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Doctor insights on: Is It Normal To Experience Horrible Agitation And Anxiety With Pristiq

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Is it normal to experience horrible agitation and anxiety with pristiq (desvenlafaxine)?

Is it normal to experience horrible agitation and anxiety with pristiq (desvenlafaxine)?

It's not "normal": Not in the true sense of the word normal. It certainly can happen with Pristiq (desvenlafaxine) and a number of other antidepressants as well. If you did not have severe anxiety and agitation prior to taking Pristiq (desvenlafaxine) and it appeared when first taking Pristiq (desvenlafaxine) it is most certainly a side effect of that medication. That requires immediate stopping of that medication. No, it's not normal and it is not common either.

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Dr. Heidi Fowler
3,258 Doctors shared insights

Anxiety (Definition)

Anxiety is a general term for several disorders that cause nervousness, fear, apprehension, and worrying. These disorders affect how we feel and behave, and they can manifest real physical symptoms. Mild anxiety is vague and unsettling, while severe anxiety can be extremely debilitating, having a serious ...Read more


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I have been taking 5-htp 100mg daily and 25mg pristiq (desvenlafaxine) for 4 weeks and starting to feel agitated, short of breath, tired. And a bit dizzy.?

I have been taking 5-htp 100mg daily and 25mg pristiq (desvenlafaxine) for 4 weeks and starting to feel agitated, short of breath, tired. And a bit dizzy.?

More needs to be: Known about 5-HTP before recommending its use. There have been recent reports of eosinophilia myalgia syndrome associated with its use or contamination. You can read about this on Web-MD. Pristiq (desvenlafaxine) can also cause a similar set of side effects in a small minority of people. Also starting two serotonergic agents at the same time is not advised. (increased risk of serotonergic syndrome) Ask your doctor.

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I have bad social anxiety and g.A.D. Is there any medication to prevent chronic blushing? Currently on pristiq (50mg)

I have bad social anxiety and g.A.D. Is there any medication to prevent chronic blushing? Currently on pristiq (50mg)

Behavioral Path: People struggling w/ social anxiety often get hyperfocused on the physical symptoms they experience in dreaded soc situations. This serves 2 magnifiy the intense discomfort that lies at heart of soc anx, viz, discomfort associated w/ the fear of embarrassing urself. Paradoxically, one way 2 "bust your shame" = If u were 2 make urself blush even harderin social situations & draw attn 2 that fact!

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50mg pristiq (desvenlafaxine) (depression anxiety) seemed to lose effectiveness after 3 months 100 stopped working after another 3 on 150 now will this keep happening?

50mg pristiq (desvenlafaxine) (depression anxiety) seemed to lose effectiveness after 3 months 100 stopped working after another 3 on 150 now will this keep happening?

Consider change: There is no evidence that anything over 100mg has more effectiveness in studies. MDs will try higher dosages as tolerability allows as off label use. I would consider adding a second medication depending on what residual symptoms recur, or try adding deplin.

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I was prescribed pristiq (desvenlafaxine) for my severe anxiety. My first day of taking it was today. I'm feeling really tired well more than usual is it a side effect?

I was prescribed pristiq (desvenlafaxine) for my severe anxiety. My first day of taking it was today. I'm feeling really tired well more than usual is it a side effect?

Pristiq (desvenlafaxine): Fairly common & temporary side-effect. Talk to your doctor about possibly adjusting the timing of taking the medication so that sedation occur while u r asleep at night.

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I've been taking Pristiq (desvenlafaxine) for years with results, tried to get off of it twice but anxiety returned. Can Pristiq (desvenlafaxine) be taken as long as needed? For life?

I've been taking Pristiq (desvenlafaxine) for years with results, tried to get off of it twice but anxiety returned. Can Pristiq (desvenlafaxine) be taken as long as needed? For life?

Yes: Am not aware of any studies or reports showing harm from long-term use of Pristiq (desvenlafaxine). If anything significant appears, doctors are notified immediately by the drug company and FDA. Keep follow-up appointments with your prescribing doctor and enjoy feeling better!

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Why is Effexor officially indicated for anxiety, but Pristiq (desvenlafaxine) only used off label for it? Seems strange given their relation.

Why is Effexor officially indicated for anxiety, but Pristiq (desvenlafaxine) only used off label for it? Seems strange given their relation.

