Doctor insights on:
Is Chronic Urticaria A Mast Cell Disease
Innate immune cell prevalent in tissue and surrounding small blood vessels. Acts as a source of histamine and other rapid acting mediators of an inflammatory response to tissue infection or damage. Inappropriate activation of mast cells is central to many allergy-related diseases including anaphylaxis. Inappropriate population expansion or activity results in ...Read more
Complex problems: There are at least five important systemic mast cell diseases (mastocytosis) and even more causes of chronic urticaria (of which some mastocytosis diseases are only one cause). Often, no cause is ever found for chronic urticaria. A hematologist will probably treat mast cell disease -- perhaps in a research study -- while a dermatologist will manage chronic urticaria. Good luck; stay proactive. ...Read more
Recent diagnosis w/autoimmune disease & skin biopsy result: urticaria or mast cell disease. Shouldn't biopsy give more definitive diagnosis?
Hard to tell: Mast cells are the cells that release histamine in the body. This is what happens in urticaria, so one will see mast cells in biopsies of urticarial (hive-like) lesions. Mast cells can also be found in increased numbers in people with mastocytosis. Thus the biopsies may be similar. As stated by my colleague, the clinical history can be key to the diagnosis. Talk with your doc. ...Read moreSee 1 more doctor answer
How common is Chronic Urticaria w/Celiac Disease? Was diagnosis w/Celiac almost 2 yrs ago but hives just started a week ago & only on areas in the sun.
Uncommon: The two issues are likely unrelated.Get a more detailed answer ›
42, no food allergies, but, I am scared to eat peanuts or fish. Does my celiac disease and my chronic urticaria increase my allergy chances to these?
No: No relative risk of peanut or fish allergy in this context. If you eat fish and peanuts without history of immediate reaction, then your risk is very low. If you strictly avoid these foods, then an Allergist can perform testing to begin to quantify risk and this can be followed by supervised food trials to confirm absence of allergy. ...Read more
Brownish lesions on: Mastocytosis is when you have collections of mast cells, usually on the skin. These are brown spots, (1 or many) if you scratch them they turn red and swollen for a while (they form a wheal as histamine is released) Usually harmless, but a systemic form exists, not very common, with lesions in bone and other organs. ...Read more
See below: It is not known exactly how sodium oxybate (xyrem) works, but it is theorized that it works via agonizing the gaba receptor (promoting sedation among other effects). It is not thought to work on histamine. It is recommended that you consult your pcp to evaluate for possible mast cell diseases, if it is concerning you based on symptoms. Hope that answers your question. ...Read more
Help please. Suspect MCAD (Mast Cell Disease) - tryptase and mutliple GI confirmations-possible organ damage. Any DFW hospitals that will admit / help?
Usually not: In rare cases where it is due to a leukemia or related illness, curing or managing this works well, and some folks respond to gleevec (imatinib). Otherwise, we're left managing the symptoms, which is usually possible. I have a colleague with mastocytosis under quite good control, and there are support groups in communities and online. Good luck, and stay proactive. ...Read more
Which type?: You have my sympathy. There are at least five different important types. Your first step will be to find out which variant you have, and of course get specialist treatment. There are several ongoing studies in which you may have the opportunity to participate -- this would be to your advantage. Good luck. ...Read more
What r symptoms & best treatment of mast cell disease? I get constant hive reactions to every med I try, freq rashes, wondering if mast is my issue.
See allergist: First you need a blood test to confirm whether you have a mast cell disorder to start with. If the blood test is positive, then one will have to work up the cause for the mast cell disorder. The usual treatment in high doses of antihistamine but you really need to find out whether your problem is from a mast cell issue or something else. A b/c allergist should be the one you consult. ...Read more
Male 22, doc suspects mast cell disease. I use Zantac (ranitidine) for my acid, can I take ceritrizine OTC myself until I get tested? Is it safe to take both?
Mast cell disease: Mast cells disease can cause acid reflux and hives and itching and you can use zantac (ranitidine) and Cetirizine to treat the symptoms. Not sure if your doctor wants to do a skin test, but zyrtec will affect it, so check with your doctor first. If the doctor only wants to do blood tests, you can go ahead and take both, but check with your doctor first. ...Read more
Need to see a doctor: Your husband need to follow-up with the doctor who made that diagnose. ...Read more
Ige=5, tryptase=3, histamine release=16% and histamine and ana=negative on blood work, are these normal? An does it clear me for a mast cell disease?
Dificult to say: These results are normal. The low tryptase level makes systemic mastocytosis (one type of mast cell disease) less likely. But, without any information about your clinical history, symptoms, etc., it is hard with only the above data to determine what is going on. Do you have hives or flushing or anaphylaxis, etc? Submit another question describing your symptoms, or talk with your doctor. ...Read more
Many meds for hives: H2 blockers are easy and inexpensive to try and they do sometimes help with treating chronic urticaria. They include cimetidine, ranitidine, Famotidine and nizatidine. They are all available over the counter without a prescription. In my experience, they rarely work well by themselves, but sometimes work well along with a good h1 blocker, like Cetirizine or fexofenadine. Use an allergist for help. ...Read more
Chronic urticaria: Can be very tough to control, but treatment modalities are present, different protocols are used, needs first to be diagnosed right as so many types are there, chronic idiopathic urticaria is only diagnosed after exhausting all possible causes, and still there's treatment to control it, takes time, and compliance is important, check aaaai. Org or acaai. Org for an allergist in your area ...Read moreSee 1 more doctor answer