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Doctor insights on: Is It Safe To Cut A Time Release Wellbutrin Tablet In Half

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Is it safe to cut a time release wellbutrin (bupropion) tablet in half?

Is it safe to cut a time release wellbutrin (bupropion) tablet in half?

Don't break these!: The active medication is contained in a special coating that permits delayed release of the therapeutic ingredients into the patient. Breatking these tablets in half will release the active ingredient much faster than intended, probably bringing about unwanted side effects. Just not worth the gamble, especially when the generic form, buproprion, is safe, easily available, and better priced. ...Read more

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Dr. Alan Ali
758 doctors shared insights

Bupropion (Definition)

Also called wellbutrin (bupropion) or zyban or aplenzin, is an atypical antidepressant & smoking cessation aid, which has mild psychostimulant action. It is a norepinephrine/dopamine reuptake inhibitor. It can lower seizure threshold at high doses, ...Read more


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Will splitting my 300mg wellbutrin (bupropion) XL in half be okay or does it affect the release time? I'd like to take 150.

Time-released pills : or capsules should not be split. If you feel that your dose is too high, discuss changing to WB XR 150 mg. with your psychiatrist. Reductions in doses of psychotropic medications must be done safely, with monitoring for symptom recurrence. I assume you took SSRI's in the past, not simultaneously with each other or with WB, as the risk of serotonin syndrome would be increased. ...Read more

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The dosage, is it safe to halve the wellbutrin (bupropion) sr pill to slowly withdraw from it?

The dosage, is it safe to halve the wellbutrin (bupropion) sr pill to slowly withdraw from it?

With your Docs help!: Ideally this should be done in conjunction with the prescribing physician. Stopping an antidepressant on your own is not a good idea. Most people do not experience withdrawal when they discontinue wellbutrin (bupropion). Officially you should not cut the sr tab in half. Unofficially if this is done cleanly and you do not crush the pill, the sustained release property will be maintained. ...Read more

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Is it safe to take wellbutrin and Effexor (venlafaxine) at the same time?

Is it safe to take wellbutrin and Effexor (venlafaxine) at the same time?

Two antidepressants: If prescribed by your doctor after one antidepressant for sufficient time produced only partial response. ...Read more

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For rapidly weight lose what medicines is ore effective Wellbutrin XL or Topamax (topiramate), (topiramate) can I use them same time or morning wellbutrin evening Topamax (topiramate)?safe?

For rapidly weight lose  what medicines is ore effective Wellbutrin XL or Topamax (topiramate), (topiramate) can I use them same time or morning wellbutrin evening Topamax (topiramate)?safe?

None Indicated: These medications ARE NOT meant to be used for weight loss and ARE NOT SAFEto be used for that indication. Rapid weight loss in itself is not safe. All medications have side effects, so should only be used when absolutely needed. If you wish to loose weight eat clean and exercise. If you are significantly overweight surgery may be an option- talk to your physician. ...Read more

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Is taking 50000 iu D2 pill 1/week for month safe, esp along with 300 mg Wellbutrin (bupropion) XL (morn) & 1.5 mg Klonopin plus 1 mg melatonin (night)?

Is taking 50000 iu D2 pill 1/week for month safe, esp along with 300 mg Wellbutrin (bupropion) XL (morn) & 1.5 mg Klonopin plus 1 mg melatonin (night)?

Pretty safe.: That is the recommended dose for that vitamin D. There is not an obvious interaction between any of the drugs except for klonapin and melatonin (they both make one sleepy) and the interaction there is quite mild. Klonapin is a controlled dangerous substance with addictive potential. ...Read more

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Is it safe to take Buspar (buspirone) and wellbutrin together, at the same time of day?

Is it safe to take Buspar (buspirone) and wellbutrin together, at the same time of day?

Yes & Yes: Yes, they are often used together & can be taken at the same time. However, it is important not to take wellbutrin (bupropion) after early afternoon or it can cause insomnia. ...Read more

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Wellbutrin (Definition)

Bupropion is an addiction reducing agent and an antidepressant which are both a ...Read more