Doctor insights on:
Irinotecan Allergy In Children
Allergy/side effect: Side effects are known adverse reactions that occur due to the metabolism of the medication or the mechanism of action of the drug that just happens to be undesirable or toxic. Typical allergic reactions (type I hsr) consist of flushing, hives, itching, swelling, respiratory symptoms or GI symptoms. True allergic reactions can be desensitized by an allergist trained to perform the procedure. ...Read more
Side effects are known adverse reactions that occur due to the metabolism of the medication or the mechanism of action of the drug that just happens to be undesirable or toxic. Typical allergic reactions (type I hsr) consist of flushing, hives, itching, swelling, respiratory symptoms or GI symptoms. True allergic reactions can be desensitized by an allergist trained ...Read more
Possible disease: CEA is a marker for monitoring the presence of active malignancy. It cant be used for diagnosis which refers to the potential existence of cancer which has not yet been defined. As a monitoring marker progressive increase in the level at present, that is 10, means failure to respond to treatment. Should levels drop, it means the patient is responding. A single level of 10 cant be interpreted. ...Read more
CEA often fluctuates: We have to give 2 months of chemo before we can assess response. CEA is not enirely reliabnle unless you have done it 3-4 times in a row, one month aprt. Then it will show us a trend for tumor being better or worse. Yet we rely much more on Imaging studies (CT scan etc) along with patient symptoms and doctor's examination. All together (these 4 items) will help us conclude if tumor is getting small ...Read more
What happens if for mcrc, Xeloda (capecitabine) n irinotecan has failed? The person has about 3, 4 mets?
Not really: Having failed does not necessarily represent progression of metastasis but possibly no evidence of extensive disease progression. In such a case if disease is in liver isotope infusion or chemoembolization may help. If new lung lesions are seen, they may be amenable to resection and if progression has occurred newer immunotherapy approaches such as with Neo 102 can give better than 1 yr. Survival. ...Read more
If Xeloda (capecitabine) n irinotecan failed does this mean person with mcrc is chemotherapy resistant?
Maybe: The treatment for metastatic colorectal Ca also includes FOLFOX which includes the platinum drugs as part of the combo. If not yet taken one should consider this protocol. I usually obtain fresh tumor from bx to send for chemosensitization. If these fail, chemo with Erbitux or Avastin (bevacizumab) may prove beneficial. ...Read more
Irinotecan: See: http://www. Drugs. Com/sfx/irinotecan-side-effects. HtmlGet a more detailed answer ›
Cea rising on irinotecan since started in October. 1 point increase each month. Cea 10 at present. Is chemo Not working?
Possibly not working: Irinotecan is an antineoplastic agent that interferes with the production of proteins necessary for cancer cell growth and reproduction. It is used primarily for treating cancer of the colon and rectum. While the CEA is of some value in monitoring one must be able to define if a rising marker does indicate drug failure. Here a PET/CAT scan can show if there is recurrence or progression of disease ...Read more
Can a 1 point CEA rise per Month on irinotecan mean chemo not working? Irinotecan started in oct. Oct cea-8 Dec cea-9 Jan cea-10
No: CEA is a crude marker for recurrent or persistent tumor. It is only of value when a significant change occurs representing progression or response to therapy. It has no value as a diagnostic marker. To be significant a 10-20 point rise monthly for at least 3 months helps determine progression or not. A one point change is within lab error. ...Read more
If on irinotecan since oct CEA is rising as Dec-9 Jan- 10 Does this mean chemo not working? It was 8 in October It was 8 before in October
Progression disease: Irinotecan (Camptosar (irinotecan)) is a drug used for the treatment of cancer. Irinotecan prevents DNA from unwinding by inhibition of topoisomerase 1. In clinical trials it is used for metastatic tumor such as colon Ca. The CEA acting as a tumor marker is only of value in monitoring response to treatment so that elevation means growing tumor. Diagnosis cant be made by presence of CEA in serum. ...Read more
Are there organizations that would assist financially for chemotherapy called camptosar (irinotecan)? Copay is too much.
Couple of options:
First, ask to make an appointment with a local social worker that is affiliated with your hospital or clinic. In addition, here are some resources:
http://www. Cancercare. Org/financial. ...Read more
Chemotherapy irinotecan failed. Mcrc pt with few small mets u under 2 cm, can ablation such as nano knife be beneficial?
Possibly: Technology still new without good long term data. Go to an institution that has a large experience, like a University Hospital ...Read more
If 1 or 2 new nodules have appeared while on irinotecan for mcrc, does this mean treatment failure? What is the most effective chemotherapy?
Yes: When irinotecani given for colon cancer it is in the adjuvant status to prevent recurrence or in the therapeutic setting to prevent progression of disease. The appearance of new nodules suggests failure of chemo. If FOLFOX has not been used it can be helpful. If progression is in liver then chemoembolization is of value. If chemo has failed, Erbitux or experimental mAb Neo 102 may help. ...Read more
Pretty good: Usually they're part of a protocol. If I were offered this as adjuvant Rx and it was affordable from my end, I'd probably go ahead if it was offered by an ethical oncologist. I'd quit if it was clearly not helping. ...Read more
Moderate: Irinotecan, (Camptosar), is used alone or in combination with cisplatin for lung Ca. It functions to prevent DNA from unwinding by inhibition of topoisomerase 1, . It has demonstrated activity in advanced non-small-cell lung cancer (NSCLC). In single-agent studies, the response rates are as high as 35% ; in combination with cisplatin, response rates have ranged as high as 50%, As new im ...Read more
It depends: Chemotherapy is the proven best treatment for most such cases. If there is only 1-2 mets, such tumors can be removed and may be curable with combined use chemotherapy and surgery. Chemo-embolization is not a standard treatment, although it has been used effectively by some oncologists. Ask your oncologist the pros and cons of your multiple choices or you should seek a second opinion to explore ...Read more
How effective is chemotherapy irinotecan for a liver met and node.? Does it only work in some patients?
Good drug: Irinotecan hydrochloride or Camptosar, (irinotecan) CPT-11 is a chemotherapy drug made from a plant alkaloid known as a topoisomerase I inhibitor. It works by blocking an enzyme in cells called topoisomerase I. needed to keep DNA in shape when dividing. The drug useful in metastatic colon cancer to liver where it can convert the mets to resectable. ...Read more
Work w/ your Dr:
This is worth discussing w/ your Dr or getting a 2nd opinion. They spent years building a knowledge base and also have examined you! Some research finds it less beneficial alone than in combo: http://www. Ncbi. Nlm. Nih. Gov/pubmed/24560487
But talk about your case w/ your team. ...Read more
Allergies occur when your immune system is triggered by envirionmental factors it should ignore--for example, pollen in the air, or dander on a cat or dog--and creates cells to fight against them. An allergic reaction typically causes itching, congestion, or drainage, and ...Read more