Doctor insights on:
Is Aml Leukemia Hereditary
2nd cousin and her father, my great uncle both had aml leukemia at 50 and 66. No other of the 22 members in 3 generations had it. Hereditary?
AML: There is a hereditary risk for aml. Multiple cases of AML developing in a family at a rate higher than predicted by chance alone have been reported. The risk of developing AML is increased threefold in first-degree relatives of patients with aml, but whether this places your family at risk is impossible to determine by internet. You might want to consult with a hematologist. ...Read more
A malignant hematologic neoplasm that originates in the bone marrow and represents a clonal proliferation of hematopoietic elements belonging to any of the myeloid, lymphoid, erythroid, and megakaryocytic lineages. Of note, other hematologic neoplasms like lymphoma or myeloma may demonstrate a leukemic phase without actually originating in the bone marrow ...Read more
Uncommon: AML is common in older people and ALL is most common in kids. Both are curable but ALL has better outcomes. But not all AML are same. Many subgroups of AML do very well. Your oncologist can answer this question. Interesting fact--using the same exact chemotherapy regimens for the some cancers, adults treated by pediatric oncologists do better than when treated by adult oncologists. ...Read more
Yes: Once you are cured from AML (usually we say if you are cancer free for 5 years, you are cured), you can participate in any sport. Just need to keep in mind, there are long term effects of chemotherapy such as heart problems, risk of secondary cancer. Therefore, it is important to be evaluated annually with clinic specialized in taking care of cancer survivors. ...Read more
Known prior damage: Secondary AML refers to the condition where the blood factory (bone marrow) has been damaged by either 1) an antecedent marrow disease such as myelodysplasia or a myeloproliferative disorder 2)prior exposure to agents such as solvents or radiation that are known to damage the blood factory and occasionally lead to the evolution of leukemia. ...Read more
If a person has AML - acut emyeloid leukemia, what percent of blast would suggest acute myeloblastic leukemia?
Blasts in blood/marr: Blasts are made in the bone marrow. Normally they are under 5% of all the white cells. So a Blast count in the bone marrow over 6% raises the question of Acute leukemia. Anything >30% blast count confirms a diagnosis of acute leukemia. As the blast cell numbers increase in the marrow, Blasts start to appear in the peripheral blood. That is how Leukemia is first diagnosed. ...Read more
Variable: The survival rate for AML is variable. Dependes on prognostic factors (clues for good or bad chances,) and that would mainly include age, dna gene mutation types, type of AML (seven types) and performance status of the patient. In general the younger the patient the chances are better. In addition there is a seconday AML (after previous chemotherapy or other dieseas,) that carry poor prognosis. ...Read more
Nothing: The acute myelogenous leukemias simply appear. There are a few uncommon genetic lesions that predispose a person, as down radiation and perhaps down's, but it is a mistake to look for a particular "cause" or "trigger" for this or most other cancers (the major exception being smoking and lung cancer). ...Read more
What does it mean if someone is given 1 week to live with aml leukemia? Are there any treatments with such a short time given?
Typically....: We are not so specific about such things unless the outcome for a person is all too clear, and even then it is difficult to be precise. People surprise us routinely, so much so that end of life can be quite humbling for us as physicians. Open dialog with your provider is key. Goals are often directed toward comfort care and meeting the needs of the family as a whole. Condolences. ...Read more
I am extremely lethargic and I have a history of aml leukemia and I have not had my blood levels checked in two years, should I be concerned?!
See below...: Considering your previous diagnosis of aml, periodic check-ups are strongly recommended, especially if symptoms are present. That is not to say that based only on your lethargy you should directly jump of the conclusion that your leukemia is back, but consulting with your physician and getting a CBC is probably a good idea. ...Read more
My blood monocytes higher by. 01 from normal range of 0.00-7.00 count & all other normal. My sister has aml leukemia subtype 2.Should I be bothered?
AML is a cancer.....: Of the bone marrow (actually a group of cancers) whose precise causes are unknown, but about which we know considerable molecular detail and are learning more each day. The disease arises from the hematopoietic stem/progenitor cells in the bone marrow when these cells acquire mutations that allow them to escape controls on growth and apoptosis. Subtype info is found on the nci website. ...Read more
Bone marrow cancer: White blood cells live and grow in the bone marrow and enter the blood stream where they travel throughout the body to fight infection. If these cells become cancerous, they grow out of control choking out the normal blood cells in the bone marrow and leaving the person vulnerable to infection, bleeding and anemia because there are not enough normal cells. All ages get AML but usually younger. ...Read more
Why does leukemia come on so fast my daughter was diagnosed on a friday and five days later died she was 8 yrs old and had aml leukemia m4
Why would a typically heatly 8 year old get aml leukemia m4 it's an adult cancer and why is there not a lot of conversations about aml leukemia?
In the vast: Majority of leukemias no cause is noted. You are correct over 80% of leukemias in childhood are all. ...Read more
What is the prognosis of a child diagnosed with aml leukemia m4 her WBC was 280000 when diagnosed she passed away but I have so many questions?
