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Doctor insights on: Is Breast Cancer Genetic

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I need your expertise, is breast cancer genetic?

I need your expertise, is breast cancer genetic?

Genetics can play a: Significant role for some women (not for others). Include: being female, increasing age, genetics, family history of breast cancer, previous breast cancer, being caucasian, dense breast tissue, some previous benign breast conditions, never having given birth or 1st child after age 30, early menarche, late menopause, radiation (chest), exposure to diethylstilbestrol, hormone replacement after >>. ...Read more

Dr. Barry Rosen
1,337 doctors shared insights

Breast Cancer (Definition)

Breast cancer results when glandular cells lining the milk ducts and lobules of the human breast begin to grow in an unregulated manner. The growth occurs initially inside the ducts but eventually breaks outside into the breast tissue and ultimately spreads both to the lymph nodes in the armpit and via the bloodstream to other parts of the body. Because of the promoting affect of estrogen almost all breast cancer occurs in women and is a rarity in men. The unregulated growth is due to both inherited and acquired genetic defects. It is the most common malignancy in women but it often curable if found early and treated effectively with surgery, hormonal therapy, chemotherapy and targeted therapy, or a combination thereof. Early detection before the malignancy becomes large enough to be felt depends on mammography/sonography and MRI imaging of the breast ...Read more


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Is breast cancer genetic or caused by the environment or both?

Is breast cancer genetic or caused by the environment or both?

Yes: App. 10-15% of all breast cancers are believed to be related to hereditary risks; therefore, in a sense, the other 85-90% are related to "environmental" factors. Unfortunately, we don't know what specific triggers are responsible for breast cancer development; but, we do know that breast cancer occurs much more frequently in developed countries. This, regrettably, is a disease of modern life. ...Read more

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Is dcis breast cancer genetic?

Is dcis breast cancer genetic?

It can be: Dcis, the earliest form of breast cancer, can be associated with brca mutations. 13% of women under 50 diagnosed with dcis had a brca mutation in retrospective (looking backwards) studies. Women with a family history of breast or ovarian cancer or dcis before age 50 should have genetic counseling. For more info: http://clincancerres.Aacrjournals.Org/content/13/14/4306.Full. ...Read more

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Who should get breast cancer genetic testing?

Start w/affected pt: Pesonal and family risk factors assoc w/brca mutation: muliple fam members, bil breast cancer, male breast cancer, ovarian cancer, ashkenazi jewish heritage (specific founder mutations), diagnosis age <50 (dx age < 60 if er/pr/her2 - or triple negative). Both maternal and paternal history is important. ...Read more

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Is there any routine breast cancer genetic testing?

Is there any routine breast cancer genetic testing?

For significant risk: It is not a routine test for everybody with breast cancer. However, if you have significant risk with more than one family member having breast cancer or ovarian cancer , at younger age especially or multiple other type of cancers in the family- a brca 1 and 2 analysis would be something that routinely be done to rule out breast-ovary hereditary syndrome. ...Read more

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What is the price for breast cancer genetic testing?

What is the price for breast cancer genetic testing?

3K: Brca comprehensive test offered by myriad is about $3, 000. They have an additional test called bart which used to be charged separately but now is often done as one. Frankly, i don't know if that adds to the cost. These are covered by most insurances if ordered in the right setting. Others labs have developed tests (such as breastnext) for other genes but insurance coverage is not as clear cut. ...Read more

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Would would you get the breast cancer genetic testing?

Would would you get the breast cancer genetic testing?

Risk for cancer: If you have a strong family history of breast or ovarian cancer (or less commonly prostate or pancreas), if you had cancer before certain age, or breast cancer with certain characteristics, you may be a candidate for brca testing. Please note that this should be done in a setting of a full risk assessment visit by a trained professional. ...Read more

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Breast cancer is genetic and not hereditary, is that correct?

Basic biology: It's easy to misunderstand. Genetic disease is usually hereditary -- only a few diseases of genes can't be inherited or passed on; new mutations are genetic but not hereditary. Inherited disease is almost always genetic. A variety of genes may be passed parent-to-child, each defining a "cancer family syndrome" but most cancer is sporadic. ...Read more

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My mom had lobular breast cancer at 52. Brca negative. Is lobular breast cancer more genetic based than ductal?

My mom had lobular breast cancer at 52. Brca negative. Is lobular breast cancer more genetic based than ductal?

No its medullary: a quote from Lancethttp://www.ncbi.nlm.nih.gov/pubmed/9167459: "The occurrence of invasive lobular carcinoma and invasive ductal carcinoma was not significantly different between carriers of BRCA1 or BRCA2 mutations and controls. Medullary or atypical medullary carcinoma was, however, found more often in BRCA1 (13%, p ...Read more

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Why can't someone prevent breast cancer? Is it genetic?

Why can't someone prevent breast cancer? Is it genetic?

5-10% genetic: At least 90% of breast canceers are acquired via virus or carcinogen. The MMTV virus infects the Wnt-1 gene to initiate ductal mucosal transformation. Where Mus domesticus is absent almost no breast cancer. There is a suggestion that endogenous sequences of the LTR of the virus can be passed thru endogenous sequences and reappear in later generations. ...Read more

Dr. Barry Rosen
4,224 doctors shared insights

Cancer (Definition)

Cancer is a group of diseases that is characterized by uncontrolled cell growth leading to invasion of surrounding tissues that spread to other parts of the body. Cancer can begin anywhere in the body and is usually related to one or more genetic mutations that allow normal cells to become malignant by interfering with internal cellular control mechanisms, such as programmed cell death or by preventing ...Read more


Genetic (Definition)

From a medical standpoint, "genetic" refers to the potential heritability of various medical conditions. While some conditions are inevitable (at some point in one's life) as a consequence of simple genetic heritability (eg huntington's disease), a large number of medical conditions (including all behaviorial health disorders) are the expressed final pathway of a ...Read more