Doctor insights on:
Is Breast Cancer Genetic
Sometimes.: It is estimated that approximately 10-15% of all breast cancers in the US are of the hereditary type. These genes can be inherited from either your father or your mother. If a woman inherits this gene, they have a 50-75% chance of developing breast cancer in their lifetime. These cancers tend to occur at any earlier age and may occur in both breasts. ...Read moreSee 3 more doctor answers
Cancer is a group of diseases that is characterized by uncontrolled cell growth leading to invasion of surrounding tissues that spread to other parts of the body. Cancer can begin anywhere in the body and is usually related to one or more genetic mutations that allow normal cells to become malignant by interfering with internal cellular control mechanisms, such as programmed cell death or by preventing ...Read more
Sometimes.: It is estimated that 10-15% of all breast cancer cases in the us occur due to hereditary factors. This risk may be identified by doing a simple blood test to check for brca mutations. We generally advise testing family members with known breast cancers first before checking unaffected family. ...Read moreSee 2 more doctor answers
It can be: Dcis, the earliest form of breast cancer, can be associated with brca mutations. 13% of women under 50 diagnosed with dcis had a brca mutation in retrospective (looking backwards) studies. Women with a family history of breast or ovarian cancer or dcis before age 50 should have genetic counseling. For more info: http://clincancerres.Aacrjournals.Org/content/13/14/4306.Full. ...Read moreSee 3 more doctor answers
Certain genetic: Risks, brca 1 & 2, are known, other are not, but familial clusters (mother, aunt sister) point to risk but the actual cause and function of the genetics are mysterious. We humans have a hard time with "risk". Some with no risk delvelop a cancer; others with high risk do not. The statistical facts work epidemiologicallyfor populations, but are not informative for an individual. They do cause worr. ...Read more
Only some: Many cancers occur sporadically. Breast cancer, ovarian cancer , familial colon adenomatosis polyposis , hereditary nonpolyposis colorectal cancer , multiple endocrine neoplasia ii, multiple endocrine neoplasia i, von hippel-lindau, ; li-fraumeni syndrome can be genetically linked. ...Read moreSee 2 more doctor answers
A minority is.: Pancreatic adenocarcinoma, arising from ducts/epithelial tissue, is mainly "sporadic", but can run in families. Pancreatic cancer has also been related to brca mutation, fammm syndrome, and some other inherited conditions. The familial pancreatic cancer registry is at johns hopkins. A minority of neuroendocrine tumors of the pancreas are associated with multiple endocrine neoplasia (men) syndromes. ...Read moreSee 1 more doctor answer
Well...: ...most breast cancers (80-90%) are not related to inherited traits so in those cases your question does not apply. However, the majority of high risk genes that cause breast and other cancers (like BRCA) are indeed transmitted as autosomal dominant traits. ...Read more
Possible: In a sense all cancer is "genetic" in that it occurs do to changes in dna that cause cancer formation. However, if your questions is about familial/inherited cancer, then most uterine cancer is not from an inherited increased cancer risk. But some uterine cancer may be related to cancer risk genes such as brca 1/2 and other genes. Genetic counselors can help determine. ...Read moreSee 1 more doctor answer
Wsh I had more space: BRCA 1 and 2 are important genes that have the purpose of repairing damaged DNA and destroying the one that can't be repaired, amongst other things. When they get mutated (or changed) in specific places, they quit working so the damaged DNA is left in there, resulting in the development of cancer. ...Read more
Basic biology: It's easy to misunderstand. Genetic disease is usually hereditary -- only a few diseases of genes can't be inherited or passed on; new mutations are genetic but not hereditary. Inherited disease is almost always genetic. A variety of genes may be passed parent-to-child, each defining a "cancer family syndrome" but most cancer is sporadic. ...Read more
For significant risk: It is not a routine test for everybody with breast cancer. However, if you have significant risk with more than one family member having breast cancer or ovarian cancer , at younger age especially or multiple other type of cancers in the family- a brca 1 and 2 analysis would be something that routinely be done to rule out breast-ovary hereditary syndrome. ...Read moreSee 1 more doctor answer
Mostly due to HPV: Most vaginal cancers are not related to any inherited genetic risk but instead are due to the sexually transmitted human papilloma virus (hpv). The same high-risk types that cause cervical cancer and precancerous changes can have the same effect on the vagina, vulva, and anus. ...Read moreSee 1 more doctor answer
Perhaps: Known genetic mutations are seen in thyroid cancers: braf in papillary; kras in follicular; ret gene (usually point mutation) involving 10q11.2 in medullary carcinoma; p53 in undifferentiated carcinoma. However, "inherited" types of thyroid carcinoma are much less common - although medullary carcinoma is the most common type. ...Read moreSee 2 more doctor answers
My mom had lobular breast cancer at 52. Brca negative. Is lobular breast cancer more genetic based than ductal?
No its medullary: a quote from Lancethttp://www.ncbi.nlm.nih.gov/pubmed/9167459: "The occurrence of invasive lobular carcinoma and invasive ductal carcinoma was not significantly different between carriers of BRCA1 or BRCA2 mutations and controls. Medullary or atypical medullary carcinoma was, however, found more often in BRCA1 (13%, p ...Read more
Occurs when glandular cells lining the milk ducts and lobules of the human breast begin to grow in an unregulated manner. Often curable if found early and treated effectively with surgery, hormonal therapy, chemotherapy and targeted therapy, or a combination thereof. Early detection before the malignancy becomes large enough to be felt depends on mammography/sonography and MRI imaging of the breast ...Read more
From a medical standpoint, "genetic" refers to the potential heritability of various medical conditions. While some conditions are inevitable (at some point in one's life) as a consequence of simple genetic heritability (eg huntington's disease), a large number of medical conditions (including all behaviorial health disorders) are the expressed final pathway of a ...Read more
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