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Doctor insights on: Is It Okay To Mix Benadryl With My Other Medications

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Is it okay to mix Benadryl (diphenhydramine) with my other medications?

Is it okay to mix Benadryl (diphenhydramine) with my other medications?

Avoid these: Older antihistamines like Benadryl (diphenhydramine) interact with many drugs. Don't mix it with alcohol, sleeping pills, sedatives, antidepressants, potassium supplements, sodium or potassium phosphate, antipsychotics, MAO inhibitors, symlin (pramlintide), sodium oxybate, Precedex (dexmedetomidine) & abilify (aripiprazole). Loratidine and fexofenadine are as effective & much safer. Discuss this with your doctor.

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Dr. John Chiu
1,046 Doctors shared insights

Diphenhydramine (Definition)

Diphenhydramine is a sedating antihistamine which is a kind of antihistamine type drug (common ...Read more


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If Benadryl's plasma clearance is about 9 hours x 5, how long would it remain active to affect the brain and interact with other medications?

If Benadryl's plasma clearance is about 9 hours x 5, how long would it remain active to affect the brain and interact with other medications?

Less than 12 hrs: It may take a long time for a drug to completely clear from the body, the biochemical effect occurs only with a certain blood level. I have yet seen anyone getting drowsy from Benadryl (diphenhydramine) for more than 12 hours. It is the drug level that matters.

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I worry a lot and need to finally sleep, is it okay to mix Benadryl and tylenol (acetaminophen)?

I worry a lot and need to finally sleep, is it okay to mix Benadryl and tylenol (acetaminophen)?

Ok short term: Benadryl is an antihistamine that makes some people sleepy. However, other people may become hyper alert on benadryl. Taking tylenol (acetaminophen) at the same time will not cause harm if taking recommended dosage on package. See your md to discuss how to better handle your "worries" if they are daily and causing you to lose sleep every night.

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Is it okay to mix ambien and benadyrl to treat insomnia? I took benadryl (diphenhydramine) around 4hrs after taking ambien bc it didn't work, are there side effects?

Is it okay to mix ambien and benadyrl to treat insomnia? I took benadryl (diphenhydramine) around 4hrs after taking ambien bc it didn't work, are there side effects?

No don't mix drugs: Please don't mix ambien with benadryl (diphenhydramine). I would first suggest you speak with your doctor who prescribed you ambien and him/her that you are still experiencing insomnia. Mixing prescription medication with drugs like benadryl (diphenhydramine) can be dangerous. Perhaps you should improve your sleep hygiene first. Sleep same time every night, bed is used only for sleep, cool dark room, no distractions (TV) etc.

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Can some drug you with benadryl (diphenhydramine)?

Can some drug you with benadryl (diphenhydramine)?

Yes: One can be drugged with anything. Benadryl (diphenhydramine) can cause drowsiness, dizziness, confusion, nausea, urinary retention and more if given high doses or to susceptible individuals.

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What type of drug is Benadryl (diphenhydramine) and what are its uses?

Benadryl (diphenhydramine): It is a first generation antihistamine. Very powerful but has side effects that many 2nd generation otc antihistamines do not have. Among it uses are for allergies and in otc sleep aides.

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Is 5 mg of Valium & 75 mg of Benadryl (diphenhydramine) a bad mix?

Is 5 mg of Valium & 75 mg of Benadryl (diphenhydramine) a bad mix?

Watch carefully: The combo can increase dizziness and drowsiness. Don't drive or do things that require clarity until you see how it affects you. Also, watch out for long term Valium use as it is addictive and intended for specific events - not regular everyday life. Also, your Benadryl (diphenhydramine) dose is fairly high unless spread throughout the day. Talk to your doctor about each issue. Be careful - be well.

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Can you mix Benadryl (diphenhydramine) with other meds in a syringe?

Can you mix Benadryl (diphenhydramine) with other meds in a syringe?

Oral syringe??: For children's medications, it's best to give them one at a time. For example, give the tylenol (acetaminophen) in it's own oral syringe, and then give Benadryl separately (using a properly sized syringe for the benadryl).

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Can melatonin and Benadryl (diphenhydramine) be mix and safe to use together?

Yes: But both have sedative properties and can lead to some hangover effects in the morning if taken for sleep, take as low a dose of melatonin as possible, 90min before desired sleep time.

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I ingested an allergen 5 days ago. I am still having a reaction and Benadryl (diphenhydramine) is the only drug working well. At 190 lbs how much can I take safely?

I ingested an allergen 5 days ago. I am still having a reaction and Benadryl (diphenhydramine) is the only drug working well. At 190 lbs how much can I take safely?

Unusual: Unless it was a drug, the allergic reaction does not usually lasts this long. As for Benadryl, (diphenhydramine) the dose is more dependent on its side effects than weight. Most people should be able to tolerate up to 50 mg 4x daily (except those

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Is it safe to mix Benadryl (diphenhydramine) with ambien?

Is it safe to mix Benadryl (diphenhydramine) with ambien?

Ambien (zolpidem): Not sure if u r using the Benadryl (diphenhydramine) for allergy or to add to sleep, but I would consult your prescribing doctor first.

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Is it ok to mix guafisen (mucinex) with diphenhydramine (benadryl)?

Is it ok to mix guafisen (mucinex) with diphenhydramine (benadryl)?

Yes.: The mix without interaction, but do not take more benedryl than indicated for your age, size, and weight.

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Can you take Benadryl (diphenhydramine) if you are taking other types of medication for allergies?

Yes: The limiting factor as to how much antihistamine one can take is generally what the side-effects are. If it makes you too sleepy when combined with other anti-histamines then you should be careful about combining them.

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Can a person be truly allergic to benadryl (diphenhydramine)? (not to the die but the drug itself) if so can desensitization work?

Diphenhydramine: Allergy to the active component can occur, very rare though, desensitazation can be performed but why? Desensitazation is resorted to for any any drug if it is the only drug available to treat certain condition and no available alternatives, which isn't the case with diphenhydramine, get a second opinion, take care

Benadryl (Definition)

Diphenhydramine is a sedating antihistamine which is a kind of antihistamine type drug (common ...Read more