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Doctor insights on: Is It Ok To Switch From Zoloft To Wellbutrin

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Dr. Alan Ali
789 doctors shared insights

Bupropion (Definition)

Also called wellbutrin (bupropion) or zyban or aplenzin, is an atypical antidepressant & smoking cessation aid, which has mild psychostimulant action. It is a norepinephrine/dopamine reuptake inhibitor. It can lower seizure threshold at high doses, ...Read more


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Is it ok to switch from Zoloft to wellbutrin (bupropion) without tapering? Because im a nervous wreck!

Is it ok to switch from Zoloft to wellbutrin (bupropion) without tapering? Because im a nervous wreck!

That depends on dose: If you were on a really low dose — it is probably fine. But if on a higher dose, you may need to taper off of zoloft (sertraline) to prevent discontinuation syndrome. ...Read more

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Can I switch from Zoloft to wellbutrin (bupropion)?

Can I switch from Zoloft to wellbutrin (bupropion)?

Switch to Zoloft (sertraline): If limited response & as directed by your prescribing doc. ...Read more

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How we can safetly switch from the combo (100 mg ZOLOFT + 150 mg WELLBUTRIN (bupropion) XL) daily to the combo (50 mg ZOLOFT + 300 mg WELLBUTRIN (bupropion) XL) daily?

How we can safetly switch from the combo (100 mg ZOLOFT + 150 mg WELLBUTRIN (bupropion) XL) daily to the combo (50 mg ZOLOFT + 300 mg WELLBUTRIN (bupropion) XL) daily?

Who are 'We'?: Is one of the 'We' your Dr? If not — it should be. And then, your Dr is the one to take responsibility for this transition. Psych meds are not a good DIY project. Find professional guidance. Best! ...Read more

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When switching from Zoloft 50mg (generic) to wellbutrin, (bupropion) how long should this switch take, on average, as it is affecting my sexual relationship.

When switching from Zoloft 50mg (generic) to wellbutrin, (bupropion) how long should this switch take, on average, as it is affecting my sexual relationship.

3 weeks: Zoloft is a long acting medications and it may take up to three weeks for it to leave your system. It will take the wellbutrin (bupropion) about three weeks to kick in. ...Read more

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I took my last 10mg Buspar (buspirone) 24 hours ago im being switched to Zoloft 50mg with Wellbutrin XL 150 is it safe to start Zoloft now? Or wait a day?

I took my last 10mg Buspar (buspirone) 24 hours ago im being switched to Zoloft 50mg with Wellbutrin XL 150 is it safe to start Zoloft now? Or wait a day?

YES: Should not be a problem beginning the Zoloft but I imagine your doctor let you know the regimen to change over. Buspar (buspirone) and Zoloft can be taken together typically as they affect serotonin in different ways. ...Read more

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I'm on 150 mg of wellbutrin (bupropion) and 50 mg of zoloft. I accidently took 2 pills of the wellbutrin (bupropion) so now I have 300 mg sr in me. Is this ok?

I'm on 150 mg of wellbutrin (bupropion) and 50 mg of zoloft. I accidently took 2 pills of the wellbutrin (bupropion) so now I have 300 mg sr in me. Is this ok?

Wellbutrin (bupropion) dose?: U should not change the dose of u medication without checking with u prescribing provider.
If u took them accidently, that would be ok. ...Read more

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What effect can weed have on wellbutrin (bupropion) and zoloft?

Probably not good.: A fully informed answer can't be given, if only because "weed" is not standardized in the way that Wellbutrin (bupropion) and Zoloft are. But the concerns are: direct or indirect interference with the pharmacodynamics and phramcokinetics of the medicines; continuation of the underlying problems by virtue of avoidance or addiction. On the other hand, some people use it and still benefit from the meds ...Read more

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What the good dose of wellbutrin (bupropion) XL to add to Zoloft 50mg?

Variable.: That is very individual. If there is an atypical component to depression — I usually start with wellbutrin (bupropion) SR 100mg and increase dose by about 50mg every four days — titrate to response and side effects. I switch over to wellbutrin (bupropion) XL — after we have reached goal dose. ...Read more

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Is Wellbutrin (bupropion) XL 150mg and Zoloft 50mg a safe combination to take? I've read a lot of mixed answers.

