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Doctor insights on: Is It Normal To Experience Horrible Agitation And Anxiety With Pristiq

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Is it normal to experience horrible agitation and anxiety with pristiq (desvenlafaxine)?

Is it normal to experience horrible agitation and anxiety with pristiq (desvenlafaxine)?

It's not "normal": Not in the true sense of the word normal. It certainly can happen with Pristiq (desvenlafaxine) and a number of other antidepressants as well. If you did not have severe anxiety and agitation prior to taking Pristiq (desvenlafaxine) and it appeared when first taking Pristiq (desvenlafaxine) it is most certainly a side effect of that medication. That requires immediate stopping of that medication. No, it's not normal and it is not common either. ...Read more

Dr. Heidi Fowler
3,299 Doctors shared insights

Anxiety (Definition)

Anxiety is a general term for several disorders that cause nervousness, fear, apprehension, and worrying. These disorders affect how we feel and behave, and they can manifest real physical symptoms. Mild anxiety is vague and unsettling, while severe anxiety can be extremely debilitating, having a serious ...Read more


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Hello, I currently take 50mg of Pristiq (desvenlafaxine) daily for both depression and anxiety. Would this make taking MDMA more risky than normal?

Hello, I currently take 50mg of Pristiq (desvenlafaxine) daily for both depression and anxiety. Would this make taking MDMA more risky than normal?

Yes: Taking both Pristiq (desvenlafaxine) and MDMA increases the risk of Serotinin syndrome: symptoms can range from mild (shivering and diarrhea) to severe (muscle rigidity, fever and seizures). ...Read more

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I have been taking 5-htp 100mg daily and 25mg pristiq (desvenlafaxine) for 4 weeks and starting to feel agitated, short of breath, tired. And a bit dizzy.?

Why are you taking: 5-Hydroxytryptophan & Pristiq together? Does your psychiatrist have any idea that you are combining these? Is your psychiatrist aware of your symptoms. Combining these medications can ^ potential for serotonin syndrome. Serotonin Syndrome can cause nausea /vomiting /diarrhea, abdominal pain, stiffness or spasm of muscles, fever, shivering, ^ sweating, hallucinations, confusion, visual changes, ^ ...Read more

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Pristiq (desvenlafaxine) not working for anxiety, what to do?

Pristiq (desvenlafaxine) not working for anxiety, what to do?

Desvenlafaxine: Does not have an FDA indication for anxeity at this time. However, that does not mean that it can't be used off-label to treat anxiety. Don't know how long you have been on it - as results don't usually occur right away. Please let your doctor know this important information. ...Read more

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I have bad social anxiety and g.A.D. Is there any medication to prevent chronic blushing? Currently on pristiq (50mg)

I have bad social anxiety and g.A.D. Is there any medication to prevent chronic blushing? Currently on pristiq (50mg)

Behavioral Path: People struggling w/ social anxiety often get hyperfocused on the physical symptoms they experience in dreaded soc situations. This serves 2 magnifiy the intense discomfort that lies at heart of soc anx, viz, discomfort associated w/ the fear of embarrassing urself. Paradoxically, one way 2 "bust your shame" = If u were 2 make urself blush even harderin social situations & draw attn 2 that fact! ...Read more

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50mg pristiq (desvenlafaxine) (depression anxiety) seemed to lose effectiveness after 3 months 100 stopped working after another 3 on 150 now will this keep happening?

50mg pristiq (desvenlafaxine) (depression anxiety) seemed to lose effectiveness after 3 months 100 stopped working after another 3 on 150 now will this keep happening?

Consider change: There is no evidence that anything over 100mg has more effectiveness in studies. MDs will try higher dosages as tolerability allows as off label use. I would consider adding a second medication depending on what residual symptoms recur, or try adding deplin. ...Read more

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I was prescribed pristiq (desvenlafaxine) for my severe anxiety. My first day of taking it was today. I'm feeling really tired well more than usual is it a side effect?

