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Doctor insights on: Is It Safe To Cut A Time Release Wellbutrin Tablet In Half

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Is it safe to cut a time release wellbutrin (bupropion) tablet in half?

Is it safe to cut a time release wellbutrin (bupropion) tablet in half?

Don't break these!: The active medication is contained in a special coating that permits delayed release of the therapeutic ingredients into the patient. Breatking these tablets in half will release the active ingredient much faster than intended, probably bringing about unwanted side effects. Just not worth the gamble, especially when the generic form, buproprion, is safe, easily available, and better priced. ...Read more

Dr. Alan Ali
792 doctors shared insights

Bupropion (Definition)

Also called wellbutrin (bupropion) or zyban or aplenzin, is an atypical antidepressant & smoking cessation aid, which has mild psychostimulant action. It is a norepinephrine/dopamine reuptake inhibitor. It can lower seizure threshold at high doses, ...Read more


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Will splitting my 300mg wellbutrin (bupropion) XL in half be okay or does it affect the release time? I'd like to take 150.

Will splitting my 300mg wellbutrin (bupropion) XL in half be okay or does it affect the release time? I'd like to take 150.

Time-released pills : or capsules should not be split. If you feel that your dose is too high, discuss changing to WB XR 150 mg. with your psychiatrist. Reductions in doses of psychotropic medications must be done safely, with monitoring for symptom recurrence. I assume you took SSRI's in the past, not simultaneously with each other or with WB, as the risk of serotonin syndrome would be increased. ...Read more

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The dosage, is it safe to halve the wellbutrin (bupropion) sr pill to slowly withdraw from it?

The dosage, is it safe to halve the wellbutrin (bupropion) sr pill to slowly withdraw from it?

With your Docs help!: Ideally this should be done in conjunction with the prescribing physician. Stopping an antidepressant on your own is not a good idea. Most people do not experience withdrawal when they discontinue wellbutrin (bupropion). Officially you should not cut the sr tab in half. Unofficially if this is done cleanly and you do not crush the pill, the sustained release property will be maintained. ...Read more

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For rapidly weight lose what medicines is ore effective Wellbutrin XL or Topamax (topiramate), (topiramate) can I use them same time or morning wellbutrin evening Topamax (topiramate)?safe?

For rapidly weight lose  what medicines is ore effective Wellbutrin XL or Topamax (topiramate), (topiramate) can I use them same time or morning wellbutrin evening Topamax (topiramate)?safe?

None Indicated: These medications ARE NOT meant to be used for weight loss and ARE NOT SAFEto be used for that indication. Rapid weight loss in itself is not safe.
All medications have side effects, so should only be used when absolutely needed.
If you wish to loose weight eat clean and exercise. If you are significantly overweight surgery may be an option- talk to your physician. ...Read more

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Is taking 50000 iu D2 pill 1/week for month safe, esp along with 300 mg Wellbutrin (bupropion) XL (morn) & 1.5 mg Klonopin plus 1 mg melatonin (night)?

Is taking 50000 iu D2 pill 1/week for month safe, esp along with 300 mg Wellbutrin (bupropion) XL (morn) & 1.5 mg Klonopin plus 1 mg melatonin (night)?

Pretty safe.: That is the recommended dose for that vitamin D. There is not an obvious interaction between any of the drugs except for klonapin and melatonin (they both make one sleepy) and the interaction there is quite mild. Klonapin is a controlled dangerous substance with addictive potential. ...Read more

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Is it safe to take Buspar (buspirone) and wellbutrin together, at the same time of day?

Is it safe to take Buspar (buspirone) and wellbutrin together, at the same time of day?

Yes & Yes: Yes, they are often used together & can be taken at the same time. However, it is important not to take wellbutrin (bupropion) after early afternoon or it can cause insomnia. ...Read more

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I've been taking Prozac 10 mg for 20 years. Lorazepam 1 mg 3 times a day. Adding Wellbutrin (bupropion) is it safe?

These meds are ok: Together. Bupropion should not be taken if history of seizures. Bupropion may increase blood levels of prozaz so your prescriber will want to know if you experience increase in side effects. Best regards for good health. ...Read more

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Is it safe to take wellbutrin sr and Xanax (alprazolam) together daily and can I take them at the same time? I'm also worried about my seizures. Will i be ok?

Is it safe to take wellbutrin sr and Xanax (alprazolam) together daily and can I take them at the same time? I'm also worried about my seizures. Will i be ok?

Yes: Wellbutrin, is a commonly prescribed antidepressant, now gone generic due to age. Xanax (alprazolam) is also "well aged" and is available in the generic form Alprazolam wellbutrin, as is the case with all rx drugs, must report every possible side effect. Dont read the package insert and follow your drs advise. The combination should be fine and work well.







My advise is to not read the package insert, . ...Read more

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I take seroquel 100mg once a day and wellbutrin (bupropion) sr 150mg 2 times a day I am starting to take garcinia cambogia is it safe to take with these?

