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Doctor insights on: Is It Okay To Take Amitriptyline With A Low Dose Of Tramadol For Pain

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Is it okay to take amitriptyline with a low dose of tramadol for pain?

Is it okay to take amitriptyline with a low dose of tramadol for pain?

Physician can decide: Tramadol and Amitriptyline both exert some effect on serotonin containing nerve pathways. There is potential interaction between the two. Treating physician can make a decision to combine the two in a regimen when benefits outweigh any potential risk. ...Read more

Dr. Jeffrey Satinover
379 Doctors shared insights

Elavil (Definition)

Elavil is a tertiary amine tricyclic which is a kind of tricyclic type drug (serotonin-norepinephrine reuptake inhibiting ...Read more


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Is it safe to take amitriptyline with a low dose of tramadol for pain?

Is it safe to take amitriptyline with a low dose of tramadol for pain?

Take Genetic Test: You might be able to take both low dose Amitriptyline and low dose tramadol for pain, depending on your genetics. You can have (cheek swab) pharmacogenomic tests done at the doctor's office (e.g. Assurex, genomind) to determine how you metabolize psychiatric and pain meds. In this way, your doctor can determine what will be a wise course of treatment. Consider tms for pain. ...Read more

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Can you take amitriptyline 75mg a day with a low dose of tramadol for pain?

Can you take amitriptyline 75mg a day with a low dose of tramadol for pain?

Usually: While it is generally safe to use the medications in combination, there is a slight risk of developing serotonin syndrome. Serotonin syndrome is characterized by restlessness, diarrhea, rapid heart beat, confusion, sweating/fever, nausea/vomiting, loss of coordination, and blood pressure changes. In addition both can sedate you so you should be careful about driving. ...Read more

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I am on a low dose of tramadol. 50-100mg per day. Is it still safe to have alcohol? Just stopped taking amitriptyline last week. 10mg per day.

I am on a low dose of tramadol. 50-100mg per day. Is it still safe to have alcohol? Just stopped taking amitriptyline last week. 10mg per day.

Not recommended: Tramadol and alcohol are depressant of the central nervous system. Mixing tramadol with alcohol could lead to drowsiness to severe depression of brain activity, coma, and ultimately death. Tramadol has a prolonged half-life about 7 hours. It is still in your system for at least 10 hours. Is not recommended. ...Read more

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Can you take tramadol and elavil (amitriptyline) together?

Can you take tramadol and elavil (amitriptyline) together?

I would not: This combination of medications could lower seizure threshold. ...Read more

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I have been prescribed amitriptyline 100mg for back pain is it ok to take it with tramadol 300mg?

I have been prescribed amitriptyline 100mg for back pain is it ok to take it with tramadol 300mg?

Drug interaction: It is not recommended to mix tramadol with antidepressants such as Amitriptyline due to increased risk of developing serotonin syndrome which can be a life threatening conditions. Please talk to your doctor before taking these medications together. ...Read more

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Can I mix tramadol and amitriptyline? My urologist gave them to me for cystitis in my bladder and I take 200mg of tramadol a day and 1 100mg of the other medicine at night, is it still okay to take both?

Medication effects: Amitriptyline is medication for Depression.
Thank you for informing about use of Xanax (alprazolam).
Using amitriptyline with Xanax (alprazolam) may increase dizziness, confusion, impairment in thinking, judgment, and motor coordination.
See your Psychiatrist to discuss Diagnosis of anxiety, depression interaction of Amitriptyline and Xanax (alprazolam), benefits and side effects, decreasing the dose, and Therapy for stresses in life. ...Read more

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My Dr prescribed me tramadol and flexarol, at bedtime I have pills I take daily as wel (elavil&mavik). Last night I was very lightheaded and felt sick.

My Dr prescribed me tramadol and flexarol, at bedtime I have pills I take daily as wel (elavil&mavik). Last night I was very lightheaded and felt sick.

Sedating medications: Elavil (amitriptylene), tramadol, and Flexeril (cyclobenzaprine) are all sedating and if taken together in someone who's not used to them could indeed make you feel ill. The Mavik (trandolapril) is a blood pressure medication which is not sedating and is not culpable here. Both tramadol and Flexeril are as-needed meds, so it is safe to reduce your own dose of these by dividing the tablets and taking 1/2. ...Read more

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Can I still take a low dose of tramadol while on butran patches?

Tramadol: Low dose tramadol may be used initially while the Butrans efficacy is being evaluated. It can also be used as a medication for any exacerbated pain that you have after the Butrans patch dose is optimized. If you are fine with Butrans alone then no need for Tramadol. ...Read more

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I take 75mg amtriptilene every night. Is it safe to take low dose tramadol - 50mg?

