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Doctor insights on: Is Getting A Tetralogy Of Fallot Hereditary

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Is getting a tetralogy of fallot hereditary?

Is getting a tetralogy of fallot hereditary?

Sometimes: Microdeletion of chromosome 22q11 (digeorge syndrome) is a genetic abnormality that has been linked to tof and other forms of congenital heart defects. It also can occur with down syndrome (trisomy 21), and in patients with no identified genetic abnormality. Heart defects occur in 0.8% of babies, but in 3-5% of those with 1st degree relatives with heart defects. There is a genetic predisposition. ...Read more

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Dr. Steven Neish
287 doctors shared insights

Tetralogy Of Fallot (Definition)

A heart defect that features four problems. A hole between the lower chambers of the heart An obstruction from the heart to the lungs The aorta (blood vessel) lies over the hole in the lower chambers The muscle surrounding the lower right ...Read more


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Is tetralogy of fallot hereditary?

Depends on variables: Most cases of complex congenital heart disease happen in a sporadic manner. The general risk of a parent with a chd having a child in these sporadic forms is about 6%.This is not specific to the same defect but includes all defects.When it is part of an autosomal disorder or chromosome deletion syndrome, the risks are higher. ...Read more

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Is tetralogy of fallot a hereditary problem?

Is tetralogy of fallot a hereditary problem?

Not typically.: Most cases are isolated and sporadic. It accounts for 5-10% of all congenital heart defects. 15% of tof cases are part of known genetic syndromes (down, digeorge, alagille, phenylketonuria) or associations (charge/vacterl) and some are linked to poorly controlled preconceptional maternal diabetes mellitus. Recurrence risk: 2.5% with one prior affected child, 8% with two. Folic acid may prevent it! ...Read more

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What causes a baby to get tetralogy of fallot?

What causes a baby to get tetralogy of fallot?

We don't know: In most cases tetralogy of fallot is thought to be "multifactorial", meaning that there are possibly genes, and also environmental factors which might increase a child's potential of having the defect. ...Read more

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What is a tetralogy of fallot?

TOF: A type of congenital (present at birth) heart disease that usually causes cyanosis (blue baby). It is characterized by a large hole in the heart (vsd) and obstruction of blood flow to the lungs (pulmonary stenosis). Babies born with tof require surgery during infancy. ...Read more

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What happens with ?Tetralogy of fallot?

What happens with ?Tetralogy of fallot?

Heart surgery: This is a congenital heart defect knows at "tetralogy" because the initial description discussed four findings: 1) ventricular septal defect, 2) overriding aorta, 3) pulmonary stenosis, 4) right ventricular hypertrophy. The cause is abnormal conotruncal septation, giving too much to the outflow to the aorta and not enough to the outflow to the lungs. This defect always requires surgical repair. ...Read more

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What are the tests for tetralogy of fallot?

Fallot: to diagnose, echocardiogram, but to follow patients with Fallot, there are several different cardiac tests that may be necessary ...Read more

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Could tetralogy of fallot be genetic?

Could tetralogy of fallot be genetic?

Yes: Definitely, some cases of tetralogy of fallot have a genetic component. For instance, in 22q deletion syndromes (digeorge syndrome) one of the common heart diseases is tetralogy of fallot and variants of tetralogy of fallot. ...Read more

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What is the treatment for tetralogy of fallot?

What is the treatment for tetralogy of fallot?

TETRALOGY OF FALLOT : For older children, a knee- chest position or squating will help the tet spell. Surgery called the blalock-taussig shunt is usually done during the first year of life. ...Read more

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What is tetralogy of fallot?

TOF: Tetrology of Fallot is a congenital heart defect consisting of defect in the wall between the ventricles, stenosis of the pulmonary artery, enlargement of the right ventricle, and an abnormally placed aorta. It occurs in about 5 out of every 10,000 babies. The defect affects boys and girls equally. It is corrected with open heart surgeries. ...Read more

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Tell me about tetralogy of fallot here?

Congenital heart dis: This is a congenital heart defect knows at "tetralogy" because the initial description discussed four findings: 1) ventricular septal defect, 2) overriding aorta, 3) pulmonary stenosis, 4) right ventricular hypertrophy. The cause is abnormal conotruncal septation, giving too much to the outflow to the aorta and not enough to the outflow to the lungs. This defect always requires surgical repair. ...Read more

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What can be done for tetralogy of fallot?