First, let me extend my condolences on the loss of your daughter. This is clearly the worst thing that can happen to a parent.
There are many factors that influence the likelihood that a child diagnosed with AML will survive. The best person to get answers from regarding your daughter's case is her oncologist. I'm sure he or she would be happy to meet with you and try to answer your questions. ...Read more
My baby girl was diagnosed with acute lymphocytic leukemia in 2006, and now he is diagnosed w/ aml. Is this possible?
Very sad but..: This is a terrible situation. Unfortunately sometimes the treatment for acute lymphocytic leukemia can lead to damage of the normal bone marrow cells and lead to a secondary AML (acute myeloid leukemia). It sounds like that may have happened in this case. So sorry to hear this. ...Read more
My moms uncle and his daughter both had leukemia at 65 and 54 years old. He had aml and she had apl. What would cause this? Genetic?
Yes: Genetics and gene inheritance is the most important factor ...Read more
25f, leukemia (aml) since 2011, can't go bk into remission, WBC is now 53.7. They started me on hdyrea, is this going to help my WBC go down?
AML and Hydrea (hydroxyurea): Hydrea (hydroxyurea) can definitely make white cells lower and will help calm down the aml, but it doesn't have the ability to put AML into remission. Its effects are usually temporary. Have a long talk with your oncologist about all possible options at this point so you can make an informed decision. Please consider stopping smoking in the meantime, because cigarettes are one of the things that can cause aml. ...Read more
My daughters WBC countwas at 280000 when diagnosed with aml leukemia could she had survived without treatment she was diagnosed with subtypem4?
Survival: Aml-4 without treatment is a universally fatal disease. ...Read more
How rare is it for a child to get aml leukemia m4 and what would the survival rate be daughters WBC count when diagnosed was 280000?
AML: Sorry to hear about the aml. High wbcs are not that uncommon with AML m4. Survival rates depend on genetics of the leukemia. These tests were sent with the initial bone marrow (usually) and take a week or so to come back. Another important test is the bone marrow after the first cycle of chemo. Good luck to you! ...Read more
Why did my daughter get aml leukemia m4 if I recognized it earlier would it have changed what she got the only symptom she had was swollen gums?
Grief: You are going through normal grieving process. She had AML & the only symptom looking back was swollen gums. But knowing that still won't bring her back. I suggest you participate in grief groups made up of parents who lost a child. Your hospital social worker can direct you to some on your area. Again, my condolences. ...Read more
What is the difference in the sub types of aml leukemia my daughter had m4 and passed away from it she had a very high WBC before a starting chemo?
Subtypes of AML: The various subtypes of AML are based on what type of cell has turned leukemic and how mature (or differentiated) the cell is. AML m4 can be dangerous because it likes to get into the brain and can cause very high counts. The leukemia and lymphoma society of america has very good information on its website that you may find useful. I am very sorry for your terrible loss. ...Read more
Was my daughter born with aml leukemia or do it form in her bone marrow over years or months and why were there no symptoms till being diagnosed?
You have many unresolved questions, as we've discussed before. There are no clear answers to your questions specifically for your daughter. Please get help for your grief process. Please see
Is aml leukemia m4 worse then the others my daughter passed away from it her WBC count was extremely high when diagnosed and doubled in two days?
AML: M4 type can be more aggressive than other types of aml. I am sorry about your daughter. ...Read more
25f, w/ aml (leukemia), not getting chemo. My CBC the other day showed my WBC jumped from 8.6 to a 26.5, whts the cause, did smear test, no results yet?
Diagnosed with Acute Myeloid Leukemia (AML). 95% blast cells in BM test. Doc starting 7+3 chemo course. What are the chances? Any other treatment?
AML: If you have been accurately diagnosed with AML, further subtyping of your diagnosis must take place before treatment is started or prognosis is estimated. This is based on examination of cell morphology, immunophenotype, genetics (karyotype), and clinical features (age at diagnosis; functional status and comorbidities). Age >55 at time of diagnosis is a negative prognosticator. ...Read more
My husband had a stem cell transplant in sept 2012 for leukemia (aml). Just told he has fully relapsed and has leukemia in his cns? Still treatable?
Difficult, but yes:
I am so sorry. Given how quickly he relapsed after transplant, there is a low, but not zero, chance of getting him in remission again. It depends on what drugs his leukemia has seen. A 2nd transplant is possible. There are a number of promising drugs in clinical trials for relapsed aml:
i wish you the best of luck. ...Read more
AML treatment: AML is treatable. Most treatment decisions are based on genetics of the leukemia cells. Favorable genetic findings can be treated and possibly c rued with standard chemotherapy. Unfavorable genetics can be more difficult to treat. These leukemias may require chemotherapy and even bone marrow transplant. Good luck. ...Read more
This is a type of leukemia. It is a cancer of a certain blood dell, originating in the bone marrow. It causes low blood counts. Diagnosis is often by evaluation of bone marrow aspirate. Treatments depend on subtypes and range from standard chemotherapy ...Read more