Tramadol: In most people this is a same combination assuming you have been on Amitriptyline for a while now. Also important is any other medication you are on, given tramadol, a great and safe pain medication, does have some interactions. ...Read more

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Could taking tramadol and amitriptyline cuaseing a sezuire?

Could taking tramadol and amitriptyline cuaseing a sezuire?

Yes: Tramadol can cause seizures. Amitriptyline can raise serum levels of Tramadol. The combination needs to be used with caution. ...Read more

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Should I be at work whilst taking tramadol and amitriptyline?

Should I be at work whilst taking tramadol and amitriptyline?

Depends, probably not: It depends on how long you have been taking each medication and what you do for a living. The safest answer is no, because both can cause sedation and lead to occupational hazards. If you have taken these for a long time and you have had no issues, you could consider returning to more sedentary work, but the two together in any dangerous situations would not be advised. ...Read more

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Can Tramadol, amitriptyline, or etolodac cause or make tinnitus worse?

Can Tramadol, amitriptyline, or etolodac cause or make tinnitus worse?

No: Unlikely. Tinnitus may be louder at different times and seems to get intense more you pay attention to it. Best treatment would be to learn to live with it and try to mask the noise but having some background noise like soft music ...Read more

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Are there any dangerous interactions between neurontin, (gabapentin) tramadol, and amitriptyline?

Are there any dangerous interactions between neurontin, (gabapentin) tramadol, and amitriptyline?

Yes: Theoretically this combination may result in mental slowing and other related central nervous system effects. Again, in theory, concomitant use of Amitriptyline and teamadol may cause seizures and so-called serotoninergic syndrome. However, if you take the medications and have no side effects, no other actions but monitoring is required. ...Read more

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I've taken 7.5mg zopiclone + 5mg Valium & 2 x 30/500 cocodamol for sleep but it is ineffective. I've now had amitriptyline & tramadol. Is this safe?

I've taken 7.5mg zopiclone + 5mg Valium & 2 x 30/500 cocodamol for sleep but it is ineffective. I've now had amitriptyline & tramadol. Is this safe?

Not Safe!: It is never safe to combine these medications. Talk to your doctor about your insomnia. You need a careful evaluation in order to obtain an accurate diagnosis and appropriate treatment. Polypharmacy is never safe! We lose too many young people each year due to unintentional overdose. Be safe and work with your doctor. ...Read more

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Does Amitriptyline, venlafaxine and tramadol all work in different ways on neuropathic pain?

Does Amitriptyline, venlafaxine and tramadol all work in different ways on neuropathic pain?

Neuropathic pain: Responds to many different agents. Its important that the treatment not exacerbate (amitriptyline) nor end up being worse for you (tramadol) than the disease / condition. Serotonergic syndrome and seizures can occur with Ultram. Elavil will cause anticholinergic symptoms and may actually worsen some types of neuropathy. Venlafaxine may help but it is not a top choice in my practice. ...Read more

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I'm taking 150mg of tramadol a day for sciatica which hasn't been working for me, the doctor today prescribed me 10mg of amitriptyline, is this ok?

Side effects: It can increase your risk of seizures and other issues, my suggestion is to discuss with your doctor. Also any other medications you are on may interact as well. ...Read more

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Taking tramadol 50mg, elavil (amitriptyline) 10mg both twice daily for radiculopathy pain/burning. Still constantly in pain. What else can I do/ask dr to give/incr?

Many options.: I would start with a good once a day non steroidal ant-inflammatory such as indomethacin. Could increase either elavil or tramadol although there is a potential interaction between tramadol and effexor (venlafaxine). Gabapentin or pregabalin is an option. Sometimes a muscle relaxant such as methocarbamol or cyclobenzaprine is helpful. ...Read more

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Is a combination of meds like tramadol, amitriptyline and Zoloft (sertraline) better for controlling nerve pain than one of the meds alone?

Is a combination of meds like tramadol, amitriptyline and Zoloft (sertraline) better for controlling nerve pain than one of the meds alone?

Depends: Presumably you're working with a neurologist or pain management specialist for neuropathic pain treatment. If not, you should see one. It is always better to treat a condition with the least number of medications and the lowest dose of each medication possible. Discuss this with your physician. Http://www. Webmd. Com/pain-management/guide/neuropathic-pain ...Read more

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I'm taking endep10 and started taking 50mg 5-htp morning and night. Just realised can't mix. Endep (amitriptyline) 10 is a Low dose. Is this ok??

I'm taking endep10 and started taking 50mg 5-htp morning and night. Just realised can't mix. Endep (amitriptyline) 10 is a Low dose. Is this ok??

