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Doctor insights on: Is Benadryl The Same As Zyrtec

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Is it okay to take zyrtec with benadryl (diphenhydramine)?

Is it okay to take zyrtec with benadryl (diphenhydramine)?

Not really: These are both antihistamines. If both are needed then physician guidance should be sought. ...Read more

Dr. John Chiu
1,049 doctors shared insights

Diphenhydramine (Definition)

Diphenhydramine is a sedating antihistamine which is a kind of antihistamine type drug (common ...Read more


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Benadryl (diphenhydramine) knocks me out, will zyrtec do the same?

Benadryl (diphenhydramine) knocks me out, will zyrtec do the same?

Less likely: Although Zyrtec can cause drowsiness in 10-15% of the people, it is likely to cause much less drowsiness than Benadryl (diphenhydramine) which is often used as a sleep-aid in OTC medications. ...Read more

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Taking zyrtec and Benadryl (diphenhydramine) at the same time okay?

Taking zyrtec and Benadryl (diphenhydramine) at the same time okay?

Depends: The combination can cause increased drowsiness; however, if you are taking zyrtec for allergies and you have an allergic reaction, you can take an additional benadryl (diphenhydramine). You should always discuss these interactions with your doctor. ...Read more

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I took zyrtec at 5 pm and Benadryl (diphenhydramine) 9 pm is that ok?

I took zyrtec at 5 pm and Benadryl (diphenhydramine) 9 pm is that ok?

Yes: If you take the recommended dose, it should be okay to combine these two medications. ...Read more

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Is it ok to take zyrtec after you've taken benadryl (diphenhydramine)?

Is it ok to take zyrtec after you've taken benadryl (diphenhydramine)?

Yes: Antihistamine is safe even with 4x the average daily dose. The major side effects would be dry mouth and drowsiness ( the latter much less common if one uses the non-sedating type). ...Read more

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Can you take zyrtec during day and Benadryl (diphenhydramine) at night?

Zyrtec and Benadryl (diphenhydramine): Hello. These two antihistamines taken together will probably cause sedation. As physicians, we often times double up on antihistamines in challenging cases but i usually use non-sedating antihistamines when I do this. There are other medications that may work better than this combination. Check with your doctor for other options. ...Read more

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Is safe if i take Benadryl (diphenhydramine) six hours after take zyrtec?

Is safe if i take Benadryl (diphenhydramine) six hours after take zyrtec?

Should be ok: While taking Benadryl (diphenhydramine) after zyrtec should be ok, it would be even better to know the underlying trigger to allow less medication usage. An allergist could determine why symptoms are not controlled with less medication. ...Read more

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Should i take Benadryl (diphenhydramine) until my zyrtec really kicks in?

Probably not helpful: Both drugs need to be absorbed by the GI system before they take effect to stop itching and sneezing (can take up to 1 hr). Benadryl (diphenhydramine) can dry up mucus (and make you sleepy), which zyrtec will not do at any time. If you have taken zyrtec for several days without relief from itching or sneezing, you may have something besides allergies (e.g. A cold) or need a different treatment. See your doctor. ...Read more

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I had zyrtec about 6 hours ago. Can i take Benadryl (diphenhydramine) now?

Yes you can: Yes you can if your symptoms are not controlled with zyrtec (cetirizine) alone for short period. ...Read more

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Is it possible for you to take zyrtec and Benadryl (diphenhydramine) in the same day?

Is it possible for you to take zyrtec and Benadryl (diphenhydramine) in the same day?

Yes you can: You can take both medications at the same time providing that you follow the recommended otc doses. ...Read more

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Can you tell me is it ok to take zyrtec for daytime and Benadryl (diphenhydramine) for night?

Can you tell me is it ok to take zyrtec for daytime and Benadryl (diphenhydramine) for night?

Yes it is ok: Yes it is ok as long as you are using it for short period when your allergy symptoms are not controlled with zyrtec (cetirizine) and you are not able to sleep due to allergy symptoms. ...Read more

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Well, i took Benadryl (diphenhydramine) about 12 hours ago and i was wondering, may i take zyrtec?

Antihistamines: Yes you can, but you really should have some doctor guidance with your medications, because you did not mention what symptoms you are treating with the antihistamines and they may not be the ideal medication if you are not responding to one and need to add another. Talk to your doctor. ...Read more

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I took a zyrtec about 12 hrs ago and was wondering if it was ok to take one benadryl (diphenhydramine)?

Yes: it is not harmful to take Benadryl (diphenhydramine) after Zyrtec- both medications are antihistamines and generally you would not need to take both of them

Benadryl (diphenhydramine) is a stronger antihistamine and may help with symptoms unresolved by Zyrtec - it often has more sedation as side effect than Zyrtec ...Read more

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Long term use of children's Benadryl (diphenhydramine) vs zyrtec. Which one works best with the least chance of becoming tolerant or non responsive ? Should i alternate

Allergy Meds: One should see an allergist to identify the allergens ang get appropriate treatment. Long term use of Benadryl (diphenhydramine) or zurtec specially at young age without physician supervision is harmful. ...Read more

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Is it safe to take both zyrtec and benadryl (diphenhydramine)?

Not a good choice: Benadryl (diphenhydramine) is a short acting antihistamine. Zyrtec is a long acting antihistamine. You may overdose if taking both at the same time or taking both in the same day. Consider a better allergy medication if zyrtec is not working well or if you have been taking Benadryl (diphenhydramine) longer than 5 days. ...Read more

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Can i take zyrtec d and benadryl (diphenhydramine) at the same time?

