Doctor insights on:
Is Avapro An Ace Inhibitor
Blood Pressure Treat: Ace inhibitors block the conversion angiotensin I to angiotensin ii, which constricts the vessels, increases the following: salt retention in the kidney, sympathetic tone, aldosterone and ADH (vasopressin) (anti-diuretic hormone) secretion. The inhibition of this conversion decreases blood pressure and wall stress in the heart muscle. ...Read more
Originally marketed under the trade name, avapro, (irbesartan) Irbesartan is now sold in generic form, produced by various manufacturers. It falls into the category of angiotensin receptor blockers or arbs. Dosages include 75, 150, and 300 mg tablets, as well as various combination forms with both 12.5 and 25mg doses of hydrochlorothiazide (hctz). Blocks a kidney mediated ...Read more
Depends: Amer heart assoc recommends both. If you have diabetes, an ace inhibitor is a good choice since it may protect against diabetic kidney disease. You & your doctor should discuss alternative treatments for htn. If you have certain kinds of heart disease, then a beta blocker or diuretic may be a better choice. That's why it's best to discuss treatment with your doctor. ...Read more
Lisinopril choices: Lisinopril is a member of the ace-inhibitor (a) class of drugs. It not only reduces blood pressure, it also reduces proteinuria. The most common adverse effect of drugs of a class is a dry cough. Another class of drugs, call angiotensin receptor blockers (arb) can do the same two things and have a much lower reported incidence of cough. Ask your physician for more advice. ...Read more
Several: There are several alternatives. It is a good drug generally. ...Read more
Any, if tolerated: Ace inhibitors are a cornerstone of almost any hypertensive patient, especially if a patient has diabetes or heart failure. Monitoring of kidney tests and potassium and watching for cough or rarely rashes or swelling of the lips and eyelids are adverse effects that need medical attention. ...Read more
Membranous nephritis: The answer to your question is too long to explain here. This link lists the most current therapies for membranous glomerulonephritis (mg): http://www. Edren. Org/pages/edreninfo/membranous-nephropathy. Php speak to your nephrologist (n) to get your n's opinion. Ace-i's can reduce proteinuria and are not the only drugs used to treat mg. Speak to your n for more advice in your case. ...Read more
Not definitively: This does not completely rule out sarcoidosis. Work up includes thorough evaluation med history, exam and several tests may be indicated depending on other symptoms. Lesions of sarcoidosis often secrete the ACE enzyme. Not always high. You listed Chest XR as completed. Often ordered. More tests on lungs if needed. Possible biopsy of any lesions such as the rash you listed, if indicated ...Read more
Have any undesirable effects been seen in long term use of the blood pressure drugs of the ACE inhibitor class?
Same as short-term: Analyses have not shown any clear risks, including with regards to risk of cancer. Risks over long-term appear to mimic that seen in short-term use (e.g. Risk of hi potassium, kidney function abnormalities); sometimes this can show up after years on the medicine. There may even be benefits to chronic use (apart from intended benefits), such as lower risk of diabetes or atrial fibrillation. ...Read more
I've had a typically low bp, 108/63, should I be concerned about taking an ACE inhibitor 5mg/day for my kidneys?
Blood pressure: For many people would be ok. Best to be judged by your doctor. ...Read more
What over-the-counter medications should I definitely avoid since they counteract my prescribed verapamil and an ACE inhibitor?
Decongestants: Since they could increase BP but this is a relative contraindication. ...Read more
The beta blocker had too many side effects and did not reduce BP well enough. Ace inhibitor is now substituted. Could this reduce the pressure better?
Depending on Pt: Each pt is different. People respond to different meds differently. Some pts ace inhibitor works very well. Some pts it does not. We have to try one med at a time and see if it works. If it doesn't will try next option. ...Read more
Cough upon Altace trial 10 yrs ago. Possible I might not have same reaction now, esp w/diff brand of Ace Inhibitor? ACE studies look better than ARB.
Altace cough: It is worth trying again as you will know quickly whether you are sensitive to it, and if you are, you can stop it. Best to check with your cardiologist. ...Read more
Hbp #: if there were to be unwanted side effects for a prescribed ACE inhibitor, would it be more prevalent with an extended release form, or not?
No difference: Side effects form the medication are no different whether given as short- or long-acting. You may feel the effect of the medication more with short-acting forms (such as lightheaded with BP meds as it brings the pressure down). The most common side effect from ace is cough which occurs with either form. ...Read more
Can an ace-inhibitor 20 mg. Tab be cut in half and taken twice daily, instead of one time, since it reduces (it's working) side effects in a patient?
Depends: I agree that twice daily dosing in clinical trials has somewhat better effects on the neuroendocrine system, however many pills are not safe to split--especially extended release formulations. It depends on the manufacturer. Aceon, mavik, (trandolapril) and univasc may be splittable ace inhibitors if you are trying to save money, but please consult your doctor first! Don't split non-scored pills! ...Read more
Relaxes vasc muscle: Angiotensin I is a hormone that is converted to angiotensin ii with the help of the angiotensin converting enzyme (ace). Angiotensin ii is a very powerful constrictor of vascular muscle and in doing so increases the pressure inside the vessels (the blood pressure). If you inhibit (or neutralize) the ace then you don't produce as much angiotensin ii and the BP does not increase. ...Read more
http://circ. Ahajournals. Org/content/108/3/e16.full
Not typically: Not typically but I've had some patients say otherwise so I listen to them & pick alternatives & see if things improve. ...Read more
1size never fits all: In medicine, one size doesn't fit all. An ace inhibitor may be more appropriate if you have diabetes, since it can protect the kidneys from diabetic damage. If you have cardiac problems, a beta blocker may be more appropriate. Sometimes, a pt needs to use more than one HTN medication. This is why you & your doctor should discuss which blood pressure med is best in your p[articular case. ...Read more
Names say it all: Angiotensin converting enzyme (ACE) inhibitor vs angiotensin receptor blocker (ARB). The names really say it all. Angiotensin which raises blood pressure needs to be activated to work. ACEs prevent that activation. ARBs directly block the activity of angiotensin. Both have similar effects but there is more evidence for heart protection with ACEs than ARBs but slightly more side effects with ACEs. ...Read more
The calcium: Channel blocker might if your hr is too low or the combination if your HTN is overtreated. ...Read more