I was prescribed pristiq (desvenlafaxine) for my severe anxiety. My first day of taking it was today. I'm feeling really tired well more than usual is it a side effect?

Pristiq (desvenlafaxine): Fairly common & temporary side-effect. Talk to your doctor about possibly adjusting the timing of taking the medication so that sedation occur while u r asleep at night. ...Read more

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I've been taking Pristiq (desvenlafaxine) for years with results, tried to get off of it twice but anxiety returned. Can Pristiq (desvenlafaxine) be taken as long as needed? For life?

I've been taking Pristiq (desvenlafaxine) for years with results, tried to get off of it twice but anxiety returned. Can Pristiq (desvenlafaxine) be taken as long as needed? For life?

Yes: Am not aware of any studies or reports showing harm from long-term use of Pristiq (desvenlafaxine). If anything significant appears, doctors are notified immediately by the drug company and FDA. Keep follow-up appointments with your prescribing doctor and enjoy feeling better! ...Read more

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Why is Effexor officially indicated for anxiety, but Pristiq (desvenlafaxine) only used off label for it? Seems strange given their relation.

Why is Effexor officially indicated for anxiety, but Pristiq (desvenlafaxine) only used off label for it? Seems strange given their relation.

Pristiq (desvenlafaxine) is newer: Effexor and Pristiq (desvenlafaxine) do work in the same way, Pristiq (desvenlafaxine) is simply the active metabolite of Effexor. The answer is that Effexor has been out much longer than Pristiq (desvenlafaxine). Drug companies must demonstrate effectiveness for different indications through expensive clinical trials to get FDA approval for that condition. If Pristiq (desvenlafaxine) is proven to be effective for anxiety, FDA will approve it for that indication. ...Read more

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I am on Pristiq (desvenlafaxine) 50 for anxiety and depression. It is day 13, my mood seems to fluctuate from energized to flat, tired and unmotivated.

I am on Pristiq (desvenlafaxine) 50 for anxiety and depression. It is day 13, my mood seems to fluctuate from energized to flat, tired and unmotivated.

Too early to tell: In general, antidepressants take about 4-6 weeks before an appreciable difference is seen. However, during the early stages of treatment, it is also possible that the symptoms you describe may be side effects of medication. Recommend discussing your concerns with your doctor, who knows your particular history. From there an appropriate clinical decision can be made on how to proceed. Best. ...Read more

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Hi, my doctor prescribed me Pristiq for anxiety and fatigue, because escitalopram didn't have any effect on 20mg. Do you think it should work well?

Only way to find out: Did you know that escitalopram WOULDN'T work BEFORE you tried it? If you had, you wouldn't have tried it, right? Same with Pristiq. Only way to know is to try it and see. ...Read more

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My doctor has given me a medicine called pristiq (desvenlafaxine) for my anxiety but didn't tell me anything about it what are the side effects will it help?

My doctor has given me a medicine called pristiq (desvenlafaxine) for my anxiety but didn't tell me anything about it what are the side effects will it help?

Pristiq (desvenlafaxine): Pristiq (desvenlafaxine) is an antidepressant that increases serotonin and nor epinephrin similar to Effexor and cymbalta
common side effects are nausea vomiting diarrhea, sexual side effects and high blood pressure
there can be withdrawal if you suddenly stop it. ...Read more

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Hi There, I was just wondering if there are any serious side effects of taking only a few percocets while on pristiq 50mg, and also how dangerous drinking alcohol REALLY is on this anxiety medication. (I am not taking perc's while drinking alcohol though)

Hi There, I was just wondering if there are any serious side effects of taking only a few percocets while on pristiq 50mg, and also how dangerous drinking alcohol REALLY is on this anxiety medication. (I am not taking perc's while drinking alcohol though)

Suspicious: Not enough info. How many is "a few? " Should you be drinking alcohol which is a CNS depressant while taking an anti-depressant, Pristiq (desvenlafaxine)? Why are you taking an opioid which is also a CNS depressant? How close if not together re perc's and alcohol? Not enough info! ...Read more

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I'm taking wellbutrin/pristiq/klonopin for depression/anxiety and Vyvanse (lisdexamfetamine) for ADHD. Is that ok with all 4 meds? I feel great!

