Top 20 Doctor insights on: Is cystic fibrosis dominant or recessive gene

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Is cystic fibrosis autosomal dominant in genetics?

Is cystic fibrosis autosomal dominant in genetics?

Recessive: Both parents must carry the gene with a 25% chance (1:4) with each conception that the baby will have cystic fibrosis. ...Read more

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Genetic (Definition)

From a medical standpoint, "genetic" refers to the potential heritability of various medical conditions. While some conditions are inevitable (at some point in one's life) as a consequence of simple genetic heritability (eg huntington's disease), a large number of medical conditions (including all behaviorial health disorders) are the expressed final pathway of a ...Read more


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Is cystic fibrosis a dominant or recessive trait?

Is cystic fibrosis a dominant or recessive trait?

Recessive: One needs two defective copies of the cystic fibrosis to develop the disease. ...Read more

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Cystic fibrosis disease is carried by a recessive allele on which gene?

CFTR: Cystic fibrosis is caused by a mutation of the cftr gene, or cystic fibrosis transmembrane regulator, on chromosome 7. Cftr works as a chloride ion channel which helps to regulate chloride and sodium movement in your lungs and sweat ducts. ...Read more

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Say I have the gene of cystic fibrosis, can my child have it?

Say I have the gene of cystic fibrosis, can my child have it?

CFF: Both the mother and father have to be carriers. It is a genetic disease and genetic counseling is available. The CF foundation also has information about CF transmission. ...Read more

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How can the cystic fibrosis gene affect tuberculosis?

How can the cystic fibrosis gene affect tuberculosis?

Lung Function: The gene itself will not affect tuberculosis. However, if an individual receives 2 recessive genes of the cftr mutation from their parents, they will develop cystic fibrosis (cf). Because CF can lead to repeated bacterial lung infections (among other things), the lungs would already be in a weakened state if exposed to the causative agent of tuberculosis. This might lead to faster disease onset. ...Read more

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Can a carrier of the Cystic Fibrosis gene ever be symptomatic?

Can a carrier of the Cystic Fibrosis gene ever be symptomatic?

Autosomal recessive: CF is an autosomal recessive genetic disorder. Complete expression of the disease (symptoms) do not typically occur in people who do not have both copies of the defective gene (carriers only have one). ...Read more

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What are the chances of passing on the Cystic Fibrosis gene if only one parent is a CARRIER? Other parent not a carrier.

What are the chances of passing on the Cystic Fibrosis gene if only one parent is a CARRIER? Other parent not a carrier.

50-50: One half of offspring will be carriers and one half will not be carriers. No offspring will be afflicted. Thanks for trusting HealthTap! ...Read more

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How does gene therapy help cystic fibrosis?

Not available yet: Gene therapy is not available for cystic fibrosis (CF) yet (2012). Having said that, the underlying concept is that since CF is a genetic disease (meaning there is a defect in a gene), by repairing that defect through gene therapy, one can, hopefully, cure the disease. ...Read more

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Does gene therapy help a cystic fibrosis sufferer?

Does gene therapy help a cystic fibrosis sufferer?

Trials: Clinical trials for genetic therapy are underway. As of this time there is no approved method for gene tx in cf. Kalydeco, (ivacaftor) a new drug, dose reverse the effects of one subtype of cf, but it dose so by aiding the damaged sodium-chloride transporter to get in proper position and function normally. ...Read more

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How can gene therapy help a cystic fibrosis sufferer?

How can gene therapy help a cystic fibrosis sufferer?

Not available: There is currently no gene therapy available for cystic fibrosis (cf). Since CF is a genetic disease, there is hope that, one day, gene therapy may provide a cure for this disease by, essentially, correcting the underlying genetic defect. ...Read more

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How can gene therapy help a cystic fibrosis sufferer?

How can gene therapy help a cystic fibrosis sufferer?

Replace gene: In cystic fibrosis the underlying problem is that a single gene is not functioning. Gene therapy would allow that gene to be replaced with a normal functional gene. In theory, this would offer a cure. In practice, such a cure has proven elusive however work continues. ...Read more

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What is possible cures for cystic fibrosis, how would gene therapy work?

What is possible cures for cystic fibrosis, how would gene therapy work?

Replace gene: In cystic fibrosis the underlying problem is that a single gene is not functioning. Gene therapy would allow that gene to be replaced with a normal functional gene. In theory, this would offer a cure. In practice, such a cure has proven elusive however work continues. ...Read more

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Is there gene therapy for cystic fibrosis and health centrefor this disease in the us?

Is there gene therapy for cystic fibrosis and health centrefor this disease in the us?

No and yes: Safe effective gene therapy for CF is a dream that we have yet to realize, but there are many excellent CF centers in the us. The CF foundation is an excellent source of information on these centers. The treatments for CF are improving, and expanding constantly. The life expectancy for patients with CF has steadily increased but is still limited by pulmonary disease. ...Read more

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There's is no cure for cystic fibrosis so what could gene therapy do?

There's is no cure for cystic fibrosis so what could gene therapy do?

Cure: Depending on the type of gene therapy, gene therapy can be a cure, if the underlying genetic problem is corrected. Of course, any damage done to the body by the disease up to that point may, or may not be, reversible. ...Read more

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Cystic fibrosis is a disorder of genes but which ones?

Cystic fibrosis is a disorder of genes but which ones?

CF gene mutations: There are currently more than 1900 mutations that are known to cause cf. About 70% of CF pts in us have deltaf508 mutation, as 1 in every 25 persons is a carrier for this mutation. All these mutations result in abnormal activity of a protein called cftr which causes all the CF related problems. Genetic testing can give the specific mutation each pt has. Talk to your local CF center. ...Read more

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Can you explain if it's possible to get cystic fibrosis without carrying the genes for it?

Can you explain if it's possible to get cystic fibrosis without carrying the genes for it?

No: Cystic fibrosis (CF) is a genetically inherited disease, so CF or cf-related disease (atypical cf, crms) rely on having at least 1 inherited gene. The other part of CF diagnosis is having an elevated sweat chloride. It is possible to have a positive sweat chloride due to other circumstances (thyroid imbalance, trisomy 21), but without CF genetics, there cannot be a diagnosis of cf. ...Read more

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Me and my partner both carry cystic fibrosis genes. How do we be sure to have a child without cystic fibrosis?

Me and my partner both carry cystic fibrosis genes. How do we be sure to have a child without cystic fibrosis?

Prenatal testing: Testing of your fetus and or placenta is available. However, there us a risk of pregnancy loss associated with these procedures. Talk with our obstetrician and genetic counselor about risks and the best procedure for your situation. ...Read more

Gene (Definition)

A hereditary unit consisting of a sequence of dna that occupies a specific location on a chromosome and determines a particular characteristic in an organism. Genes undergo mutation when their dna sequence ...Read more


Dr. William Walsh
992 Doctors shared insights

Cystic Fibrosis (Definition)

A genetic disorder of the lungs and digestive tract. It causes recurrent lung infections and inhibits growth in patients and average life expectancy of patients with cystic fibrosis ...Read more