Top
20
Doctor insights on: Is Chronic Urticaria A Mast Cell Disease

Share

Mast Cell (Definition)

Innate immune cell prevalent in tissue and surrounding small blood vessels. Acts as a source of histamine and other rapid acting mediators of an inflammatory response to tissue infection or damage. Inappropriate activation of mast cells is central to many allergy-related diseases including anaphylaxis. Inappropriate population expansion or activity results in ...Read more


2

2
What's chronic urticaria vs mast cell disease?

What's chronic urticaria vs mast cell disease?

Complex problems: There are at least five important systemic mast cell diseases (mastocytosis) and even more causes of chronic urticaria (of which some mastocytosis diseases are only one cause). Often, no cause is ever found for chronic urticaria. A hematologist will probably treat mast cell disease -- perhaps in a research study -- while a dermatologist will manage chronic urticaria. Good luck; stay proactive. ...Read more

3

3
Recent diagnosis w/autoimmune disease & skin biopsy result: urticaria or mast cell disease. Shouldn't biopsy give more definitive diagnosis?

Recent diagnosis w/autoimmune disease & skin biopsy result: urticaria or mast cell disease. Shouldn't biopsy give more definitive diagnosis?

Hard to tell: Mast cells are the cells that release histamine in the body. This is what happens in urticaria, so one will see mast cells in biopsies of urticarial (hive-like) lesions. Mast cells can also be found in increased numbers in people with mastocytosis. Thus the biopsies may be similar. As stated by my colleague, the clinical history can be key to the diagnosis. Talk with your doc. ...Read more

See 1 more doctor answer
5

5
42, no food allergies, but, I am scared to eat peanuts or fish. Does my celiac disease and my chronic urticaria increase my allergy chances to these?

42, no food allergies, but, I am scared to eat peanuts or fish. Does my celiac disease and my chronic urticaria increase my allergy chances to these?

No: No relative risk of peanut or fish allergy in this context. If you eat fish and peanuts without history of immediate reaction, then your risk is very low. If you strictly avoid these foods, then an Allergist can perform testing to begin to quantify risk and this can be followed by supervised food trials to confirm absence of allergy. ...Read more

6

6
What is mast cell disease and how does it manifest in infants?

What is mast cell disease and how does it manifest in infants?

Brownish lesions on: Mastocytosis is when you have collections of mast cells, usually on the skin. These are brown spots, (1 or many) if you scratch them they turn red and swollen for a while (they form a wheal as histamine is released) Usually harmless, but a systemic form exists, not very common, with lesions in bone and other organs. ...Read more

7

7
Does the med, xyrem release histamine? What do you suggest for mast cell disease?

Does the med, xyrem release histamine? What do you suggest for mast cell disease?

See below: It is not known exactly how sodium oxybate (xyrem) works, but it is theorized that it works via agonizing the gaba receptor (promoting sedation among other effects). It is not thought to work on histamine. It is recommended that you consult your pcp to evaluate for possible mast cell diseases, if it is concerning you based on symptoms. Hope that answers your question. ...Read more

8

8
Help please. Suspect MCAD (Mast Cell Disease) - tryptase and mutliple GI confirmations-possible organ damage. Any DFW hospitals that will admit / help?

Help please. Suspect MCAD (Mast Cell Disease) - tryptase and mutliple GI confirmations-possible organ damage. Any DFW hospitals that will admit / help?

See allergist: Your problem can usually be handled by your allergist and there is nothing more that can be done at a hospital unless you have organ failure. You likely need a bone marrow biopsy by a hematologist as well. I also note that you are not taking any antihistamine at all. ...Read more

9

9
Are there any cures for mast cell disease?

Are there any cures for mast cell disease?

Usually not: In rare cases where it is due to a leukemia or related illness, curing or managing this works well, and some folks respond to gleevec (imatinib). Otherwise, we're left managing the symptoms, which is usually possible. I have a colleague with mastocytosis under quite good control, and there are support groups in communities and online. Good luck, and stay proactive. ...Read more

10

10
I have just been diagnosed with systemic mast cell disease. Where can I learn about it?

I have just been diagnosed with systemic mast cell disease. Where can I learn about it?