Multiple medication: Welbutrin is medication for treatment of depression.
Pristiq (desvenlafaxine) is medication for treatment of depression
and anxiety.
Klonopin is medication for treatment of anxiety
Vyvance is a medication for treatment of ADHD. Its side effect include symptoms of anxiety and depression.
Welbutrin, Pristiq (desvenlafaxine) and Klonopin also have side effects. Please see a Psychiatrist for definitive diagnosis and side effect ...Read more

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If pristiq (desvenlafaxine) 50 is causing rapid heart beat and anxiety. How possible would pristiq (desvenlafaxine) 75 help? That. Doesn't make sense at all..

If pristiq (desvenlafaxine) 50 is causing rapid heart beat and anxiety. How possible would pristiq (desvenlafaxine) 75 help? That. Doesn't make sense at all..

Other symptoms?: Perhaps a change in dose was recommended to address other symptoms? You are correct that increasing the dose would probably not reduce your heart beat. ...Read more

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Can I take ephedra for fatigue while also taking pristiq (desvenlafaxine) and lyrca for mdd, irritable, and anxiety? I'm finding myself spending 18 hours a day in bed

Can I take ephedra for fatigue while also taking pristiq (desvenlafaxine) and lyrca for mdd, irritable, and anxiety? I'm finding myself spending 18 hours a day in bed

Ephedra: Ephedra can be dangerous, raising bp, causing cardiovascular problems. It also can aggravate your anxiety. I would suggest a discussion with md to consider med adjustments and possibly a provigil/nuvigil augmentation for pathological fatigue. Your meds may be a major contributor as well. Also lab work to rule out thyroid, anemia, metabolic causes of fatigue, sleep study for osa sleep apnea. ...Read more

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My babys 3months & breastfed. I've tried the safe meds but don't work for me for depression & anxiety. Can I use pristiq (desvenlafaxine) I've read no & yes w/monitoring?

My babys 3months & breastfed. I've tried the safe meds but don't work for me for depression & anxiety. Can I use pristiq (desvenlafaxine) I've read no & yes w/monitoring?

Should not.: Pristiq (desvenlafaxine) is least safe because more of it can get into the breast milk than the other antidepressants. I would try all the other antidepressants first. If you really need pristiq, (desvenlafaxine) you should seriously consider stopping breastfeeding. If you decide to take Pristiq (desvenlafaxine) and still breastfeed, you have to understand that there are risks as your baby is getting some Pristiq (desvenlafaxine) which each feed. ...Read more

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Can using nuvigil and pristiq (desvenlafaxine) cause serotonin syndrome? I have symptoms after weaning off of pristiq (desvenlafaxine). Could this be anxiety from weaning off?

Can using nuvigil and pristiq (desvenlafaxine) cause serotonin syndrome? I have symptoms after weaning off of pristiq (desvenlafaxine). Could this be anxiety from weaning off?

YES/NO: It is unlikely to get 'serotonin syndrome" from the combination. Coming off Pristiq (desvenlafaxine) can be associated with two things; one is resurfacing of the symptoms that were target of treatment such as anxiety or depression. The other is discontinuation syndrome including nausea, irritability, dizziness, "head zaps' headache among other symptoms. Usually weaning off meds is carried out very slowly. ...Read more

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13yr old takes pristiq (desvenlafaxine) for anxiety for the last year, he is a slow metabolizer of the enzyme for all other anti depressants. He just started having days where he is depressed next day he is fine?

13yr old takes pristiq (desvenlafaxine) for anxiety for the last year, he is a slow metabolizer of the enzyme for all other anti depressants. He just started having days where he is depressed next day he is fine?

