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Doctor insights on: Is Letrozole Different From Tamoxifen

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Is letrozole different from tamoxifen?

Is letrozole different from tamoxifen?

Yes: Same general effect - decreases effects of estrogen and improves outcome in er + breast cancer. Mechanism of action (how it works) is different. Letrozole cannot be used in premenopausal women. ...Read more

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Dr. Sean Canale
638 doctors shared insights

Tamoxifen (Definition)

This medication is used to: treat breast cancer that has spread to other parts of the body in men and women. Treat early breast cancer in women who have already been treated with surgery, radiation, and/or chemotherapy. Reduce the risk of developing a more serious type of breast cancer in women who have had ductal carcinoma in situ (dcis; a type of breast cancer ...Read more


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What is the difference in nolvadex (tamoxifen) and nolvadex (tamoxifen) d?

What is the difference in nolvadex (tamoxifen) and nolvadex (tamoxifen) d?

Check ingredients: As far as I know there is only one Nolvadex (tamoxifen). The chemical ingredient in it is called Tamoxifen which is an anti-estrogen commonly used to treat breast Cancer. ...Read more

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What is the difference between tamoxifen and femara (letrozole)?

Different: Tamoxifen is a selective estrogen agonist/antagonist. It binds to estrogen receptors and depends on which organ it's on, it either exerts anti-estrogen or estrogen effects. Femara (letrozole) is an aromatase inhibitor. It inhibits enzymatic conversion of androgens to estrogen thereby lowering estrogen level. ...Read more

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My doctor switched me from Clomid (clomiphene) to tamoxifen. Is there the same increased chance for multiples with the tamoxifen?

My doctor switched me from Clomid (clomiphene) to tamoxifen. Is there the same increased chance for multiples with the tamoxifen?

Difficult to tell: Tamoxifen works very similarly to clomid (clomiphene). Because there is not a lot of published research on tamoxifen, it is difficult to compare the multiple birth rates. If you are 41 you indicated above, it is not a bad idea to see a specialist and consider more potent medications. Multiple births are not particularly common in 41 year olds, but pregnancy rates are lower. ...Read more

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What is the difference in novedex xt and nolvadex (tamoxifen)?

Novedex vs Nolvadex (tamoxifen): Novedex xt is a product used to increase testosterone & muscle mass; it blocks the conversion of testosterone to estrogen, but apparently does not increase muscle mass.Nolvadex (tamoxifen) is used to treat breast cancer, but it reportedly is used by bodybuilders who use Anabolic steroids to prevent gynecomastia (enlarged breasts due to breast tissue rather than muscle. See following comment. ...Read more

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Tamoxifen is given to breast cancer patients to suppress estrogen or both estrogen & progesterone?

Tamoxifen is given to breast cancer patients to suppress estrogen or both estrogen & progesterone?

Estrogen: Tamoxifen is given to individuals with specific breast cancers that are driven to grow by the presence of estrogen receptors. Tamoxifen interferes with the activity of estrogen in the breast, preventing cancer growth. The role of Progesterone receptors is unclear, though Progesterone receptors in breast cancer are generally associated with estrogen receptors, making tamoxifen an effective therapy. ...Read more

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Is arimidex (anastrozole) an effective treatment for the reduction of estrogen in males?

Is arimidex (anastrozole) an effective treatment for the reduction of estrogen in males?

Yes: Anastrazole may raise testosterone in older men. Estrogen levels usually remain in the normal range. Men taking testosterone may see an increase in estrogen and an aromatase inhibitor may decrese this production. ...Read more

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Is arimidex (anastrozole) when given as prevention of recurrence of breast cancer only used with estrogen receptive cancer?

Is arimidex (anastrozole) when given as prevention of recurrence of breast cancer only used with estrogen receptive cancer?

Yes*: Arimidex (anastrozole) belongs to a category of drugs called aromatase inhibitors. These are effective chemotherapeutic agents for people with either estrogen-sensitive or *progesterone-sensitive breast cancers. This is only effective after menopause; premenopausal women may use tamoxifen for a similar response rate. ...Read more

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What is the difference between femara (letrozole) and arimidex?

