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Doctor insights on: Is It Okay To Mix Benadryl With My Other Medications

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Is it okay to mix Benadryl (diphenhydramine) with my other medications?

Is it okay to mix Benadryl (diphenhydramine) with my other medications?

Depends on situation: It works ok with many other medications but can increase the sedative effect of some. Either clear the combo with your doc or try it when you don't plan to be driving or operating machinery. ...Read more

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Dr. John Chiu
1,011 doctors shared insights

Diphenhydramine (Definition)

Diphenhydramine is a sedating antihistamine which is a kind of antihistamine type drug (common ...Read more


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If Benadryl's plasma clearance is about 9 hours x 5, how long would it remain active to affect the brain and interact with other medications?

If Benadryl's plasma clearance is about 9 hours x 5, how long would it remain active to affect the brain and interact with other medications?

Less than 12 hrs: It may take a long time for a drug to completely clear from the body, the biochemical effect occurs only with a certain blood level. I have yet seen anyone getting drowsy from Benadryl (diphenhydramine) for more than 12 hours. It is the drug level that matters. ...Read more

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I worry a lot and need to finally sleep, is it okay to mix Benadryl and tylenol (acetaminophen)?

I worry a lot and need to finally sleep, is it okay to mix Benadryl and tylenol (acetaminophen)?

Ok short term: Benadryl is an antihistamine that makes some people sleepy. However, other people may become hyper alert on benadryl. Taking tylenol (acetaminophen) at the same time will not cause harm if taking recommended dosage on package. See your md to discuss how to better handle your "worries" if they are daily and causing you to lose sleep every night. ...Read more

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Is it okay to mix ambien and benadyrl to treat insomnia? i took benadryl (diphenhydramine) around 4hrs after taking ambien bc it didnt work, are there side effects?

Is it okay to mix ambien and benadyrl to treat insomnia? i took benadryl (diphenhydramine) around 4hrs after taking ambien bc it didnt work, are there side effects?

No don't mix drugs: Please don't mix ambien with benadryl (diphenhydramine). I would first suggest you speak with your doctor who prescribed you ambien and him/her that you are still experiencing insomnia. Mixing prescription medication with drugs like benadryl (diphenhydramine) can be dangerous. Perhaps you should improve your sleep hygiene first. Sleep same time every night, bed is used only for sleep, cool dark room, no distractions (TV) etc. ...Read more

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Can some drug you with benadryl (diphenhydramine)?

Can some drug you with benadryl (diphenhydramine)?

Yes: One can be drugged with anything. Benadryl (diphenhydramine) can cause drowsiness, dizziness, confusion, nausea, urinary retention and more if given high doses or to susceptible individuals. ...Read more

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What type of drug is Benadryl (diphenhydramine) and what are its uses?

Benadryl (diphenhydramine): It is a first generation antihistamine. Very powerful but has side effects that many 2nd generation otc antihistamines do not have. Among it uses are for allergies and in otc sleep aides. ...Read more

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Is 5 mg of Valium & 75 mg of Benadryl (diphenhydramine) a bad mix?

Is 5 mg of Valium & 75 mg of Benadryl (diphenhydramine) a bad mix?

Watch carefully: The combo can increase dizziness and drowsiness. Don't drive or do things that require clarity until you see how it affects you. Also, watch out for long term Valium use as it is addictive and intended for specific events - not regular everyday life. Also, your Benadryl (diphenhydramine) dose is fairly high unless spread throughout the day. Talk to your doctor about each issue. Be careful - be well. ...Read more

Benadryl (Definition)

Diphenhydramine is a sedating antihistamine which is a kind of antihistamine type drug (common ...Read more