Top
20
Doctor insights on: Irinotecan

Share
1

1
What is Irinotecan?

What is Irinotecan?

Irinotecan: Irinotecan is used in combination with other meds to treat colon & rectal cancer. ...Read more

2

2
Who should not use Irinotecan?

Who should not use Irinotecan?

Irinotecan: "Irinotecan hydrochloride injection is contraindicated in patients with a known hypersensitivity to the drug or its excipients." See: http://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=2361c88c-124e-4f6c-aef2-c70612f0eb64 ...Read more

3

3
What are Irinotecan injections used for?

What are Irinotecan injections used for?

Irinotecan: Irinotecan is used in combination with other meds to treat colon & rectal cancer. ...Read more

4

4
Who should not use Irinotecan injections?

Irinotecan: "Irinotecan hydrochloride injection is contraindicated in patients with a known hypersensitivity to the drug or its excipients." See: http://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=2361c88c-124e-4f6c-aef2-c70612f0eb64 ...Read more

5

5
What side effects are associated with Irinotecan?

Irinotecan: See: http://www.drugs.com/sfx/irinotecan-side-effects.html

Get a more detailed answer ›
6

6
What can it mean it CEA is 10 while on irinotecan ?

What can it mean it CEA is 10 while on irinotecan ?

Possible disease: CEA is a marker for monitoring the presence of active malignancy. It cant be used for diagnosis which refers to the potential existence of cancer which has not yet been defined. As a monitoring marker progressive increase in the level at present, that is 10, means failure to respond to treatment. Should levels drop, it means the patient is responding. A single level of 10 cant be interpreted. ...Read more

8

8
What side effects are associated with Irinotecan injections?

Irinotecan: See: http://www.drugs.com/sfx/irinotecan-side-effects.html

Get a more detailed answer ›
Dr. Alan Ali Dr. Ali
1 doctor agreed:
9

9
Whats camptosar (irinotecan) for?

Dr. Alan Ali Dr. Ali
1 doctor agreed:
Whats camptosar (irinotecan) for?

Camptosar (irinotecan): Is hormonal antineoplastic medication given by injection in treatment of metastatic colorectal cancers. ...Read more

10

10
Can pregnant women use Irinotecan?

Can pregnant women use Irinotecan?

Irinotecan: Irinotecan is FDA Pregnancy Category D (Positive evidence of risk). ...Read more

12

12
Can pregnant women use Irinotecan injections?

Can pregnant women use Irinotecan injections?

Irinotecan: Irinotecan is FDA Pregnancy Category D (Positive evidence of risk). ...Read more

13

13
If chemotherapy irinotecan does not work for metastic colonncancer , what options are there ?

If chemotherapy irinotecan does not work for metastic colonncancer , what options are there ?

Other chemo drug: FOLFOX chemo has been employed and temporarily successful. If lesions localized to liver or lung then resection if possible or chemoembolization. Monclonaql antibody with mAb NPC 102 in FDA trials may be of value when all chemo has failed. ...Read more

14

14
Cea rising on irinotecan since started in October . 1 point increase each month . Cea 10 at present . Is chemo Not working ?

Possibly not working: Irinotecan is an antineoplastic agent that interferes with the production of proteins necessary for cancer cell growth and reproduction. It is used primarily for treating cancer of the colon and rectum. While the CEA is of some value in monitoring one must be able to define if a rising marker does indicate drug failure. Here a PET/CAT scan can show if there is recurrence or progression of disease ...Read more

15

15
Can a 1 point CEA rise per Month on irinotecan mean chemo not working ? Irinotecan started in oct. Oct cea-8 Dec cea-9 Jan cea-10

No: CEA is a crude marker for recurrent or persistent tumor. It is only of value when a significant change occurs representing progression or response to therapy. It has no value as a diagnostic marker. To be significant a 10-20 point rise monthly for at least 3 months helps determine progression or not. A one point change is within lab error. ...Read more

See 2 more doctor answers
16

16
If on irinotecan since oct CEA is rising as Dec-9 Jan- 10 Does this mean chemo not working?it was 8 in October It was 8 before in October

Progression disease: Irinotecan (Camptosar (irinotecan) ) is a drug used for the treatment of cancer. Irinotecan prevents DNA from unwinding by inhibition of topoisomerase 1. In clinical trials it is used for metastatic tumor such as colon Ca. The CEA acting as a tumor marker is only of value in monitoring response to treatment so that elevation means growing tumor. Diagnosis cant be made by presence of CEA in serum. ...Read more

See 2 more doctor answers
17

17
Are there organizations that would assist financially for chemotherapy called camptosar (irinotecan)? Copay is too much.

Are there organizations that  would assist financially for chemotherapy called camptosar (irinotecan)? Copay is too much.

Couple of options: First, ask to make an appointment with a local social worker that is affiliated with your hospital or clinic. In addition, here are some resources: http://www.Cancer.Org/treatment/findingandpayingfortreatment/index?Sssourcesiteid=null http://www.Cancercare.Org/financial. ...Read more

18

18
What is the definition or description of: irinotecan allergy?

What is the definition or description of: irinotecan allergy?

Allergy/side effect: Side effects are known adverse reactions that occur due to the metabolism of the medication or the mechanism of action of the drug that just happens to be undesirable or toxic. Typical allergic reactions (type i hsr) consist of flushing, hives, itching, swelling, respiratory symptoms or GI symptoms. True allergic reactions can be desensitized by an allergist trained to perform the procedure. ...Read more

19

19
Cea is rising 1 point per month while on irinotecan . Does this mean not responding to treatment ?

CEA often fluctuates: We have to give 2 months of chemo before we can assess response. CEA is not enirely reliabnle unless you have done it 3-4 times in a row, one month aprt. Then it will show us a trend for tumor being better or worse. Yet we rely much more on Imaging studies(CT scan etc) along with patient symptoms and doctor's examination. All together(these 4 items) will help us conclude if tumor is getting small ...Read more

See 1 more doctor answer
20

20
What happens if for mcrc, Xeloda (capecitabine) n irinotecan has failed ? The person has about 3,4 mets ?

What happens if for mcrc, Xeloda (capecitabine) n irinotecan has failed ? The person has about 3,4 mets ?

Not really: Having failed does not necessarily represent progression of metastasis but possibly no evidence of extensive disease progression. In such a case if disease is in liver isotope infusion or chemoembolization may help. If new lung lesions are seen, they may be amenable to resection and if progression has occurred newer immunotherapy approaches such as with Neo 102 can give better than 1 yr. survival . ...Read more