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Is Age A Factor In Down Syndrome
Down syndrome is the classic presentation clinically of the congenital malformation syndrome also known as Trisomy 21. Classic features may include simian creases, epicanthal folds, upslanting palpebral fissures, flat nasal bridge, hypertelorism, low set ears, endocardial cushion defects of the heart, atlanto-axial joint instability, blood ...Read more
I have a cousin who is down syndrome. Is it true that they die at an early age? And that they don't live longer than 20 years?
No: Although some ds kids have life threatening conditions at birth these are usually recognized & fixed as they would for any other newborn. In life they have many challenges but generally live out a long life if these issues are managed. Expected lifespan of a newborn with ds today exceeds 60 yrs. ...Read moreSee 1 more doctor answer
Statistical risks: The risks of DS are at the low point in the early twenties, (~1/2700) and climb past 1/100 at 45 and over 1/20 after 55. The usual explanation is the accumulated toxic events of a woman's life can cause the eggs that sit in her ovary to become damaged as they age. ...Read more
A woman's eggs are : as old as she is. An embryo receives ½ it's chromosomes from Dad & ½ from Mom. DNA replicates in each parental chromosome pair & crosses over between 2 sister chromatids joined in the center that then split into egg cells. At 35 & >, cohesion of maternal sister chromatids is progressively impaired, ^ing the risk of an egg's receiving 2 or 0 copies of a chromosome. Her 2 + Dad's 1 Chr. 21 = DS ...Read moreSee 1 more doctor answer
In most cases: The basic risk of a female having a ds offspring increases from a low in the early 20's (1/2000) to 1/100 @40 & 1/12 @ 49.Chromosome origination studies suggest the anomaly ares in egg rather than the sperm, likely because a blighted sperm doesn't swim as effectively.Age is therefore less an issue for the male. In rare translocation ds, gender is not as much an issue. ...Read more
Chromosome defect: Ds is one of the more common chromosome(c) defects that can survive pregnancy (many others miscarry). It usually happens when an egg with an extra 21c combines with a normal sperm & creates a baby with the extra 21c in all tissues.Risks vary with age and are lowest in the early 20's(1/2000), rising to 1/100 at about 40 & 1/12 at 49.Various prenatal tests can pick up signs early on. ...Read more
I'm 36 years old trying to get pregnant but I'm concerned about having a Down syndrome because of my age how at risk I will be if I conceived?
For giving birth: to a child with DS your risk is 1:275. At 16 weeks gestation your risk of having a fetus with DS is 1:200. This is assuming there is no FH of Down Syndrome. These numbers are approximations based on no other risk factors. They all, however, calculate your risk of having a child without DS at greater than 99 percent. ...Read more
Doctor queried Down syndrome in my baby(72 hrs old). Echo test is ok, no short hand, no groove between toes, no white spots in eye, mother age 20, ears ok?
Any age mom: Ds can occur at ang maternal age but numbers climb a lot for older moms. If doc suspects some unusual issue it is best that s/he be up front about it and do appropriate screening or specific tests to define it.Proper diagnosis can either relieve you or make sure early treatments are started. ...Read moreSee 1 more doctor answer
Chromosome defect: Ds is one of the more common chromosome(c) defects that can survive pregnancy (many others miscarry).Eggs are supposed to have a single 21c & combine with the 21 from dads normal sperm.Here a pair of moms 21c +dad's 21 creates a baby with the extra 21c in all tissues.This extra material confuses the creation of body parts causing ds..Various prenatal tests can pick up signs early on. ...Read more
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