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Doctor insights on: Intrinsic Factor Blocking Ab

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Dr. James Lin
6 doctors shared insights

Intrinsic Factor Blocking Ab (Overview)

Pernicious anemia is a chronic illness caused by impaired absorption of vitamin b-12 because of a lack of intrinsic factor (if) in gastric secretions. It occurs as a relatively common adult form of anemia that is associated with gastric atrophy and a loss of if production and as a rare congenital autosomal recessive form in which if production is lacking without gastric atrophy.


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What is the definition or description of: intrinsic factor blocking ab?

What is the definition or description of: intrinsic factor blocking ab?

Leads to B12 defic: Pernicious anemia is a chronic illness caused by impaired absorption of vitamin b-12 because of a lack of intrinsic factor (if) in gastric secretions. It occurs as a relatively common adult form of anemia that is associated with gastric atrophy and a loss of if production and as a rare congenital autosomal recessive form in which if production is lacking without gastric atrophy. ...Read more

Dr. James Lin
6 doctors shared insights

Intrinsic Factor Blocking Ab (Overview)

Pernicious anemia is a chronic illness caused by impaired absorption of vitamin b-12 because of a lack of intrinsic factor (if) in gastric secretions. It occurs as a relatively common adult form of anemia that is associated with gastric atrophy and a loss of if production and as a rare congenital autosomal recessive form in which if production is lacking without gastric atrophy.


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What does intrinsic factor mean?

What does intrinsic factor mean?

Gastric receptor B12: It is a glycoprotein produced by the parietal cells of the stomach. There are many cell types in the stomach, but the parietal cell makes this factor. It is necessary for the absorption of vitamin b12, which occurs in the small intestines. If you don't absorb b12, you can develop macrocytic anemia. ...Read more

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Can you replace intrinsic factor?

Can you replace intrinsic factor?

Intrinsic Factor: The main issue with intrinsic factor is that it helps with absorption of B12 (a vitamin) and a low B12 level will eventually effect your red blood cells. The optimal way to prevent this in those with intrinsic factor depletion is to supplement their B12 intake with injections that bypass the GI tract. If this is a condition you are suffering from, you would benefit from seeing a GI specialist soon. ...Read more

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What causes b12 levels drop rapidly in may it was 100 after injections in June 600 again today its 140 how sudden drop m waiting for reports of intrinsic factor?

What causes b12 levels drop rapidly in may it was 100 after injections in June 600 again today its 140 how sudden drop m waiting for reports of intrinsic factor?

Dropping B12: It would be most unusual for the level to drop from 600 to 140 in 2 months. I would suspect that one of those levels was inaccurate and would urge you to have your level rechecked to see if there was a lab error. Perhaps a hematologist would have more experience with markedly fluctuating B12 levels. ...Read more

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Does taking b12 a week before an intrinsic factor blood test cause a false reading? Would it affect a b12 test too?

Does taking b12 a week before an intrinsic factor blood test cause a false reading? Would it affect a b12 test too?

Depends on the test: The test for intrinsic factor is usually antibody to intrinsic factor and that would not be affected. If the B12 test is measuring the blood level of the vitamin, then that would be affected and yield a higher reading than the baseline, without the B 12 supplement. ...Read more

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Any way to cure the intrinsic factor in the digestion system for the absorption of vitamin B12 complex?

Any way to cure the intrinsic factor in the digestion system for the absorption of vitamin B12 complex?

Yes and No: Most intrinsic factor deficiencies are due to either partial gastrectomy or auto-antibodies that attacked the parietal cells of the stomach. In both, the damage may already be done. However, you can get B12 in the body in a few ways. 1) take a higher dose of B12 starting at 2mg (literature supported), 2) take sublingual drops (salivary gland absorption), 3) get im injections of methyl b12. ...Read more

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How long does it take for intrinsic factor to become compromised due to h pylori infection? How can one check whether if and B12 are affected by hp?

How long does it take for intrinsic factor to become compromised due to h pylori infection? How can one check whether if and B12 are affected by hp?

Years: Only a small minority of folks with helicobacter infection develop autoimmune gastritis as a result, and the process itself smolders for years. It's the autoimmune gastritis that compromises the intrinsic factor etc. Let's hope you can get those little critters eradicated before this happens. ...Read more

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What would cause intrinsic factor to dissipate or not bind to elements in digestion, assuming no hereditary factors or gastric bypass?

Vitamin deficiency: old age and vitamin deficiency are believed to be causes of intrinsic factor loss. It remains crucial for b 12 uptake. The stomach has cells to help but the discovery of intrinsic factor dissipation or non uptake should be thoroughly discussed with your doctor . ...Read more