Doctor insights on:
Is Lou Gehrigs Disease Sex Linked Or Autosomal
No: Most of it is sporadic. I do not know any variants of lou gehrig's that travel on the x-chromosome. This is in contrast with duchenne's / becker's muscular dystrophy, a weakness syndrome on the x chromosome that might be mistaken for lou gehrig's by a very inept physician. Lou gehrig's is amyotrophic lateral sclerosis. It is also unrelated to sexual activity. ...Read more
Neither: 90-90% of case of ALS are not inherited, it occurs at random at its cause is not known. In 5-10% of cases there is a familial form of the disease. In these 5-10% of cases it is usually dominant (meaning it is only necessary to have one copy of the defective gene) remember however most of the time it is not inherited at all. ...Read moreSee 1 more doctor answer
Neither: Celiac disease inheritance pattern is undetermined, there is genetic predisposition though, some individuals who have certain genes are more susceptible to develop the disease than others. Good question, but by HealthTap rules you are a minor! ask an adult to ask on your behalf next time, you need to be above 18 years to be able to register and ask questions, good luck ...Read more
None of the above: Down syndrome happens when an extra 21 chromosome is present in all the cells of the body. It happens before conception when the donor egg fails to shed one of its 21 chromosomes in the formation of the egg; the male 21 joins the female pair & creates an embryo with 3 number 21's. It has nothing to do with traits or mutations in the gene code. ...Read moreSee 1 more doctor answer
X-linked: It is an X-linked inheritance. That means it is found as a mutation on the X chromosome . Males are XY and so one gene mutation in that X chromosome that affects the alpa-galactosidase enzyme will cause the disease. Females are XX and so if one x chromosome has the mutation ,they will often experience a lesser form of Fabry Disease or no symptoms at all. ...Read more
Most are sporadic: While most cases of lou gehrigs disease do not have a known cause ("sporadic als"), approximately 5% of cases do run in families ("familial als"). There have been many proposed risk factors for developing sporadic als, but no clear smoking gun has been found to date. ...Read moreSee 1 more doctor answer
Celiac Disease: Celiac disease (cd) may have a higher prevalence in females but sex-linked genetic transmission has not been determined. The immune response genes are autosomal and there has been some linkage with certain genetic alleles hla-dq2 & dq8. If you do not have these alleles you will probably not get cd, but not everyone with these immune responce genes has cd. 30% of caucasions have dq2. ...Read more
No: Down syndrome is an abnormality of chromosome numbers, not a mutation on a sex chromosome. During conception only one of chromosome of each pair is given by both parents to the fertile egg.If a parent adds their 2 # 21 chm to the other parents # 21, 3 end up in the egg ; the excess 21 causes the all the problems.Rare forms are causes by a extra piece of a 21, but that's another issue. ...Read moreSee 1 more doctor answer
Specifics: Amyotrophic lateral sclerosis is a disease of the motor nerve cell in brain and spinal cord, is progressive, irreversible, and causes muscle weakness, muscle flickering, and atrophy, in arms, legs, tongue, and leads to progressive disability, loss of ability to breathe and swallow. No cure, sole drug approved is Riluzole, which helps delay tracheostomy but not effect on weakness. ...Read moreSee 1 more doctor answer
Interesting history: When lou gehrig died, no autopsy was ever done, and it was thought that he did suffer als, but retrospective analysis raises question of what we now know to be a chronic traumatic encephalopathy. Regardless, his name is associated with degeneration of motor nerve cells in brain and spinal cord. ...Read moreSee 2 more doctor answers
None of the above: Edward syndrome is brought on by an abnormality of chromosome numbers, specifically an extra 18. The abnormal egg with a single chromosome 1-17 & 19-22 + x has a pair of 18's. When the sperm brings a single chromosome 1-22 + x or y then the embryo ends up with 47 chromosomes rather than 46 in every cell.(3-18's) the excess distorts the organ building information & defects arise. ...Read moreSee 1 more doctor answer
Some comments: Pku is a problem with children and this needs early diagnosis to prevent profound complications. Huntington's chorea is an autosomal dominant disorder occurring later in life, and is relatively rare, but genetic counseling might be valuable. Neither disorder has any relationship to the other. ...Read moreSee 1 more doctor answer
Huntington's disease, an often fatal disease of the central nervous system, is inherited from a dominant alle, is this right?
Yes: Autosomal dominant disorder with the presence of excess numbers of tri-nucleotide repeats within the Huntington's gene on human chromosome 4. ...Read more
Is there a difference between autosomal dominant and autosomal recessive polycystic kidney disease?
Yes: The dominant form occurs mostly in adults. It is inherited but it takes time to show up as a diagnosable disease in middle to later age. Depending on your luck you either have it from your parent or not( 50% chance).The recessive form could be carried by seemingly healthy persons and when manifests as a disease in the offspring, it shows up at a much earlier age. ...Read more
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- Is down syndrome autosomal or sex linked?
- Down syndrome autosomal or sex linked
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