Doctor insights on:
Iron Overload (Hemochromatosis)
Too much bodily iron: As a result of the inability to increase iron loss, iron overload is an inevitable response to increased iron entry into the body. This can occur by one of three mechanisms - nutritional intake, increased absorption, parenteral sources (i.e. Transfusions). Hemochromatosis is abnormally high absorption of iron as result of a genetic defect. Extra iron can be toxic. ...Read moreSee 1 more doctor answer
Can be deadly: Over time, excesses of iron build up in major organs such as the heart, liver, pancreas, joints and pituitary. If the extra iron is not removed, these organs can become diseased, causing conditions like diabetes mellitus, irregular heart beat or heart attack, arthritis, cirrhosis of the liver or liver cancer, gall bladder disease, depression, impotence, infertility, hypothyroidism, hypogonadism. ...Read moreSee 2 more doctor answers
A few: Lack of energy, abdominal pain, memory fog, loss of sex drive, heart flutters, irregular heart beat. When symptoms are associated with hemochromatosis, these usually begin in men in their late 20’s to early 30’s. In women, symptoms usually start about 10-15 years after they stop having a period due to menopause, birth control pills or hysterectomy. ...Read moreSee 1 more doctor answer
Labs and Bx: Labs that include ferritin and transferrin saturation. All patients being evaluated for hhc should have c282y and h63d mutation analysis. This may help in determine risk for hhc but is not always diagnostic by itself. Lastly a liver biopsy with a iron index or MRI may help to confirm suspected cases. ...Read moreSee 1 more doctor answer
Transferrin sat: Your best screen is transferrin saturation. Many of us think that the current recommendation of 45% or more for women, 50% of more for men miss too many people. If you actually have evidence of liver troubles (elevated SGOT / SGPT, for example), think about getting a serum ferritin. With a family history, get the gene testing to know early. ...Read moreSee 2 more doctor answers
I'm 25&Male, Rbc=5.9(H),hb=15.5,mch=26.3(L)
iron=80,Tibc=260,ferritin=250.4(ref:20-250),have i a iron overload?(hemochromatosis)
How can I know if I have iron overload/hemochromatosis? What tests should be performed? I hear that there is a DNA genetic test kit for hemochromatosis, is that true?
Blood tests: Iron and TIBC (total iron binding capacity) can be used to detect iron overload (iron/tibc >45 increases suspicion). Hemochromatosis, one cause for iron overload, can be detected by a gene study. As a general rule, patients with hemochromatosis are referred to gastroenterologist for a liver biopsy, as iron overload can do significant damage to the liver. ...Read moreSee 2 more doctor answers
Is it possible for a person to get iron overload from eating a lot of meat but doesn't have gene for hemochromatosis?
Does hemochromatosis ever cause compensatory hyperventilation? Does this signal that heart damage from iron overload is already done?
The heart!: The heart is one of the last organs to be significantly damaged from hemochromatosis. Lfts indicationg liver damage, pancreatic, and gonadal dysfuction would occur first, as would joint issues caused by secondary hemochromatosis. Also, a female would never have this issue at 19! ...Read moreSee 1 more doctor answer
Isn't the diagnosis for hemochromatosis based on irish hemochromatosis? Other races like far east have different gene for iron overload
Let me help: Most hemochromatosis worldwide is caused by mutations at the hfe gene locus; most europeans with a worrisome mutation here have c282y, but there are other alleles at this locus, and several other less common loci. Further, having the gene won't give you the disease unless you actually get iron-overloaded, which is how we pick it up. Any primary care doc can diagnose & rx is easy. Stay proactive. ...Read more
If I have the double gene mutation (homozygous) for hemochromatosis but am not clinically iron overloaded (have high iron levels on lab results) at this time, can I develop iron overload later, such as in 2, 5, or 10 or more years later?
Hemachromatosis: The single gene carrier will likely not develop any symptoms or problems from increased iron absorption. You will still need to have regular blood work to check for increased iron, and not use any supplements with iron. If you have two genes, your chance is good that you will have high levels of iron, and possibly get damage from the extra iron. Timing is unknown, too many variables. ...Read moreSee 1 more doctor answer
Every time my son donates blood they tell him his iron is too high . This time it was 51. My uncle has hemochromatosis , should I be concerned .
I have hemochromatosis but my iron levels are Ferritin 8 Iron 7 Transferrin 2.1 Transferrin Sat 13?
I have been doing phlebotomy for hemochromatosis. i got my ferritin down to 50 then it went back up to 300! why?! do not drink low iron diet
Iron accumulates: In Hemochromatosis, your body absorbs too much iron. Even if your diet is low iron, as it should be, you can still over time accumulate iron in your tissues again since the underlying problem with iron metabolism is ever present. Ferritin is also a marker of inflammation, and often rises during infection etc. If you have had any such issues lately, it could be a result of that as well. ...Read more
Can u have hemochromatosis if your blood tests show high iron and tsat levels in 2 out of 4 tests over 3 years - t'ferrin & ferritin levels are normal?
Proper testing: The transferrin saturation needs to be done on fasting blood samples. A cut-off of 45% is best used. If the ts > 45% on fasting specimens, although the ferritin might be normal, can be seen with some iron overload disorders including hemochromatosis. A normal fasting ferritin and tsast. ...Read more
- Iron hemochromatosis
- Can iron overload be acquired?
- Complications iron overload
- Liver iron overload
- Selenium iron overload
- Worrisome iron levels in iron overload
- Frequency of treatment in iron overload
- Hypothyroidism and iron overload
- Dangers of iron overload
- Diet for iron overload