Doctor insights on:
Is It Safe To Von Willebrand
Not as safe as norma: Stressful pregnancies were carried with von willebrans diseases in all 3 types. Type i where factor xi is low, in ii not functioning problem is with type iii besides factor xi, viii will be low behaves like hemophilia , all types, excessive bleeding is expected, need to administer factors, to the optimal levels by experienced team ( ob, perinatologist , hematologist etc ). ...Read more
Homozygous vWD: Pts with type 3 VWD have loss or mutations of both vwf genes, and produce almost no vwf protein. Clinically they behave like severe hemophilia a patients as their factor viii levels are very low as well, since vwf also carries factor viii in the blood. ...Read moreSee 1 more doctor answer
Von Willebrand ....: Factor . Vwf is a glycoprotein important for primary hemostasis. It cross links collagen at a site of injury with gpib on platelets. Deficiency leads to failure of primary hemostasis (ie, bleeding). Vwf also protects fviii from degradation. Fviii also promotes clotting. So, vwf deficiency also causes secondary fviii dysfunction. Vwf def has many variants. Severity is variable. Most have type i. ...Read moreSee 1 more doctor answer
Bleeding disorder: This is relatively common hereditary bleeding disorder,the bleeding episodes can be corrected transiently by infusion of fresh or fresh-frozen plasma or cryoprecipitate. ...Read more
A bleeding problem: Platelets stop bleeding by patching holes in blood vessels. von Willebrand factor is the glue that sticks platelets to those holes. If von Willebrand factor is low, or if the structure of VWF is abnormal, it doesn't stick platelets to the sites of bleeding. Most people have nosebleeds, gum bleeding, or bleeding after tooth extraction. There are 4 types of VW disease with different symptoms. ...Read moreSee 1 more doctor answer
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