Antidepressants: This event should be discussed with the psychiatrist. It is possible that a mood stabilizer would work better (lamotrigine in particular, divalproex, lithium) in regulating the mood up. There is a chance of being bipolar ii (a particular firm of mood disorder) or having add, which also would evidence by drops in mood, due to "exhaustion" of the noradrenergic system. Check with the specialist. ...Read more

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I suffer from anxiety and depresion. Can I take Zoloft and pristiq (desvenlafaxine) along with xanax..

I'm old fashioned: I have a feeling that more and more people are self diagnosing and selecting the drugs the want to take. I'm almost always against this idea. Helping your doctor make these decisions is fine - even important - but I think it should be their responsibility. Please discuss this with the doctor and work together. ...Read more

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I started taking pristiq (desvenlafaxine) 2 weeks ago. But now I'm having panick attacks evry day. Anxiety level very high. Terrified of heart attack. Pristiq (desvenlafaxine) doing this?

I started taking pristiq (desvenlafaxine) 2 weeks ago. But now I'm having panick attacks evry day. Anxiety level very high. Terrified of heart attack. Pristiq (desvenlafaxine) doing this?

Hard to tell: Panic attacks usually respond to drugs that raise serotonin (ssris--prozac zoloft Paxil Lexapro etc) Pristiq (desvenlafaxine) is a dual acting antidepressant that also raises norepinephrine which is stimulating--let your doc know what is going on. ...Read more

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I am currently on 50mg pristiq and stilnox. It seems like I have gained weight. I do have anxiety / depression and bulimic. And also a chain smoker and have sleeping issues. Will any other medication would work better for me? I do afraid of gaining weight

I am currently on 50mg pristiq and stilnox. It seems like I have gained weight. I do have anxiety / depression and bulimic. And also a chain smoker and have sleeping issues. Will any other medication would work better for me? I do afraid of gaining weight

Need medical eval: Yes, Pristiq (desvenlafaxine) can cause weight gain but so can bulimia, depression, thyroid disorder, abnormal blood sugar etc. Get checked by your pcp to rule out medical factors for weight gain. Talk to prescribing doctor about weight gain on Pristiq (desvenlafaxine) and review alternate meds. Would add therapy to help you work on eating disorder, depression and chain smoking. I hope this helps and you feel better soon. ...Read more

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On bupropion & pristiq (desvenlafaxine) for dep/ social anxiety. Is therapy alone or meds/therapy combo the best route? Quit job cuz anxiety severe. Isolating & crying

On bupropion & pristiq (desvenlafaxine) for dep/ social anxiety. Is therapy alone or meds/therapy combo the best route? Quit job cuz anxiety severe. Isolating & crying

Combination: Research shows that results are better when psychotherapy is combined with medications -- in other words, medications alone will not give as good a benefit as combined treatment. Please ask your psychiatrist for therapy referrals, if s/he does not provide psychotherapy. If considering suicide, call your psychiatrist today. If in suicidal crisis you can also be seen in an er. ...Read more

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17 yr old male. Had depression. Anxiety and ocd. He's on Zoloft and wellbutrin. Would it be wise to try pristiq (desvenlafaxine)?

Not necessarily: Pristiq (desvenlafaxine) is a seratonin reuptake inhibitor such as Zoloft., so it does not necessarily have more to offer than Zoloft. ...Read more

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I'v been getting anxiety & panic attacks, also pain around the chest and collar bone area, my doctor put me on pristiq, (desvenlafaxine) will this help my problem.?

I'v been getting anxiety & panic attacks, also pain around the chest and collar bone area, my doctor put me on pristiq, (desvenlafaxine) will this help my problem.?

