Doctor insights on:
Is Letrozole Different From Tamoxifen
This medication is used to: treat breast cancer that has spread to other parts of the body in men and women. Treat early breast cancer in women who have already been treated with surgery, radiation, and/or chemotherapy. Reduce the risk of developing a more serious type of breast cancer in women who have had ductal carcinoma in situ (dcis; a type of breast cancer ...Read more
Different: Tamoxifen is a selective estrogen agonist/antagonist. It binds to estrogen receptors and depends on which organ it's on, it either exerts anti-estrogen or estrogen effects. Femara (letrozole) is an aromatase inhibitor. It inhibits enzymatic conversion of androgens to estrogen thereby lowering estrogen level. ...Read moreSee 1 more doctor answer
My doctor switched me from Clomid (clomiphene) to tamoxifen. Is there the same increased chance for multiples with the tamoxifen?
Difficult to tell: Tamoxifen works very similarly to clomid (clomiphene). Because there is not a lot of published research on tamoxifen, it is difficult to compare the multiple birth rates. If you are 41 you indicated above, it is not a bad idea to see a specialist and consider more potent medications. Multiple births are not particularly common in 41 year olds, but pregnancy rates are lower. ...Read more
Novedex vs Nolvadex (tamoxifen): Novedex xt is a product used to increase testosterone & muscle mass; it blocks the conversion of testosterone to estrogen, but apparently does not increase muscle mass.Nolvadex (tamoxifen) is used to treat breast cancer, but it reportedly is used by bodybuilders who use Anabolic steroids to prevent gynecomastia (enlarged breasts due to breast tissue rather than muscle. See following comment. ...Read more
Tamoxifen is given to breast cancer patients to suppress estrogen or both estrogen & progesterone?
Estrogen: Tamoxifen is given to individuals with specific breast cancers that are driven to grow by the presence of estrogen receptors. Tamoxifen interferes with the activity of estrogen in the breast, preventing cancer growth. The role of Progesterone receptors is unclear, though Progesterone receptors in breast cancer are generally associated with estrogen receptors, making tamoxifen an effective therapy. ...Read moreSee 2 more doctor answers
Is arimidex (anastrozole) when given as prevention of recurrence of breast cancer only used with estrogen receptive cancer?
Yes*: Arimidex (anastrozole) belongs to a category of drugs called aromatase inhibitors. These are effective chemotherapeutic agents for people with either estrogen-sensitive or *progesterone-sensitive breast cancers. This is only effective after menopause; premenopausal women may use tamoxifen for a similar response rate. ...Read moreSee 1 more doctor answer
Both interfere with : Estrogen production and are used in treatment of breast cancer where the primary was er+. Side effects are similar, cost is much higher fro Letrozole (femara). It is newer. These are each used only in postmenopausal patients. Tamoxifen around for decades is used in premenopausal. ...Read moreSee 1 more doctor answer
Breast cancer: Hormonal adjuvant for treatment.Get a more detailed answer ›
Different action: Tamoxifen blocks the estrogen receptor, while Femara (letrozole) blocks the formation of estrogen. Estrogen levels are not lowered by tamoxifen, but they are lowered by femara (letrozole). Both cause hot flashes, bone loss, depression, memory problems and decreased libido. Tamoxifen increases blood clot and uterine cancer risk and causes vaginal discharge, while Femara (letrozole) causes more joint pain and vaginal dryness. ...Read moreSee 1 more doctor answer
Not very successfull: No medical treatment has ever been shown to be effective in treating stage IV endo. This stage means that there is deeply invasive endo usually between the rectum and vagina or cervix. Endo nodules are by definition deeper than 5mm, and the hormones can't penetrate well and they don't respond. You need a surgeon very experienced in complex procedures to remove the endo. ...Read moreSee 1 more doctor answer
No: Tamoxifen belongs to a class of drugs called selective estrogen receptor modulators (serms). It works by blocking the binding of estrogen to estrogen receptors, thus disabling hormone-sensitive breast cancer cells. Aromatase inhibitors block the conversion of androgens to estrogens, effectively removing estrogen from the body (in postmenopausal women). ...Read moreSee 1 more doctor answer
What is the percentage of her2 breast cancer recurring after 3 years with 2 1/2 years on femara (letrozole). I want to stop the femara (letrozole) due to the side effects.?
Hard to say: Hard to say without more details. You are lucky in a way to have a tumor that. Can be attacked with chemo, herceptin, (trastuzumab) and hormone blockade. Not all patients tolerate femara. There are other ai drugs and other options. Talk to your oncologist for options. ...Read moreSee 1 more doctor answer
Depends: The success rate varies tremendously based on many factors including diagnosis (for instance ovulation problems, sperm problems, endometriosis, etc), the age of the woman, how the fallopian tubes work, . Etc. Pregnancy rates can be as low as 1% or as high as 20-25% per month. ...Read moreSee 1 more doctor answer
Out of fsh, lh, oestrogen and progesterone, what fertility drug most likely to cause cancer in the women?
Not related: The effect of Femara (letrozole) or of chemo on the cancer is unrelated to the platelet count. The choice between the two has to do with clinical characteristics of the cancer and the patient, not the blood counts. That said, if a patient's platelets are too low, it may not be possible to give chemo but that has to do with side effects, not effectiveness against the cancer. ...Read more
Letrozole is a commonly used medicine for the prevention/treatment of certain types of breast cancer. It is a safe medicine. It prevents the conversion of male to female hormones. It is also commonly used now for fertility treatment. It can help ovulation and can help a woman make an extra egg sometimes. It is often used instead of Clomid (clomiphene) for fertility treatment ...Read more