Is Wellbutrin (bupropion) XL 150mg and Zoloft 50mg a safe combination to take? I've read a lot of mixed answers.

SHOULD BE OK: This is not an unusual combination and is worth trying a
Zoloft is a selective serotonin reuptake inhibitor and Wellbutrin (bupropion) is a dopamine and norepinephrine reuptake blocker. So these two medications augment each other. The doses that you are trying are certainly conservative enough. ...Read more

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My pdoc prescribed me wellbutrin (bupropion) and I take lithium and zoloft. What are the interactions when I take the meds? What should I expect?

Depends on dose: Zoloft and wellbutrin (bupropion) are moderate, dose-related inhibitors of cyp450 2d6 for which zoloft partly depends upon for its metabolism. Zoloft usually only inhibits 2d6 at higher doses (150-200mg). It might be worthy to be genotyped for this enzyme to assure you are an extensive metobolizer (em) type. Lithium is mostly excreted unchanged by kidneys. Please follow-up regularly with your doctor. ...Read more

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Is there a link between Zoloft & wellbutrin (bupropion) to intrusive/obsessive thoughts and anxiety?

Is there a link between Zoloft & wellbutrin (bupropion) to intrusive/obsessive thoughts and anxiety?

Not sure what: You are asking here. Zoloft and other SSRI's are often used in treatment of OCD. Wellbutrin (bupropion) is an antidepressant that is often used in treatment of atypical depressive symptoms. The medications can compliment each other well in treatment of some conditions — not necessarily OCD. Take care. ...Read more

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I'm on Zoloft and gained 40 pounds so i'm on wellbutrin (bupropion) and Zoloft now. Will the wellbutrin (bupropion) help me lose weight?

I'm on Zoloft and gained 40 pounds so i'm on wellbutrin (bupropion) and Zoloft now. Will the wellbutrin (bupropion) help me lose weight?

See below: Weight gain is usually the end result of multiple contributory processes which can include untreated &/or treatment resistant mental health conditions (which themselves can influence unhealthy lifestyle behaviors). From a reductionistic perspective, wellbutrin (bupropion) as compared to zoloft may have a relatively lower likelihood of promoting weight gain (& may actually result in weight loss). ...Read more

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Is Wellbutrin (bupropion) and Zoloft a commonly used combination these days? How do these meds interact with each other achieve therapeutic effects?

The combination of: Two antidepressants is used less often than a single agent. There may be increased benefit in your case but be on the look out for symptoms of serotonergic syndrome. (increased muscle tone, fever, elevated heart rate, confusion). ...Read more

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Accidentally skipped a dose of my zoloft, and now I feel kind of nauseous and anxious. Normal? Also, how is wellbutrin (bupropion) different from zoloft?

Yes; very different: First, abrupt discontinuation of zoloft (a ssri antidepressant) can lead to a variety of physical symptoms, including nausea; and possibly a return of some anxiety (if it was prescribed to treat anxiety). Wellbutrin (bupropion) is in a different chemical class — it works on norepinephrine and dopamine, and not serotonin. It is also an antidepressant but is not generally prescribed for anxiety conditions. ...Read more

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Can y'all help me figure out a way to lose weight? I'm on Zoloft 75mg and wellbutrin (bupropion) 100 mg sr. I gained 45 pounds since I started. I need help!

Unwanted weight: Exercise. Exercise, exercise. Not only will it help you control your weight, but natural endorphins will "kick in" and help you feel better. ...Read more

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I take Zoloft a.M. Plus wellbutrin 150 in the morning and at night. I travel a lot and cannot always obtain wellbutrin. Friends have advised effexor (venlafaxine).?

I take Zoloft a.M. Plus wellbutrin 150 in the morning and at night.  I travel a lot and cannot always obtain wellbutrin. Friends have advised effexor (venlafaxine).?

