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Doctor insights on: Is It Normal To Paget's Disease Of Bone

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Is it possible to have paget's disease of the nipple?

Is it possible to have paget's disease of the nipple?

Yes: Paget's disease of the bone and paget's disease of the nipple are two very different problems. The bone condition involves abnormal growth. Paget's of the breast describes a certain kind of breast cancer. ...Read more

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Bone (Definition)

Bone is a living growing tissue made mostly of collagen (protein that provides soft framework) & the mineral calcium phosphate that adds strength & hardens the framework. Two types of bone are found in the body; cortical (dense compact outer layer) & trabecular (makes up inner layer, ...Read more


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What is paget's disease of the bone like?

What is paget's disease of the bone like?

Bone disorder: Paget' disease is a localized disorder of bone remodeling that involves excessive bone resorption, followed by increased bone formation. This overactivity followed by compensatory bone cell activity leads to a structurally disorganized mass of bone (woven bone), which is weaker, larger, more vascular, and more susceptible to fracture. It can be seen on x-rays, and can be a cause for bone pain. ...Read more

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What is mds-rars? Is it a sign of bone marrow failure?

Myelodysplastia: (MDS) is classified according to the appearance of bone marrow cells. RARS (Refractory Anemia with Ringed Sideroblasts) is a relatively benign form, with abnormal red cells that show little rings of iron inside. It is not really a marrow failure (like aplastic anemia) because there are often plenty of cells in the marrow. Anemia can be severe and require transfusions or other therapies. ...Read more

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What is Paget disease of the nipple?

What is Paget disease of the nipple?

Cancer: Paget's disease of the breast is a scaly eczema-like skin change usually near or on the nipple, which is a malignant disease and is often associated with an underlying breast cancer. ...Read more

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If paget's breast cancer spreads to the bones, then does that person have paget's bone disease?

If paget's breast cancer spreads to the bones, then does that person have paget's bone disease?

Two different things: Paget's disease of the breast is a particular type of breast cancer that starts under the nipple. Most are very treatable, but like any other breast cancer - advanced cases may metastasize. Paget's disease of the bone is a chronic problem that is not realted to cancer. ...Read more

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Is myelofibrosis a terminal disease? Does it just keep progressing until all bone marrow is replaced by scar tissue that can't produce blood?

Is myelofibrosis a terminal disease? Does it just keep progressing until all bone marrow is replaced by scar tissue that can't produce blood?

Progressive: Yes, you described it well. New treatments are becoming available all the time, and they could extend your life! get treated! ...Read more

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What is the beginning stage of paget's disease, what causes it and and can it be severe?

What is the beginning stage of paget's disease, what causes it and and can it be severe?

Thickened bone: Pagets disease of bone is characterized by thickening and then enlargement of involved bone. The normal bone recycling process, in which old bone tissue is replaced with new bone tissue is lost, the mechanism not defined. Affected bones become fragile and misshapen mostly in the pelvis, skull, spine and legs. In the skull, invasion of brain can occur. Bisphosphonates used to strengthen bone. ...Read more

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What is the name of the condition that the bone marrow stops producing platlets? Is it a disease? How does one get it? Cures? Treatment?

What is the name of the condition that the bone marrow stops producing platlets? Is it a disease? How does one get it? Cures? Treatment?

Several causes: Bone marrow may fail to make platelets, however, there are reasons for low platelets other than bone marrow failure. A health evaluation will show whether the bone marrow is failing, or if there is another cause. Bone marrow failure states include myelodysplasia, myelofibrosis, leukemia, lymphoma, aplastic anemia, cancer. Some are curable. Certain medications can also lead to low platelets. ...Read more

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Leukemia is a type of cancer.. So if it is then how does bone marrow stop the cancer?

Leukemia is a type of cancer.. So if it is then how does bone marrow stop the cancer?

Two Ways: Bone marrow transplants help cure aggressive leukemia in two ways. First, it allows doctors to give high dose chemotherapy and sometimes total body radiation therapy therapy that have a higher chance of killing every last leukemia cell. Second, it essentially gives the patient a new immune system that will hopefully recognize and kill any remaining leukemia cells. ...Read more

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Relation of Paget disease of bone and giant cell tumor is what?

Giant: Cell tumor is a rare complication of paget's disease of bone. ...Read more

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What is a neoplasm? is it related to a bone tumor?

Occassionally: A neoplasm is a tumor when classified as malignant has potential to metastasize. Depending on surface glycoproteins developing in the primary lesion, metatastsis is predefined when tumor invades blood stream. Certain lesion only go to lung or liver or to bone. When small e-cadherons form they promote spread and one site is a metastatic bone tumor. Some neoplasms are primary bone in origin. ...Read more

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What is a neoplasm? is it related to a bone tumor?

What is a neoplasm? is it related to a bone tumor?

It is a tumor: A new growth or tumor can also be called a neoplasm. it basically raises question that there is a growth which can be cancerous. So you must seek medical attention and find out what this growth is all about and seek immediate medical treatments. ...Read more

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What is the disease rickets? Is it still common?

What is the disease rickets? Is it still common?

Very uncommon: Hi. Rickets is pediatric disease that is now very uncommon in the US. The most common cause 100 years ago was vitamin D deficiency (milk wasn't fortified, and many people then, as now, weren't in the sun enough to manufacture their own). Now vitamin D deficiency to the point of rickets is VERY uncommon. There are genetic causes such as Vitamin D receptor mutation/deletion and others. Rare! ...Read more

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Thymectomy diagnosis is extra nodal marginal zone lymphoma, how likely is it that it spread to bone? Borderline osteoporosis, have possible RA.

Thymectomy diagnosis is extra nodal marginal zone lymphoma,  how likely is it that it spread to bone? Borderline osteoporosis,  have possible RA.

Not likely: It would be very unlikely for your disease to be in the bone. There is a chance that it has spread to the bone marrow (inside the bone - different from spreading to the bone itself) so a biopsy will be done to rule that out. There is no correlation with osteoporosis or RA. ...Read more

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Is it "better" to have sclerotic bone lesions, than lytic ones with bone metases? Is there still a greater chance of fracture of the affected bone, whether it is lytic or now sclerotic?

Is it "better" to have sclerotic bone lesions, than lytic ones with bone metases? Is there still a greater chance of fracture of the affected bone, whether it is lytic or now sclerotic?

Good question: Excellent question.Unfortunately not an easy answer. But overall, either will do structural damage to the bone and leave it more vulnerable to a fracture or collapse.The lytic ones are quite a bit weaker,however, and can break with little or even no trauma.Both can be very painful and difficult to treat.Also,remember the source: breast,prostate,lung,thyroid, and kidney are more apt to go to bone. ...Read more

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What is the function of HER2/neu and how is it related to breast cancer?

What is the function of HER2/neu and how is it related to breast cancer?

Growth signal: Her2 is a receptor on the surface of some breast cancers. It is like a light switch that tells the cancer to grow. Breast cancer cells that have many Her2 receptors have the light switch always turned on, telling the cells to grow. Fortunately, newer drugs block the receptor, turning off the growth switch and making these cancers very treatable. ...Read more

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Dr. Michael Thompson
555 doctors shared insights

Bone Diseases (Definition)

Any disease process that affects the skeletal system. Some can be metabolic, such as osteoporosis; others can be infectious, ...Read more