Doctor insights on:
Is It Safe To Von Willebrand
Should be no problem: Although women with von willebrand's disease can have problems with heavy periods, their fertility is normal. As long as they don't need to be on birth control pills to control their menstrual bleeding they should be able to get pregnant as easily as any other women. If you have von willebrand's and want to get pregnant, your doctor can help manage you medicines in order to accomplish this. ...Read more
Yes, but: Yes, but you should be tested to know your status if you plan to have children. The thalassemia minor won't hurt you at all. If your partner has thalassemia minor (i.e. Thalassemia trait), i would bet they are fine and have no issues. If you also have thalassemia trait, there is a chance you could have a baby with thalassemia (disease). You should see a genetic counselor. ...Read moreSee 1 more doctor answer
Not as safe as norma: Stressful pregnancies were carried with von willebrans diseases in all 3 types. Type i where factor xi is low, in ii not functioning problem is with type iii besides factor xi, viii will be low behaves like hemophilia , all types, excessive bleeding is expected, need to administer factors, to the optimal levels by experienced team ( ob, perinatologist , hematologist etc ). ...Read more
A bleeding disorder.: It is the most common inherited bleeding disorder.Type 1 is mild , more symptomat in females with menorrhagia and mucous membrane bleeds DDAVP (desmopressin) , inhaler is effective. Type 3 severe , Joint bleeds in addition. Type 1 clotting protein is decreased but missing in type 3 and defective in type 2 ( several sub types). So the VW factor is to be given by infusion In most types 2 and 3 . ...Read more
No big deal usually.: Depending on whether you have a diagnosis of lupus or prior clotting problems, this may or may not be significant for your pregnancy. Studies show that most women with lac have normal pregnancies. Lupus anticoagulant (lac) is a laboratory finding and in and of itself not significant for predicting clinical outcomes. If you have systemic lupus erythematosus the plot thickens and you need to see mfm. ...Read more
See below. : The genetics of the leukemia are acquired by the leukemia cells. This creates genetic abnormalities in the leukemia cells, but you are not born with these genetic abnormalities. Neither the genetic abnormality of the leukemia nor the predisposition to acquire this disease is hereditary that we know of. ...Read moreSee 1 more doctor answer
Possibly: With vwb, you may be at extra bleeding risk. It depends on the platelet count and the function of your blood clotting. So often your doctors will take special precautions. But anything can happen in surgery and with childbirth so being prepared is the most important thing. That being said, in most patients everything is fine. ...Read moreSee 1 more doctor answer
Can you tell me if someone is heterozygous w/ the hemophilia gene, is it possible for them to still have factor viii deficiency?
See below: It is generally very safe , and you can survive on one kidney. You need to be evaluated for donating a kidney and make sure you have no health problems and you yourself have normal kidney function. ...Read more
Rare disease: This is a rare but life-threatening disease; approx 2-3 cases per 100,000 population in the USA are seen. ...Read more
Different but....: Related. Vwf is a glycoprotein important for primary hemostasis. It cross links collagen at a site of injury with gpib on platelets. Deficiency leads to failure of primary hemostasis (ie, bleeding). Vwf also protects fviii from degradation. Fviii partners with fix to activate fx to ultimately promote clotting. So, while different, fviii & vwf deficiency can have similar presentations. Simplified! ...Read more
Yes!: Always use good hand hygiene when visiting anyone who is sick. You didn't mention what type of hepatitis your friend has--some types like hepatitis b and c are spread by contact with blood or sexual contact, so it is very unlikely you could be exposed to them by just a casual visit. Hepatitis a is commonly spread via food. You can have a nice visit without any direct physical contact. ...Read moreSee 1 more doctor answer
It is what it is ...: Thalassemia is a number of inborn (genetic) disorders of hemoglobin (check out http://www.Mayoclinic.Com/health/thalassemia/ds00905 & http://www.Nhlbi.Nih.Gov/health/health-topics/topics/thalassemia/). Carries have just one gene while those w/full blown disorder have both. As a carrier, there're few clinical symptoms so it's "safe" for you, not that you could do anything about it! ...Read more
Does anyone know the genetics behind the bleeding disorder von willebrand's? Which parent(s) pass it to you?
Correction: I agree with dr. Ball's answer, but the inheritance pattern he described is autosomal dominant. Autosomal means you can get it from either parent; dominant means only one parent needs to give it to you for you to get it. The rare, severe type 3 VWD is recessive; both parents need to pass on an abnormal gene for one to get it. ...Read moreSee 2 more doctor answers
Agatroban: Agatroban is an anticoagulant. Its use in pregnancy and gestational thrombocytopenia is not well known or studied. It is a class b drug and may be used in pregnancy if medically necessary but under strict monitoring by the physician. It may cause excessive bleeding with gestational thrombocytopenia. ...Read more
59 Deaths in 2013: Transfusion is safer today than ever, but as any other intervention in medicine has risks associated with it. The infectious disease most commonly associated with transfusion is bacterial contamination in platelet components about 1 in 12, 000 transfusions. To put it in perspective HIV is about 1 in 2 million. The most common adverse event (1%) is fever and hives along with volume overload (TACO) ...Read more
Ver rare: Sideroblastic anemias are a group of disorders in which hemoglobin is insufficiently synthesized, because of defective use of iron (although plasmatic iron levels may be normal or elevated). They are said to be sideroblastic because of the presence of ringed sideroblasts in the blood cells due to accumulated ferritin in mitochondria. The prevalence of RA is rare at 1 in 1000, 000. ...Read more
See experts early: Ideally a woman with sle would see her rheumatologist and a maternal-fetal medicine subspecialist before trying to conceive (ttc). Then lab tests could be ordered, records reviewed and risks discussed. Those include preeclampsia and poor fetal growth. She should ask her OB to refer her to the mfm doctor early in the pregnancy and on ongoing basis to help evaluate mom + baby and plan for delivery. ...Read moreSee 2 more doctor answers
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