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Doctor insights on: Is It Okay To Take Two Benadryl

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Dr. John Chiu
1,047 Doctors shared insights

Diphenhydramine (Definition)

Diphenhydramine is a sedating antihistamine which is a kind of antihistamine type drug (common ...Read more


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Is it okay if to take 2 benadryls (diphenhydramine) and I melatonin?

Is it okay if to take 2 benadryls (diphenhydramine) and I melatonin?

Doses?: Depends on the dose of Benadryl (diphenhydramine). If you have insomnia, sleep hygiene is an often overlooked, yet more effective treatment, than medications. In addition, the combination of medications could impair decision making, cause undesired drowsiness, and other side effects. Speak with your doctor, before taking any combination of medications. Do not drive/operate heavy machinery under their influence. ...Read more

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I had two drinks at 7pm. Can I take 25mg or 50mg or Benadryl?

I had two drinks at 7pm. Can I take 25mg or 50mg or Benadryl?

Yes if: You are planning to go the bed. Some studies have shown that the sedative effect of one Benadryl= 1 shot of alcohol (likely more so for women). Be sure you will not be driving after this combination. ...Read more

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Can I take two extra strength Benadryl (diphenhydramine) night time?

Can I take two extra strength Benadryl (diphenhydramine) night time?

50 mg total: You can take a total of 50 mg up to every 4 hours. I've never heard of extra strength Benadryl (diphenhydramine) (they do make a 50 mg tablet, but I've always seen it behind the counter at a pharmacy). All the over-the-counter strengths I've ever seen are 25 mg, so you can take 2 of those. ...Read more

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I am now 95 pounds & I took 10 25mg Benadryl (diphenhydramine) pills and I think it's been two hours why am I not high. How long does it take to feel the high?

I am now 95 pounds & I took 10 25mg Benadryl (diphenhydramine) pills and I think it's been two hours why am I not high. How long does it take to feel the high?

WILL MAKE YOU SICK: It is not a good idea to overdose on 250mgm of Benadryl (diphenhydramine) to get high
it can make you sick. It will cause extreme sleepiness, confusion, weakness, ringing in the ears, blurred vision, large pupils, flushing, fever, shaking, insomnia, hallucinations and possibly seizures
go to er if you have any of the serious symptoms.
Please if you have drug problem consult a therapist or your doctor. ...Read more

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Is it safe to take Benadryl (diphenhydramine) if I took two 10mg loratadine tablets a few hours ago?

Is it safe to take Benadryl (diphenhydramine) if I took two 10mg loratadine tablets a few hours ago?

Yes: The two are compatible in the short term. Benadryl (diphenhydramine) is potentially sedating, so caution is advised. By the way, studies show the regular adult dose of loritadine is 10 mg and 20 mg is not found to be any more effective. ...Read more

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Can I take one cup of NyQuil for my cold, and two Benadryl's for my allergies?

Can I take one cup of NyQuil for my cold, and two Benadryl's for my allergies?

2AntihistaminsSimila: Nyquil cantains aDoxylamine.Acetaminophen and Dextromethorfan
Benadryl (diphenhydramine) is an antihistamine and Doxylamine is also antihistamine. Both are first generation antihistamines and cause sedation. I will not advice to take 50 mgm (2x25mgm)of Benadryl (diphenhydramine) and Nyquil. ...Read more

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If my Benadryl (diphenhydramine) contains phenylephrine is it not a good idea to take two tablets for sleep?

If my Benadryl (diphenhydramine) contains phenylephrine is it not a good idea to take two tablets for sleep?

Drop phenylephrine: Find a product that does not contain the phenylephrine. For most people, that med is stimulating and will make you stay awake, not help you sleep. Make sure you also use good sleep hygiene - bedtime routine, minimize distractions around you, warm milk, and consider melatonon for sleep aid rather than more and more benadryl (diphenhydramine). ...Read more

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I'm having a bad anxiety attack and I want more than my usual dose of xanax. Would it be okay to take a Benadryl (diphenhydramine) or two with it?

Consult with MD: I can answer this question for my individual patients (whom I know well). However, this is really an important question for you to address with your physician. I am afraid that by telling you how to take your meds that I would be providing medical treatment (which only your providers should do). Take care. ...Read more

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Can you take two oxycodone 5-325 and liquid Benadryl (diphenhydramine) together?

Can you take two oxycodone 5-325 and liquid Benadryl (diphenhydramine) together?

No: You don't want to do that, more-over monitor your oxycodone dosage carefully. Combining both drugs or overdosing oxycodone can lead to CNS depression and untoward side effects as respiratory depression. If you are experiencing itching or other symtoms that can be a side effect of drug use, please see your doctor, best wishes ...Read more

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I just took Tylenol (acetaminophen) pm about two hours ago, Can I take one Benadryl?

