Doctor insights on:
Is It Possible To Have Both Alpha Thalassemia And Beta Thalassemia
Traits, yes: Because the Alpha and beta thalassemia gene mutations are common, it is possible for a baby to inherit one from mom and another from dad. The child could be "trait" in both Alpha and beta, or less likely, be "disease" in one and "trait" in the other. It is hard to imagine being "disease" in both and still survive. ...Read moreSee 1 more doctor answer
Of course you can: A person can marry anyone they like. From a thalassemia perspective, and assuming your Alpha thal trait is in cis, your child has a 50/50 chance of being Alpha thal trait vs. Normal and a 50/50 chance of being beta thal trait vs. Normal. Given there is consideration of inheriting two distinct trait states, it would be prudent to sit with a genetic counselor to understand the implications clearly. ...Read more
Yes: Marriage is no problem. Getting pregnant, however, may not be recommended if they have moderate or severe thalassemia. If they have only "trait", they will be fine if their children only inherit "no trait" or "trait from either mom or dad". If a child inherits "trait" from both mom and dad, the child might have a problem. A geneticist and hematologist can give more details for individual cases. ...Read moreSee 1 more doctor answer
Similar but differen: Alpha and beta thalassemia are distinct and different disorders since they diminish the production of distinct and different globin polypeptide chains and particularly in the homozygous state that has distinct and different consequences. Alpha and Beta Thal minor are similar Alpha Thal major is not compatable with life and results in miscarriage. Beta Thal major requires prolonged treatments etc. ...Read more
Should you go ahead and get the h1n1 vaccine for your child if they have alpha beta thalassemia minor?
Conventional: As scientists investigated hemoglobin, the complicated compound in red blood cells that carries oxygen, they learned that it was made up of 5 parts; 4 of these are 2 copies each of 2 different proteins. They named these Alpha chains and beta chains. If you inherit a condition where the Alpha chains are produced in smaller amounts than normal, you have Alpha thalassemia. ...Read moreSee 1 more doctor answer
Not quite: People normally have 4 Alpha globulin genes. A mutation in 1, 2, 3, or all 4 genes leads to the 4 levels of Alpha thalassemia. The genetics of the disorder is not all-or-none, not dominant-recessive. Instead, the more mutations, the worse the disease. One mutation = silent carrier (no symptoms), 2 muta. = Alpha trait (mild symptoms), 3 muta. = HGB h (moderate symptoms), 4 muta. = bart's (deaths). ...Read moreSee 1 more doctor answer
Hemoglobin problem: Alpha thal is caused by mutations that effect the production of a part of the hemoglobin molecule (Alpha chain). There are 4 genes involved in this production. Mutations can occur in 1 to 4 of these genes. The disease is more problematic the more genes are mutated. This disease is inherited from parents. ...Read more
4 alpha genes...: It is a bit complicated given that there are 4 Alpha chain genes and Alpha thalassemia can involve mutations in one, two (in two different ways) or three genes (mutations in four genes is usually not compatible with life). For excellent website, see: http://www.Stjude.Org/stjude/v/index.Jsp?Vgnextoid=d966885309c6f110vgnvcm1000001e0215acrcrd. ...Read moreSee 1 more doctor answer
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