Can i take zyrtec d and benadryl (diphenhydramine) at the same time?

Better not: Unless you have severe allergic reaction, and only once, otherwise it is not advisable, if you have uncontrollable allergies, better see an allergist, check aaaai.org or caai.org for an allergist in your area ...Read more

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Is it safe to take zyrtec and Benadryl (diphenhydramine) at the same time?

Is it safe to take zyrtec and Benadryl (diphenhydramine) at the same time?

No: Both zyrtec and Benadryl (diphenhydramine) belong to the same class of medicines called antihistamines. Taking both at the same time would be taking a double dose of medicine.
Zyrtec is taken once every 12 hours, whereas Benadryl (diphenhydramine) is taken every 4 to 6 hours. ...Read more

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Can you give a 8 month old zyrtec and Benadryl (diphenhydramine) in the same day?

Yes, but...: That's a lot of medicine for an 8 month old. Make sure it has been ok'd by your pediatrician, and this is not a good long term combination. If that little one has that severe of allergies, might consider adding a med like singulair (montelukast) to get allergies under control. Also, try to reduce exposure to the allergens rather than adding more medicine. ...Read more

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What can occur if i took 2 Benadryl (diphenhydramine) and a zyrtec to help sleep before a big day?

Too much med: I don't think it is a good idea as it is too much antihistamine.I will recommend you discuss it with your doctor or allergist. ...Read more

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I took Zyrtec this morning but am so congested would it be okay to take Benadryl (diphenhydramine) too?

Decongestant: zyrtec and benadryl (diphenhydramine) are antihistamines. If you are congested, you might consider taking a decongestant ...Read more

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I take 1 zyrtec in the morning and 2 benadryl (diphenhydramine) at bedtime. is that to much antihistmine?

Yes: First depends on the dose and age but yes, zyrtec is a 24 hour medication and Benadryl (diphenhydramine) is a 6-8 hour med. Routinely this should not be ongoing. If symptoms are persistent look into another cause. ...Read more

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Please help! after 3 benadryls (diphenhydramine) and 2 zyrtec, still no relief from allergies. Please help?

Please help! after 3 benadryls (diphenhydramine) and 2 zyrtec, still no relief from allergies. Please help?

Antihistamines + ?: Bendrly (diphenhydramine) and zyrtec (cetirizine) are both antihistamines and only serve to block histamine. During an allergic reactions, there are many other chemical mediators of inflammation that trigger symptoms. An allergist can assist in finding the right combination of medications for relief. When it comes to antihistamines, more is not necessarily better. ...Read more

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I gave my daughter zyrtec at 2pm today and was wondering if i would be able to give her benadryl around 9-10pm?

I gave my daughter zyrtec at 2pm today and was wondering if i would be able to give her benadryl around 9-10pm?

Yes, but: How old is your daughter? And what for ? At any rate don't exceed recommend dosage for her age / weight, wish you both wellness ...Read more

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Can you give a 15-year-old Zyrtec and Benadryl (diphenhydramine) D at the same time... He weighs hundred pounds?

No: Zyrtec and Benadryl (diphenhydramine) are both antihistamines which should not be given simultaneously because the total dose will be too high. You can add a decongestant that does not contain any antihistamine. With allergies that are so severe that one antihistamine is not adequate, the next step is to add a nasal steroid spray. This can be prescribed by your MD. Good allergan avoidance is also important. ...Read more

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Can I give my 2 year old children's Benadryl (diphenhydramine) at night.... and how much.....she takes zyrtec in the morning?

Can I give my 2 year old children's Benadryl (diphenhydramine) at night.... and how much.....she takes zyrtec in the morning?

Zyrtec (cetirizine) + Benedryl: The occassional use of Benedryl for breakthrough allergy symptoms in addition to regular use of Zyrtec (cetirizine) should generally not cause any problems. Dosing of Benedryl is based on your child's current weight. A simple phone call to your pediatrician should be all that is needed to confirm that the appropriate doses of Zyrtec (cetirizine) and Benedryl are being given. ...Read more

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My 8 year old, 72 lbs. Inadvertently just took a Benadryl (diphenhydramine) and Zyrtec at The same time, What are the Ramifications of the Double dose?

Without knowing : the doses of either, all I can say is that using cetirizine together with diphenhydramine can increase side effects like dizziness, drowsiness, and difficulty concentrating. If you're worried about how woozy he is, call his doctor for instructions about seeking after-hours care. ...Read more

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I just took zyrtec for hives, can I take Benadryl (diphenhydramine) at night?

Zyrtec ; Benadryl (diphenhydramine): Hello, you can take zyrtec and Benadryl (diphenhydramine) together on the same day. You may notice a little sedation. If so., do not put yourself or anyone else in harm's way. ...Read more

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Is it possible to take zyrtec in the morning and Benadryl (diphenhydramine) at night for my allergies?

Is it possible to take zyrtec in the morning and Benadryl (diphenhydramine) at night for my allergies?

Yes: As long as you tolerate the medicines and do not experience drowsiness that is ok. Otherwise ask you doctor for a prescription nasal spray to take with zyrtec. ...Read more

Benadryl (Definition)

Diphenhydramine is a sedating antihistamine which is a kind of antihistamine type drug (common ...Read more


Dr. John Chiu
575 doctors shared insights

Cetirizine (Definition)

Ceftirizine is the generic name of an antihistamine previously marketed under the ...Read more