibrosis. These are called hepatopulmonary syndrome and portopulmonary hypertension. These only occur if cirrhosis is present. If it goes on long enough without treatment, portopulmonary hypertension can cause permanent injury to the lung. ...Read more

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Can pulmonary fibrosis cause heart trouble?

At the very end: At the end stages of pulmonary fibrosis, it can cause elevated blood pressure in the lungs, which can affect the heart. Also, the lack of oxygen from the fibrosis can also affect the heart. But, again, this occurs in the very end stages of the disease, usually. ...Read more

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I have pulmonary fibrosis, cause as yet undetermined (never smoked). Please comment on the safety of putting nebulized DMSO into the lungs.

I have pulmonary fibrosis, cause as yet undetermined (never smoked).  Please comment on the safety of putting nebulized DMSO into the lungs.

Not safe: I would advise you not to put any such chemical into your lungs. I do not know of any good medical/scientifically valid data that supports such a use for dmso. You could actually make matters worse by putting any foreign body/chemicals into your lung. So play it safe. ...Read more

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Can GERD cause pulmonary fibrosis?

Yes: This is one of the theories, that persistent reflux causes damage to sensitive predispose area & cause scar & tissue destruction called fibrosispulmonary fibrosis. ...Read more

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Dr. Aaron Milstone
614 doctors shared insights

Pulmonary Fibrosis (Definition)

Pulmonary fibrosis is a lung condition in which there is progressive scarring of the lung tissue. Symptoms include shortness of breath, chest pain, fatigue, ...Read more


Respiratory (Definition)

Respiratory is also known as Respiratory system. Pertaining to the work of breathing done by the chest ...Read more