Doctor insights on:
Is Glyburide Safe In Pregnancy
If you're pregnant or planning to get pregnant, there are many things you can do to give your baby a healthy start: Regular prenatal visits along with laboratory testing, ultrasounds, prenatal vitamins and immunizations (like the flu shot and whopping cough booster). Now's the time to eat healthy, stay hydrated, and ...Read more
An insulin releaser: Glyburide (called glibenclamide outside the U.S.) Is a sulfonylurea anti-diabetic agent. It causes the pancreas to release insulin. It can do this even in the absence of food, so can cause the sugar to get too low. Glyburide can be a problem in the elderly, again because of the risk for low blood sugar. If you take this medicine, it could be dangerous to skip meals. ...Read moreSee 2 more doctor answers
A sulfonylurea: A drug to treat diabetes by stimulating beta cell to produce/secrete more insulin but works no matter what blood sugar is- thus high rate hypoglycemia-low blood sugar; and weight gain significantly increased risk of adverse cardiovascular events amer assoc of clinical endocrinology recommends it be "used rarely, if at all" incretins much safer;no hypoglycemic risk if used without Insulin or su. ...Read moreSee 1 more doctor answer
Varies (1 - 2 hours): Depending on the formulation ingested (micronized (glynase) or conventional Glyburide (diabeta, micronase)) onset of action ranges from about 1 to 2 hours with a maximum reduction of blood sugar seen within 3-4 hours. May last in body for over 18 to 24 hours. Should be taken with breakfast or main meal of the day to help reduce symptoms of low blood sugar (tremors, sweating, irritable, fatigue). ...Read more
Hypoglycemia: Prolonged hypoglycemia (mild to severe -low blood sugar- noted as tremor, sweating, headache, fatigue, confusion ) is the most common/ concerning side effect of glyburide, this is due to its long half- life / active metabolite compared to other 2nd generation sulfonylureas. Minor weight gain seen. Nausea, heartburn (GI) are transient/ dose related. Rash/itching may occur. Liver injury is rare. ...Read more
Probably: B"sd In general glyburide and other sulfonamides are well documented to increase risk of MI about 20% - there are safer options. Invokana is a SGLTP2i- sodium glucose transport protein inhibitor, that results in sugar in the urine. It has actually been shown to protect kidney function over the long term. It also has a diuretic effect so should skip if you are dehdrated from scan or other reason ...Read more
Similar mechanisms: Hi. Glyburide & glimepiride (& glipizide & others in the sulfonylurea class, for that matter) all work by the same mechanism to stimulate endogenous insulin release. They differ in duration of action, metabolites, accumulation in kidney disease, etc. They're archaic drugs that I never use anymore. There are much better type 2 drugs out there. Their one benefit - they're cheap. ...Read more
Same family: Hi. Glyburide is a second generation sulfonylurea and glimepiride is a 3rd generation. They work at the same receptors on the beta cell (the pancreatic cells that make insulin) and stimulate insulin release. Glimepiride is preferable because of less metabolite build up in kidney disease, but they're VERY similar. I never use them. In my opinion, based on good science, we have much better drugs. ...Read more
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