Doctor insights on:
Mcrc patient aged 65. Drs not willing to
Give any 5-FU drugs due to chest tightness . Tried Xeloda (capecitabine) n irinotecan . What can we do now ?
Define met site.: Regardless of site and extent of mets, primary resection essential. This eliminates any other site of spread. PET/CT will determine met areas after primary removed. If as is usual, mets are to liver, microwave ablation, or chemo embolization or radioactive microspheres given to liver to control disease. Any pulmonary nodes removed thru thorascope. Most protocols contain 5FU (fluorouracil). ...Read more
Can any targeted therapies or other drugs help with metastic colon cancer when Xeloda (capecitabine) n irinotecan has failed ?
Yes: Target agents that have activity either as single agent or as combination for recurrent or refractory metastatic colon cancer as a second line include: Avastin (bevacizumab) or Cetuximab/Panitumumab (if k-ras, n-ras, b-raf are wide type) or Regorafenib (inhibitor of angiogenic receptor) or aflibercept. FOLFOX may be effective too after irinotecan has failed. Clinical trials are aslo available. ...Read more
Possible disease: CEA is a marker for monitoring the presence of active malignancy. It cant be used for diagnosis which refers to the potential existence of cancer which has not yet been defined. As a monitoring marker progressive increase in the level at present, that is 10, means failure to respond to treatment. Should levels drop, it means the patient is responding. A single level of 10 cant be interpreted. ...Read more
Irinotecan: See: http://www.drugs.com/sfx/irinotecan-side-effects.htmlGet a more detailed answer ›
Are there organizations that would assist financially for chemotherapy called camptosar (irinotecan)? Copay is too much.
Couple of options: First, ask to make an appointment with a local social worker that is affiliated with your hospital or clinic. In addition, here are some resources: http://www.Cancer.Org/treatment/findingandpayingfortreatment/index?Sssourcesiteid=null http://www.Cancercare.Org/financial. ...Read more
Cea rising on irinotecan since started in October . 1 point increase each month . Cea 10 at present . Is chemo
Not working ?
Possibly not working: Irinotecan is an antineoplastic agent that interferes with the production of proteins necessary for cancer cell growth and reproduction. It is used primarily for treating cancer of the colon and rectum. While the CEA is of some value in monitoring one must be able to define if a rising marker does indicate drug failure. Here a PET/CAT scan can show if there is recurrence or progression of disease ...Read more
Can a 1 point CEA rise per Month on irinotecan mean chemo not working ?
Irinotecan started in oct.
No: CEA is a crude marker for recurrent or persistent tumor. It is only of value when a significant change occurs representing progression or response to therapy. It has no value as a diagnostic marker. To be significant a 10-20 point rise monthly for at least 3 months helps determine progression or not. A one point change is within lab error. ...Read moreSee 2 more doctor answers
If on irinotecan since oct CEA is rising as
Does this mean chemo not working?it was 8 in October
It was 8 before in October
Progression disease: Irinotecan (Camptosar (irinotecan) ) is a drug used for the treatment of cancer. Irinotecan prevents DNA from unwinding by inhibition of topoisomerase 1. In clinical trials it is used for metastatic tumor such as colon Ca. The CEA acting as a tumor marker is only of value in monitoring response to treatment so that elevation means growing tumor. Diagnosis cant be made by presence of CEA in serum. ...Read moreSee 2 more doctor answers
Allergy/side effect: Side effects are known adverse reactions that occur due to the metabolism of the medication or the mechanism of action of the drug that just happens to be undesirable or toxic. Typical allergic reactions (type i hsr) consist of flushing, hives, itching, swelling, respiratory symptoms or GI symptoms. True allergic reactions can be desensitized by an allergist trained to perform the procedure. ...Read more