Need to discuss: In order to answer your question correctly it would be best to either speak with you or have you speak with your provider. It is correct that these two medicine should not be combined because of the risk of serotonin syndrome. If you're asking if your endep (amitriptyline) is ok to take (if you do not take the other) You should discuss with your doctor. ...Read more

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Am prone to constipation and excruciating hemorrhoids. Will 10mgs amitriptyline make problem more extreme, or are side effcs unlikely at low dose?

Depends: If you get side effects, you get them. Every patient is different. If you aren't already, you should be on fiber supplements 2-3 times a day, plenty of fluids (apple juice is wonderful) and lots of fruit and veggies. Use vaseline down below. If you still struggle, you have to weight the benefit of the medicine vs the problems it causes. Many have stopped Amitriptyline due to the contstipation. ...Read more

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I have had serotonin syndrome from SSRIs. Would taking amitriptyline at a low dose (for headaches) be safe? Will I be at a high risk of SS?

I have had serotonin syndrome from SSRIs. Would taking amitriptyline at a low dose (for headaches) be safe? Will I be at a high risk of SS?

MIssing info: While amitriptyline is serotonergic, it would be hazardous to to consider it without knowing more about your prior serotonin syndrome. ...Read more

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I have frequent minor palpitations. No serious heart conditions tho. Is amitriptyline at a low dose safe for me? I've read it causes arrhythmia.

I have frequent minor palpitations. No serious heart conditions tho. Is amitriptyline at a low dose safe for me? I've read it causes arrhythmia.

Depends on history: Amitriptyline is more likely to cause serious palpitations in those over age 60, with a history of heart disease or arrhythmias, and usually at higher doses. Accordingly it's hard to say in your case without knowing more of your medical history. ...Read more

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Does elavil (amitriptyline) help sensitive esophagus pain from gerd? My dr gave it to me said it helps digestive nerves? But doesn't it relax the les valve? Or is a low dose not enough to affect it and out weighs it

Don't overthink doc: You haven't told us the dose of Elavil (amitriptyline) prescribed, nor what symptoms are being treated with it. Like any drug, Elavil (amitriptyline) has desirable and undesirable effects--call your doctor about your concerns instead of trying to overthink him and then not taking your prescribed medication. ...Read more

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Why do Drs RX Tramadol w/out say its snri besides painkiller? To someone w/ anxiety disorder? Short term low dose use taper but 3day long panic attack

Why do Drs RX Tramadol w/out say its snri besides painkiller? To someone w/ anxiety disorder? Short term low dose use taper but 3day long panic attack

Inform your doctor: Tramadol affects opiate receptors and inhibits reuptake of serotonin and norepinephrine. It is classified as a pain medication used to treat moderate to severe pain. Serotonin and norepinephrine reuptake inhibitors are used to treat anxiety as well as depression. However, susceptible individuals can have problems with discontinuation of SNRIs. The same goes for opiates. Discuss with your doctor. ...Read more

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My dr has me on low dose methotrexate, tramadol, Wellbutrin xr, buspar, (buspirone) Xanax and ambien. Are all these drugs safe together?

My dr has me on low dose methotrexate, tramadol, Wellbutrin xr, buspar, (buspirone) Xanax and ambien. Are all these drugs safe together?

Comments: I would not be surprised to encounter drug-drug interactions here, which could enhance adverse effects, and even compromise intended efficacy. Not having a clue as to why you take any of these, I cannot advise further, but think you would do well to have an extensive discussion with your doctor about all of this. ...Read more

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I have high bp, tachycardia, daily take Effexor (venlafaxine) XR, soma, ultram, zonegran, methergine, metoprolol tar, elavil, neurontin. What OTC cold med can I take?

I have high bp, tachycardia, daily take Effexor (venlafaxine) XR, soma, ultram, zonegran, methergine, metoprolol tar, elavil, neurontin. What OTC cold med can I take?

None: I would not recommend any further medication, since the chance for adverse drug interactions is high. You are are already taking several medications that act on the serotonin system and may result in adverse interaction. ...Read more

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So taking low dose adderall and low dose ultram are not good to take together? I am prescribed by my Dr one 10mg adderall twice a day, 50mg ultram 3 times a day, and one klonopin twice daily.... I trust my doctor but people are human and make mistakes? I

So taking low dose adderall and low dose ultram are not good to take together? I am prescribed by my Dr one 10mg adderall twice a day, 50mg ultram 3 times a day, and one klonopin twice daily.... I trust my doctor but people are human and make mistakes? I

Interactions: Technically, Ultram and Adderall (dextroamphetamine and racemic amphetamine) do have an interaction in that they can increase the risk of seizures, more so with higher doses of each. And Ultram and Klonopin can cause central nervous system depression (can make you extra sleepy and not know what you're doing) as well as respiratory depression (decrease you're breathing). So you might want to talk to your docs about these interactions. ...Read more

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Could 100mg tramadol. 1mg clonidine and 50 mg amitripyline cause serotonin toxicity and death?