Pristiq (desvenlafaxine) is newer: Effexor and Pristiq (desvenlafaxine) do work in the same way, Pristiq (desvenlafaxine) is simply the active metabolite of Effexor. The answer is that Effexor has been out much longer than Pristiq (desvenlafaxine). Drug companies must demonstrate effectiveness for different indications through expensive clinical trials to get FDA approval for that condition. If Pristiq (desvenlafaxine) is proven to be effective for anxiety, FDA will approve it for that indication.

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Hi, my doctor prescribed me Pristiq for anxiety and fatigue, because escitalopram didn't have any effect on 20mg. Do you think it should work well?

Only way to find out: Did you know that escitalopram WOULDN'T work BEFORE you tried it? If you had, you wouldn't have tried it, right? Same with Pristiq. Only way to know is to try it and see.

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I am on Pristiq (desvenlafaxine) 50 for anxiety and depression. It is day 13, my mood seems to fluctuate from energized to flat, tired and unmotivated.

I am on Pristiq (desvenlafaxine) 50 for anxiety and depression. It is day 13, my mood seems to fluctuate from energized to flat, tired and unmotivated.

This is something: That you should inform your prescribing physician about if you're still feeling this way by day 21. Meanwhile, continue taking it as prescribed. Best wishes. Dr. Anne.

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My doctor has given me a medicine called pristiq (desvenlafaxine) for my anxiety but didn't tell me anything about it what are the side effects will it help?

My doctor has given me a medicine called pristiq (desvenlafaxine) for my anxiety but didn't tell me anything about it what are the side effects will it help?

Pristiq (desvenlafaxine): Pristiq (desvenlafaxine) is an antidepressant that increases serotonin and nor epinephrin similar to Effexor and cymbalta common side effects are nausea vomiting diarrhea, sexual side effects and high blood pressure there can be withdrawal if you suddenly stop it.

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Hi There, I was just wondering if there are any serious side effects of taking only a few percocets while on pristiq 50mg, and also how dangerous drinking alcohol REALLY is on this anxiety medication. (I am not taking perc's while drinking alcohol though)

Hi There, I was just wondering if there are any serious side effects of taking only a few percocets while on pristiq 50mg, and also how dangerous drinking alcohol REALLY is on this anxiety medication. (I am not taking perc's while drinking alcohol though)

Suspicious: Not enough info. How many is "a few? " Should you be drinking alcohol which is a CNS depressant while taking an anti-depressant, Pristiq (desvenlafaxine)? Why are you taking an opioid which is also a CNS depressant? How close if not together re perc's and alcohol? Not enough info!

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I'm taking wellbutrin/pristiq/klonopin for depression/anxiety and Vyvanse (lisdexamfetamine) for ADHD. Is that ok with all 4 meds? I feel great!

Multiple medication: Welbutrin is medication for treatment of depression. Pristiq (desvenlafaxine) is medication for treatment of depression and anxiety. Klonopin is medication for treatment of anxiety Vyvance is a medication for treatment of ADHD. Its side effect include symptoms of anxiety and depression. Welbutrin, Pristiq (desvenlafaxine) and Klonopin also have side effects. Please see a Psychiatrist for definitive diagnosis and side effect

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If pristiq (desvenlafaxine) 50 is causing rapid heart beat and anxiety. How possible would pristiq (desvenlafaxine) 75 help? That. Doesn't make sense at all..

If pristiq (desvenlafaxine) 50 is causing rapid heart beat and anxiety. How possible would pristiq (desvenlafaxine) 75 help? That. Doesn't make sense at all..

Other symptoms?: Perhaps a change in dose was recommended to address other symptoms? You are correct that increasing the dose would probably not reduce your heart beat.

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Can I take ephedra for fatigue while also taking pristiq (desvenlafaxine) and lyrca for mdd, irritable, and anxiety? I'm finding myself spending 18 hours a day in bed

Can I take ephedra for fatigue while also taking pristiq (desvenlafaxine) and lyrca for mdd, irritable, and anxiety? I'm finding myself spending 18 hours a day in bed

Ephedra: Ephedra can be dangerous, raising bp, causing cardiovascular problems. It also can aggravate your anxiety. I would suggest a discussion with md to consider med adjustments and possibly a provigil/nuvigil augmentation for pathological fatigue. Your meds may be a major contributor as well. Also lab work to rule out thyroid, anemia, metabolic causes of fatigue, sleep study for osa sleep apnea.

Dr. Alan Ali
433 Doctors shared insights

Agitation (Definition)

Agitation can be demonstrated emotionally or physically. Agitation is an expression of emotion that is a little less than anger but a little more than mildly irritated. One may become agitated quickly. In this case it can be problematic and one might need ...Read more