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Doctor insights on: Is It Possible To Have Lupus Without Specific Markers In Your Lab Work

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Is it possible to have lupus without specific markers in your lab work?

Is it possible to have lupus without specific markers in your lab work?

There are many marke: Usually most people with lupus have specific laboratory tests. There are a variety of markers such as ana, ds dna, sm, rnp, ssa, ssb, histone etc to name a few and there are some that are not routinely tested like su. Everyone with lupus is a specific individual with differences. No two snowflakes are the same and no 2 people with lupus are the same, even identical twins. Your tests will see. ...Read more

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Dr. Gregory Moneta
4 doctors shared insights

Laboratory (Definition)

Is facility that provides controlled conditions in which scientific research, experiments & measurements are performed. An example is medical (clinical) lab where tests are done on clinical specimens in order to get info. About the health of a patient in terms ...Read more


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If a dr suspects u have lupus but your lab work is borderline will a rheumatologist treat you for it to see if it helps?

Wait and see: Go to a rheumatologist. They have seen far more lupus then most doctors and they can best put together your clinical picture and your lab results. Lab tests are not the only thing that decides if you have lupus. ...Read more

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Can 1 have lupus diagnosis only by sx, repeatedana1:640, & prednisone works? Other labs always neg.Md thinks lupus but i'm afraid he'll start 2 think i'm crazy

Can 1 have lupus diagnosis only by sx, repeatedana1:640, & prednisone works? Other labs always neg.Md thinks lupus but i'm afraid he'll start 2 think i'm crazy

May or may not be: A positive ANA and improvement of symptoms with Prednisone does not make a specific diagnosis of sle. Lupus is not the only cause of a positive ana. A careful evaluation will help define what you have. Just because you respond to Prednisone does not mean you have lupus. ...Read more

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Past md said not lupus flare because normal labs at time of flare.New md put me on methotrexate.Flare stopped.Wouldn't it not work if not autoimmune?

Past md said not lupus flare because normal labs at time of flare.New md put me on methotrexate.Flare stopped.Wouldn't it not work if not autoimmune?

Lupus Flare: Lupus flares are diagnosed based on symptoms. Labs sometimes help... But often they do not. Finding new markers of a lupus flare is an area of active research now. Therefore your doctor put you on Methotrexate because they thought your symptoms were from a flare (autoimmune), despite the normal labs. ...Read more

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Have lupus.Doing well.Labs good.MD says my lupus is doing great.Work full time.Active.Still need frequent rest.Fatigue likely not related to lupus?

Have lupus.Doing well.Labs good.MD says my lupus is doing great.Work full time.Active.Still need frequent rest.Fatigue likely not related to lupus?

Question?: I am glad that your lupus is under pretty good control but one can't rule out that lupus may or may not be a cause for your fatigue without exploring other probabilities. For example, anemia is a common feature in lupus and a common cause for fatigue. Make sure that you get a comprehensive evaluation on both the physical and psychologic aspects of your health. ...Read more

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Can you have anti ssdna in your blood a month b4 showing symptoms of a kidney Infection? I had the lab work for lupus but I think ssdna from infection

Can you have anti ssdna in your blood a month b4 showing symptoms of a kidney Infection? I had the lab work for lupus but I think ssdna from infection

See details: The single stranded DNA is not a specific testing and is not ordered by any rheumatologist. The double stranded DNA is the one with clinical significance. ...Read more

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Why do symptoms often show up yrs before labs (specific antinuclear antibodies, etc) in a diagnosis of lupus? I'm near diagnosis with only high +ana. What causes the sx?

Why do symptoms often show up yrs before labs (specific antinuclear antibodies, etc) in a diagnosis of lupus? I'm near diagnosis with only high +ana.  What causes the sx?

Lupus is a mystery: Lupus is a famous master of masquerade--it can mimmic many disease states. Lupus symptoms may be present much earlier than when it can be diagnosed, thus lab measurement only provide a guide. This only means the lab has its limitation and medical science has only gotten this far. Don't rely on the lab, but rather rely on your bopdy--maybe something else is going on. Consult your doc. Good luck. ...Read more

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What lab work should be done before a diagnosis of chronic fatigue syndrome is given? Lupus, Lyme disease, heptatitis, anything else?

What lab work should be done before a diagnosis of chronic fatigue syndrome is given? Lupus, Lyme disease, heptatitis, anything else?

Varied: There are many different reasons for a person to suffer from fatigue: anemia, hypothyroidism, and many of the autoimmubne diseases. It is generally a diagnosis of exclusion. So lab work should include routine studies such as blood counts, liver and renal function and thyroid function studies. Only if all of these are normal would i pursue further studies. ...Read more

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All lupus blood tests negative but have all the symptoms. Pcp agrees. Seeing lupus doctor in 1 month. Is it possible to have lupus with negative labs?

Rarely: There is a rare individual who may have ANA negative lupus. However, if the ANA is negative, the ssa is often positive. I have personally not seen a true ANA negative lupus patient in years. ...Read more

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How difficult is it to diagnose lupus in a teen with no positive labs?

See details: If all of your tests are negative then the diagnosis of lupus is very unlikely. ...Read more

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Is it possible to be in a lupus flare and even while all inflammatory labs are negative?

Is it possible to be in a lupus flare and even while all inflammatory labs are negative?

Not common!: Since many symptoms of lupus are vague and non-specific, the answer is usually not, unless your sympoms or clinical findings are part of the clinical diagnostic criteria for sle. Aches and pains have many causes, as does fatigue, fever, etc. It is imprudent to overtreat any conditions, if hard signs for flares do not exist! i hope your problem will be resolved! ...Read more

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My hemoglobin is always slightly low (in the 10's all the time) my RDW is always high, every other lab normal- is this related to lupus?

May be : Lupus is reaponsible for several types of anemia . Chronic disease , iron deficiencymhemolysisn. Your dr needsnto study the type of anemia you have and givebthe proper therapynor find out what isbthe reason fornthe anemiantomunderstand what is going on. ...Read more

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Might someone have lupus, but still have normal lab results?

Highly unlikely: If the ANA and other autoantibodies are negative, the risk is very low. ...Read more

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In routine lab tests what are they looking at after someone is diagnosed with lupus?

In routine lab tests what are they looking at after someone is diagnosed with lupus?

See details: The rheumatologist will test to determine the activity and severity of the involvement. Blood and urine will be tested for blood counts, coagulation issues, kidney involvement, the degree of inflammation and other areas. ...Read more

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Can lab test results differ if you currently are not having a lupus flare vs having a flare?

It depends: It depends on the specific lab tests. The best is that some certainly change with the degree of disease activity. For instance the sed rate or CRP will rise with flares and fall with disease control. ...Read more

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I got test results b ack saying my lupus lab results are abnormal. What does that mean and what should be my next step?

Not enough info: What specific labs do you mean? No one can say what they mean when you do not supply specifics. Speak with your rheumatologist. ...Read more

Marker (Definition)

A "marker" is a protein or enzyme that can represent a disease process. Some markers are specific for a particular disease, while ...Read more