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Doctor insights on: Is It Possible To Have Ovarian Cancer And Have A Normal Ca 125 Blood Test

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Is it possible to have ovarian cancer and have a normal ca 125 blood test?

Is it possible to have ovarian cancer and have a normal ca 125 blood test?

Yes.: Ca125 can vary from person to person and can change under various circumstances not related to cancer. It is more useful as a way to track disease progression or treatment success. ...Read more

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Dr. Barry Rosen
4,214 doctors shared insights

Cancer (Definition)

Cancer is a group of diseases that is characterized by uncontrolled cell growth leading to invasion of surrounding tissues that spread to other parts of the body. Cancer can begin anywhere in the body and is usually related to one or more genetic mutations that allow normal cells to become malignant by interfering with internal cellular control mechanisms, such as programmed cell death or by preventing ...Read more


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Can a woman have a normal ca125 blood test and still have ovarian cancer?

Can a woman have a normal ca125 blood test and still have ovarian cancer?

Ovarian cancer: Yes. Only 85% of ovarian cancers have an elevated ca 12 at presentation. Therefore, 15 of every 100 women with a diagnosis of ovarian cancer have a ca 125 within the normal range. Ca 125 is not a diagnostic test. But is used to follow the progress of chemotherapy. ...Read more

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I have a 2.8cm ovarian cyst. I have the brca1 mutated gene. My ca125 blood test came back normal. Could it still be early stage of ovarian cancer?

Rare: Ovarian cysts are of concern when over 5 cm. If the small cyst is not complex it is usually followed by ultrasound. Ca 125 has no diagnostic implication but is only of value for monitoring. Brca1 suggests the cyts should be followed. ...Read more

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Why is the ca-125 blood test to check for ovarian cancer not part of a woman's checkup?

Why is the ca-125 blood test to check for ovarian cancer not part of a woman's checkup?

Not useful: It is neither sensitive nor specific for ovarian cancer and is not useful as a screening test. If elevated at diagnosis of ovarian cancer, it is useful in following the progress of tumor and response to treatment. ...Read more

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Why is the ca-125 blood test for ovarian cancer not part of a yearly checkup?

Not beneficial: The ca125 test is not used for screening for ovarian cancer because it does not work in the general female population. The ca125 can be abnormal in situations without any cancer and most importantly using this test does not save any lives like in the case of maamograms for breast cancer. ...Read more

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Does a ca125 blood test check for cancers other than ovarian cancer?

Yes: There are other cancers that will have a positive ca-125. They include cancer of the pancreas, stomach, esophagus, liver, breast, colon, or lung. Cancer of the lining of the abdominal cavity, and cancer of the fallopian tubes or lining of uterus. ...Read more

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Can they detect ovarian cancer through a blood test?

Can they detect ovarian cancer through a blood test?

Backward: There is no screening test for ovca. However, if you have ovarian cancer, a ca-125 level may or may not be elevated. If it is, it may be one thing monitired for response. Getting ca-125, an expensive blood test of unproven value before knowing you have the cancer is inded backward, costly, non-specific and can led to unnecessary worry. ...Read more

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What do doctors look for in an ovarian cancer blood test?

CA-125,OVA1BRCA1&2: The test are not for screening patients but for risk indicators ca-125 ova1 brca1 brca2 ova1s used for early prediction of ovarian cancer.It is helpful in predicting if ovarian tumor is malignant before starting any treatment. ...Read more

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Any good easy blood test to screen for ovarian cancer yet?

Any good easy blood test to screen for ovarian cancer yet?

No: Some may offer a ca-125 blood test as a screening for ovarian cancer. Unfortunately, while ca-125 is found in 80-90% of ovarian cancer patients, it is not very specific (meaning it is elevated in a number of conditions) and is not found in early cancers. It is better used as a method of following cancer treatment and progression, once it is diagnosed. ...Read more

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Any reliable blood test for ovarian cancer?

Any reliable blood test for ovarian cancer?

NO: There is no good / reliable blood test for ovarian cancer as a screening test. However, if you have ovarian cancer , a cancer marker- ca-125, in majority times is elevated in ovarian cancer and this can be used to monitor response to treatment. ...Read more

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Dr. Gurmukh Singh
480 doctors shared insights

Ovarian Cancer (Definition)

It is a cancer which arises from the ovary. This cancer is typically silent, producing little or no symptoms till it spreads, first into the pelvic area and later into the peritoneal cavity leading to fluid accumulation(ascites) which is often the first symptom. Despite its late presentation, there is a reasonable treatment for it, with some long term survivors even ...Read more


Dr. Adam Lewis
125 doctors shared insights

Ca125 (Definition)

Ca-125 (cancer antigen 125 or carbohydrate antigen 125) is a biomarker/tumor marker for ovarian cancer (etc); however, it is not sensitive or specific enough to use as a screening test. Also, a uk study showed that treating based on ca125 level did not improve outcomes. "125" comes from the 125th attempt to develop a marker. It was introduced by bast ...Read more