The only concerns: I could find are diabetes because it may lower blood sugars. There is a slight risk of serotonin syndrome because there is a slight serotonin effect with garcinia cambogia which is also present in your seroquel. Garcinia is often combined with calcium and potassium for absorption purposes so you need to bear that in mind. 65% of people who smoke develop depression. Wellbutrin (bupropion) could help a lot. ...Read more

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Wellbutrin and topamax (topiramate) I have overweight 55 pounds. I need to loss weight ASAP. I have been depression and migrane.Can Use both of them same time?safe

Wellbutrin and topamax (topiramate) I have overweight 55 pounds. I need to loss weight ASAP. I have been depression and migrane.Can Use both of them same time?safe

Yes you can,: definitely. Very good combination because a common side effects of the topamax (topiramate) are loss of appetite, diarrhea, and weight loss. Also topamax (topiramate) is a prophylactic medication for migraine. Your doctor made a good choice adjusting your medications. Hope it helps. ...Read more

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Can just one tablet of wellbutrin (bupropion) XL 150mg cause an increase in anxiety and an out of it feeling for two or more days?

Yes: The half-life of wellbutrin (bupropion) xl is about 24 hours, so it would still be in your system for 5 times that. Wellbutrin (bupropion) may exacerbate anxiety. Please contact your physician and let him/her know what you're experiencing. ...Read more

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Can you half wellbutrin (bupropion) sr pill safely?

Can you half  wellbutrin (bupropion) sr pill safely?

Well......: Officially you should not, however the mechanism with which wellbutrin (bupropion) sr provides sustained release would be maintained if it is halved without crushing. This is not the case with wellbutrin (bupropion) xl, it can not be divided. ...Read more

Dr. Alan Ali Dr. Ali
2 doctors agreed:
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Could you split a wellbutrin (bupropion) sr pill in half?

Dr. Alan Ali Dr. Ali
2 doctors agreed:

Wellbutrin (bupropion): In general, it is not advised to split or crush slow release or extended release meds. ...Read more

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I took one 300mg wellbutrin pill.... How long until that single pill is out of my system??

Days: One 300 mgm could take days and longer if you have kidney trouble. Consult your prescriber. ...Read more

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Can wellbutrin (bupropion) be safe to take if it is making me feel jittery?

Only jittery?: If that is the only or worst side effect, you are probably safe - but you may want to discuss alternatives.
Most of these drugs have side effects, so it could be worse. Be careful. Consider (with professional) trying talk therapy to help deal with issues and slowly get off meds. Ask a dr or pharmacist about interactions with all other things you take. Perhaps you can make changes that way. Best! ...Read more

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Wat does Wellbutrin (bupropion) do and is it safe?

Wellbutrin (bupropion): Wellbutrin (bupropion) is a commonly used medication for major depression disorders, and has some common side effects but is considered safe ...Read more

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Is it safe for a recovered bulimic to take wellbutrin (bupropion)?

Hmm!: I treated one eating disorder patient with wellbutrin (bupropion) & tracked her very closely. I was very concerned when i learned that she had restarted her dysfunctional eating behaviors even though she had denied it. The problem is that people with eating disorders often will not admit when their eating symptoms return or increase. ...Read more

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Is it ok to take my levothyroxine and wellbutrin (bupropion) at the same time?

Is it ok to take my levothyroxine and wellbutrin (bupropion) at the same time?

Probably not: The "by the book" answer is that any thyroid preparation - levothyroxine or Cytomel (liothyronine) (t3) should be taken by itself - that means with clear liquids - and with no other vitamin or prescription medication. The reason is the concern that fillers in medications, or calcium, specifically, in vitamins, will bind with the thyroid hormones and decrease the efficacy of your dose. ...Read more

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Whats the best time to take concerta and wellbutrin (bupropion) if taken separately?

Ask the Dr: Dosage and scheduling is part of prescribing. Ask the Dr who prescribed the meds. A second best source might be your pharmacist. In both cases also advise them of ALL meds you take and ask for things to watch for. Best! ...Read more

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My dr recently prescribed me luvox and wellbutrin (bupropion). Is this a safe combination?

Yes it is safe: yes it is safe. Of course individual sensitivity and doses are very important for safety reason. Also many factors will influence effectiveness of this combo. Please discuss in detail with your doctor risk and benefits. ...Read more

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I am being prescribed Lexapro, wellbutrin and elavil for depression and anxiety. Is this combo safe?

I am being prescribed Lexapro, wellbutrin and elavil for depression and anxiety.  Is this combo safe?

Drug Interactions: Elavil (amitriptyline) + Wellbutrin (bupropion) ^ es seizure risk. Escitalopram +amitriptyline ^'es risk of serotonin syndrome. Wellbutrin + Lexapro ^es seizure risk. I am assuming that the Elavil is added in for insomnia or pain control and not for depression/ anxiety. This does not mean that these drugs can't be used together but there are possible drug interactions. D/W your physician. ...Read more

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Is luvox and wellbutrin (bupropion) a safe combo in treating ocd, anxiety and depression?

Alternative: These meds. have the possibility of interacting with each other (although this can be minimized by starting with a low dose). That said, there are safer alternatives. Personally, I tend to try Pristiq (desvenlafaxine) + Wellbutrin XL for patients who aren't doing well on an SSRI alone. But this is a matter of prescriber preference and what your physician feels is the most appropriate for you. Hope that helps! ...Read more

Wellbutrin (Definition)

Bupropion is an addiction reducing agent and an antidepressant which are both a ...Read more