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Doctor insights on: Long Term Use Of Gabapentin For Relief Of Peripheral Neuropathy

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Is long term use of gabapentin for relief of peripheral neuropathy a good idea?

Is long term use of gabapentin for relief of peripheral neuropathy a good idea?

Gabapentin: In general, Gabapentin is well tolerated and used safely long term. But as with any other medications, it has potential side effects such as mood disturbances, dizziness, fatigue, leg swelling, low white cell count, low platelet count, and renal failure. In rats, pancreatic cancer is reported. It should be used with caution in chronic kidney disease and should not be stopped suddenly.

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Dr. Olav Jaren
1,339 Doctors shared insights

Nerve Damage (Definition)

A complete nerve transection will leave an area totally numb. The distribution of the numbers depends upon where the nerve was cut. A partial nerve injury may leave the area tingly or incompletely numb. Finally even if the nerve is not cut the swelling and bruising to the tea can affect the nerve as well. Usually we consider sharp penetrating injuries as likely having nerve lacerations when sensation is lost. A hand surgeon can examine the hand and pinpoint the site or extent of nerve injury and recommend ...Read more


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What is a good med for peripheral neuropathy? I can't take Gabapentin.

What is a good med for peripheral neuropathy? I can't take Gabapentin.

Not major problem: Many choices including Lyrica (which may be tolerated better than gabapentin, but also consider Horizant and Gralise). Might try Cymbalta, Savella, (milnacipran) amitryptyline, but may benefit from lamotrigine, levetiracetam, other tricyclics or even SSNRI's. But maybe find etiology of neuropathy and treat cause directly.

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Was prescribed Neurontin (gabapentin) 1200 mg a day. Does it help releive peripheral neuropathy symptoms and how long does it take to have an effect?

Was prescribed Neurontin (gabapentin) 1200 mg a day. Does it help releive peripheral neuropathy symptoms and how long does it take to have an effect?

Sometimes: Neurontin (gabapentin) can be an effective therapy for a peripheral neuropathy. It is not universally successful and you may need a higher dose before you can determine in this medication will help.

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Does gabapentin prevent peripheral neuropathy from getting worse?

Does gabapentin prevent peripheral neuropathy from getting worse?

Not exactly: Gabapentin can help control the symptoms of a peripheral neuropathy but it is less likely to really alter the ultimate course.

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What is the average dosage of gabapentin for peripheral neuropathy?

What is the average dosage of gabapentin for peripheral neuropathy?

Neurontin (gabapentin) dosage: It varies depending on individual conditions and response to medication. It is difficult for say in your conditions. For most of my patients, they are taking 600-800mg three times daily for peripheral neuropathy.

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I take gabapentin 300 mg twice a day for severe bilateral peripheral neuropathy pain. Is 900 mg a day safe for kidneys? I'm stage 3, PKD patient.

Increase Gabapentin?: Gabapentin (g) toxicity in patients with chronic kidney disease (ckd) is under recognized. Patients with ckd often receive inappropriately high g dosage for their kidney function, occasioning overt toxicity; advanced age and comorbidity predispose ckd patients to toxicity. I would ask your nephrologist's (c) opinion before increasing the dose, as the n knows you the best.

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Can I take cymbalta (duloxetine) and gabapenten together for sudden onset peripheral neuropathy of the feet. What is the usual dose that cymbalta (duloxetine) startsvto be effe?

Go to your PCP: It would be best to start one medication at a time to see your response. Every individual response to Cymbalta (duloxetine) is different but you can start at 30 mg. Once you've established the dose for Cymbalta (duloxetine) and your neuropathy is still troublesome, you can add Gabapentin. It is best to have your doctor monitor your medication.

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Md recommended I change from Neurontin to lyrica (pregabalin) for peripheral neuropathy. Should I expect to have decreased feelings of numbness in toes and feet?

Different treatments: Peripheral neuropathy is when the nerves do not function as they should when the sensory nerves are affected, the sensations can range from complete lack of sensation to a "lightning bolt" pain that occurs sporadically. Both of these medications are used to treat peripheral neuropathy as well as several others. Not all medications work for everybody so use it for a while to be sure.

