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Doctor insights on: Is Gender A Factor In Thalassemia

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Do environmental factors play a role in the progression of beta-thalassemia?

Do environmental factors play a role in the progression of beta-thalassemia?

No, but. . .: Environmental factors generally do not play a role in beta thalassemia. However, a patient can be worsened by conditions that typically worsen anemia, such as dietary iron deficiency, other nutrient deficiencies (such as folate (folic acid) or vitamin b12), lead poisoning, or infections with viruses that can cause anemia (such as parvovirus b19). Vacationing at high altitudes may cause symptoms of low oxygen. ...Read more

Dr. Michael Engel
272 doctors shared insights

Thalassemia (Definition)

An inherited condition ...Read more


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If a girl with G6PD want to marry someone with thalasemia what are the risk factors of having kids? Is it bad?

If a girl with G6PD want to marry someone with thalasemia what are the risk factors of having kids? Is it bad?

How severe?: Thal minor and mild G6PD deficiency are both very minor and very common clinical problems. If you're in love, then I'm happy for you both. ...Read more

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My brother has Thalasemia, little liver sweeling. Recently 17mm gallstones has diagnosed. What will be the treatment and risk factors for him?

My brother has Thalasemia, little liver sweeling. Recently 17mm gallstones has diagnosed. What will be the treatment and risk factors for him?

Gallstone ? disease: Stones in the gallbladder (gb) seldom cause symptoms unless they migrate into the neck of the gb (& block exit of bile) or into the common bile duct. Symptomless gallstones may be diagnosed by chance by imaging or during investigation for some other condition. Only 10% become symptomatic within 5 years of detection. Ultrasound, ct scan, mrcp finds stones; cck-hida scan can tell if gb is diseased. ...Read more

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What is thalassemia?

What is thalassemia?

Thalassemia: Thalassemia is a deficiency in the production of one of the globin chains (alpha or beta) that make up hemoglobin. Normally synthesis of these is balanced. When imbalanced, one globin accumulates relative to the other forming inclusions that are damaging to the red cells that contain them. There are many thal variants that manifest a wide severity of symptoms from none to transfusion dependence. ...Read more

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What is thalassemia?

What is thalassemia?

Familial blood trait: Thalassemia runs in families. It is caused by variations (mutations) in DNA, which is then passed on to future generations. There are many variations in the DNA (genes) that code for hemoglobin molecules inside red blood cells. Some of these variations cause the hemoglobin production to be very slow, so blood cells stay too small because they can't form enough hemoglobin to grow to normal size. ...Read more

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How common is thalassemia?

How common is thalassemia?

Millions of carriers: Thalassemia is one of the most common gene mutations in the world. Overall, an estimated 20-25 million people are carriers (1/300) (about 1/1000 in low-risk peoples, and about 1/30 in high-risk peoples). Low risk: japanese, korean, n. European caucasians, native canadians, native americans. High risk: mediterranean, middle eastern, south asian, south-east Asian (western pacific rim), caribbean. ...Read more

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What exactly is thalassemia?

What exactly is thalassemia?

See below: Thalassemia is a blood disorder passed down through families (inherited) in which the body makes an abnormal form of hemoglobin, the protein in red blood cells that carries oxygen. The disorder results in excessive destruction of red blood cells, which leads to anemia. ...Read more

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How is thalassemia diagnosed?

How is thalassemia diagnosed?

Blood tests: Thalassemia is diagnosed by blood tests: routine blood counts, hemoglobin electrophoresis to find out the types of hemoglobin one has in one's blood, and dna analysis to try to see if certain mutations are present. ...Read more

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How is thalassemia inherited?

How is thalassemia inherited?

From Mom and/or Dad: Alpha thalassemia is caused by a mutation in one or more of the 4 genes that code for (holds the dna for) Alpha globulin, which is needed to make hemoglobin for new red blood cells. Beta thalassemia is caused by a mutation in one or both of the 2 beta globulin genes. Mom and/or dad can carry the mutations. A child can inherit a mutation from mom, from dad, or from both mom and dad. ...Read more

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How was thalassemia discovered?

How was thalassemia discovered?

Microscope: Thalassemia causes microcytic anemia — tiny red blood cells. ...Read more

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What does thalassemia mean exactly?

Start with this link: There are several types. This is a good starting resource.
http://www.nlm.nih.gov/medlineplus/ency/article/000587.htm ...Read more

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How we can get thalassemia details?

See below: http://www.childrenscbf.org/resource_detail.php?id=41&gclid=cis2n4o2mrycfzfamgodxqiafq.

Get a more detailed answer ›
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What are the symptoms of thalassemia?

Thalassemia: Thalassemia major can cause severe anemia and cardiac decompensation in first few months of life if not treated. Thalassemia minor causes mild anemia.
Thalassmia intermedia may require transfusions.

Severity of anemia causes pallor, jaundice, hematopoises in other organs causing splenomegaly, neurological symptoms, pallor, deformilty of bones of face/skull ...Read more

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Who should get tested for thalassemia?