Yes: Yes, you can, but you need to wait a couple more hours as the Tylenol (acetaminophen) PM has the Benadryl medication in it. It may help you sleep and may help with allergy symptoms. These two drugs can definitely be taken together, though Just take them 4-6 hours apart. Best wishes to you. ...Read more

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I take benadryl (diphenhydramine) everyday about 250mg not at once but during the day for chonic allergies. Been doing this for two years will this damage my liver?

I take benadryl (diphenhydramine) everyday about 250mg not at once but during the day for chonic allergies. Been doing this for two years will this damage my liver?

No, but...: That is really a lot of benadryl (diphenhydramine) and while it will not damage your liver it can have a lot of side effects such as fatigue, dry mouth, constipation and mental slowing. Discuss a change to a non-sedating antihistamine, nasal saline and some nasal steroids with your doctor and try to get off this large dose of benadryl (diphenhydramine). Singulair may also be helpful. ...Read more

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My daughter (age 13) took two Benadryl (diphenhydramine) at 9:00 pm. It is now 11:30 pm. Her nose is stuffy and she can't sleep. Is there anything she can take now?

My daughter (age 13) took two Benadryl (diphenhydramine) at 9:00 pm. It is now 11:30 pm. Her nose is stuffy and she can't sleep. Is there anything she can take now?

Yes, but no antihist: Amine--I presume she took two 25 mg tabs, so she shouldn't take another antihistamine. I recommend an over-the-counter decongestant nasal spray like Afrin. Follow the directions. Alternative--otc sudafed. With no stuffy nose, she should sleep better. ...Read more

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Hi I took benadryl (75 mgs) now can I take two Tylenol (acetaminophen) pms?

Hi I took benadryl (75 mgs) now can I take two Tylenol (acetaminophen) pms?

No: Maximum one time dose is 100mg and maximum daily dose is 300mg. You've already taken 150 mg and each Tylenol (acetaminophen) PM contains 25 mg of Benadryl. ...Read more

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Hello Jonathan I would like to know if I could take benadryl night time while on amoxicillin, I have had pneumonia two moths ago and now I have the same symptoms I went to my family doctor and all he did was give me amoxicillinan, so far it hasn't do

Hello Jonathan I would like to know if I could take benadryl night time while on amoxicillin, I have had pneumonia two moths ago and now I have the same symptoms I went to my family doctor and all he did was give me amoxicillinan, so far it hasn't do

Mgt: Most respiratory illness, including bronchitis infections are caused by viruses. Since you were treated for a bacterial illness, there should be diminished fever and improvement during the next week. Watch for any signs of fever, chills, thick sputum and if these occur please notify your PCP. A chest radiograph can be performed at that time if needed. A virtual appt to discuss online advised. ...Read more

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I have sulfa allergy. I have itching, burning rashes all over my body. Can I take one Claritin (24 hr) in the morning and two Benadryl (diphenhydramine) at night?

I have sulfa allergy. I have itching, burning rashes all over my body. Can I take one Claritin (24 hr) in the morning and two Benadryl (diphenhydramine) at night?

Allergic rash: You can take 4 10mg Claritin (loratadine) a day for chronic hives. Be sure it is Claritin (loratadine) plain without decongestant. Avoid Sulfite-containing foods like wine, dried fruits, radishes, potatoes, shrimp ...Read more

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I had an allergic reaction to bell peppers two days ago. Should I take Benadryl (diphenhydramine) for the residual swelling in my throat or stick with advil?

I had an allergic reaction to bell peppers two days ago. Should I take Benadryl (diphenhydramine) for the residual swelling in my throat or stick with advil?

As needed: Unfortunately, food reactions can persist for several days as the material proceeds through your digestive tract. If you tolerate Benadryl (diphenhydramine) ok you can certainly use it for several days. The advil is unlikely to influence allergic swelling. ...Read more

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What happens if I take two medicines both containing diphenhydramine?

Too much Benadryl (diphenhydramine): You should read how much Benadryl (diphenhydramine) is in each one. If you only take it in therapeutic doses you will mostl likely be ok, but will feel drowsy and sometimes hypotensive. You should ask your docotr if you should take the two meds together, that is hte best answer. ...Read more

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Had 100mg of diphenhydramine last night at 10PM. Is it normally safe to take that dose two nights in a row?

Yes: THe maximum daily dosage of diphenhydramine is 400mg/day

However, the recommended dosage of the medication for insomnia is 50mg at night.

Would recommend to reduce the dosage to 50mg at night

Please see your doctor if still have issues with insomnia. ...Read more

Benadryl (Definition)

Diphenhydramine is a sedating antihistamine which is a kind of antihistamine type drug (common ...Read more