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Doctor insights on: Is Age A Factor In Down Syndrome

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Why does the risk of having a Down syndrome baby increase for women over 35 years of age?

Why does the risk of having a Down syndrome baby increase for women over 35 years of age?

Aging: There is a risk for a baby with down syndrome at all ages, not just in women over 35. The risk gradually increases with age. It has to do with how the egg and sperm half the chromosomes so the next generation has the same number of chromosomes as the parents. ...Read more

Dr. Kathryn Akin
641 doctors shared insights

Down Syndrome (Definition)

Down syndrome is the classic presentation clinically of the congenital malformation syndrome also known as Trisomy 21. Classic features may include simian creases, epicanthal folds, upslanting palpebral fissures, flat nasal bridge, hypertelorism, low set ears, endocardial cushion defects of the heart, atlanto-axial joint instability, blood ...Read more


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I have a cousin who is down syndrome. Is it true that they die at an early age? And that they don't live longer than 20 years?

I have a cousin who is down syndrome. Is it true that they die at an early age? And that they don't live longer than 20 years?

No: Although some ds kids have life threatening conditions at birth these are usually recognized & fixed as they would for any other newborn. In life they have many challenges but generally live out a long life if these issues are managed. Expected lifespan of a newborn with ds today exceeds 60 yrs. ...Read more

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What does maternal age have to do with the possibility of down syndrome?

Statistical risks: The risks of DS are at the low point in the early twenties, (~1/2700) and climb past 1/100 at 45 and over 1/20 after 55. The usual explanation is the accumulated toxic events of a woman's life can cause the eggs that sit in her ovary to become damaged as they age. ...Read more

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Why would maternal age be associated with an increase in errors that lead to down syndrome?

Why would maternal age be associated with an increase in errors that lead to down syndrome?

A woman's eggs are : as old as she is. An embryo receives ½ it's chromosomes from Dad & ½ from Mom. DNA replicates in each parental chromosome pair & crosses over between 2 sister chromatids joined in the center that then split into egg cells. At 35 & >, cohesion of maternal sister chromatids is progressively impaired, ^ing the risk of an egg's receiving 2 or 0 copies of a chromosome. Her 2 + Dad's 1 Chr. 21 = DS ...Read more

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Does the gender or age of the parent affect the risk of the offspring having down syndrome?

Does the gender or age of the parent affect the risk of the offspring having down syndrome?

In most cases: The basic risk of a female having a ds offspring increases from a low in the early 20's (1/2000) to 1/100 @40 & 1/12 @ 49.Chromosome origination studies suggest the anomaly ares in egg rather than the sperm, likely because a blighted sperm doesn't swim as effectively.Age is therefore less an issue for the male. In rare translocation ds, gender is not as much an issue. ...Read more

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What is Down syndrome in pregnancy and what are the risk factors for it?

Chromosome defect: Ds is one of the more common chromosome(c) defects that can survive pregnancy (many others miscarry). It usually happens when an egg with an extra 21c combines with a normal sperm & creates a baby with the extra 21c in all tissues.Risks vary with age and are lowest in the early 20's(1/2000), rising to 1/100 at about 40 & 1/12 at 49.Various prenatal tests can pick up signs early on. ...Read more

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I'm 36 years old trying to get pregnant but I'm concerned about having a Down syndrome because of my age how at risk I will be if I conceived?

For giving birth: to a child with DS your risk is 1:275. At 16 weeks gestation your risk of having a fetus with DS is 1:200. This is assuming there is no FH of Down Syndrome. These numbers are approximations based on no other risk factors. They all, however, calculate your risk of having a child without DS at greater than 99 percent. ...Read more

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If the 1st trimester screening for Down syndrome was negative, how much does an echogenic focus at 20 week screening factor in?

Amniocentesis is key: If you had amniocentesis which did not reveal abnormalities consistent with .Down syndrome, then the only concern would be structural abnormalities, such as heart abnormalities. If you have not had amniocentesis, you should have it. ...Read more

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Doctor queried Down syndrome in my baby(72 hrs old). Echo test is ok, no short hand, no groove between toes, no white spots in eye, mother age 20, ears ok?

Doctor queried Down syndrome in my baby(72 hrs old). Echo test is ok, no short hand, no groove between toes, no white spots in eye, mother age 20, ears ok?

Any age mom: Ds can occur at ang maternal age but numbers climb a lot for older moms. If doc suspects some unusual issue it is best that s/he be up front about it and do appropriate screening or specific tests to define it.Proper diagnosis can either relieve you or make sure early treatments are started. ...Read more

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What is down syndrome?

What is down syndrome?

Chromosome defect: Ds is one of the more common chromosome(c) defects that can survive pregnancy (many others miscarry).Eggs are supposed to have a single 21c & combine with the 21 from dads normal sperm.Here a pair of moms 21c +dad's 21 creates a baby with the extra 21c in all tissues.This extra material confuses the creation of body parts causing ds..Various prenatal tests can pick up signs early on. ...Read more