Anemia: Patients who have a certain type of anemia that is not caused by iron deficiency could have thalassemia. If the anemia is severe and unexplained by other causes your doctor may wish to obtain a hemoglobin electrophoresis test for thalassemia. ...Read more

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What happens when you have thalassemia?

Trouble making blood: Alpha thalassemia is caused by a mutation in one or more of the 4 genes that code for (holds the dna for) Alpha globulin, which is needed to make hemoglobin for new red blood cells. Beta thalassemia is caused by a mutation in one or both of the 2 beta globulin genes. Persons with thalassemia have less or little ability to make Alpha and/or beta globulin, so they can't make enough red blood cells. ...Read more

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How we can know we have thalassemia risk?

Get tested: As your doctor to test you for thalassemia. There is a simple genetic test you can do or else a doctor may be able to tell you by looking at your blood counts. You should consider seeing a genetic counselor. ...Read more

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How many people are thalassemia carriers?

Millions: Thalassemia is likely the most common one-gene mutation in the world. Overall, an estimated 20-25 million people are carriers (1/300) (about 1/1000 in low-risk peoples, and about 1/30 in high-risk peoples). Low risk: japanese, korean, n. European caucasians, native canadians, native americans. High risk: mediterranean, middle eastern, south asian, south-east Asian (western pacific rim), caribbean. ...Read more

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How rare is thalassemia in a young adult (20s)?

Age doesn't matter: Thalassemia is an inherited condition; if you have it, you're born with it. The frequency doesn't change with age. It's more important where your ancestors are from. Thalassemia is common in Southeast Asians, African-Americans, and persons from around the Mediterranean Sea. If you come from these areas it's more likely you have it than if you're from Northern Europe, but still not really likely. ...Read more

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Any advice? What system does thalassemia affect?

More info: Depends on whether thalassemia is trait (minor) or disease (major)---which requires frequent transfusions for major.
Also, depends on whether you have alpha or beta thalassemia. All thalassema will cause some anemia which can affect the blood system and cardiovascular system as well. Ask your physician to discuss with you the type you have.

Good luck. ...Read more

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How common is it for somebody to get thalassemia?

Trait is more common: The thalassemia trait is a fairly common finding in certain ethnic groups (those of mediterranean, african, and some Asian descents). The trait is generally a mild condition the contributes to a mild form of anemia that generally does not cause any problems. If both genes are affected, a child will have thalassemia which causes a much more significant type of anemia. That condition is more rare. ...Read more

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Person have thalassemia, what food should be taken?

I'm not aware...: Of a thalassemia specific diet. A few thoughts though. A balanced diet is advised for anyone. Thalassemia pts can have ineffective erythropoiesis, and more rapid red cell turnover. Thus, a folate (folic acid) supplement could be warranted. Also, pts often have more robust fe absorption, so monitoring may be warranted. You should be followed by a hematologist or a primary provider comfortable w/ thalassemia. ...Read more

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I was wondering what are the effects of thalassemia?

More info needed: Effects are entirely dependent on what form of thal you have. Thal minor is not usually a problem, but causes a problem for a baby born to parents who both have thal minor and the baby received a gene for thal from each parent--this produces a condition known as thal major, and requires transfusion therapy, usually monthly. Iron overload from transfusions and extramedullary erythropoiesis--. ...Read more

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Is there any specific pattern of inheritance in thalassemia?

Autosomal recessive: It is autosomal recessive inheritance. If two parents are carriers, 25% normal, 50% carriers, and 25% affected with disease. I hope this helps. :) ...Read more

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How many children are diagnosed with thalassemia a year?

Thalassemia: One study estimates that symptomatic individuals arise at 1 in 100,000 throughout the world each year. The number is closer to 1 in 10,000 in the European Union where the disease is more frequently expressed. Currently, there are approx. 1000 patients with severe thalassemia in the US. ...Read more

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Is it possible that thalassemia be detected before the symptoms appear?

Yes: The presence of a thalassemia syndrome can often be suspected from new born screening, which leads to diagnosis very early in childhood. All states perform newborn screening for qualitative and quantitative hemoglobin disorders. But, there are hundreds of such disorders, so we can't (nor should we) test for all of them routinely. Making sure your pediatrician knows your family history is importan. ...Read more

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I'm suffering from thalassemia. Is there anything I should eat and should not eat?

Depending upon the..: Type and severity of your thalassemia syndrome, you could experience hemolysis from damage to the red cell membrane that accompanies the accumulation of globin aggregates. As such folate (folic acid) and a multivitamin with B12 is reasonable. Some pts with thal ayndromes are also at risk for iron overload from increased absorption and/or transfusions. Otherwise, I'm not aware of a specific thalassemia diet. ...Read more

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Is thalassemia have something should and should not do or eat? I am 24 years old and just know that I have thalassemia

No: No food restrictions for thallassemia (a congenital condition causing hemolytic anemia not responsive to iron and folate). ...Read more

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Hello! I am a pre med student. I am currently writing a definition essay about thalassemia right now. Any recommendations?

Do your research: You're supervising teachers will want to see evidence that you went to reliable sources, compiled an appropriate list of these references and your essay demonstrates a true understanding of the disorder. The national library of medicine is such a source. ...Read more