Do not listen : To friends. Effexxor and wellbutrin work on different parts of the brain. You can not substitue one for the other. If you miss a dose of wellbutrin you will not have ill effects of withdrawal. If you missed medications on several days of either zoloft or Effexor (venlafaxine) you would. You should stick with the wellbutrin especially if it is working with you. There is a vacation override to get enough for trav. ...Read more

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Is it possible to take Prozac or Zoloft with Wellbutrin ?

Is it possible to take Prozac or Zoloft with Wellbutrin ?

Yes: Under a physician's care, of course. In fact, Wellbutrin (an atypical antidepressant) is frequently prescribed with SSRI's or SNRI's like Prozac, Zoloft, Celexa, Cymbalta, etc. to counteract some of their side-effects and add extra anti-depressive or anti-anxiety control. ...Read more

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Can I take Advocare mns while on Wellbutrin (bupropion) and Zoloft?

Yes You Can: Yes you can take Advocare mns supplement with Zoloft and Wellbutrin (bupropion) ...Read more

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Is it safe to take 150mg Wellbutrin (bupropion) with 25mg zoloft and 40mg vyvanse?

Discuss this with: Your psychiatrist. Make sure you are being monitored for side effects (precipitation of mania if you are bipolar, serotonergic syndrome, and seizures). Do not abruptly discontinue medications without consulting your psychiatrist. ...Read more

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Can Wellbutrin (bupropion) be taken simultaneously with Zoloft to eliminate difficulty orgasming side effect?

Yes: Zoloft (sertraline) can have an unfortunate side effect of anorgasmia. It is really unacceptable, but if Zoloft (sertraline) is helping, it is hard to give it up. It is a common practice among psychiatrists to prescribe a medicine to counteract that side effect, and buproprion is often a first choice. It is a safe combination, although the dose may have to be optimized. Experience says it often works. Good luck! ...Read more

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Why did my dr perscribe wellbutrin and zoloft for depression and anxiety. How do they work together? Is there much success rate with this combo?

Why did my dr perscribe wellbutrin and zoloft for depression and anxiety. How do they work together? Is there much success rate with this combo?

Different mechanisms: These two medications have different mechanisms of action and could have an additive effect without additive side effects. You should have posed the question to your doctor.
Exercise is a good treatment for depression. It is not easy getting started, but it is more than worth it.
For good health — Have a diet rich in fresh vegetables, fruits, whole grains, milk and milk products, nuts, beans, legumes, lentils and small amounts of lean meats. Avoid saturated fats. Drink enough water daily, so that your urine is mostly colorless. Exercise at least 150 minutes/week and increase the intensity of exercise gradually. Do not use tobacco, alcohol, weed or street drugs in any form.
Practice safe sex.
Get HPV vaccine. ...Read more

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Is it safe to take over counter appitite suppressants if I'm taking low dosages of Zoloft and wellbutrin (bupropion)? I have no other medical issues

In short, No.: The otc supplements are likely stimulants (which will adversely affect your heart and even how well your antidepressants work) and made by companies that are unregulated by the fda. Eating differently and less is a start along with changing the amount you move. That's the long game to staying healthy. The short? Chew gum after lunch, drink water instead of soda, and eat a nutritious breakfast. ...Read more

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Just started taking 150mL of wellbutrin (bupropion) 5 days ago(along with 25mg Zoloft), have been feeling weird the last 2 nights(anxiety, heavy head). Bad???

Initial reaction: It appears that you are experiencing an initial reaction to the norepinephrine and dopamine action, which is the basic pharmacologic effect of Wellbutrin (bupropion). It is advisable to start with the immediate release Bupropion, at 37.5 mg daily for about a week, increase to 75 mg and then the Wellbutrin (bupropion) XL 150 mg daily. If you also started the Zoloft recently, that could also cause some initial side effects ...Read more

Dr. Heidi Fowler
1,087 doctors shared insights

Sertraline (Definition)

Also called zoloft, (sertraline) is one of selective serotonin reuptake inhibitors, with antidepressant/anti-anxiety actions. May cause headaches, nausea & ...Read more


Wellbutrin (Definition)

Bupropion is an addiction reducing agent and an antidepressant which are both a ...Read more