Which type?: You have my sympathy. There are at least five different important types. Your first step will be to find out which variant you have, and of course get specialist treatment. There are several ongoing studies in which you may have the opportunity to participate -- this would be to your advantage. Good luck. ...Read more

11

11
What r symptoms & best treatment of mast cell disease? I get constant hive reactions to every med I try, freq rashes, wondering if mast is my issue.

See allergist: First you need a blood test to confirm whether you have a mast cell disorder to start with. If the blood test is positive, then one will have to work up the cause for the mast cell disorder. The usual treatment in high doses of antihistamine but you really need to find out whether your problem is from a mast cell issue or something else. A b/c allergist should be the one you consult. ...Read more

12

12
Male 22, doc suspects mast cell disease. I use Zantac (ranitidine) for my acid, can I take ceritrizine OTC myself until I get tested? Is it safe to take both?

Mast cell disease: Mast cells disease can cause acid reflux and hives and itching and you can use zantac (ranitidine) and Cetirizine to treat the symptoms. Not sure if your doctor wants to do a skin test, but zyrtec will affect it, so check with your doctor first. If the doctor only wants to do blood tests, you can go ahead and take both, but check with your doctor first. ...Read more

13

13
My husband was diagnosed with mast cell disease. Can anyone help?

My husband was diagnosed with mast cell disease. Can anyone help?

Need to see a doctor: Your husband need to follow-up with the doctor who made that diagnose. ...Read more

14

14
Ige=5, tryptase=3, histamine release=16% and histamine and ana=negative on blood work, are these normal? An does it clear me for a mast cell disease?

Dificult to say: These results are normal. The low tryptase level makes systemic mastocytosis (one type of mast cell disease) less likely. But, without any information about your clinical history, symptoms, etc., it is hard with only the above data to determine what is going on. Do you have hives or flushing or anaphylaxis, etc? Submit another question describing your symptoms, or talk with your doctor. ...Read more

15

15
I have chronic urticaria. What can I do? I heard that h2 blockers can help.

I have chronic urticaria. What can I do? I heard that h2 blockers can help.

Many meds for hives: H2 blockers are easy and inexpensive to try and they do sometimes help with treating chronic urticaria. They include cimetidine, ranitidine, Famotidine and nizatidine. They are all available over the counter without a prescription. In my experience, they rarely work well by themselves, but sometimes work well along with a good h1 blocker, like Cetirizine or fexofenadine. Use an allergist for help. ...Read more

16

16
Treatment for chronic urticaria?

Treatment for chronic urticaria?

Chronic urticaria: Can be very tough to control, but treatment modalities are present, different protocols are used, needs first to be diagnosed right as so many types are there, chronic idiopathic urticaria is only diagnosed after exhausting all possible causes, and still there's treatment to control it, takes time, and compliance is important, check aaaai. Org or acaai. Org for an allergist in your area ...Read more

See 1 more doctor answer
17

17
What is best treatment for chronic idiopathic urticaria?

Xolair: Xolair, a synthesized monoclonal antibody against IgE, is likely the most effective treatment today when high-dose antihistamine failed. It may work within a few weeks. ...Read more

18

18
What are the causes & treatment of chronic urticaria pl advise?

What are the causes & treatment of chronic urticaria pl advise?

Complex: Chronis urticaria is a riddle we have not been able to crack yet. Some people have underlying autoimmune disease and others we don't know. Treatment is antihistamines and sometimes immunosuppressants, depending on the severity of the symptoms. ...Read more

19

19
Can I take 2 10mg Claritin (loratadine) a day for chronic urticaria?

Can I take 2 10mg Claritin (loratadine) a day for chronic urticaria?

No: Claritin (loratadine) is not approved at 20 mg. My experience is that zyrtec is better. Take 10 mg. You can add Pepcid otc in combination with the zyrtec for even greater efficacy. ...Read more

Dr. Hirenkumar Italia
3 Doctors shared insights

Hives (Definition)

An outbreak of red bumps or wheals that appear quickly after exposure to certain allergens (foods, medications, other substances). They can vary in size, are itchy, can burn, and can last for up to ...Read more