It should help: Pristiq (desvenlafaxine) can help with panic attacks, but it will take at least 4-6 weeks to show its effect. Work with your doctor and be patient. This may not be easy sometimes, but hopefully you'll have relief. Please don't forget that psychotherapy is an important part of treatment for panic and anxiety too. ...Read more

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My dr took me off Pristiq and put me on Prozac to help taper down, however, I've still had awful withdrawals- increased anxiety, paranoia, "brain zaps", amplified negative feelings, etc. Is there a point I should be "concerned" enough to seek medical care

Talk to doctor: In my practice, with my patients, I have never taken a patient off Pristiq (desvenlafaxine) cold turkey. I always recommend tapering down gently, to avoid the withdrawal symptoms you describe. Talk to your treating physician about restarting the Pristiq (desvenlafaxine) and tapering. ...Read more

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Increased pristiq (desvenlafaxine) to 100mg Feeling restless, can't retain memory or hold conversation. How many weeks to give before asking dr to go back to 50mg?

Call if concerned: Starting and stopping anti depressants can be associated with "start up" or "discontinuation" side effects, but usually reasonably well tolerated. IF you are concerned something does not seem right to you, then notify your prescriber. Significant memory or conversation impairment concerns that are new would warrant calling back sooner rather than later. ...Read more

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Hi I start Zoloft (sertraline) 3 dayes ago I have low agitation and anxiety is that normal?

Hi I start Zoloft (sertraline) 3 dayes ago I have low agitation and anxiety is that normal?

Yes: It can happen in the first 7-14 days then disappears. Discuss it with your doctor. ...Read more

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My husband just started taking mirtazapine for anxiety. He has been extremely agitated and has slept almost constantly since he started taking. Normal?

Talk to a doctor: You may want to discuss the side effects you are describing with the prescribing physician. It could be that this medication is not a good match for him. However, if there is not a realistic chance to discuss these side effects with the prescribing physician in a timely manner then the emergency department may be your best bet. Stay safe! ...Read more

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Always feel anxiety. My resting heart rate is usually higher than normal and I feel restless due to that. What could be the reason? Any disorder?

Some: The disorder that can cause that could be a thyroid problem, a heart problem or anxiety. Get your PCP check you and possibly even have a 24 hour holter monitor to check your heart rate. ...Read more

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What medication works like pristique that you can get a much lower dosage. I have really bad anxiety and depression has gotten much better.

Why switch?: Though Effexor (venlafaxine) may be cheaper- (dosage is actually higher but only because they are not quite equivalent-) it sounds like you have hit on something that may be working. Working through medicines can be exhausting for patients and finding the right one may be worth hanging in there come what cost, dose--sometimes. ...Read more

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I take 20 celexa (citalopram) and pristque 50 per day. They don't seem to help the depression or anxiety. My dr not being helpful, just to see a therapist. What to?

I take 20 celexa (citalopram) and pristque 50 per day. They don't seem to help the depression or anxiety. My dr not being helpful, just to see a therapist. What to?

Second opinion: You may benefit from seeing another psychiatrist for a second opinion. There are other medications that could be tried, and there are also ways to augment the medications you're already taking. A fresh review may open up possibilities that help you. You can also ask your doctor about adding l-methyfolate to your regimen (deplin may help) and making sure to take 1-2 g epa (in fish oil)/day. ...Read more

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Leryca can help anxiety and agitation?

Lyrica (pregabalin)?: Are you asking about lyrica (pregabalin)? Lyrica (pregabalin) has been used to treat anxiety in some patients. ...Read more

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How long does the pain or agitation last after an anxiety attack?

How long does the pain or agitation last after an anxiety attack?

Depends: While actual panic attack generally lasts fro 20 to 40 minuts for most, the residual affects last quite a bit longer. Although this tends to vary from person to person, in general, residual symptoms diminish and resolve from 2 to 6 hours, depending on the circumstances. ...Read more

Dr. Alan Ali
433 Doctors shared insights

Agitation (Definition)

Agitation can be demonstrated emotionally or physically. Agitation is an expression of emotion that is a little less than anger but a little more than mildly irritated. One may become agitated quickly. In this case it can be problematic and one might need ...Read more