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Doctor insights on: Is Down Syndrome Hereditary

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Is Down syndrome inherited?

Is Down syndrome inherited?

Not usually: The only way to inherit down syndrome is if one parent has down syndrome and passes 2 copies of chromosome 21. Few people with ds reproduce, so that is not usually a factor. ...Read more

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Dr. Kathryn Akin
641 doctors shared insights

Down Syndrome (Definition)

Down syndrome is the classic presentation clinically of the congenital malformation syndrome also known as Trisomy 21. Classic features may include simian creases, epicanthal folds, upslanting palpebral fissures, flat nasal bridge, hypertelorism, low set ears, endocardial cushion defects of the heart, atlanto-axial joint instability, blood ...Read more


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How is Down syndrome inherited?

How is Down syndrome inherited?

Rarely: Downs syndrome is usually related to a trisomy defect that develops during the initial cleavage of the cells during primary fetal development. A form can occur as a translocation that may be carried by a parent. An assumption is that the 21 chromosome may be damaged by maternal age or by some environmental factor that then results in downs syndrome. Most cases are just by chance. ...Read more

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Why is Down syndrome more maternally inherited?

Why is Down syndrome more maternally inherited?

It isn't...: Maternally inherited, unless the mother has down's syndrome. Inherited means it's passed from generation to generation. When down's occurs, the egg has two copies of chromosome 21 instead of the usual one copy, so when the egg is fertilized, it ends up with three copies instead of the usual two. This is a new event, not an inheritance. The risk of down's syndrome increases with maternal age. ...Read more

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Can you please define Down syndrome inheritance pattern ?

There is none: You do not inherit ds from your parents in the traditional dominant or recessive fashion. During formation of the egg, only one of a pair of the 23 separate chromosomes is present so the sperm bringing 23 will reestablish the 46. Ds occurs when an extra 21 (or piece of a 21) is present in the egg after conception. This is a chromosome number change, not an inherited trait. ...Read more

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How do I make a punnutt square for Down Syndrome. Yes, it's a chromosome defect, but it can also be inherited. answer asap. Thanks!

See below: Approximately, 92-94% of cases of Down syndrome is the result of nondisjunction of chromosome during the meiosis process. Only 4% of cases are inherited from the faulty chrosome, i.e., translocation. ...Read more

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Grandauhter has epicanthal folds, does not have down syndrome. Has 1/2 brother with d.S. Is this merely a characteristic inherited from him?

Grandauhter has epicanthal folds, does not have down syndrome. Has 1/2 brother  with d.S.  Is this merely  a characteristic inherited from him?

Epicanthal Meaning: By itself an epicanthal fold does not mean downs syndrome in most cases. An epicanthal fold refers to skin fold from your upper eyelid that covers part of the inside corner of your eye. It is most common in asians. ...Read more

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What is down syndrome?

What is down syndrome?

Chromosome defect: Ds is one of the more common chromosome(c) defects that can survive pregnancy (many others miscarry).Eggs are supposed to have a single 21c & combine with the 21 from dads normal sperm.Here a pair of moms 21c +dad's 21 creates a baby with the extra 21c in all tissues.This extra material confuses the creation of body parts causing ds..Various prenatal tests can pick up signs early on. ...Read more

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What causes down syndrome?

DNA defects: Chromosome 21 seems to be the cause. Two most common types are trisomy 21 where ther is an entire extra chromosome in each cell. The other is translocation where only an extra piece of the chromosome is found. It can be an isolated defect or an inherited defect. Rare exotic forms include polyploidy and haploid forms and chimeras. Sorry you asked? ...Read more

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How is down syndrome treated?

How is down syndrome treated?

Medical/education: Children with Downs Syndrome have special medical and educational needs that should be determined in each individual. Doctors and Psychologists or educational specialists can determine what the needs are and how best to meet them. ...Read more

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