Doctor insights on:
Is Getting A Tetralogy Of Fallot Hereditary
Microdeletion of chromosome 22q11 (digeorge syndrome) is a genetic abnormality that has been linked to tof and other forms of congenital heart defects. It also can occur with Down syndrome (trisomy 21), and in patients with no identified genetic abnormality. Heart defects occur in 0.8% of babies, but in 3-5% of those with 1st degree relatives with heart defects.
There is a genetic predisposition. ...Read more
Depends on variables: Most cases of complex congenital heart disease happen in a sporadic manner. The general risk of a parent with a chd having a child in these sporadic forms is about 6%.This is not specific to the same defect but includes all defects. When it is part of an autosomal disorder or chromosome deletion syndrome, the risks are higher. ...Read more
Not typically.: Most cases are isolated and sporadic. It accounts for 5-10% of all congenital heart defects. 15% of tof cases are part of known genetic syndromes (down, digeorge, alagille, phenylketonuria) or associations (charge/vacterl) and some are linked to poorly controlled preconceptional maternal diabetes mellitus. Recurrence risk: 2.5% with one prior affected child, 8% with two. Folic acid may prevent it! ...Read more
We don't know: In most cases tetralogy of fallot is thought to be "multifactorial", meaning that there are possibly genes, and also environmental factors which might increase a child's potential of having the defect. ...Read more
I have Tetralogy of Fallot, and I recently got the "okay" to get tattoos and piercings from my Cardiologist. I would like another opinion. Canyouhelp?
Infection risk: Tattoos drive ink under the skin and any bacteria on the skin surface can also be driven into small blood vessels and capillaries in that location. This can increase the risk of those bacteria being carried to the heart valves and causing a serious infection known as bacterial endocarditis which is life threatening. Most people cannot live without a functioning heart, so think about the risk. ...Read more
Heart surgery: This is a congenital heart defect knows at "tetralogy" because the initial description discussed four findings: 1) ventricular septal defect, 2) overriding aorta, 3) pulmonary stenosis, 4) right ventricular hypertrophy. The cause is abnormal conotruncal septation, giving too much to the outflow to the aorta and not enough to the outflow to the lungs. This defect always requires surgical repair. ...Read more
TOF: Tetrology of Fallot is a congenital heart defect consisting of defect in the wall between the ventricles, stenosis of the pulmonary artery, enlargement of the right ventricle, and an abnormally placed aorta. It occurs in about 5 out of every 10, 000 babies. The defect affects boys and girls equally. It is corrected with open heart surgeries. ...Read more
Congenital heart dis: This is a congenital heart defect knows at "tetralogy" because the initial description discussed four findings: 1) ventricular septal defect, 2) overriding aorta, 3) pulmonary stenosis, 4) right ventricular hypertrophy. The cause is abnormal conotruncal septation, giving too much to the outflow to the aorta and not enough to the outflow to the lungs. This defect always requires surgical repair. ...Read more
Heart Surgery: Tof is a complex type of congenital heart disease characterized by a large hole in the heart (vsd) and obstruction of pulmonary blood flow (pulmonary stenosis). Babies with tof require heart surgery during infancy. The surgery involves closing the hole and establishing unobstructed pulmonary blood flow. Survival rates are very good. ...Read more
TOF: Tof is a condition where there is a vsd (hole between bottom two pumping chambers or ventricle), a displaced aorta, right ventricular hypertrophy and restriction of blood flow to lungs. The early course is usually determined by amount of blood flow to lungs. If restricted, the child will appear blue (cyanotic), breathe fast, be very irritable. A child at baseline does not have pain. ...Read more
TETRALOGY OF FALLOT: The tet spells are sudden lethal episodes of severe cyanosis and dyspnea or hyperpnea leading to seizures and occacionally death. ...Read more
Condition with this American Heart Association definition: heart defect that features four problems.
a hole between the lower chambers of the heart
an obstruction from the heart to the lungs
The aorta (blood vessel) lies over the hole in the lower chambers
The muscle surrounding the lower right chamber becomes overly thickened ...Read more
If your son has: A tetrology of fallot, he should be followed closely by a pediatric cardiologist pre and post op. Speak first with your peds cardiologist about any medications you would consider using. ...Read more
Genetics and TOF: The short answer is yes. TOF is the most common of presenting congenital heart disease and multiple studies have been done trying to determine and isolate various genetic mutations. In a paper published in 2006, 20% of the patients with TOF were identified with genetic mutations. ...Read more
Tetralogy of fallot:
Is a congenital malformation. Uneven septation of the embryological troncus: small PA, larger Aorta with overriding the VSD, RV hypertrophy, presence of a VSD,
Obstruction of the RV outflow, diminished blood flow to the lungs, usually requires an arterial shunt to the PA to increase blood flow in to the lungs, the surgery is done as neonatal. Total repair by the age of 4-5 years. ...Read more
YES: Tetralogy of fallot is repaired surgically and patients do very well. ...Read more
Fairly accurate: In experienced centers, a fetal diagnosis of tetralogy of fallot should be reasonably accurate, although some of the specific anatomic details that may have an impact on the timing and type of surgical approach may not be readily apparent until after birth. ...Read more
Several hours: The thinking nowadays is to try and correct the defect in the newborn period if possible or at least within the first 2-3 months. In the past tetralogy of fallot was repaired in two steps, a simple surgery within the first several months to connect blood from a branch of the aorta to the lung arteries followed by complete repair at 3-5 years of age. ...Read more
If my daughter had tetralogy of fallot, is it likely that my future children will have similar problems?
Open heart surgery: Tetralogy of fallot is a congenital heart defect where the outflow from the right side of the heart to the lungs is limited. It is the most common cyanotic (blue) heart defect. Some babies are blue at birth and require a surgically placed connection (shunt) but many newborns appear well. In either case, open heart surgery is required to correct the problem, and is usually done at 6-8 months. ...Read more
Over a VSD: The aorta is normally attached to the left ventricle and carries oxygenated blood to the body. In tetralogy of fallot, the aorta arises over a ventricular septal defect (vsd, a hole between the left and right ventricles of the heart). This means that unoxygenated blood from the right ventricle also flows into the aorta. ...Read more
What is the possible timing of repair of av canal defect with tetralogy of fallot in a child aged 3 months?
My son has tetralogy of fallot. He is a month old & hasn't had surgery yet. I have a cold. Would it be very dangerous for him to catch it?
Yes, possibly: Keep in mind that infants in general have smaller airways, smaller reserve and can have more significant symptoms and morbidity than adults. Now add to this that this pt has a congenital heart lesion and you can understand that you want to try to keep this pt as healthy as possible, and although he may do well with a cold, his likelyhood of not doing well is higher than the general population. ...Read more
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