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Doctor insights on: Is Letrozole Different From Tamoxifen

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Is letrozole different from tamoxifen?

Is letrozole different from tamoxifen?

Yes: Same general effect - decreases effects of estrogen and improves outcome in er + breast cancer. Mechanism of action (how it works) is different. Letrozole cannot be used in premenopausal women. ...Read more

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Dr. Sean Canale
638 doctors shared insights

Tamoxifen (Definition)

This medication is used to: treat breast cancer that has spread to other parts of the body in men and women. Treat early breast cancer in women who have already been treated with surgery, radiation, and/or chemotherapy. Reduce the risk of developing a more serious type of breast cancer in women who have had ductal carcinoma in situ (dcis; a type of breast cancer ...Read more


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What is the difference between tamoxifen and femara (letrozole)?

What is the difference between tamoxifen and femara (letrozole)?

Different: Tamoxifen is a selective estrogen agonist/antagonist. It binds to estrogen receptors and depends on which organ it's on, it either exerts anti-estrogen or estrogen effects. Femara (letrozole) is an aromatase inhibitor. It inhibits enzymatic conversion of androgens to estrogen thereby lowering estrogen level. ...Read more

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What are the similarities and differences between tamoxifen and femara (letrozole)?

What are the similarities and differences between tamoxifen and femara (letrozole)?

Different action: Tamoxifen blocks the estrogen receptor, while Femara (letrozole) blocks the formation of estrogen. Estrogen levels are not lowered by tamoxifen, but they are lowered by femara (letrozole). Both cause hot flashes, bone loss, depression, memory problems and decreased libido. Tamoxifen increases blood clot and uterine cancer risk and causes vaginal discharge, while Femara (letrozole) causes more joint pain and vaginal dryness. ...Read more

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What are some similarities and differences between tamoxefen and femara (letrozole)?

What are some similarities and differences between tamoxefen and femara (letrozole)?

Requires long answer: The answer is too long to fit into 400 characters but there is a nice summary at http://www.Health.Com/health/condition-article/0, 20188924, 00.Html. ...Read more

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What is the difference in nolvadex (tamoxifen) and nolvadex (tamoxifen) d?

What is the difference in nolvadex (tamoxifen) and nolvadex (tamoxifen) d?

Check ingredients: As far as I know there is only one Nolvadex (tamoxifen). The chemical ingredient in it is called Tamoxifen which is an anti-estrogen commonly used to treat breast Cancer. ...Read more

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What are some side effects when you stop taking nolvadex (tamoxifen) d?

Not that many: let us start with the paradox that stopping seems to work as a cancer therapy ?!? http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3180409/?report=classic Then, not blocking female hormones whoe allow these hormones to begin working. Menstrual cycling possibly returning, breast growth pssible (not likely) mood changes. ...Read more

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Why d & c is needed if a woman does not have no bleeding and thinks she menopausal because of her advance age which is 54year. Currently on tamoxifen?

Why d & c is needed if a woman does not have no bleeding and thinks she menopausal because of her advance age which is 54year. Currently on tamoxifen?

Not sure: Tamoxifen increases your risk of uterine cancer. If you had an ultrasound that showed thickened uterine lyning, your doctor may want to do a d;c to check for precancerous condition of your uterus. Without an abnormal ultrasound and without postmenopausal bleeding, i can't think of any reason why you need a d;c. ...Read more

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How does tamoxifen actually work?

How does tamoxifen actually work?

Blocks estrogen: Some breast cancer cells have receptors on them that bind to estrogen in order to grow. Tamoxifen acts as an "antagonist" and blocks estrogen from binding to these receptors on the cancer cells by binding to them first. With tamoxifen sitting in estrogen's place, the cancer cell can no longer grow. ...Read more

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Who should avoid taking tamoxifen?

Blood clots: Pts with a history of blood clots and/or a history of abnormal pap smears should not take tamoxifen. If there is a family history of clotting disorders or uterine cancer, tamoxifen should not be used. ...Read more

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Dr. Scott Keith
73 doctors shared insights

Letrozole (Definition)

Letrozole is a commonly used medicine for the prevention/treatment of certain types of breast cancer. It is a safe medicine. It prevents the conversion of male to female hormones. It is also commonly used now for fertility treatment. It can help ovulation and can help a woman make an extra egg sometimes. It is often used instead of Clomid (clomiphene) for fertility treatment ...Read more