Doctor insights on:
Is Gender A Factor In Thalassemia
No, but. . .: Environmental factors generally do not play a role in beta thalassemia. However, a patient can be worsened by conditions that typically worsen anemia, such as dietary iron deficiency, other nutrient deficiencies (such as folate (folic acid) or vitamin b12), lead poisoning, or infections with viruses that can cause anemia (such as parvovirus b19). Vacationing at high altitudes may cause symptoms of low oxygen. ...Read more
If a girl with G6PD want to marry someone with thalasemia what are the risk factors of having kids? Is it bad?
My brother has Thalasemia, little liver sweeling. Recently 17mm gallstones has diagnosed. What will be the treatment and risk factors for him?
Gallstone ? disease: Stones in the gallbladder (gb) seldom cause symptoms unless they migrate into the neck of the gb (& block exit of bile) or into the common bile duct. Symptomless gallstones may be diagnosed by chance by imaging or during investigation for some other condition. Only 10% become symptomatic within 5 years of detection. Ultrasound, ct scan, mrcp finds stones; cck-hida scan can tell if gb is diseased. ...Read more
Thalassemia: Thalassemia is a deficiency in the production of one of the globin chains (alpha or beta) that make up hemoglobin. Normally synthesis of these is balanced. When imbalanced, one globin accumulates relative to the other forming inclusions that are damaging to the red cells that contain them. There are many thal variants that manifest a wide severity of symptoms from none to transfusion dependence. ...Read more
Familial blood trait: Thalassemia runs in families. It is caused by variations (mutations) in DNA, which is then passed on to future generations. There are many variations in the DNA (genes) that code for hemoglobin molecules inside red blood cells. Some of these variations cause the hemoglobin production to be very slow, so blood cells stay too small because they can't form enough hemoglobin to grow to normal size. ...Read more
Millions of carriers: Thalassemia is one of the most common gene mutations in the world. Overall, an estimated 20-25 million people are carriers (1/300) (about 1/1000 in low-risk peoples, and about 1/30 in high-risk peoples). Low risk: japanese, korean, n. European caucasians, native canadians, native americans. High risk: mediterranean, middle eastern, south asian, south-east Asian (western pacific rim), caribbean. ...Read more
From Mom and/or Dad: Alpha thalassemia is caused by a mutation in one or more of the 4 genes that code for (holds the dna for) Alpha globulin, which is needed to make hemoglobin for new red blood cells. Beta thalassemia is caused by a mutation in one or both of the 2 beta globulin genes. Mom and/or dad can carry the mutations. A child can inherit a mutation from mom, from dad, or from both mom and dad. ...Read more
Thalassemia major can cause severe anemia and cardiac decompensation in first few months of life if not treated. Thalassemia minor causes mild anemia.
Thalassmia intermedia may require transfusions.
Severity of anemia causes pallor, jaundice, hematopoises in other organs causing splenomegaly, neurological symptoms, pallor, deformilty of bones of face/skull ...Read more
Trouble making blood: Alpha thalassemia is caused by a mutation in one or more of the 4 genes that code for (holds the dna for) Alpha globulin, which is needed to make hemoglobin for new red blood cells. Beta thalassemia is caused by a mutation in one or both of the 2 beta globulin genes. Persons with thalassemia have less or little ability to make Alpha and/or beta globulin, so they can't make enough red blood cells. ...Read more
Millions: Thalassemia is likely the most common one-gene mutation in the world. Overall, an estimated 20-25 million people are carriers (1/300) (about 1/1000 in low-risk peoples, and about 1/30 in high-risk peoples). Low risk: japanese, korean, n. European caucasians, native canadians, native americans. High risk: mediterranean, middle eastern, south asian, south-east Asian (western pacific rim), caribbean. ...Read more
Age doesn't matter: Thalassemia is an inherited condition; if you have it, you're born with it. The frequency doesn't change with age. It's more important where your ancestors are from. Thalassemia is common in Southeast Asians, African-Americans, and persons from around the Mediterranean Sea. If you come from these areas it's more likely you have it than if you're from Northern Europe, but still not really likely. ...Read more
Depends on whether thalassemia is trait (minor) or disease (major)---which requires frequent transfusions for major.
Also, depends on whether you have alpha or beta thalassemia. All thalassema will cause some anemia which can affect the blood system and cardiovascular system as well. Ask your physician to discuss with you the type you have.
Good luck. ...Read more
Trait is more common: The thalassemia trait is a fairly common finding in certain ethnic groups (those of mediterranean, african, and some Asian descents). The trait is generally a mild condition the contributes to a mild form of anemia that generally does not cause any problems. If both genes are affected, a child will have thalassemia which causes a much more significant type of anemia. That condition is more rare. ...Read more