Heart Surgery: Tof is a complex type of congenital heart disease characterized by a large hole in the heart (vsd) and obstruction of pulmonary blood flow (pulmonary stenosis). Babies with tof require heart surgery during infancy. The surgery involves closing the hole and establishing unobstructed pulmonary blood flow. Survival rates are very good. ...Read more

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How much pain is a baby in with tetralogy of fallot?

How much pain is a baby in with tetralogy of fallot?

TOF: Tof is a condition where there is a vsd (hole between bottom two pumping chambers or ventricle), a displaced aorta, right ventricular hypertrophy and restriction of blood flow to lungs. The early course is usually determined by amount of blood flow to lungs. If restricted, the child will appear blue (cyanotic), breathe fast, be very irritable. A child at baseline does not have pain. ...Read more

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What are the visible symptoms of tetralogy of fallot?

TETRALOGY OF FALLOT: Symptoms include cyanosis, dyspnea, poor feeding, poor growth, and the tet spell which is sudden severe episode of severe cyanosis with dyspnea. ...Read more

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What is the main health emergency with tetralogy of fallot?

What is the main health emergency with tetralogy of fallot?

TETRALOGY OF FALLOT: The tet spells are sudden lethal episodes of severe cyanosis and dyspnea or hyperpnea leading to seizures and occacionally death. ...Read more

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What is the definition or description of: Tetralogy of Fallot?

What is the definition or description of: Tetralogy of Fallot?

Congenital heart: condition with this American Heart Association definition: heart defect that features four problems. They are: a hole between the lower chambers of the heart an obstruction from the heart to the lungs The aorta (blood vessel) lies over the hole in the lower chambers The muscle surrounding the lower right chamber becomes overly thickened ...Read more

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My child has mild tetralogy of fallot, what meds should we avoid giving him until it's repaired?

If your son has : A tetrology of fallot, he should be followed closely by a pediatric cardiologist pre and post op. Speak first with your peds cardiologist about any medications you would consider using. ...Read more

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What is the survival rate for tetralogy of fallot?

Depends: Tetralogy of fallot is a complex type of congenital heart disease. Milder subtypes have a better long term survival than the more severe subtypes. Studies have demonstrated overall actuarial 10-, 20-, 30- and 36-year survival rates of 97%, 94%, 89% and 85%, respectively. ...Read more

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Could tetralogy of fallot be due to genetics?

Could tetralogy of fallot be due to genetics?

Genetics and TOF: The short answer is yes. TOF is the most common of presenting congenital heart disease and multiple studies have been done trying to determine and isolate various genetic mutations. In a paper published in 2006, 20% of the patients with TOF were identified with genetic mutations. ...Read more

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What is the pathophysiology of tetralogy of fallot?

Tetralogy of fallot: Is a congenital malformation. Uneven septation of the embryological troncus: small PA, larger Aorta with overriding the VSD , RV hypertrophy, presence of a VSD, Obstruction of the RV outflow, diminished blood flow to the lungs, usually requires an arterial shunt to the PA to increase blood flow in to the lungs, the surgery is done as neonatal. Total repair by the age of 4-5 years. ...Read more

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Tetralogy of fallot diagnosed in fetus? How accurate is scan?

Fairly accurate: In experienced centers, a fetal diagnosis of tetralogy of fallot should be reasonably accurate, although some of the specific anatomic details that may have an impact on the timing and type of surgical approach may not be readily apparent until after birth. ...Read more

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How long of a surgery is needed to correct a tetralogy of fallot?

How long of a surgery is needed to correct a tetralogy of fallot?

Several hours: The thinking nowadays is to try and correct the defect in the newborn period if possible or at least within the first 2-3 months. In the past tetralogy of fallot was repaired in two steps, a simple surgery within the first several months to connect blood from a branch of the aorta to the lung arteries followed by complete repair at 3-5 years of age. ...Read more

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Since tetralogy of fallot is congenital will all of our children have it?

No: In most cases if one of the parents, or a previous child, has tetralogy of fallot, there is about a 2-3% risk of another child having the defect. ...Read more

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Emily Lu Dr. Lu
3 doctors agreed:
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If my daughter had tetralogy of fallot, is it likely that my future children will have similar problems?

Emily Lu Dr. Lu
3 doctors agreed:
If my daughter had tetralogy of fallot, is it likely that my future children will have similar problems?

Not very likely: In general, tetralogy of fallot has a 3% chance of recurrence unless your daughter developed it as part of another syndrome that is more directly inherited and predisposes future children for congenital heart defects, e.g. Down's syndrome. ...Read more

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