What is the difference between femara (letrozole) and arimidex?

Both interfere with : Estrogen production and are used in treatment of breast cancer where the primary was er+. Side effects are similar, cost is much higher fro Letrozole (femara). It is newer. These are each used only in postmenopausal patients. Tamoxifen around for decades is used in premenopausal. ...Read more

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How good is the cancer drug femara (letrozole)?

How good is the cancer drug femara (letrozole)?

A good drug: It is used to prevent recurrence of breast cancer after surgery. It also is an effective treatment for hormone receptor positive recurrent breast cancer. ...Read more

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What are the similarities and differences between tamoxifen and femara (letrozole)?

What are the similarities and differences between tamoxifen and femara (letrozole)?

Different action: Tamoxifen blocks the estrogen receptor, while Femara (letrozole) blocks the formation of estrogen. Estrogen levels are not lowered by tamoxifen, but they are lowered by femara (letrozole). Both cause hot flashes, bone loss, depression, memory problems and decreased libido. Tamoxifen increases blood clot and uterine cancer risk and causes vaginal discharge, while Femara (letrozole) causes more joint pain and vaginal dryness. ...Read more

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What problems are there switching from degarelix to eligard (leuprolide)?

What  problems  are  there switching  from  degarelix to  eligard (leuprolide)?

Not many problems: One problem may be insurance coverage unfortunately but overall symptoms between the two are likely to be similar. Studies have shown perhaps increased effectiveness of degarelix vs Eligard (leuprolide) when treating prostate cancer. ...Read more

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Are femara (letrozole) and norethindrone used for stage 4 endometriosis?

Are femara (letrozole) and norethindrone used for stage 4 endometriosis?

Not very successfull: No medical treatment has ever been shown to be effective in treating stage IV endo. This stage means that there is deeply invasive endo usually between the rectum and vagina or cervix. Endo nodules are by definition deeper than 5mm, and the hormones can't penetrate well and they don't respond. You need a surgeon very experienced in complex procedures to remove the endo. ...Read more

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Is tamoxifen the same as aromatase inhibitor?

Is tamoxifen the same as aromatase inhibitor?

No: Tamoxifen belongs to a class of drugs called selective estrogen receptor modulators (serms). It works by blocking the binding of estrogen to estrogen receptors, thus disabling hormone-sensitive breast cancer cells. Aromatase inhibitors block the conversion of androgens to estrogens, effectively removing estrogen from the body (in postmenopausal women). ...Read more

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What is the percentage of her2 breast cancer recurring after 3 years with 2 1/2 years on femara (letrozole). I want to stop the femara (letrozole) due to the side effects.?

Hard to say: Hard to say without more details. You are lucky in a way to have a tumor that. Can be attacked with chemo, herceptin, (trastuzumab) and hormone blockade. Not all patients tolerate femara. There are other ai drugs and other options. Talk to your oncologist for options. ...Read more

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What is the success rate of femara (letrozole) for infertility?

What is the success rate of femara (letrozole) for infertility?

Depends: The success rate varies tremendously based on many factors including diagnosis (for instance ovulation problems, sperm problems, endometriosis, etc), the age of the woman, how the fallopian tubes work, . Etc. Pregnancy rates can be as low as 1% or as high as 20-25% per month. ...Read more

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How effective is femara (letrozole) drug instead of chemotherapy in a person with low platelets?

How effective is femara (letrozole) drug instead of chemotherapy in a person with low platelets?

Not related: The effect of Femara (letrozole) or of chemo on the cancer is unrelated to the platelet count. The choice between the two has to do with clinical characteristics of the cancer and the patient, not the blood counts. That said, if a patient's platelets are too low, it may not be possible to give chemo but that has to do with side effects, not effectiveness against the cancer. ...Read more

Dr. Wendy Askew
78 doctors shared insights

Letrozole (Definition)

Letrozole is a commonly used medicine for the prevention/treatment of certain types of breast cancer. It is a safe medicine. It prevents the conversion of male to female hormones. It is also commonly used now for fertility treatment. It can help ovulation and can help a woman make an extra egg sometimes. It is often used instead of Clomid (clomiphene) for fertility treatment ...Read more