Doctor insights on:
Is It Normal To Paget's Disease Of Bone
Bone is a living growing tissue made mostly of collagen (protein that provides soft framework) & the mineral calcium phosphate that adds strength & hardens the framework. Two types of bone are found in the body; cortical (dense compact outer layer) & trabecular (makes up inner layer, ...Read more
Bone disorder: Paget' disease is a localized disorder of bone remodeling that involves excessive bone resorption, followed by increased bone formation. This overactivity followed by compensatory bone cell activity leads to a structurally disorganized mass of bone (woven bone), which is weaker, larger, more vascular, and more susceptible to fracture. It can be seen on x-rays, and can be a cause for bone pain. ...Read more
Myelodysplastia: (MDS) is classified according to the appearance of bone marrow cells. RARS (Refractory Anemia with Ringed Sideroblasts) is a relatively benign form, with abnormal red cells that show little rings of iron inside. It is not really a marrow failure (like aplastic anemia) because there are often plenty of cells in the marrow. Anemia can be severe and require transfusions or other therapies. ...Read more
What is cure for bone disease which is increasing white cells in body at aproximate number of 200000...Can it cause blood cancer.
Two different things: Paget's disease of the breast is a particular type of breast cancer that starts under the nipple. Most are very treatable, but like any other breast cancer - advanced cases may metastasize. Paget's disease of the bone is a chronic problem that is not realted to cancer. ...Read moreSee 1 more doctor answer
Is myelofibrosis a terminal disease? Does it just keep progressing until all bone marrow is replaced by scar tissue that can't produce blood?
Thickened bone: Pagets disease of bone is characterized by thickening and then enlargement of involved bone. The normal bone recycling process, in which old bone tissue is replaced with new bone tissue is lost, the mechanism not defined. Affected bones become fragile and misshapen mostly in the pelvis, skull, spine and legs. In the skull, invasion of brain can occur. Bisphosphonates used to strengthen bone. ...Read more
What is the name of the condition that the bone marrow stops producing platlets? Is it a disease? How does one get it? Cures? Treatment?
Several causes: Bone marrow may fail to make platelets, however, there are reasons for low platelets other than bone marrow failure. A health evaluation will show whether the bone marrow is failing, or if there is another cause. Bone marrow failure states include myelodysplasia, myelofibrosis, leukemia, lymphoma, aplastic anemia, cancer. Some are curable. Certain medications can also lead to low platelets. ...Read moreSee 4 more doctor answers
Two Ways: Bone marrow transplants help cure aggressive leukemia in two ways. First, it allows doctors to give high dose chemotherapy and sometimes total body radiation therapy therapy that have a higher chance of killing every last leukemia cell. Second, it essentially gives the patient a new immune system that will hopefully recognize and kill any remaining leukemia cells. ...Read moreSee 1 more doctor answer
Giant: Cell tumor is a rare complication of paget's disease of bone. ...Read more
Occassionally: A neoplasm is a tumor when classified as malignant has potential to metastasize. Depending on surface glycoproteins developing in the primary lesion, metatastsis is predefined when tumor invades blood stream. Certain lesion only go to lung or liver or to bone. When small e-cadherons form they promote spread and one site is a metastatic bone tumor. Some neoplasms are primary bone in origin. ...Read more
It is a tumor: A new growth or tumor can also be called a neoplasm. it basically raises question that there is a growth which can be cancerous. So you must seek medical attention and find out what this growth is all about and seek immediate medical treatments. ...Read more
Very uncommon: Hi. Rickets is pediatric disease that is now very uncommon in the US. The most common cause 100 years ago was vitamin D deficiency (milk wasn't fortified, and many people then, as now, weren't in the sun enough to manufacture their own). Now vitamin D deficiency to the point of rickets is VERY uncommon. There are genetic causes such as Vitamin D receptor mutation/deletion and others. Rare! ...Read more
I have myelofibrosis. How does the disease progress? Does your marrow just keep becoming scar tissue that can't produce blood? Is bone pain common?
Thymectomy diagnosis is extra nodal marginal zone lymphoma, how likely is it that it spread to bone? Borderline osteoporosis, have possible RA.
Is it "better" to have sclerotic bone lesions, than lytic ones with bone metases? Is there still a greater chance of fracture of the affected bone, whether it is lytic or now sclerotic?
Good question: Excellent question.Unfortunately not an easy answer. But overall, either will do structural damage to the bone and leave it more vulnerable to a fracture or collapse.The lytic ones are quite a bit weaker,however, and can break with little or even no trauma.Both can be very painful and difficult to treat.Also,remember the source: breast,prostate,lung,thyroid, and kidney are more apt to go to bone. ...Read more
Growth signal: Her2 is a receptor on the surface of some breast cancers. It is like a light switch that tells the cancer to grow. Breast cancer cells that have many Her2 receptors have the light switch always turned on, telling the cells to grow. Fortunately, newer drugs block the receptor, turning off the growth switch and making these cancers very treatable. ...Read moreSee 2 more doctor answers
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