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I'm not responding to any meds given for sudden onset peripheral neuropathy of the feet. Can dilaten help. Tried gabapenten lyrica (pregabalin) Elavil cymbalta.

I'm not responding to any meds given for sudden onset peripheral neuropathy of the feet. Can dilaten help. Tried gabapenten lyrica (pregabalin) Elavil cymbalta.

Dilantin: The use of Dilantin is unlikely to reduce the pain of peripheral neuropathy if the other anti-convulsant medications have failed to relieve the pain. Alternative treatments such as transcutaneous electrical nerve stimulation, capsaicin cream, Lidocaine patches and identifying and treating the cause of the neuropathy may help you feel better.

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Severe leg pain for at least 4 decades and reflexes in knees now non-existent. Diangosis peripheral neuropathy ten years ago. Low back pain 10 yrs. Any idea?

Severe leg pain for at least 4 decades and reflexes in knees now non-existent. Diangosis peripheral neuropathy ten years ago. Low back pain 10 yrs. Any idea?

Peripheral Neuropath: Different possibilities exist for leg pains: neuropathy, vascular disease, and sciatica. Each of these can be ruled in/out based upon history, examination, and studies. Neuropathy is typically diagnosed with history of diabetes, chemo, toxic exposures, or no cause, and is associated with numbness/pain in a stocking distribution with absent reflexes. Emg/ncv can be helpful. Mri/ct usually negative.

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Is chronic diffuse sensorimotor peripheral neuropathy with predominant external & secondary demyelinative changes a long-term disability?

Is chronic diffuse sensorimotor peripheral neuropathy with predominant external & secondary demyelinative changes a long-term disability?

It can be: Sensorimotor peripheral neuropathies have many types and various causes. Some of them can be disabling, even long term in some cases. A thorough search will have to include blood tests and urine tests. In some cases spinal tab (lumbar puncture) can be necessary. In delineating the diagnosis.

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I'm using lidocaine for peripheral neuropathy on my feet. How long before it takes effect?

I'm using lidocaine for peripheral neuropathy on my feet. How long before it takes effect?

Not sure: Lidocaine should work very quickly for you. If you haven't felt any changes over the first 30 minutes, then I'm not sure if it's going to work for you. Best of luck!

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Baclofen good medication for spasticity due to peripheral neuropathy? Cyclobenzaprine better choice??

Rx and muscle spasms: Either one of these may be helpful for muscle spasm symptoms. Sometimes neither of them is helpful. Both of them are worth a try. Spasticity is increased muscle tone that occurs due to a spinal cord or brain injury, not peripheral neuropathy.

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How long will drop foot last with peripheral neuropathy?

How long will drop foot last with peripheral neuropathy?

Depends on the cause: It depends on the cause of your peripheral neuropathy (diabetes, hereditary condition, nerve impingement, stroke, prior surgeries). A neurologist would be best served to give you an educated answer based on nerve testing.

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Can myelin sheath heal in peripheral nerves. (Peripheral neuropathy) And how long does it take?

Can myelin sheath heal in peripheral nerves. (Peripheral neuropathy) And how long does it take?

Peripheral Neuropath: It depends on how the myelin was injured. If myelin was severed/ traumatized axon only damage neuron will grow ideal conditions 1mm / month Instead if disease process responsible for myelin damage (autoimmune disease i.e. MS, ALS,) this damage is permanent myelin sheath will not grow back damage is permanent. Peripheral diabetic Neuropathy if addressed before perm damag meylin can regenerate

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How long will I need to take vitamin B6 for peripheral neuropathy that was caused by chemotherapy?

How long will I need to take vitamin B6 for peripheral neuropathy that was caused by chemotherapy?

Get it from food: All people need vitamin b6 but most get it from food and so should you. It is present in many green vegetables. Eat well and you don't need to take it in pill form.

Gabapentin (Definition)

Also called neurontin, (gabapentin) is an anticonvulsant medication used to treat seizure, also for post-herpetic neuralgia & other neuropathic pains, as well as restless leg syndrome. It works by lowering excitation ...Read more


Dr. Adam Lewis
501 Doctors shared insights

Peripheral Neuropathy (Definition)

A generic medical term for dysfunction of the nerves that carry information to and from the central nervous system (the ...Read more