Could 100mg tramadol. 1mg clonidine and 50 mg amitripyline cause serotonin toxicity and death?

TramadolAmitriptylin: The reported prevalence of serotonin syndrome is unknown possibly because of underdiagnosis or misdiagnosis. However, it is a potentially life-threatening condition with symptoms that can appear from 30 minutes to 48 hours after a new serotonergic medication is taken. Any drug or combinations of drugs that induce an excess of 5-ht can cause serotonin syndrome.
Rec.: talk to your treating doctor. ...Read more

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Can amatriptaline or tramadol cause you to have to push to pee I am a 36 year old female with amatriptaline helps depression not my fibromyalgia?

Can amatriptaline or tramadol cause you to have to push to pee I am a 36 year old female with amatriptaline helps depression not my fibromyalgia?

Yes: Amitriptylene for sure can interfere with urinating. It's a tricyclic antidepressant that can also cause constipation, dry eyes, dry mouth, sedation, and some other effects. Please tell your doctor you're having this problem --a dose adjustment may be needed. ...Read more

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Is Lexapro (escitalopram) plus a low dose of amitryptaline a good combo for anxiety and insomnia? Dr prescribed both and want to double check.

Is Lexapro (escitalopram) plus a low dose of amitryptaline a good combo for anxiety and insomnia? Dr prescribed both and want to double check.

Polypharmacy: Clonazepam & Zyrtec (cetirizine) are also part of your medication regimen? The combination of all the drugs you list can result in reactions of lethargy, fatigue, & depression of your central nervous system. & the word "depression" means both the FUNCTION of your body as a whole as well as in the psychological sense. Have the root causes of your anxiety/insomnia been investigated? Any alternatives to the meds? ...Read more

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What is the best treatment for vestibular vulvydinia? Was recntly diagnosed and am taking low dose amitriptiline and antihistimine along with some pt.

What is the best treatment for vestibular vulvydinia? Was recntly diagnosed and am taking low dose amitriptiline and antihistimine along with some pt.

Vuvodyinia: I would see a doctor or clinic that specializes in comprehensive vulvodynia treatment. The use of vaginal dilators is often helpful, but there is no one product that works for everyone. ...Read more

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I've taken norco n a low dose of Xanax (alprazolam) 4 12 yrs w/great results. New doc will only give tramodol, non narc, since I'm on Xanax (alprazolam). I'm in agony! What to do?

I've taken norco n a low dose of Xanax (alprazolam) 4 12 yrs w/great results. New doc will only give tramodol, non narc, since I'm on Xanax (alprazolam). I'm in agony! What to do?

MedicationDependence: Norco and Fentanyl are opioid pain medication for moderate to severe pain. May be habit-forming
Xanax (alprazolam) is a medication for treatment of Anxiety, may be habit-forming
All 3 medications taken together can cause CNS Depression
Go to ER for severe abdominal pain, Nausea, enlarged spleen, use of Norco, Fentanyl and Xanax (alprazolam) for diagnosis.
See a Psychiatrist for Pain management and Anxiety including Therapy ...Read more

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Can low dose of amitriptyline take away symptoms of celiac disease? Specifically, chronic diarrhea and lack of appetite?

Can low dose of amitriptyline take away symptoms of celiac disease? Specifically, chronic diarrhea and lack of appetite?

Combating symptoms: Amitriptylene has anticholinergic and antihistaminic side effects that can slow the bowel and increase appetite. In this way it can counteract some of the symptoms you're having (the chronic diarrhea and poor appetite). You'll need to work with your doctor to arrive at a dose that works well for you, balancing out these processes in a positive way. You'll still need to avoid gluten. ...Read more

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Just put on 50mg trazodone, take 36mg concerta, & 1/2 of a 50mg tramadol 4 x day (100 total am weening off). Doc said its ok since low doses. Is ok?

Depends: Only your dr knows the answer. Med. Doses are calculated carefully and depend on the nature of your symptoms and how you have responded to meds so far.
Ps tramadol is an opioid medication that can cause dependence / addiction. ...Read more

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Can I take amitriptyline and xanax (alprazolam) simultaneously? I'm prescribed both but usually wait a few hours between different doses.

Talk to your doctor: Both medications can be sedating. When combined there is an increased sedating effect. It depends upon your age and the dose of your medication and your overall health in order to determine if it is safe to combine the two. Talk to your doctor for the safest answer to your question. ...Read more

Dr. Heidi Fowler
327 Doctors shared insights

Endep (Definition)

Endep is a tertiary amine tricyclic which is a kind of tricyclic type drug (serotonin-norepinephrine reuptake inhibiting ...Read more


Tramadol (Definition)

A synthetic analgesic for treatment of ...Read more